Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mori TA | Dietary n-3 PUFA and CVD: a review of the evidence. | 2014 | Proc Nutr Soc | pmid:24119287 |
Hua J et al. | The resolvin D1 analogue controls maturation of dendritic cells and suppresses alloimmunity in corneal transplantation. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25146982 |
Navarro-Guillén C et al. | Effect of varying dietary levels of LC-PUFA and vegetable oil sources on performance and fatty acids of Senegalese sole post larvae: puzzling results suggest complete biosynthesis pathway from C18 PUFA to DHA. | 2014 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:24120522 |
Fedorova-Dahms I et al. | A 3-week dietary bioequivalence study in preweaning farm piglets of two sources of docosahexaenoic acid produced from two different organisms. | 2014 | Food Chem. Toxicol. | pmid:24333867 |
Lee EJ et al. | Down-regulation of lipid raft-associated onco-proteins via cholesterol-dependent lipid raft internalization in docosahexaenoic acid-induced apoptosis. | 2014 | Biochim. Biophys. Acta | pmid:24120917 |
Fernández-González R et al. | Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. | 2014 | Sci. Total Environ. | pmid:24095964 |
Amiano P et al. | Intake of total omega-3 fatty acids, eicosapentaenoic acid and docosahexaenoic acid and risk of coronary heart disease in the Spanish EPIC cohort study. | 2014 | Nutr Metab Cardiovasc Dis | pmid:24360762 |
Huang X et al. | Serum and adipose tissue fatty acid composition as biomarkers of habitual dietary fat intake in elderly men with chronic kidney disease. | 2014 | Nephrol. Dial. Transplant. | pmid:23229929 |
Currais A et al. | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. | 2014 | Aging Cell | pmid:24341874 |
Fleming JA and Kris-Etherton PM | The evidence for α-linolenic acid and cardiovascular disease benefits: Comparisons with eicosapentaenoic acid and docosahexaenoic acid. | 2014 | Adv Nutr | pmid:25398754 |
Lager S et al. | Reply to "Letter to the editor: 'fatty acids and placental transport: insight or in vitro artifact?'". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452383 |
Keelan JA | Letter to the editor: "fatty acids and placental transport: insight or in vitro artifact?". | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25452382 |
Wales KM et al. | N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. | 2014 | PLoS ONE | pmid:25398022 |
Hsiao HM et al. | Resolvin D1 attenuates polyinosinic-polycytidylic acid-induced inflammatory signaling in human airway epithelial cells via TAK1. | 2014 | J. Immunol. | pmid:25320283 |
Hiram R et al. | Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:25281570 |
Arnardottir HH et al. | Aging delays resolution of acute inflammation in mice: reprogramming the host response with novel nano-proresolving medicines. | 2014 | J. Immunol. | pmid:25217168 |
Bremer AA et al. | Fish oil supplementation ameliorates fructose-induced hypertriglyceridemia and insulin resistance in adult male rhesus macaques. | 2014 | J. Nutr. | pmid:24108131 |
Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
Rodrigues PO et al. | Influence of feeding graded levels of canned sardines on the inflammatory markers and tissue fatty acid composition of Wistar rats. | 2014 | Br. J. Nutr. | pmid:24775714 |
Torok VA et al. | Influence of dietary docosahexaenoic acid supplementation on the overall rumen microbiota of dairy cows and linkages with production parameters. | 2014 | Can. J. Microbiol. | pmid:24779577 |
Burns-Whitmore B et al. | Effects of supplementing n-3 fatty acid enriched eggs and walnuts on cardiovascular disease risk markers in healthy free-living lacto-ovo-vegetarians: a randomized, crossover, free-living intervention study. | 2014 | Nutr J | pmid:24673793 |
Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
Al-Zaubai N et al. | Resolvin D2 supports MCF-7 cell proliferation via activation of estrogen receptor. | 2014 | J. Pharmacol. Exp. Ther. | pmid:25077525 |
