DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hypothyroidism D007037 32 associated lipids
Vision Disorders D014786 10 associated lipids
Melanoma D008545 69 associated lipids
Pain, Postoperative D010149 13 associated lipids
Asthma D001249 52 associated lipids
Kidney Diseases D007674 29 associated lipids
Weight Gain D015430 101 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Glioma D005910 112 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Innis SM et al. Marine and freshwater fish oil varying in arachidonic, eicosapentaenoic and docosahexaenoic acids differ in their effects on organ lipids and fatty acids in growing rats. 1995 J. Nutr. pmid:7666244
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Romon M et al. Comparison between fat intake assessed by a 3-day food record and phospholipid fatty acid composition of red blood cells: results from the Monitoring of Cardiovascular Disease-Lille Study. 1995 Metab. Clin. Exp. pmid:7666786
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Maehle L et al. Effects of n-3 fatty acids during neoplastic progression and comparison of in vitro and in vivo sensitivity of two human tumour cell lines. 1995 Br. J. Cancer pmid:7710930
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Kirmani ZA et al. Effects of supplemented omega-3 and omega-6 fatty acid rich oils on the cardiovascular system of thermally injured rabbits: changes in plasma and platelet fatty acids. 1995 Mar-Apr J Burn Care Rehabil pmid:7775514
Noguchi M et al. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. 1995 Jul-Aug Oncology pmid:7777237
Denzlinger C et al. Modulation of the endogenous leukotriene production by fish oil and vitamin E. 1995 J Lipid Mediat Cell Signal pmid:7780681
Leaf A Omega-3 fatty acids and prevention of ventricular fibrillation. 1995 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:7784457
Shimizu S et al. omega-Hydroxylation of docosahexaenoic acid or arachidonic acid in human colonic well differentiated adenocarcinoma homogenate. 1995 Biochim. Biophys. Acta pmid:7786890
Burdge GC and Postle AD Effect of maternal ethanol consumption during pregnancy on the phospholipid molecular species composition of fetal guinea-pig brain, liver and plasma. 1995 Biochim. Biophys. Acta pmid:7786898
Jenski LJ et al. Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine splenocytes. 1995 Biochim. Biophys. Acta pmid:7794954
Zerouga M et al. Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers. 1995 Biochim. Biophys. Acta pmid:7794965
Kinoshita K et al. Inhibitory effects of purified eicosapentaenoic acid and docosahexaenoic acid on growth and metastasis of murine transplantable mammary tumor. 1994 May-Jun In Vivo pmid:7803721
Mallampalli RK et al. Regulation of CTP:choline-phosphate cytidylyltransferase by polyunsaturated n-3 fatty acids. 1994 Am. J. Physiol. pmid:7810669
Kim HY et al. Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization. 1994 Anal. Chem. pmid:7810900
Roche H and Gibney MJ The effect of consumption of fish oil-enriched spreadable fats on platelet phospholipid fatty acid composition in human volunteers. 1994 Int J Vitam Nutr Res pmid:7814240
Khair-el-Din TA et al. Docosahexaenoic acid, a major constituent of fetal serum and fish oil diets, inhibits IFN gamma-induced Ia-expression by murine macrophages in vitro. 1995 J. Immunol. pmid:7822798
Petroni A et al. Inhibition by n-3 fatty acids of arachidonic acid metabolism in a primary culture of astroglial cells. 1994 Neurochem. Res. pmid:7824073
Gazzah N et al. Evidence for brain docosahexaenoate recycling in the free-moving adult rat: implications for measurement of phospholipid synthesis. 1994 Neurosci. Lett. pmid:7824158
Das UN Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824535
Christensen MS et al. Intestinal absorption and lymphatic transport of eicosapentaenoic (EPA), docosahexaenoic (DHA), and decanoic acids: dependence on intramolecular triacylglycerol structure. 1995 Am. J. Clin. Nutr. pmid:7825539
Delton I et al. Distribution and metabolism of arachidonic and docosahexaenoic acids in rat pineal cells. Effect of norepinephrine. 1995 Biochim. Biophys. Acta pmid:7827119
Gazzah N et al. Decrease of brain phospholipid synthesis in free-moving n-3 fatty acid deficient rats. 1995 J. Neurochem. pmid:7830085
Bazan NG and Rodriguez de Turco EB Review: pharmacological manipulation of docosahexaenoic-phospholipid biosynthesis in photoreceptor cells: implications in retinal degeneration. 1994 J Ocul Pharmacol pmid:7836869
Kurlandsky LE et al. The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. 1994 Pediatr. Pulmonol. pmid:7838619
Popp-Snijders C and Blonk MC Omega-3 fatty acids in adipose tissue of obese patients with non-insulin-dependent diabetes mellitus reflect long-term dietary intake of eicosapentaenoic and docosahexaenoic acid. 1995 Am. J. Clin. Nutr. pmid:7840075
Terasawa F et al. Effects of dietary casein and soy-protein on metabolic conversion of eicosapentaenoic acid to docosahexaenoic acid in the liver of rat. 1994 J. Nutr. Sci. Vitaminol. pmid:7844642
Yamashiro Y et al. Docosahexaenoic acid status of patients with extrahepatic biliary atresia. 1994 J. Pediatr. Surg. pmid:7844720
Vaidyanathan VV et al. Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. 1994 Neurosci. Lett. pmid:7845615
Lokesh BR and Kinsella JE Effects of n-3 polyunsaturated fatty acids on the reacylation of arachidonic acid in peritoneal macrophages. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7846090
