| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Bone Diseases, Metabolic | D001851 | 9 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Solakivi T et al. | Serum fatty acid profile in subjects with irritable bowel syndrome. | 2011 | Scand. J. Gastroenterol. | pmid:21073373 |
| Danthiir V et al. | The older people, omega-3, and cognitive health (EPOCH) trial design and methodology: a randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. | 2011 | Nutr J | pmid:22011460 |
| Titos E et al. | Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype. | 2011 | J. Immunol. | pmid:22013115 |
| Vasickova L et al. | Possible effect of DHA intake on body weight reduction and lipid metabolism in obese children. | 2011 | Neuro Endocrinol. Lett. | pmid:22101886 |
| Wang RX et al. | [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. | 2011 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:21624312 |
| van de Lagemaat M et al. | Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21995887 |
| Labayen I et al. | Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study. | 2011 | Atherosclerosis | pmid:21550607 |
| Larqué E et al. | Placental transfer of fatty acids and fetal implications. | 2011 | Am. J. Clin. Nutr. | pmid:21562082 |
| Draper E et al. | Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ. | 2011 | J. Nutr. Biochem. | pmid:21111596 |
| Yan J et al. | Enzymatic enrichment of polyunsaturated fatty acids using novel lipase preparations modified by combination of immobilization and fish oil treatment. | 2011 | Bioresour. Technol. | pmid:21565494 |
| Tian H et al. | 14S,21R-dihydroxydocosahexaenoic acid remedies impaired healing and mesenchymal stem cell functions in diabetic wounds. | 2011 | J. Biol. Chem. | pmid:21112969 |
| Bousquet M et al. | Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease. | 2011 | J. Lipid Res. | pmid:21115966 |
| Niinivirta K et al. | Dietary counseling to improve fat quality during pregnancy alters maternal fat intake and infant essential fatty acid status. | 2011 | J. Nutr. | pmid:21593355 |
| Sayanova O and Napier JA | Transgenic oilseed crops as an alternative to fish oils. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21596549 |
| Czerner M et al. | Ripening of salted anchovy (Engraulis anchoita): development of lipid oxidation, colour and other sensorial characteristics. | 2011 | J. Sci. Food Agric. | pmid:21302314 |
| McNamara RK et al. | Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats. | 2011 | Eur. J. Pharmacol. | pmid:21118685 |
| Kim HY et al. | N-Docosahexaenoylethanolamide promotes development of hippocampal neurons. | 2011 | Biochem. J. | pmid:21281269 |
| Ulven SM et al. | Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. | 2011 | Lipids | pmid:21042875 |
| Bazan NG et al. | Endogenous signaling by omega-3 docosahexaenoic acid-derived mediators sustains homeostatic synaptic and circuitry integrity. | 2011 | Mol. Neurobiol. | pmid:21918832 |
| Altenburg JD et al. | A novel 2,6-diisopropylphenyl-docosahexaenoamide conjugate induces apoptosis in T cell acute lymphoblastic leukemia cell lines. | 2011 | Biochem. Biophys. Res. Commun. | pmid:21749860 |
| Liu JC et al. | Long-chain omega-3 fatty acids and blood pressure. | 2011 | Am. J. Hypertens. | pmid:21753804 |
| Luan HM et al. | Antioxidant activities and antioxidative components in the surf clam, Mactra veneriformis. | 2011 | Nat. Prod. Res. | pmid:21756123 |
| Bazan NG et al. | Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases. | 2011 | Annu. Rev. Nutr. | pmid:21756134 |
| Andreo U et al. | Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. | 2011 | FASEB J. | pmid:21757500 |
| Mischoulon D | The impact of omega-3 fatty acids on depressive disorders and suicidality: can we reconcile 2 studies with seemingly contradictory results? | 2011 | J Clin Psychiatry | pmid:22244020 |
| Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
| Sekikawa A et al. | Differential association of docosahexaenoic and eicosapentaenoic acids with carotid intima-media thickness. | 2011 | Stroke | pmid:21757663 |
| Yang R et al. | Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals. | 2011 | J. Biol. Chem. | pmid:21757729 |
| Gajos G | The fish oil story--back to Greenland? | 2011 | Cardiology | pmid:21757896 |
| Lespérance F et al. | The efficacy of omega-3 supplementation for major depression: a randomized controlled trial. | 2011 | J Clin Psychiatry | pmid:20584525 |
| Fredman G and Serhan CN | Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution. | 2011 | Biochem. J. | pmid:21711247 |
| Oh SF et al. | Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. | 2011 | Biochim. Biophys. Acta | pmid:21712098 |
| Gélinas R et al. | Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21685264 |
| Mozurkewich E et al. | The mothers, Omega-3 and mental health study. | 2011 | BMC Pregnancy Childbirth | pmid:21696635 |
| Alves SP et al. | Acetonitrile covalent adduct chemical ionization tandem mass spectrometry of non-methylene-interrupted pentaene fatty acid methyl esters. | 2011 | Rapid Commun. Mass Spectrom. | pmid:21698676 |
| Szajewska H and Makrides M | Is early nutrition related to short-term health and long-term outcome? | 2011 | Ann. Nutr. Metab. | pmid:21701166 |
| Serebruany VL et al. | Early impact of prescription Omega-3 fatty acids on platelet biomarkers in patients with coronary artery disease and hypertriglyceridemia. | 2011 | Cardiology | pmid:21701167 |
| McGee SL et al. | DHA protects against zinc mediated alterations in neuronal cellular bioenergetics. | 2011 | Cell. Physiol. Biochem. | pmid:21865858 |
| Liu SJ et al. | Effect of ruminal pulse dose of polyunsaturated fatty acids on ruminal microbial populations and duodenal flow and milk profiles of fatty acids. | 2011 | J. Dairy Sci. | pmid:21605768 |
| Ethier S et al. | Continuous culture of the microalgae Schizochytrium limacinum on biodiesel-derived crude glycerol for producing docosahexaenoic acid. | 2011 | Bioresour. Technol. | pmid:20570140 |
| Serhan CN et al. | Novel proresolving aspirin-triggered DHA pathway. | 2011 | Chem. Biol. | pmid:21867913 |
| Terre'Blanche G et al. | Treatment of an adrenomyeloneuropathy patient with Lorenzo's oil and supplementation with docosahexaenoic acid--a case report. | 2011 | Lipids Health Dis | pmid:21871076 |
| Wang TM et al. | Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells. | 2011 | J. Nutr. Biochem. | pmid:20573493 |
| Campoy C et al. | Effects of prenatal fish-oil and 5-methyltetrahydrofolate supplementation on cognitive development of children at 6.5 y of age. | 2011 | Am. J. Clin. Nutr. | pmid:21849596 |
| Miles EA et al. | The Salmon in Pregnancy Study: study design, subject characteristics, maternal fish and marine n-3 fatty acid intake, and marine n-3 fatty acid status in maternal and umbilical cord blood. | 2011 | Am. J. Clin. Nutr. | pmid:21849598 |
| O'Sullivan TA et al. | Dietary intake and food sources of fatty acids in Australian adolescents. | 2011 | Nutrition | pmid:20338727 |
| Wu A et al. | The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. | 2011 | J. Neurotrauma | pmid:21851229 |
| Weise C et al. | Inhibition of IgE production by docosahexaenoic acid is mediated by direct interference with STAT6 and NFκB pathway in human B cells. | 2011 | J. Nutr. Biochem. | pmid:20576420 |
| Ohtsuka Y et al. | ω-3 fatty acids attenuate mucosal inflammation in premature rat pups. | 2011 | J. Pediatr. Surg. | pmid:21376198 |
| Stark DT and Bazan NG | Neuroprotectin D1 induces neuronal survival and downregulation of amyloidogenic processing in Alzheimer's disease cellular models. | 2011 | Mol. Neurobiol. | pmid:21431475 |