Makrides M et al. | Four-year follow-up of children born to women in a randomized trial of prenatal DHA supplementation. | 2014 | JAMA | pmid:24794375 |
Jung JY et al. | Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. | 2014 | Acta Derm. Venereol. | pmid:24553997 |
Mirakaj V et al. | Vagus nerve controls resolution and pro-resolving mediators of inflammation. | 2014 | J. Exp. Med. | pmid:24863066 |
Chen R et al. | [Effects of docosahexaenoic acid on hypoxia-induced pulmonary arterial hypertension]. | 2014 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:24796591 |
Djoussé L et al. | Repeated versus single measurement of plasma omega-3 fatty acids and risk of heart failure. | 2014 | Eur J Nutr | pmid:24395612 |
Ooi SY and Andrews JM | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803245 |
Chan SS and Hart AR | Commentary: The association between high dietary intake of docosahexaenoic acid and reduced risk of Crohn's disease--authors' reply. | 2014 | Aliment. Pharmacol. Ther. | pmid:24803246 |
Betsholtz C | Physiology: Double function at the blood-brain barrier. | 2014 | Nature | pmid:24828036 |
Nguyen LN et al. | Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid. | 2014 | Nature | pmid:24828044 |
Chua A et al. | Effect of docosahexaenoic acid and furan fatty acids on cytokinesis block micronucleus cytome assay biomarkers in astrocytoma cell lines under conditions of oxidative stress. | 2014 | Environ. Mol. Mutagen. | pmid:24828973 |
Hong S et al. | Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25273880 |
Ma QL et al. | Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. | 2014 | J. Neurosci. | pmid:24849348 |
McCauley LK et al. | Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. | 2014 | J. Immunol. | pmid:24890726 |
Ramon S et al. | The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? | 2014 | J. Immunol. | pmid:25392529 |
Heemskerk MM et al. | Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile. | 2014 | J. Lipid Res. | pmid:25320342 |
Mulder KA et al. | Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. | 2014 | PLoS ONE | pmid:24427279 |
Portillo-Reyes V et al. | Clinical significance of neuropsychological improvement after supplementation with omega-3 in 8-12 years old malnourished Mexican children: a randomized, double-blind, placebo and treatment clinical trial. | 2014 | Res Dev Disabil | pmid:24508294 |
Oh DY et al. | A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice. | 2014 | Nat. Med. | pmid:24997608 |
Hughbanks-Wheaton DK et al. | Safety assessment of docosahexaenoic acid in X-linked retinitis pigmentosa: the 4-year DHAX trial. | 2014 | Invest. Ophthalmol. Vis. Sci. | pmid:25015354 |
Velten M et al. | Maternal dietary docosahexaenoic acid supplementation attenuates fetal growth restriction and enhances pulmonary function in a newborn mouse model of perinatal inflammation. | 2014 | J. Nutr. | pmid:24453131 |
Mereghetti P et al. | A Fourier transform infrared spectroscopy study of cell membrane domain modifications induced by docosahexaenoic acid. | 2014 | Biochim. Biophys. Acta | pmid:25018005 |
Lager S et al. | Differential regulation of placental amino acid transport by saturated and unsaturated fatty acids. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:25143349 |
Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
Purushothaman D et al. | Flaxseed oil supplementation alters the expression of inflammatory-related genes in dogs. | 2014 | Genet. Mol. Res. | pmid:25078588 |
Domenichiello AF et al. | Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats. | 2014 | J. Lipid Res. | pmid:24212299 |
Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Sato K et al. | Pharmacological evidence showing significant roles for potassium channels and CYP epoxygenase metabolites in the relaxant effects of docosahexaenoic acid on the rat aorta contracted with U46619. | 2014 | Biol. Pharm. Bull. | pmid:24369179 |
