| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypothyroidism | D007037 | 32 associated lipids |
| Vision Disorders | D014786 | 10 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Pain, Postoperative | D010149 | 13 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Davidson MH et al. | Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. | 1997 | J Am Coll Nutr | pmid:9176830 |
| Connor WE et al. | Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. | 1997 | J. Clin. Endocrinol. Metab. | pmid:9177405 |
| Shimura T et al. | Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). | 1997 | Biol. Pharm. Bull. | pmid:9178930 |
| Jones CR et al. | Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. | 1997 | Neurochem. Res. | pmid:9178948 |
| Ikemoto A et al. | Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. | 1997 | Neurochem. Res. | pmid:9178949 |
| Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
| Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9186612 |
| Innis SM and Dyer R | Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. | 1997 | J. Nutr. | pmid:9202085 |
| Petrukhina GN et al. | [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. | 1997 Mar-Apr | Eksp Klin Farmakol | pmid:9206567 |
| Murakami T et al. | Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9219094 |
| Reynaud D and Pace-Asciak CR | Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. | 1997 | Biochim. Biophys. Acta | pmid:9219915 |
| Hempenius RA et al. | Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. | 1997 | Food Chem. Toxicol. | pmid:9225015 |
| Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
| Panchenko VM et al. | [Effects of eifitol on lipid metabolism in patients with clinically different ischemic heart diseases]. | 1997 | Klin Med (Mosk) | pmid:9229613 |
| Huang ZH et al. | N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. | 1997 | Biochem. J. | pmid:9230140 |
| Takahashi M et al. | Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9230276 |
| Rotstein NP et al. | Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. | 1997 | J. Neurochem. | pmid:9231708 |
| Schønberg SA and Skorpen F | Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. | 1997 Jul-Aug | Anticancer Res. | pmid:9252660 |
| Oliveira FL et al. | Triglyceride hydrolysis of soy oil vs fish oil emulsions. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252949 |
| Vidgren HM et al. | Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. | 1997 | Lipids | pmid:9252957 |
| Kanazawa A et al. | Increased hepatic beta-oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid-enriched diet. | 1997 | Lipids | pmid:9252962 |
| Hishinuma T et al. | Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. | 1997 | Prostaglandins | pmid:9261859 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
| Weete JD et al. | Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. | 1997 | Lipids | pmid:9270975 |
| Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
| Grimsgaard S et al. | Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. | 1997 | Am. J. Clin. Nutr. | pmid:9280188 |
| Suzuki H et al. | Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9285258 |
| Carlson SE | Functional effects of increasing omega-3 fatty acid intake. | 1997 | J. Pediatr. | pmid:9290597 |
| Jensen CL et al. | Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. | 1997 | J. Pediatr. | pmid:9290604 |
| Van Elswyk ME | Comparison of n-3 fatty acid sources in laying hen rations for improvement of whole egg nutritional quality: a review. | 1997 | Br. J. Nutr. | pmid:9292775 |
| Brossard N et al. | Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. | 1997 | J. Lipid Res. | pmid:9300779 |
| Lovegrove JA et al. | Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. | 1997 | Br. J. Nutr. | pmid:9301413 |
| Colombo DT et al. | Comparison of hexadecylphosphocholine with fish oil as an antitumor agent. | 1997 | J Lipid Mediat Cell Signal | pmid:9302654 |
| Carvajal O and Angulo O | Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. | 1997 May-Jun | Salud Publica Mex | pmid:9304226 |
| Gibson RA et al. | Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. | 1997 | Eur J Clin Nutr | pmid:9306083 |
| Ratnayake WM et al. | Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. | 1997 | Br. J. Nutr. | pmid:9306886 |
| Halvorsen DS et al. | The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. | 1997 | Lipids | pmid:9307933 |
| Ikeda I et al. | Effects of triolein or oleic acid on lymphatic recovery of docosahexaenoic acid given as ethyl ester and their intramolecular distribution in lymph triglyceride of rats. | 1997 | Lipids | pmid:9307935 |
| Watanabe K et al. | Lipid and fatty acid compositions of a novel docosahexaenoic acid-producing marine bacterium. | 1997 | Lipids | pmid:9307940 |
| Singh RB et al. | Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: the Indian experiment of infarct survival--4. | 1997 | Cardiovasc Drugs Ther | pmid:9310278 |
| Abran D et al. | Metabolism of 4,7,10,13,16,19-docosahexaenoic acid in isolated perfused adult and newborn pig eyes. | 1997 | Biol. Neonate | pmid:9313833 |
| Crawford MA et al. | Are deficits of arachidonic and docosahexaenoic acids responsible for the neural and vascular complications of preterm babies? | 1997 | Am. J. Clin. Nutr. | pmid:9322584 |
| Frøyland L et al. | Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism. | 1997 | J. Lipid Res. | pmid:9323594 |
| Yamada N et al. | Changes in blood coagulation, platelet aggregation, and lipid metabolism in rats given lipids containing docosahexaenoic acid. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9339545 |
| Scherer JM et al. | Spleen cell survival and proliferation are differentially altered by docosahexaenoic acid. | 1997 | Cell. Immunol. | pmid:9341745 |
| Singh A and Ward OP | Microbial production of docosahexaenoic acid (DHA, C22:6). | 1997 | Adv. Appl. Microbiol. | pmid:9342829 |
| Atkinson TG et al. | DHA feeding provides host protection and prevents fibrosarcoma-induced hyperlipidemia while maintaining the tumor response to araC in Fischer 344 rats. | 1997 | Nutr Cancer | pmid:9343830 |
| Aguirre GD et al. | Diets enriched in docosahexaenoic acid fail to correct progressive rod-cone degeneration (prcd) phenotype. | 1997 | Invest. Ophthalmol. Vis. Sci. | pmid:9344362 |
| Durot I et al. | Influence of phospholipid long chain polyunsaturated fatty acid composition on neonatal rat cardiomyocyte function in physiological conditions and during glucose-free hypoxia-reoxygenation. | 1997 | Mol. Cell. Biochem. | pmid:9350058 |
| Dharmsthiti S and Ammaranond P | Purification and characterization of lipase from a raw-milk yeast (Trichosporon asteroides). | 1997 | Biotechnol. Appl. Biochem. | pmid:9357107 |