Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Florent S et al. | Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers. | 2006 | J. Neurochem. | pmid:16300635 |
[Long-chain omega-3 fatty acids: highly concentrated only as ethyl ester]. | 2005 | MMW Fortschr Med | pmid:16302427 | |
Yanagita T et al. | Conjugated linoleic acid-induced fatty liver can be attenuated by combination with docosahexaenoic acid in C57BL/6N mice. | 2005 | J. Agric. Food Chem. | pmid:16302788 |
Taber DF and Jackson Roberts L | Nomenclature systems for the neuroprostanes and for the neurofurans. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303600 |
Hong S et al. | Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303609 |
Xiang M et al. | Long-chain polyunsaturated fatty acids in Chinese and Swedish mothers: diet, breast milk and infant growth. | 2005 | Acta Paediatr. | pmid:16303692 |
Quilty MC et al. | Alpha-synuclein is upregulated in neurones in response to chronic oxidative stress and is associated with neuroprotection. | 2006 | Exp. Neurol. | pmid:16310772 |
Patch CS et al. | The use of novel foods enriched with long-chain n-3 fatty acids to increase dietary intake: a comparison of methodologies assessing nutrient intake. | 2005 | J Am Diet Assoc | pmid:16321598 |
Sala-Vila A et al. | Influence of dietary source of docosahexaenoic and arachidonic acids on their incorporation into membrane phospholipids of red blood cells in term infants. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16326086 |
Patten GS et al. | Dietary fish oil dose-response effects on ileal phospholipid fatty acids and contractility. | 2005 | Lipids | pmid:16329465 |
Saito H et al. | High docosahexaenoic acid levels in both neutral and polar lipids of a highly migratory fish: Thunnus tonggol (Bleeker). | 2005 | Lipids | pmid:16329467 |
Lyberg AM et al. | Monitoring the oxidation of docosahexaenoic acid in lipids. | 2005 | Lipids | pmid:16329470 |
Min Y et al. | Unfavorable effect of type 1 and type 2 diabetes on maternal and fetal essential fatty acid status: a potential marker of fetal insulin resistance. | 2005 | Am. J. Clin. Nutr. | pmid:16332647 |
Kuratko C et al. | Importance of arachidonic acid in long-chain polyunsaturated fatty acid-supplemented infant formula. | 2005 | Am. J. Clin. Nutr. | pmid:16332670 |
Ishigamori H et al. | Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. | 2005 | Mol. Cell. Biochem. | pmid:16335792 |
Li T et al. | In vivo delivery of a XIAP (BIR3-RING) fusion protein containing the protein transduction domain protects against neuronal death induced by seizures. | 2006 | Exp. Neurol. | pmid:16336964 |
Bazinet RP et al. | Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. | 2006 | Psychopharmacology (Berl.) | pmid:16344985 |
Joardar A et al. | Docosahexaenoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes. | 2006 | J. Lipid Res. | pmid:16352524 |
Lindskog M et al. | Neuroblastoma cell death in response to docosahexaenoic acid: sensitization to chemotherapy and arsenic-induced oxidative stress. | 2006 | Int. J. Cancer | pmid:16353135 |
Agostoni C et al. | Reduced docosahexaenoic acid synthesis may contribute to growth restriction in infants born to mothers who smoke. | 2005 | J. Pediatr. | pmid:16356447 |
Song C et al. | Existence of lipid microdomains in bilayer of dipalmitoyl phosphatidylcholine (DPPC) and 1-stearoyl-2-docosahexenoyl phosphatidylserine (SDPS) and their perturbation by chlorpromazine: a 13C and 31P solid-state NMR study. | 2006 | Biophys. Chem. | pmid:16356624 |
Vaughan DK et al. | Light-induced exacerbation of retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. | 2006 | Exp. Eye Res. | pmid:16360150 |
Robert SS | Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition. | 2006 Mar-Apr | Mar. Biotechnol. | pmid:16372159 |
Birch DG | A randomized placebo-controlled clinical trial of docosahexaenoic acid (DHA) supplementation for X-linked retinitis pigmentosa. | 2005 | Retina (Philadelphia, Pa.) | pmid:16374336 |
Kumon Y et al. | A new labyrinthulid isolate that produces only docosahexaenoic acid. | 2006 Mar-Apr | Mar. Biotechnol. | pmid:16380808 |