Nishinaka T et al. | Involvement of the long-chain fatty acid receptor GPR40 in depression-related behavior. | 2014 | J. Pharmacol. Sci. | pmid:24758921 |
Torres M et al. | Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease. | 2014 | Biochim. Biophys. Acta | pmid:24374316 |
Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
Nagao K et al. | Comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells. | 2014 | J Oleo Sci | pmid:25213447 |
De Felice C et al. | Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome. | 2014 | Neurobiol. Dis. | pmid:24769161 |
Aursnes M et al. | Total synthesis of the lipid mediator PD1n-3 DPA: configurational assignments and anti-inflammatory and pro-resolving actions. | 2014 | J. Nat. Prod. | pmid:24576195 |
Nobili V et al. | Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease. | 2014 | PLoS ONE | pmid:24505350 |
Tateishi N et al. | Dietary supplementation of arachidonic acid increases arachidonic acid and lipoxin Aâ‚„ contents in colon, but does not affect severity or prostaglandin Eâ‚‚ content in murine colitis model. | 2014 | Lipids Health Dis | pmid:24507383 |
Zhang M et al. | Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. | 2014 | J. Neurosci. | pmid:24478369 |
Kabeya N et al. | Modification of the n-3 HUFA biosynthetic pathway by transgenesis in a marine teleost, nibe croaker. | 2014 | J. Biotechnol. | pmid:24389067 |
Sengupta A and Ghosh M | Effect of sterol esters on lipid composition and antioxidant status of erythrocyte membrane of hypercholesterolemic rats. | 2014 | J Oleo Sci | pmid:24770475 |
Casanova E et al. | Epigallocatechin gallate counteracts oxidative stress in docosahexaenoxic acid-treated myocytes. | 2014 | Biochim. Biophys. Acta | pmid:24486445 |
Taltavull N et al. | Eicosapentaenoic acid/docosahexaenoic acid 1:1 ratio improves histological alterations in obese rats with metabolic syndrome. | 2014 | Lipids Health Dis | pmid:24512213 |
Nanjappa D et al. | Oxylipin diversity in the diatom family Leptocylindraceae reveals DHA derivatives in marine diatoms. | 2014 | Mar Drugs | pmid:24445306 |
Begum G et al. | Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. | 2014 | J. Neurosci. | pmid:24599472 |
Koppenol A et al. | Effect of the ratio of dietary n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid on broiler breeder performance, egg quality, and yolk fatty acid composition at different breeder ages. | 2014 | Poult. Sci. | pmid:24604849 |
Gil-Zamorano J et al. | Docosahexaenoic acid modulates the enterocyte Caco-2 cell expression of microRNAs involved in lipid metabolism. | 2014 | J. Nutr. | pmid:24623846 |
Buckley CD et al. | Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. | 2014 | Immunity | pmid:24656045 |
Cui ZG et al. | Molecular mechanisms of hyperthermia-induced apoptosis enhanced by docosahexaenoic acid: implication for cancer therapy. | 2014 | Chem. Biol. Interact. | pmid:24661947 |
Dayaker G et al. | Total synthesis of neuroprotectin D1 analogues derived from omega-6 docosapentaenoic acid (DPA) and adrenic acid (AdA) from a common pivotal, late-stage intermediate. | 2014 | J. Org. Chem. | pmid:24571431 |
Adarme-Vega TC et al. | Towards sustainable sources for omega-3 fatty acids production. | 2014 | Curr. Opin. Biotechnol. | pmid:24607804 |
Aronow ME and Chew EY | Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions. | 2014 | Curr Opin Ophthalmol | pmid:24614146 |
Martorell M et al. | Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. | 2014 | Food Funct | pmid:24955731 |
Røsjø E et al. | Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis. | 2014 | J. Neuroimmunol. | pmid:24713402 |
Koizumi K et al. | Lipid and fatty acids of three edible myctophids, Diaphus watasei, Diaphus suborbitalis, and Benthosema pterotum: high levels of icosapentaenoic and docosahexaenoic acids. | 2014 | J Oleo Sci | pmid:24717543 |
Xue M et al. | Docosahexaenoic acid inhibited the Wnt/β-catenin pathway and suppressed breast cancer cells in vitro and in vivo. | 2014 | J. Nutr. Biochem. | pmid:24290517 |
