Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kim HY et al. | Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. | 2000 | J. Biol. Chem. | pmid:10903316 |
de Turco EB et al. | Strong association of unesterified [3H]docosahexaenoic acid and [3H-docosahexaenoyl]phosphatidate to rhodopsin during in vivo labeling of frog retinal rod outer segments. | 2000 | Neurochem. Res. | pmid:10905632 |
Martin RE et al. | Uptake and incorporation of docosahexaenoic acid (DHA) into neuronal cell body and neurite/nerve growth cone lipids: evidence of compartmental DHA metabolism in nerve growth factor-differentiated PC12 cells. | 2000 | Neurochem. Res. | pmid:10905634 |
Ghebremeskel K et al. | Blood fatty acid composition of pregnant and nonpregnant Korean women: red cells may act as a reservoir of arachidonic acid and docosahexaenoic acid for utilization by the developing fetus. | 2000 | Lipids | pmid:10907792 |
Ando Y et al. | Reinvestigation of positional distribution of fatty acids in docosahexaenoic acid-rich fish oil triacyl-sn-glycerols. | 2000 | Lipids | pmid:10907794 |
Matthews KR et al. | Effect of whole linseed (Linum usitatissimum) in the diet of finishing pigs on growth performance and on the quality and fatty acid composition of various tissues. | 2000 | Br. J. Nutr. | pmid:10911772 |
Smit EN et al. | Effect of supplementation of arachidonic acid (AA) or a combination of AA plus docosahexaenoic acid on breastmilk fatty acid composition. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913225 |
Mukhopadhyay S et al. | Preferential distribution of long chain polyunsaturated fatty acids in phospatidyl ethanolamine fraction of guinea pig alveolar apical membranes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913226 |
Everts S and Davis JH | 1H and (13)C NMR of multilamellar dispersions of polyunsaturated (22:6) phospholipids. | 2000 | Biophys. J. | pmid:10920020 |
Kimura S | [Antihypertensive effect of docosahexaenoic acid in stroke-prone spontaneously hypertensive rats]. | 2000 | Yakugaku Zasshi | pmid:10920715 |
Arterburn LM et al. | A developmental safety study in rats using DHA- and ARA-rich single-cell oils. | 2000 | Food Chem. Toxicol. | pmid:10930697 |
Healy DA et al. | Effect of low-to-moderate amounts of dietary fish oil on neutrophil lipid composition and function. | 2000 | Lipids | pmid:10941877 |
Vanderhoof J et al. | A multicenter long-term safety and efficacy trial of preterm formula supplemented with long-chain polyunsaturated fatty acids. | 2000 | J. Pediatr. Gastroenterol. Nutr. | pmid:10941962 |
Fritsche KL et al. | Consumption of eicosapentaenoic acid and docosahexaenoic acid impair murine interleukin-12 and interferon-gamma production in vivo. | 2000 | J. Infect. Dis. | pmid:10944484 |
Albino AP et al. | Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. | 2000 | Cancer Res. | pmid:10945621 |
Guo X and Ota Y | Incorporation of eicosapentaenoic and docosahexaenoic acids by a yeast (FO726A). | 2000 | J. Appl. Microbiol. | pmid:10945786 |
Retterstøl K et al. | Metabolism of some radiolabeled essential fatty acids in isolated rat hepatocytes is affected by dietary ethanol. | 2000 | Alcohol | pmid:10946154 |
Surai PF and Sparks NH | Tissue-specific fatty acid and alpha-tocopherol profiles in male chickens depending on dietary tuna oil and vitamin E provision. | 2000 | Poult. Sci. | pmid:10947182 |
Kohno H et al. | Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats. | 2000 Sep-Oct | Oncol. Rep. | pmid:10948340 |
Liu QY and Tan BK | Effects of cis-unsaturated fatty acids on doxorubicin sensitivity in P388/DOX resistant and P388 parental cell lines. | 2000 | Life Sci. | pmid:10954054 |