| Kiso Y | Pharmacology in health foods: effects of arachidonic acid and docosahexaenoic acid on the age-related decline in brain and cardiovascular system function. | 2011 | J. Pharmacol. Sci. | pmid:21436600 |
| Fernandes FS et al. | Maternal intake of flaxseed-based diet (Linum usitatissimum) on hippocampus fatty acid profile: implications for growth, locomotor activity and spatial memory. | 2011 | Nutrition | pmid:21439792 |
| Poulia KA et al. | Omega-3 fatty acids supplementation does not affect serum lipids in chronic hemodialysis patients. | 2011 | J Ren Nutr | pmid:21439849 |
| Bentley S et al. | Comparative effectiveness of a prenatal medical food to prenatal vitamins on hemoglobin levels and adverse outcomes: a retrospective analysis. | 2011 | Clin Ther | pmid:21440300 |
| Wietrzych-Schindler M et al. | Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. | 2011 | Biol. Psychiatry | pmid:21334601 |
| Kuipers RS et al. | Postpartum changes in maternal and infant erythrocyte fatty acids are likely to be driven by restoring insulin sensitivity and DHA status. | 2011 | Med. Hypotheses | pmid:21388747 |
| Mayurasakorn K et al. | Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. | 2011 | Curr Opin Clin Nutr Metab Care | pmid:21178607 |
| Lebold KM et al. | Vitamin E deficiency decreases long-chain PUFA in zebrafish (Danio rerio). | 2011 | J. Nutr. | pmid:22013196 |
| Ladesich JB et al. | Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea. | 2011 | J Clin Sleep Med | pmid:21897776 |
| Raatz SK et al. | Baking reduces prostaglandin, resolvin, and hydroxy-fatty acid content of farm-raised Atlantic salmon (Salmo salar). | 2011 | J. Agric. Food Chem. | pmid:21919483 |
| Huffman SL et al. | Essential fats: how do they affect growth and development of infants and young children in developing countries? A literature review. | 2011 | Matern Child Nutr | pmid:21929635 |
| Isaacs EB et al. | 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. | 2011 | Pediatrics | pmid:21930549 |
| Amtul Z et al. | DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? | 2011 | PLoS ONE | pmid:21931647 |
| Sublette ME et al. | Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. | 2011 | J Clin Psychiatry | pmid:21939614 |
| Norling LV et al. | Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. | 2011 | J. Immunol. | pmid:21460209 |
| Wang B et al. | Resolvin D1 protects mice from LPS-induced acute lung injury. | 2011 | Pulm Pharmacol Ther | pmid:21501693 |
| Astarita G and Piomelli D | Towards a whole-body systems [multi-organ] lipidomics in Alzheimer's disease. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21543199 |
| Righi V et al. | EPA or DHA supplementation increases triacylglycerol, but not phospholipid, levels in isolated rat cardiomyocytes. | 2011 | Lipids | pmid:21544603 |
| Giltay EJ et al. | Effects of n-3 fatty acids on depressive symptoms and dispositional optimism after myocardial infarction. | 2011 | Am. J. Clin. Nutr. | pmid:22030221 |
| Engström KS et al. | Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study. | 2011 | Environ Health | pmid:21504558 |
| Dewell A et al. | Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome. | 2011 | J. Nutr. | pmid:22031659 |
| Siddiqui NF et al. | Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34(+) cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium. | 2011 | Cytotherapy | pmid:20230224 |
| Decsi T and Kennedy K | Sex-specific differences in essential fatty acid metabolism. | 2011 | Am. J. Clin. Nutr. | pmid:22089435 |
| Yamada T et al. | Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice. | 2011 | FASEB J. | pmid:20959515 |
| Lynch ML et al. | Varying coefficient function models to explore interactions between maternal nutritional status and prenatal methylmercury toxicity in the Seychelles Child Development Nutrition Study. | 2011 | Environ. Res. | pmid:20961536 |