Hussar DA | New drugs: pregabalin and omega-3-acid ethyl esters. | 2005 Nov-Dec | J Am Pharm Assoc (2003) | pmid:16381426 |
Bryan DL et al. | Modulation of respiratory syncytial virus-induced prostaglandin E2 production by n-3 long-chain polyunsaturated fatty acids in human respiratory epithelium. | 2005 | Lipids | pmid:16382572 |
Sørensen BM et al. | Storage lipid accumulation and acyltransferase action in developing flaxseed. | 2005 | Lipids | pmid:16382576 |
Fang PC et al. | The effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants. | 2005 | Chang Gung Med J | pmid:16382755 |
Kulkarni A et al. | Successful outcome of pregnancy in a patient with familial hypertriglyceridaemia. | 2006 | J Obstet Gynaecol | pmid:16390715 |
Butovich IA | A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase. | 2006 | J. Lipid Res. | pmid:16391324 |
Higuchi T et al. | Reduction in plasma glucose after lipid changes in mice fed fish oil, docosahexaenoic acid, and eicosapentaenoic acid diets. | 2006 | Ann. Nutr. Metab. | pmid:16391470 |
Onuki Y et al. | Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane. | 2006 | Chem. Pharm. Bull. | pmid:16394552 |
Flachs P et al. | Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. | 2006 | Diabetologia | pmid:16397791 |
Akbar M et al. | Ethanol promotes neuronal apoptosis by inhibiting phosphatidylserine accumulation. | 2006 | J. Neurosci. Res. | pmid:16397898 |
Bourre JM et al. | Fatty acid alterations in liver peroxisomes from n-3-deficient mice. | 2006 | Ann. Nutr. Metab. | pmid:16407648 |
Ren H et al. | Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16410047 |
Alexander JW et al. | Can immunonutrients reduce rejection rates in African Americans? | 2005 | Exp Clin Transplant | pmid:16417441 |
Jia Q et al. | Docosahexaenoic acid consumption inhibits deoxynivalenol-induced CREB/ATF1 activation and IL-6 gene transcription in mouse macrophages. | 2006 | J. Nutr. | pmid:16424113 |
Serhan CN et al. | Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes. | 2006 | J. Immunol. | pmid:16424216 |
Tsuzuki T et al. | Conjugated docosahexaenoic acid inhibits lipid accumulation in rats. | 2006 | J. Nutr. Biochem. | pmid:16426831 |
Hashimoto M et al. | Docosahexaenoic acid-induced amelioration on impairment of memory learning in amyloid beta-infused rats relates to the decreases of amyloid beta and cholesterol levels in detergent-insoluble membrane fractions. | 2005 | Biochim. Biophys. Acta | pmid:16427803 |
Christensen JH et al. | Prostate tissue and leukocyte levels of n-3 polyunsaturated fatty acids in men with benign prostate hyperplasia or prostate cancer. | 2006 | BJU Int. | pmid:16430627 |
Haugaard SB et al. | Dietary intervention increases n-3 long-chain polyunsaturated fatty acids in skeletal muscle membrane phospholipids of obese subjects. Implications for insulin sensitivity. | 2006 | Clin. Endocrinol. (Oxf) | pmid:16430716 |
Samadi P et al. | Docosahexaenoic acid reduces levodopa-induced dyskinesias in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine monkeys. | 2006 | Ann. Neurol. | pmid:16437566 |
Burdge GC et al. | Docosahexaenoic acid is selectively enriched in plasma phospholipids during pregnancy in Trinidadian women--results of a pilot study. | 2006 Jan-Feb | Reprod. Nutr. Dev. | pmid:16438916 |
Mayes C et al. | Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | 2006 | Pediatr. Res. | pmid:16439591 |
Arab K et al. | Docosahexaenoic acid enhances the antioxidant response of human fibroblasts by upregulating gamma-glutamyl-cysteinyl ligase and glutathione reductase. | 2006 | Br. J. Nutr. | pmid:16441913 |
Tapia-Salazar M et al. | Effect of DHA supplementation on digestible starch utilization by rainbow trout. | 2006 | Br. J. Nutr. | pmid:16441919 |
Williams CM and Burdge G | Long-chain n-3 PUFA: plant v. marine sources. | 2006 | Proc Nutr Soc | pmid:16441943 |
Julien C et al. | Postmortem brain fatty acid profile of levodopa-treated Parkinson disease patients and parkinsonian monkeys. | 2006 | Neurochem. Int. | pmid:16442670 |
Perez MA et al. | Dietary docosahexaenoic acid alters pregnant rat reproductive tissue prostaglandin and matrix metalloproteinase production. | 2006 | J. Nutr. Biochem. | pmid:16457997 |