Alexander-North LS et al. Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells. 1994 J. Lipid Res. pmid:7852854
Al MD et al. The relationship between the essential fatty acid status of mother and child and the occurrence of pregnancy-induced hypertension. Intermediate results of a prospective longitudinal study. 1994 World Rev Nutr Diet pmid:7856218
Tessier C et al. Docosahexaenoic acid is a potent inhibitor of rat uterine stromal cell proliferation. 1995 Biochem. Biophys. Res. Commun. pmid:7864887
Poling JS et al. Time- and voltage-dependent block of delayed rectifier potassium channels by docosahexaenoic acid. 1995 Mol. Pharmacol. pmid:7870048
Chen LY et al. Reduction in human neutrophil superoxide anion generation by n-3 polyunsaturated fatty acids: role of cyclooxygenase products and endothelium-derived relaxing factor. 1994 Thromb. Res. pmid:7871491
Bazan NG et al. Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. 1994 World Rev Nutr Diet pmid:7871812
Anderson RE et al. The accretion of docosahexaenoic acid in the retina. 1994 World Rev Nutr Diet pmid:7871813
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Santos MJ et al. Influence of dietary supplementation with fish on plasma fatty acid composition in coronary heart disease patients. 1995 Ann. Nutr. Metab. pmid:7872656
Purasiri P et al. Modulation of cytokine production in vivo by dietary essential fatty acids in patients with colorectal cancer. 1994 Clin. Sci. pmid:7874864
Gibney MJ and Daly E The incorporation of n-3 polyunsaturated fatty acids into plasma lipid and lipoprotein fractions in the postprandial phase in healthy volunteers. 1994 Eur J Clin Nutr pmid:7889895
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Ghebremeskel K et al. Fatty acid composition of plasma and red cell phospholipids of preterm babies fed on breast milk and formulae. 1995 Eur. J. Pediatr. pmid:7895755
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Anderson GJ and Connor WE Accretion of n-3 fatty acids in the brain and retina of chicks fed a low-linolenic acid diet supplemented with docosahexaenoic acid. 1994 Am. J. Clin. Nutr. pmid:7911000
Makrides M et al. Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. 1994 Am. J. Clin. Nutr. pmid:7913291
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Tremoli E et al. n-3 fatty acid ethyl ester administration to healthy subjects and to hypertriglyceridemic patients reduces tissue factor activity in adherent monocytes. 1994 Arterioscler. Thromb. pmid:7918310
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Ikeda I et al. alpha-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. 1994 J. Nutr. pmid:7931698
Karanian JW et al. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619)-induced smooth muscle contraction. 1994 J. Pharmacol. Exp. Ther. pmid:7932158
Kang JX and Leaf A Effects of long-chain polyunsaturated fatty acids on the contraction of neonatal rat cardiac myocytes. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:7937911
Eritsland J et al. Long-term effects of n-3 fatty acids on serum lipids and glycaemic control. 1994 Scand. J. Clin. Lab. Invest. pmid:7939369
Anti M et al. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas. 1994 Gastroenterology pmid:7958682
Saito M and Nakatsugawa K Increased susceptibility of liver to lipid peroxidation after ingestion of a high fish oil diet. 1994 Int J Vitam Nutr Res pmid:7960494
Carlson SE Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials. 1994 J. Pediatr. pmid:7965451
Gibson RA et al. Ratios of linoleic acid to alpha-linolenic acid in formulas for term infants. 1994 J. Pediatr. pmid:7965453
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Yano Y et al. Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. 1994 Lipids pmid:7968276
Imre SG et al. Increased proportion of docosahexanoic acid and high lipid peroxidation capacity in erythrocytes of stroke patients. 1994 Stroke pmid:7974583
Thies F et al. Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain. 1994 Am. J. Physiol. pmid:7977854
Brossard N et al. Stable isotope tracer and gas-chromatography combustion isotope ratio mass spectrometry to study the in vivo compartmental metabolism of docosahexaenoic acid. 1994 Anal. Biochem. pmid:7978245
Bright JM et al. The effects of n-3 fatty acid supplementation on bleeding time, plasma fatty acid composition, and in vitro platelet aggregation in cats. 1994 Jul-Aug J. Vet. Intern. Med. pmid:7983618
Belluzzi A et al. Effects of new fish oil derivative on fatty acid phospholipid-membrane pattern in a group of Crohn's disease patients. 1994 Dig. Dis. Sci. pmid:7995183
Carlson SE et al. Long-chain fatty acids and early visual and cognitive development of preterm infants. 1994 Eur J Clin Nutr pmid:7995262
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Sacks FM et al. Short report: the effect of fish oil on blood pressure and high-density lipoprotein-cholesterol levels in phase I of the Trials of Hypertension Prevention. 1994 J. Hypertens. pmid:8021472
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Wang H et al. The effects of n-3 fatty acids on the secretion of carboxyl-terminally truncated forms of human apoprotein B. 1994 J. Biol. Chem. pmid:8034600
Felouati BE et al. Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct: specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine. 1994 Biochem. J. pmid:8042978