| Yu YH et al. | The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes. | 2011 | J. Nutr. Biochem. | pmid:20970313 |
| Suzuki T | Maternal depression and child development after prenatal DHA supplementation. | 2011 | JAMA | pmid:21266681 |
| Assies J et al. | Maternal depression and child development after prenatal DHA supplementation. | 2011 | JAMA | pmid:21266682 |
| Lopez LB et al. | High dietary and plasma levels of the omega-3 fatty acid docosahexaenoic acid are associated with decreased dementia risk: the Rancho Bernardo study. | 2011 | J Nutr Health Aging | pmid:21267518 |
| Schif-Zuck S et al. | Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids. | 2011 | Eur. J. Immunol. | pmid:21268007 |
| Kuipers RS et al. | Maternal DHA equilibrium during pregnancy and lactation is reached at an erythrocyte DHA content of 8 g/100 g fatty acids. | 2011 | J. Nutr. | pmid:21270355 |
| Sasaki K et al. | Total synthesis and bioactivities of two proposed structures of maresin. | 2011 | Chem Asian J | pmid:21254430 |
| Belin RJ et al. | Fish intake and the risk of incident heart failure: the Women's Health Initiative. | 2011 | Circ Heart Fail | pmid:21610249 |
| Itoh T et al. | Efficient synthesis of the very-long-chain n-3 fatty acids, tetracosahexaenoic acid (C24:6n-3) and tricosahexaenoic acid (C23:6n-3). | 2011 | Lipids | pmid:21347745 |
| Cottin SC et al. | The differential effects of EPA and DHA on cardiovascular risk factors. | 2011 | Proc Nutr Soc | pmid:21349231 |
| Sapieha P et al. | 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids. | 2011 | Sci Transl Med | pmid:21307302 |
| Saito E et al. | Docosahexaenoic acid content in plasma phospholipids and desaturase indices in obese children. | 2011 | J. Atheroscler. Thromb. | pmid:21307609 |
| Yano Y et al. | Regional differences in hypertensive cardiovascular remodeling between fishing and farming communities in Japan. | 2011 | Am. J. Hypertens. | pmid:21311505 |
| Dartt DA et al. | Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation. | 2011 | J. Immunol. | pmid:21357260 |
| Kawabata T et al. | [Comparison of long-chain polyunsaturated fatty acids in plasma and erythrocyte phospholipids for biological monitoring]. | 2011 | Nihon Eiseigaku Zasshi | pmid:21358141 |
| Nagao T et al. | One-pot enzymatic synthesis of docosahexaenoic acid-rich triacylglycerols at the sn-1(3) position using by-product from selective hydrolysis of tuna oil. | 2011 | N Biotechnol | pmid:20709631 |
| Schwinkendorf DR et al. | Effects of central administration of distinct fatty acids on hypothalamic neuropeptide expression and energy metabolism. | 2011 | Int J Obes (Lond) | pmid:20714328 |
| DeFina LF et al. | Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. | 2011 | Am. J. Clin. Nutr. | pmid:21159785 |
| Konkel A and Schunck WH | Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. | 2011 | Biochim. Biophys. Acta | pmid:20869469 |
| Mihailescu M et al. | Structure and dynamics of cholesterol-containing polyunsaturated lipid membranes studied by neutron diffraction and NMR. | 2011 | J. Membr. Biol. | pmid:21161517 |
| Tishinsky JM et al. | Eicosapentaenoic acid and rosiglitazone increase adiponectin in an additive and PPARγ-dependent manner in human adipocytes. | 2011 | Obesity (Silver Spring) | pmid:20814411 |
| Am-in N et al. | Lipid profiles of sperm and seminal plasma from boars having normal or low sperm motility. | 2011 | Theriogenology | pmid:21167582 |
| Siener R et al. | Effect of n-3 fatty acid supplementation on urinary risk factors for calcium oxalate stone formation. | 2011 | J. Urol. | pmid:21168878 |
| Marc I et al. | Early docosahexaenoic acid supplementation of mothers during lactation leads to high plasma concentrations in very preterm infants. | 2011 | J. Nutr. | pmid:21169226 |
| Turk HF et al. | Linoleic acid and butyrate synergize to increase Bcl-2 levels in colonocytes. | 2011 | Int. J. Cancer | pmid:20232381 |