Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Ng Y et al. | The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. | 2005 | Carcinogenesis | pmid:15975958 |
Tonon T et al. | Fatty acid desaturases from the microalga Thalassiosira pseudonana. | 2005 | FEBS J. | pmid:15978045 |
Puglia C et al. | In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts. | 2005 | Int J Pharm | pmid:15979259 |
Blankenship J | Increasing maternal docosahexaenoic acid levels. | 2005 | J Am Diet Assoc | pmid:15983528 |
Schley PD et al. | Mechanisms of omega-3 fatty acid-induced growth inhibition in MDA-MB-231 human breast cancer cells. | 2005 | Breast Cancer Res. Treat. | pmid:15986129 |
Bazinet RP et al. | Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. | 2005 | Psychopharmacology (Berl.) | pmid:15986187 |
Guizy M et al. | {Omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15987770 |
Otsuka K et al. | Comparison of the inhibitory effects of docosahexaenoic acid (DHA) on U46619- and phenylephrine-induced contractions in guinea-pig aorta. | 2005 | Biol. Pharm. Bull. | pmid:15997118 |
Jensen CL et al. | Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. | 2005 | Am. J. Clin. Nutr. | pmid:16002810 |
Judé S et al. | Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. | 2006 Jan-Apr | Prog. Biophys. Mol. Biol. | pmid:16005051 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. | 2005 | Pediatr. Res. | pmid:16006428 |
Heird WC and Lapillonne A | The role of essential fatty acids in development. | 2005 | Annu. Rev. Nutr. | pmid:16011478 |
Lu J et al. | [Analysis of fatty acids in tissues of Penaeus vannamei cultured in sea- and fresh-waters by ultrasonic extraction-capillary gas chromatography]. | 2005 | Se Pu | pmid:16013568 |
Hoff S et al. | Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. | 2005 | Eur J Clin Nutr | pmid:16015268 |
Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
Morais S et al. | Dietary protein:lipid ratio and lipid nature affects fatty acid absorption and metabolism in a teleost larva. | 2005 | Br. J. Nutr. | pmid:16022750 |
Leonardi F et al. | Effect of arachidonic, eicosapentaenoic and docosahexaenoic acids on the oxidative status of C6 glioma cells. | 2005 | Free Radic. Res. | pmid:16036367 |
Feller SE and Gawrisch K | Properties of docosahexaenoic-acid-containing lipids and their influence on the function of rhodopsin. | 2005 | Curr. Opin. Struct. Biol. | pmid:16039844 |
Akbar M et al. | Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:16040805 |
André A et al. | Plasmalogen metabolism-related enzymes in rat brain during aging: influence of n-3 fatty acid intake. | 2006 | Biochimie | pmid:16046045 |
Ajuwon KM and Spurlock ME | Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. | 2005 | J. Nutr. | pmid:16046706 |
Yoshizawa K and Tsubura A | [Characteristics of N-methyl-N-nitrosourea-induced retinal degeneration in animals and application for the therapy of human retinitis pigmentosa]. | 2005 | Nippon Ganka Gakkai Zasshi | pmid:16047940 |
Bou R et al. | Effect of dietary fat sources and zinc and selenium supplements on the composition and consumer acceptability of chicken meat. | 2005 | Poult. Sci. | pmid:16050130 |
Wang Y et al. | Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate. | 2005 | Bioorg. Med. Chem. | pmid:16084097 |
McCann JC and Ames BN | Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. | 2005 | Am. J. Clin. Nutr. | pmid:16087970 |
Rosell MS et al. | Long-chain n-3 polyunsaturated fatty acids in plasma in British meat-eating, vegetarian, and vegan men. | 2005 | Am. J. Clin. Nutr. | pmid:16087975 |
Valenzuela A et al. | Tissue accretion and milk content of docosahexaenoic acid in female rats after supplementation with different docosahexaenoic acid sources. | 2005 Sep-Oct | Ann. Nutr. Metab. | pmid:16088098 |
Morita N et al. | Cultivation of microorganisms in the cultural medium made from squid internal organs and accumulation of polyunsaturated fatty acids in the cells. | 2005 | Biotechnol. Lett. | pmid:16091889 |
Demar JC et al. | alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. | 2005 | J. Neurochem. | pmid:16092947 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion. | 2006 | J. Nutr. Biochem. | pmid:16098734 |
Calon F et al. | Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. | 2005 | Eur. J. Neurosci. | pmid:16101743 |
Watkins BA et al. | Dietary ratio of n-6/n-3 PUFAs and docosahexaenoic acid: actions on bone mineral and serum biomarkers in ovariectomized rats. | 2006 | J. Nutr. Biochem. | pmid:16102959 |
Li Y et al. | Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis. | 2005 | J. Lipid Res. | pmid:16106047 |
Mahéo K et al. | Differential sensitization of cancer cells to doxorubicin by DHA: a role for lipoperoxidation. | 2005 | Free Radic. Biol. Med. | pmid:16109304 |
Donnelly SM et al. | Effect of n-3 fatty acids from fish oil on hemostasis, blood pressure, and lipid profile of dialysis patients. | 1992 | J. Am. Soc. Nephrol. | pmid:1610984 |
