| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypothyroidism | D007037 | 32 associated lipids |
| Vision Disorders | D014786 | 10 associated lipids |
| Melanoma | D008545 | 69 associated lipids |
| Pain, Postoperative | D010149 | 13 associated lipids |
| Asthma | D001249 | 52 associated lipids |
| Kidney Diseases | D007674 | 29 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Calviello G et al. | Low-dose eicosapentaenoic or docosahexaenoic acid administration modifies fatty acid composition and does not affect susceptibility to oxidative stress in rat erythrocytes and tissues. | 1997 | Lipids | pmid:9358434 |
| Herzberg GR and Skinner C | Differential accumulation and release of long-chain n-3 fatty acids from liver, muscle, and adipose tissue triacylglycerols. | 1997 | Can. J. Physiol. Pharmacol. | pmid:9360007 |
| Boehm G et al. | Docosahexaenoic and arachidonic acid absorption in preterm infants fed LCP-free or LCP-supplemented formula in comparison to infants fed fortified breast milk. | 1997 | Ann. Nutr. Metab. | pmid:9363295 |
| Schønberg SA et al. | Evidence that changes in Se-glutathione peroxidase levels affect the sensitivity of human tumour cell lines to n-3 fatty acids. | 1997 | Carcinogenesis | pmid:9363997 |
| Paulsen JE et al. | A fish oil derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl ester suppresses the formation and growth of intestinal polyps in the Min mouse. | 1997 | Carcinogenesis | pmid:9363998 |
| Takahashi M et al. | Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9364003 |
| Mizutani M et al. | Omega-3 polyunsaturated fatty acids inhibit migration of human vascular smooth muscle cells in vitro. | 1997 | Life Sci. | pmid:9364203 |
| Garcia MC and Kim HY | Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells. | 1997 | Brain Res. | pmid:9369299 |
| Goldberg EM and Zidovetzki R | Effects of dipalmitoylglycerol and fatty acids on membrane structure and protein kinase C activity. | 1997 | Biophys. J. | pmid:9370455 |
| Raclot T et al. | Site-specific regulation of gene expression by n-3 polyunsaturated fatty acids in rat white adipose tissues. | 1997 | J. Lipid Res. | pmid:9374119 |
| Katan MB et al. | Kinetics of the incorporation of dietary fatty acids into serum cholesteryl esters, erythrocyte membranes, and adipose tissue: an 18-month controlled study. | 1997 | J. Lipid Res. | pmid:9374124 |
| Minami M et al. | Effects of dietary docosahexaenoic acid on survival time and stroke-related behavior in stroke-prone spontaneously hypertensive rats. | 1997 | Gen. Pharmacol. | pmid:9378247 |
| Suzuki I et al. | Inhibitory effects of oleic and docosahexaenoic acids on lung metastasis by colon-carcinoma-26 cells are associated with reduced matrix metalloproteinase-2 and -9 activities. | 1997 | Int. J. Cancer | pmid:9389579 |
| Kubo K et al. | Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexaenoic acid and vitamin E. | 1997 | Br. J. Nutr. | pmid:9389890 |
| Garcia MC et al. | Effects of chronic ethanol on the mobilization of arachidonate and docosahexaenoate stimulated by the type 2A serotonin receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride in C6 glioma cells. | 1997 | Alcohol. Clin. Exp. Res. | pmid:9394119 |
| Clandinin MT et al. | Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: fatty acid composition of erythrocyte membrane lipids. | 1997 | Pediatr. Res. | pmid:9396564 |
| Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
| Nelson GJ et al. | The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans. | 1997 | Lipids | pmid:9397397 |
| Nelson GJ et al. | The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. | 1997 | Lipids | pmid:9397398 |
| Minami M et al. | Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408223 |
| Wu X et al. | Demonstration of biphasic effects of docosahexaenoic acid on apolipoprotein B secretion in HepG2 cells. | 1997 | Arterioscler. Thromb. Vasc. Biol. | pmid:9409332 |
| van Niel MH and Beynen AC | The intake of polyunsaturated fatty acids by cats is reflected in their adipose tissue. | 1997 | Vet Q | pmid:9413110 |
| Anil K et al. | Effect of n-3 fatty acids on VLDL production by hepatocytes is mediated through prostaglandins. | 1997 | Biochem. Mol. Biol. Int. | pmid:9415816 |
| Kelso KA et al. | The effects of dietary supplementation with docosahexaenoic acid on the phospholipid fatty acid composition of avian spermatozoa. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9417994 |
