| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Bone Diseases, Metabolic | D001851 | 9 associated lipids |
| Obesity | D009765 | 29 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Uterine Neoplasms | D014594 | 18 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kanno S et al. | Albumin modulates docosahexaenoic acid-induced cytotoxicity in human hepatocellular carcinoma cell lines. | 2011 | Toxicol. Lett. | pmid:21108996 |
| Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
| Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
| Kaur P et al. | Role of docosahexaenoic acid in modulating methylmercury-induced neurotoxicity. | 2007 | Toxicol. Sci. | pmid:17728287 |
| Domingo JL et al. | Benefits and risks of fish consumption Part I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants. | 2007 | Toxicology | pmid:17161894 |
| Aspenström-Fagerlund B et al. | Oleic acid and docosahexaenoic acid cause an increase in the paracellular absorption of hydrophilic compounds in an experimental model of human absorptive enterocytes. | 2007 | Toxicology | pmid:17560003 |
| Balaji T et al. | Localization of cyclooxygenase-2 in mice vas deferens and its effects on fertility upon suppression using nimesulide: a preferential cyclooxygenase-2 inhibitor. | 2007 | Toxicology | pmid:17382448 |
| Mancini I et al. | Fatty acid composition of common barbel (Barbus barbus) roe and evaluation of its haemolytic and cytotoxic activities. | 2011 | Toxicon | pmid:21510968 |
| Zhu G et al. | A modified n-3 fatty acid desaturase gene from Caenorhabditis briggsae produced high proportion of DHA and DPA in transgenic mice. | 2008 | Transgenic Res. | pmid:18322818 |
| Truksa M et al. | Metabolic engineering of plants to produce very long-chain polyunsaturated fatty acids. | 2006 | Transgenic Res. | pmid:16604455 |
| Alimuddin G et al. | Enhancement of EPA and DHA biosynthesis by over-expression of masu salmon delta6-desaturase-like gene in zebrafish. | 2005 | Transgenic Res. | pmid:16022387 |
| Le-Niculescu H et al. | Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. | 2011 | Transl Psychiatry | pmid:22832392 |
| Amminger GP et al. | Predictors of treatment response in young people at ultra-high risk for psychosis who received long-chain omega-3 fatty acids. | 2015 | Transl Psychiatry | pmid:25585167 |
| Nordgren TM et al. | Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. | 2015 | Transl Res | pmid:25655838 |
| Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
| Chambon M et al. | Influence of orthotopic liver transplantation on docosehexaenoic acid deficiency in cholestatic children. | 1996 | Transplant. Proc. | pmid:8908096 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
| Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
| Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit the CD28-lymphocyte activation pathway in vitro. | 1998 | Transplant. Proc. | pmid:9865267 |
| Ku K et al. | The effects of omega-3 polyunsaturated (correction of polyunsatulated) fatty acids on the recovery of cardiac function following cold preservation and reperfusion in hyperlipidemic rats. | 1996 | Transplantation | pmid:8824469 |