Poulos A et al. | Effect of 22-32 carbon n-3 polyunsaturated fatty acids on superoxide production in human neutrophils: synergism of docosahexaenoic acid with f-met-leu-phe and phorbol ester. | 1991 | Immunology | pmid:1646160 |
Mamalakis G et al. | Depression and long chain n-3 fatty acids in adipose tissue in adults from Crete. | 2006 | Eur J Clin Nutr | pmid:16465199 |
Gough NR | Focus issue: signaling lipids. | 2006 | Sci. STKE | pmid:16467192 |
Glomset JA | Role of docosahexaenoic acid in neuronal plasma membranes. | 2006 | Sci. STKE | pmid:16467193 |
Delarue J et al. | Interaction of fish oil and a glucocorticoid on metabolic responses to an oral glucose load in healthy human subjects. | 2006 | Br. J. Nutr. | pmid:16469141 |
Seo J et al. | Docosahexaenoic acid selectively inhibits plasma membrane targeting of lipidated proteins. | 2006 | FASEB J. | pmid:16469846 |
Sekine S et al. | Dietary docosahexaenoic acid-induced generation of liver lipid peroxides is not suppressed further by elevated levels of glutathione in ODS rats. | 2006 | Nutrition | pmid:16472975 |
Pfrommer CA et al. | Docosahexaenoic acid induces ciap1 mRNA and protects human endothelial cells from stress-induced apoptosis. | 2006 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16473961 |
Hubbard AF et al. | Association of adipose and red blood cell lipids with severity of dominant Stargardt macular dystrophy (STGD3) secondary to an ELOVL4 mutation. | 2006 | Arch. Ophthalmol. | pmid:16476896 |
Mori TA and Woodman RJ | The independent effects of eicosapentaenoic acid and docosahexaenoic acid on cardiovascular risk factors in humans. | 2006 | Curr Opin Clin Nutr Metab Care | pmid:16477172 |
Hossain Z et al. | Docosahexaenoic acid and eicosapentaenoic acid-enriched phosphatidylcholine liposomes enhance the permeability, transportation and uptake of phospholipids in Caco-2 cells. | 2006 | Mol. Cell. Biochem. | pmid:16477371 |
Park YS et al. | Prolyl endopeptidase inhibitory activity of unsaturated fatty acids. | 2006 | J. Agric. Food Chem. | pmid:16478242 |
Mamalakis G et al. | Depression and adipose and serum cholesteryl ester polyunsaturated fatty acids in the survivors of the seven countries study population of Crete. | 2006 | Eur J Clin Nutr | pmid:16482070 |
Goyens PL and Mensink RP | Effects of alpha-linolenic acid versus those of EPA/DHA on cardiovascular risk markers in healthy elderly subjects. | 2006 | Eur J Clin Nutr | pmid:16482073 |
Bauch A et al. | Dietary intake and sources of long-chain n-3 PUFAs in German adults. | 2006 | Eur J Clin Nutr | pmid:16482078 |
Arachchige PG et al. | Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. | 2006 | Metab. Clin. Exp. | pmid:16483883 |
Perveen Z et al. | Isolation and characterization of a novel thraustochytrid-like microorganism that efficiently produces docosahexaenoic acid. | 2006 | Biotechnol. Lett. | pmid:16489498 |
López-Alarcón M et al. | [The effect of docosahexaenoic acid on the loss of appetite in pediatric patients with pneumonia]. | 2006 Jan-Feb | Rev Med Inst Mex Seguro Soc | pmid:16497254 |
Levant B et al. | Reduced brain DHA content after a single reproductive cycle in female rats fed a diet deficient in N-3 polyunsaturated fatty acids. | 2006 | Biol. Psychiatry | pmid:16499882 |
Ramaprasad TR et al. | Spray-dried milk supplemented with alpha-linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. | 2006 | Steroids | pmid:16499938 |
Parker GB et al. | Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. | 2006 | Psychiatry Res | pmid:16499974 |
da Silva TL et al. | Effect of n-dodecane on Crypthecodinium cohnii fermentations and DHA production. | 2006 | J. Ind. Microbiol. Biotechnol. | pmid:16501933 |
Chattipakorn N et al. | Effects of n-3 polyunsaturated fatty acid on upper limit of vulnerability shocks. | 2006 | Int. J. Cardiol. | pmid:16503251 |
Ko WC et al. | Efficient hydrolysis of tuna oil by a surfactant-coated lipase in a two-phase system. | 2006 | J. Agric. Food Chem. | pmid:16506843 |
Heinemann KM and Bauer JE | Docosahexaenoic acid and neurologic development in animals. | 2006 | J. Am. Vet. Med. Assoc. | pmid:16506930 |