Kim W et al. | Dietary fish oil and DHA down-regulate antigen-activated CD4+ T-cells while promoting the formation of liquid-ordered mesodomains. | 2014 | Br. J. Nutr. | pmid:23962659 |
Levy BD and Serhan CN | Resolution of acute inflammation in the lung. | 2014 | Annu. Rev. Physiol. | pmid:24313723 |
Dendelé B et al. | Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway. | 2014 | Chem. Biol. Interact. | pmid:24246761 |
Murali G et al. | Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. | 2014 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24332315 |
Walhovd KB et al. | Blood markers of fatty acids and vitamin D, cardiovascular measures, body mass index, and physical activity relate to longitudinal cortical thinning in normal aging. | 2014 | Neurobiol. Aging | pmid:24332985 |
Eto M et al. | A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24333445 |
Nelson JW et al. | ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24259417 |
Zanfini A et al. | GC-EI-MS analysis of fatty acid composition in brain and serum of twitcher mouse. | 2014 | Lipids | pmid:25208498 |
Sertoglu E et al. | Comparison of plasma and erythrocyte membrane fatty acid compositions in patients with end-stage renal disease and type 2 diabetes mellitus. | 2014 | Chem. Phys. Lipids | pmid:24384240 |
Stoffel W et al. | Obesity resistance and deregulation of lipogenesis in Δ6-fatty acid desaturase (FADS2) deficiency. | 2014 | EMBO Rep. | pmid:24378641 |
Liu M et al. | Protectin DX, a double lipoxygenase product of DHA, inhibits both ROS production in human neutrophils and cyclooxygenase activities. | 2014 | Lipids | pmid:24254970 |
Shinohara M et al. | Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. | 2014 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25217660 |
Hutchins-Wiese HL et al. | High-dose eicosapentaenoic acid and docosahexaenoic acid supplementation reduces bone resorption in postmenopausal breast cancer survivors on aromatase inhibitors: a pilot study. | 2014 | Nutr Cancer | pmid:24274259 |
Hong S et al. | Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. | 2014 | Chem. Biol. | pmid:25200603 |
Yao QH et al. | ω-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro. | 2014 | Mol Med Rep | pmid:24276408 |
Jiang M et al. | Isolation and characterization of the diatom Phaeodactylum Δ5-elongase gene for transgenic LC-PUFA production in Pichia pastoris. | 2014 | Mar Drugs | pmid:24608969 |
Luxwolda MF et al. | Interrelationships between maternal DHA in erythrocytes, milk and adipose tissue. Is 1 wt% DHA the optimal human milk content? Data from four Tanzanian tribes differing in lifetime stable intakes of fish. | 2014 | Br. J. Nutr. | pmid:24175990 |
Gladine C et al. | Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. | 2014 | PLoS ONE | pmid:24558496 |
Hixson SM et al. | Changes in tissue lipid and fatty acid composition of farmed rainbow trout in response to dietary camelina oil as a replacement of fish oil. | 2014 | Lipids | pmid:24264359 |
Chen F et al. | Resolvin D1 improves survival in experimental sepsis through reducing bacterial load and preventing excessive activation of inflammatory response. | 2014 | Eur. J. Clin. Microbiol. Infect. Dis. | pmid:24072678 |
Park J et al. | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. | 2014 | PLoS ONE | pmid:24465474 |
Eady TN et al. | Docosahexaenoic acid complexed to albumin provides neuroprotection after experimental stroke in aged rats. | 2014 | Neurobiol. Dis. | pmid:24063996 |
Chang D et al. | Serum free fatty acids level in senile cataract. | 2014 | J Am Coll Nutr | pmid:25079310 |
Purcell R et al. | High-fat meals rich in EPA plus DHA compared with DHA only have differential effects on postprandial lipemia and plasma 8-isoprostane F2α concentrations relative to a control high-oleic acid meal: a randomized controlled trial. | 2014 | Am. J. Clin. Nutr. | pmid:25099540 |