Cao D et al. | Effects of docosahexaenoic acid on the survival and neurite outgrowth of rat cortical neurons in primary cultures. | 2005 | J. Nutr. Biochem. | pmid:16115542 |
Hart SL et al. | Brief report: newborn behavior differs with decosahexaenoic acid levels in breast milk. | 2006 | J Pediatr Psychol | pmid:16120762 |
Thiébaut AC et al. | [Unsaturated fatty acids intake and breast cancer risk: epidemiological data review]. | 2005 | Bull Cancer | pmid:16123005 |
Esquenazi S et al. | Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16123410 |
Taha AY et al. | Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats. | 2005 | Metab. Clin. Exp. | pmid:16125522 |
Lim SY et al. | An extraordinary degree of structural specificity is required in neural phospholipids for optimal brain function: n-6 docosapentaenoic acid substitution for docosahexaenoic acid leads to a loss in spatial task performance. | 2005 | J. Neurochem. | pmid:16135079 |
Decsi T et al. | Effect of N-3 polyunsaturated fatty acid supplementation in pregnancy: the Nuheal trial. | 2005 | Adv. Exp. Med. Biol. | pmid:16137113 |
Machida T et al. | Docosahexaenoic acid enhances cyclooxygenase-2 induction by facilitating p44/42, but not p38, mitogen-activated protein kinase activation in rat vascular smooth muscle cells. | 2005 | J. Pharmacol. Sci. | pmid:16141635 |
Dalfó E et al. | Evidence of oxidative stress in the neocortex in incidental Lewy body disease. | 2005 | J. Neuropathol. Exp. Neurol. | pmid:16141792 |
Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
Butovich IA | On the structure and synthesis of neuroprotectin D1, a novel anti-inflammatory compound of the docosahexaenoic acid family. | 2005 | J. Lipid Res. | pmid:16150835 |
Lukiw WJ et al. | A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. | 2005 | J. Clin. Invest. | pmid:16151530 |
Lee KW et al. | Effects of omega-3 polyunsaturated fatty acids on plasma indices of thrombogenesis and inflammation in patients post-myocardial infarction. | 2006 | Thromb. Res. | pmid:16154181 |
Kruger MC and Schollum LM | Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16154334 |
Vaculová A et al. | TRAIL and docosahexaenoic acid cooperate to induce HT-29 colon cancer cell death. | 2005 | Cancer Lett. | pmid:16157217 |
Oda E et al. | A case-control pilot study on n-3 polyunsaturated fatty acid as a negative risk factor for myocardial infarction. | 2005 | Int Heart J | pmid:16157949 |
Hashimoto M et al. | Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16165346 |
Siddiqui RA et al. | Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells. | 2005 | Breast Cancer Res. | pmid:16168109 |
Lina BA et al. | Subchronic (13-week) oral toxicity study, preceded by an in utero exposure phase, with arachidonate-enriched triglyceride oil (SUNTGA40S) in rats. | 2006 | Food Chem. Toxicol. | pmid:16168548 |
Zhao G et al. | Anti-inflammatory effects of polyunsaturated fatty acids in THP-1 cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16169525 |
Bairati I et al. | Effects of a fish oil supplement on blood pressure and serum lipids in patients treated for coronary artery disease. | 1992 Jan-Feb | Can J Cardiol | pmid:1617510 |
Lee HJ et al. | Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. | 2005 | Neurochem. Res. | pmid:16176072 |
Bazan NG et al. | Brain response to injury and neurodegeneration: endogenous neuroprotective signaling. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179516 |
Bazinet RP et al. | Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. | 2006 | Biol. Psychiatry | pmid:16182257 |
Dentin R et al. | Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation. | 2005 | J. Clin. Invest. | pmid:16184193 |
Lauritzen L et al. | Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188206 |
Young GS et al. | Effect of randomized supplementation with high dose olive, flax or fish oil on serum phospholipid fatty acid levels in adults with attention deficit hyperactivity disorder. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188207 |
Stillwell W et al. | Docosahexaenoic acid affects cell signaling by altering lipid rafts. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188208 |
Burdge GC and Calder PC | Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188209 |
Sergeeva M et al. | Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. | 2005 Sep-Oct | Reprod. Nutr. Dev. | pmid:16188212 |
Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
Lim SY et al. | N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks. | 2005 | Pediatr. Res. | pmid:16189203 |
Erkkilä AT et al. | Association between school performance, breast milk intake and fatty acid profile of serum lipids in ten-year-old cleft children. | 2005 | J Craniofac Surg | pmid:16192854 |
Xiao Y et al. | Distribution, depletion and recovery of docosahexaenoic acid are region-specific in rat brain. | 2005 | Br. J. Nutr. | pmid:16197579 |
Itoh T et al. | Synthesis of docosahexaenoic acid derivatives designed as novel PPARgamma agonists and antidiabetic agents. | 2006 | Bioorg. Med. Chem. | pmid:16198578 |