| Garcia MC et al. | Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells. | 1998 | J. Neurochem. | pmid:9422343 |
| Achard F et al. | Eicosapentaenoic and docosahexaenoic acids reduce PGH synthase 1 expression in bovine aortic endothelial cells. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9425302 |
| Frøyland L et al. | Hypotriacylglycerolemic component of fish oil. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430383 |
| Agren JJ et al. | Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430389 |
| Yasuda S et al. | Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. | 1997 | Lipids | pmid:9438234 |
| Song JH et al. | Oxidative stability of docosahexaenoic acid-containing oils in the form of phospholipids, triacylglycerols, and ethyl esters. | 1997 | Biosci. Biotechnol. Biochem. | pmid:9438988 |
| Baur LA et al. | The fatty acid composition of skeletal muscle membrane phospholipid: its relationship with the type of feeding and plasma glucose levels in young children. | 1998 | Metab. Clin. Exp. | pmid:9440487 |
| Campan P et al. | Pilot study on n-3 polyunsaturated fatty acids in the treatment of human experimental gingivitis. | 1997 | J. Clin. Periodontol. | pmid:9442428 |
| Nourooz-Zadeh J et al. | F4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid (DHA). | 1998 | Biochem. Biophys. Res. Commun. | pmid:9446796 |
| Ding C et al. | Changes in fatty acid profile in plasma and very low density lipoprotein lipids after fish oil supplementation. | 1997 | Biochem. Soc. Trans. | pmid:9450114 |
| Murphy MG et al. | Diets enriched in menhaden fish oil, seal oil, or shark liver oil have distinct effects on the lipid and fatty-acid composition of guinea pig heart. | 1997 | Mol. Cell. Biochem. | pmid:9450671 |
| Crawford MA et al. | The inadequacy of the essential fatty acid content of present preterm feeds. | 1998 | Eur. J. Pediatr. | pmid:9462903 |
| Zheng Z et al. | Effect of ganglioside GM1 on ethanol-induced changes in the incorporation of free fatty acids into membrane phospholipids in mouse brain. | 1997 Nov-Dec | Alcohol Alcohol. | pmid:9463723 |
| Yamane M et al. | Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2. | 1998 | Cancer Lett. | pmid:9464491 |
| Germain E et al. | Enhancement of doxorubicin cytotoxicity by polyunsaturated fatty acids in the human breast tumor cell line MDA-MB-231: relationship to lipid peroxidation. | 1998 | Int. J. Cancer | pmid:9466659 |
| Mani I et al. | Upregulation of nuclear PKC and MAP-kinase during hyperproliferation of guinea pig epidermis: modulation by 13-(S)-hydroxyoctadecadienoic acid (13-HODE). | 1998 | Cell. Signal. | pmid:9481490 |
| Das UN et al. | Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482165 |
| Prasad MR et al. | Regional membrane phospholipid alterations in Alzheimer's disease. | 1998 | Neurochem. Res. | pmid:9482271 |
| Nieuwenhuys CM and Hornstra G | The effects of purified eicosapentaenoic and docosahexaenoic acids on arterial thrombosis tendency and platelet function in rats. | 1998 | Biochim. Biophys. Acta | pmid:9487152 |
| Ramesh G and Das UN | Effect of cis-unsaturated fatty acids on Meth-A ascitic tumour cells in vitro and in vivo. | 1998 | Cancer Lett. | pmid:9489490 |
| Calviello G et al. | Dietary supplementation with eicosapentaenoic and docosahexaenoic acid inhibits growth of Morris hepatocarcinoma 3924A in rats: effects on proliferation and apoptosis. | 1998 | Int. J. Cancer | pmid:9495237 |
| Alessandri JM et al. | Docosahexaenoic acid concentrations in retinal phospholipids of piglets fed an infant formula enriched with long-chain polyunsaturated fatty acids: effects of egg phospholipids and fish oils with different ratios of eicosapentaenoic acid to docosahexaenoic acid. | 1998 | Am. J. Clin. Nutr. | pmid:9497179 |
| Hirafuji M et al. | [Specific modulation of vascular smooth muscle cell functions by docosahexaenoic acid]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503427 |
| Woltil HA et al. | Long-chain polyunsaturated fatty acid status and early growth of low birth weight infants. | 1998 | Eur. J. Pediatr. | pmid:9504790 |
| Morita N and Shirai J | Effects of microcapsulated docosahexaenoic acid preparation on properties of dough and bread. | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9505244 |
| Hansen JB et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. | 1998 | Lipids | pmid:9507234 |