| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Bone Diseases, Metabolic | D001851 | 9 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Conquer JA and Holub BJ | Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. | 1996 | J. Nutr. | pmid:9001371 |
| Tamura M and Suzuki H | Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. | 1996 | Ann. Nutr. Metab. | pmid:9001686 |
| Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
| Noguchi M et al. | Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. | 1997 | Br. J. Cancer | pmid:9020478 |
| Badalamenti S et al. | Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. | 1997 | Hepatology | pmid:9021940 |
| Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
| Delton-Vandenbroucke I et al. | Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9034209 |
| Kresiun VI et al. | [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. | 1996 Mar-Apr | Lik. Sprava | pmid:9035880 |
| Wainwright PE et al. | Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. | 1997 | J. Nutr. | pmid:9040564 |
| Iigo M et al. | Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. | 1997 | Br. J. Cancer | pmid:9043019 |
| Dacremont G and Vincent G | Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. | 1995 | J. Inherit. Metab. Dis. | pmid:9053558 |
| Orth M and Luley C | Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. | 1997 | Eur J Clin Chem Clin Biochem | pmid:9056751 |
| Infante JP and Huszagh VA | On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. | 1997 | Mol. Cell. Biochem. | pmid:9062899 |
| Yamane M and Abe A | Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. | 1995 | Neurosci. Lett. | pmid:9064612 |
| Kelso KA et al. | Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. | 1997 | J. Reprod. Fertil. | pmid:9068407 |
| Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
| Kimura S et al. | Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072405 |
| Atkinson TG et al. | Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. | 1997 | Lipids | pmid:9076666 |
| Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
| Bouglé D et al. | Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. | 1996 | Ann. Nutr. Metab. | pmid:9087310 |