Pardini RS et al. | Nutritional intervention with omega-3 Fatty acids in a case of malignant fibrous histiocytoma of the lungs. | 2005 | Nutr Cancer | pmid:16201843 |
Merendino N et al. | Docosahexaenoic acid induces apoptosis in the human PaCa-44 pancreatic cancer cell line by active reduced glutathione extrusion and lipid peroxidation. | 2005 | Nutr Cancer | pmid:16201853 |
Flachs P et al. | Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. | 2005 | Diabetologia | pmid:16205884 |
Marszalek JR and Lodish HF | Docosahexaenoic acid, fatty acid-interacting proteins, and neuronal function: breastmilk and fish are good for you. | 2005 | Annu. Rev. Cell Dev. Biol. | pmid:16212510 |
Cao D et al. | Chronic administration of ethyl docosahexaenoate decreases mortality and cerebral edema in ischemic gerbils. | 2005 | Life Sci. | pmid:16214179 |
Eitsuka T et al. | Polyunsaturated fatty acids inhibit telomerase activity in DLD-1 human colorectal adenocarcinoma cells: a dual mechanism approach. | 2005 | Biochim. Biophys. Acta | pmid:16216547 |
Ariel A et al. | The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. | 2005 | J. Biol. Chem. | pmid:16216871 |
Ly LH et al. | Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16221546 |
Botolin D et al. | Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways. | 2006 | J. Lipid Res. | pmid:16222032 |
Lloyd-Still JD et al. | Bioavailability and safety of a high dose of docosahexaenoic acid triacylglycerol of algal origin in cystic fibrosis patients: a randomized, controlled study. | 2006 | Nutrition | pmid:16226012 |
Gregor JI et al. | Does enteral nutrition of dietary polyunsaturated fatty acids promote oxidative stress and tumour growth in ductal pancreatic cancer? Experimental trial in Syrian Hamster. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16226437 |
Mjøs SA | Properties of trans isomers of eicosapentaenoic acid and docosahexaenoic acid methyl esters on cyanopropyl stationary phases. | 2005 | J Chromatogr A | pmid:16236287 |
Markesbery WR et al. | Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. | 2005 | Ann. Neurol. | pmid:16240347 |
Cohen JT et al. | A quantitative analysis of prenatal intake of n-3 polyunsaturated fatty acids and cognitive development. | 2005 | Am J Prev Med | pmid:16242603 |
Chen W et al. | Anti-inflammatory effect of docosahexaenoic acid on cytokine-induced adhesion molecule expression in human retinal vascular endothelial cells. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:16249517 |
Yu-Poth S et al. | Long-chain polyunsaturated fatty acids upregulate LDL receptor protein expression in fibroblasts and HepG2 cells. | 2005 | J. Nutr. | pmid:16251608 |
Foran JA et al. | Quantitative analysis of the benefits and risks of consuming farmed and wild salmon. | 2005 | J. Nutr. | pmid:16251623 |
Mihailescu M and Gawrisch K | The structure of polyunsaturated lipid bilayers important for rhodopsin function: a neutron diffraction study. | 2006 | Biophys. J. | pmid:16258049 |
Milatovic D et al. | Suppression of murine cerebral F2-isoprostanes and F4-neuroprostanes from excitotoxicity and innate immune response in vivo by alpha- or gamma-tocopherol. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16260380 |
Omega-3 polyunsaturated fatty acids (Omacor) for hypertriglyceridemia. | 2005 | Med Lett Drugs Ther | pmid:16267495 | |
Okuyama H | [Need to change the direction of cholesterol-related medication--a problem of great urgency]. | 2005 | Yakugaku Zasshi | pmid:16272805 |
Wu K et al. | [Effects of phytohormones on growth and DHA production by Thraustochytrium roseum]. | 2003 | Wei Sheng Wu Xue Bao | pmid:16276880 |
Wu WH et al. | Effects of docosahexaenoic acid supplementation on blood lipids, estrogen metabolism, and in vivo oxidative stress in postmenopausal vegetarian women. | 2006 | Eur J Clin Nutr | pmid:16278686 |
Umhau JC et al. | The relationship between folate and docosahexaenoic acid in men. | 2006 | Eur J Clin Nutr | pmid:16278690 |
Nirmalananthan N and Greensmith L | Amyotrophic lateral sclerosis: recent advances and future therapies. | 2005 | Curr. Opin. Neurol. | pmid:16280684 |
Friesen R and Innis SM | Maternal dietary fat alters amniotic fluid and fetal intestinal membrane essential n-6 and n-3 fatty acids in the rat. | 2006 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:16282365 |
Li HX and Yang GS | [Effects of docosahexaenoic acid on rat adipocytes proliferation and differentiation]. | 2005 | Sheng Wu Gong Cheng Xue Bao | pmid:16285532 |
Howe P et al. | Dietary intake of long-chain omega-3 polyunsaturated fatty acids: contribution of meat sources. | 2006 | Nutrition | pmid:16289978 |
Geppert J et al. | Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. | 2005 | Lipids | pmid:16296399 |
Hirunpanich V et al. | Demonstration of docosahexaenoic acid as a bioavailability enhancer for CYP3A substrates: in vitro and in vivo evidence using cyclosporin in rats. | 2006 | Drug Metab. Dispos. | pmid:16299163 |