Jumpsen JA et al. | Fatty acids in blood and intestine following docosahexaenoic acid supplementation in adults with cystic fibrosis. | 2006 | J. Cyst. Fibros. | pmid:16507353 |
Chiu LC et al. | Cytostatic and cytotoxic effects of cyclooxygenase inhibitors and their synergy with docosahexaenoic acid on the growth of human skin melanoma A-375 cells. | 2005 | Biomed. Pharmacother. | pmid:16507396 |
Sanders TA et al. | Influence of an algal triacylglycerol containing docosahexaenoic acid (22 : 6n-3) and docosapentaenoic acid (22 : 5n-6) on cardiovascular risk factors in healthy men and women. | 2006 | Br. J. Nutr. | pmid:16512939 |
Abedin M et al. | N-3 fatty acids inhibit vascular calcification via the p38-mitogen-activated protein kinase and peroxisome proliferator-activated receptor-gamma pathways. | 2006 | Circ. Res. | pmid:16514067 |
Scambi C et al. | Can 5-methyltetrahydrofolate modify the phospholipid fatty acid pattern in cystic fibrosis pediatric patients? | 2006 | J. Cyst. Fibros. | pmid:16516563 |
Li CC et al. | n-6 and n-3 polyunsaturated fatty acids down-regulate cytochrome P-450 2B1 gene expression induced by phenobarbital in primary rat hepatocytes. | 2006 | J. Nutr. Biochem. | pmid:16517146 |
Shoji H et al. | Effect of docosahexaenoic acid and eicosapentaenoic acid supplementation on oxidative stress levels during pregnancy. | 2006 | Free Radic. Res. | pmid:16517502 |
Usami M et al. | Phospholipid fatty acid composition and diamine oxidase activity of intestinal mucosa from rats treated with irinotecan hydrochloride (CPT-11) under vegetable oil-enriched diets: comparison between perilla oil and corn oil. | 2006 Mar-Apr | JPEN J Parenter Enteral Nutr | pmid:16517957 |
Qiu C et al. | Erythrocyte omega-3 and omega-6 polyunsaturated fatty acids and preeclampsia risk in Peruvian women. | 2006 | Arch. Gynecol. Obstet. | pmid:16520922 |
Shi Y and Pestka JJ | Attenuation of mycotoxin-induced IgA nephropathy by eicosapentaenoic acid in the mouse: dose response and relation to IL-6 expression. | 2006 | J. Nutr. Biochem. | pmid:16524712 |
Kawakita E et al. | Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. | 2006 | Neuroscience | pmid:16527422 |
Cerolini S et al. | Effect of docosahexaenoic acid and alpha-tocopherol enrichment in chicken sperm on semen quality, sperm lipid composition and susceptibility to peroxidation. | 2006 | Theriogenology | pmid:16530814 |
Tian Q et al. | Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. | 2006 | Chem. Biol. Interact. | pmid:16540100 |
Pall H et al. | Decreased peroxisome proliferator activated receptor alpha is associated with bile duct injury in cystic fibrosis transmembrane conductance regulator-/- mice. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540796 |
Hoffman DR et al. | Docosahexaenoic acid in red blood cells of term infants receiving two levels of long-chain polyunsaturated fatty acids. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540798 |
Straarup EM et al. | The stereospecific triacylglycerol structures and Fatty Acid profiles of human milk and infant formulas. | 2006 | J. Pediatr. Gastroenterol. Nutr. | pmid:16540799 |
Li Q et al. | Effect of docosahexaenoic acid on interleukin-2 receptor signaling pathway in lipid rafts. | 2006 | Sci. China, C, Life Sci. | pmid:16544577 |
Fer M et al. | Determination of polyunsaturated fatty acid monoepoxides by high performance liquid chromatography-mass spectrometry. | 2006 | J Chromatogr A | pmid:16545829 |
Wang WP et al. | Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. | 2006 | Brain Res. | pmid:16546145 |
Lyberg AM and Adlercreutz P | Monitoring monohydroperoxides in docosahexaenoic acid using high-performance liquid chromatography. | 2006 | Lipids | pmid:16555474 |
Li D et al. | A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. | 2006 | Lipids | pmid:16555476 |
Strokin M et al. | Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2. | 2006 | Neuroscience | pmid:16563639 |
Bhattacharya A et al. | Different ratios of eicosapentaenoic and docosahexaenoic omega-3 fatty acids in commercial fish oils differentially alter pro-inflammatory cytokines in peritoneal macrophages from C57BL/6 female mice. | 2007 | J. Nutr. Biochem. | pmid:16563716 |