DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Alzheimer Disease D000544 76 associated lipids
Arteriosclerosis D001161 86 associated lipids
Leukemia D007938 74 associated lipids
Magnesium Deficiency D008275 9 associated lipids
Neuroblastoma D009447 66 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Liver Cirrhosis D008103 67 associated lipids
Colorectal Neoplasms D015179 10 associated lipids
Optic Nerve Diseases D009901 6 associated lipids
Cholestasis D002779 23 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mustafa M et al. Resolvin D1 protects periodontal ligament. 2013 Am. J. Physiol., Cell Physiol. pmid:23864609
Gelsomino G et al. Omega 3 fatty acids chemosensitize multidrug resistant colon cancer cells by down-regulating cholesterol synthesis and altering detergent resistant membranes composition. 2013 Mol. Cancer pmid:24225025
Cederholm T et al. ω-3 fatty acids in the prevention of cognitive decline in humans. 2013 Adv Nutr pmid:24228198
Amminger GP et al. Omega-3 fatty acid supplementation in adolescents with borderline personality disorder and ultra-high risk criteria for psychosis: a post hoc subgroup analysis of a double-blind, randomized controlled trial. 2013 Can J Psychiatry pmid:23870722
Lotrich FE et al. Anger induced by interferon-alpha is moderated by ratio of arachidonic acid to omega-3 fatty acids. 2013 J Psychosom Res pmid:24182638
Pande G et al. Enzymatic synthesis of extra virgin olive oil based infant formula fat analogues containing ARA and DHA: one-stage and two-stage syntheses. 2013 J. Agric. Food Chem. pmid:24117100
Murphy EJ A lipid neurochemist's siren: docosahexaenoic acid and its elusive function in the central nervous system. 2013 J. Neurochem. pmid:24117623
Milic I et al. Simultaneous detection of low and high molecular weight carbonylated compounds derived from lipid peroxidation by electrospray ionization-tandem mass spectrometry. 2013 Anal. Chem. pmid:23186270
Mizwicki MT et al. 1α,25-dihydroxyvitamin D3 and resolvin D1 retune the balance between amyloid-β phagocytosis and inflammation in Alzheimer's disease patients. 2013 J. Alzheimers Dis. pmid:23186989
Carlson SJ et al. The role of the ω-3 fatty acid DHA in the human life cycle. 2013 JPEN J Parenter Enteral Nutr pmid:23192455
Le HD et al. The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. 2013 Metab. Clin. Exp. pmid:23151438
Lee LK et al. The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. 2013 J. Nutr. Biochem. pmid:22898566
Fiol-deRoque MA et al. Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. 2013 Biogerontology pmid:24114505
Olson MV et al. Docosahexaenoic acid reduces inflammation and joint destruction in mice with collagen-induced arthritis. 2013 Inflamm. Res. pmid:24008816
Sato SB et al. Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. 2013 Biochim. Biophys. Acta pmid:23085420
Marze S et al. In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. 2013 Food Funct pmid:23086175
Paschoal VA et al. Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. 2013 Lipids pmid:23086551
Metherel AH et al. Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. 2013 Lipids Health Dis pmid:23425563
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Kataoka Y et al. Epanova(®) and hypertriglyceridemia: pharmacological mechanisms and clinical efficacy. 2013 Future Cardiol pmid:23463969
Mocking RJ et al. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. 2013 Psychoneuroendocrinology pmid:23465556
McNamara RK Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521863
Raatz SK et al. Dose-dependent consumption of farmed Atlantic salmon (Salmo salar) increases plasma phospholipid n-3 fatty acids differentially. 2013 J Acad Nutr Diet pmid:23351633
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Usami M et al. Analysis of fecal microbiota, organic acids and plasma lipids in hepatic cancer patients with or without liver cirrhosis. 2013 Clin Nutr pmid:23068014
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Dalli J et al. The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. 2013 FASEB J. pmid:23504711
Arem H et al. Omega-3 and omega-6 fatty acid intakes and endometrial cancer risk in a population-based case-control study. 2013 Eur J Nutr pmid:22915050
Mickleborough TD Omega-3 polyunsaturated fatty acids in physical performance optimization. 2013 Int J Sport Nutr Exerc Metab pmid:23400626
Kim HY and Spector AA Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22959887
Minihane AM Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. 2013 Eur J Clin Nutr pmid:23403872
Miyahara T et al. D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. 2013 FASEB J. pmid:23407709
Huang LL et al. Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23474173
Saha SS and Ghosh M Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. 2013 Nutrition pmid:23422533
Rahman MM et al. DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. 2013 Breast Cancer Res. Treat. pmid:24062211
Wijendran V et al. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24075244
Liu X et al. Oxidized fatty acid analysis by charge-switch derivatization, selected reaction monitoring, and accurate mass quantitation. 2013 Anal. Biochem. pmid:23850559
Miller E et al. A short-term n-3 DPA supplementation study in humans. 2013 Eur J Nutr pmid:22729967
Khaled M et al. Effects of resolvin D1 on cell survival and cytokine expression of human gingival fibroblasts. 2013 J. Periodontol. pmid:23398023
Gao F et al. Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. 2013 Age (Dordr) pmid:22388930
Friedman AN et al. Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis. 2013 Am. J. Nephrol. pmid:23816975
Arnold C et al. Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. 2013 JAMA Ophthalmol pmid:23519529
Xu MX et al. Resolvin D1, an endogenous lipid mediator for inactivation of inflammation-related signaling pathways in microglial cells, prevents lipopolysaccharide-induced inflammatory responses. 2013 CNS Neurosci Ther pmid:23521911
Zulyniak MA et al. Fish oil supplementation alters circulating eicosanoid concentrations in young healthy men. 2013 Metab. Clin. Exp. pmid:23522836
Qadhi R et al. Differential responses to docosahexaenoic acid in primary and immortalized cardiac cells. 2013 Toxicol. Lett. pmid:23523905
Gódor-Kacsándi A et al. Developmental docosahexaenoic and arachidonic acid supplementation improves adult learning and increases resistance against excitotoxicity in the brain. 2013 Acta Physiol Hung pmid:23524180
Muldoon MF et al. Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. 2013 J. Nutr. pmid:23884386
Watson AM et al. Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. 2013 Lipids pmid:23884630
Mocellin MC et al. Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. 2013 Lipids pmid:23888317
Zhang J et al. Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. 2013 Nutr Res pmid:23890350
Yao C et al. Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. 2013 Mol Med Rep pmid:23799606
Davidson MH Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid. 2013 Curr. Opin. Lipidol. pmid:24184945
Al-Farsi YM et al. Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. 2013 Nutrition pmid:23800562
Aslan M et al. LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. 2013 Lipids Health Dis pmid:24195588
Leino O et al. Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. 2013 Food Chem. Toxicol. pmid:21723361
Mizia-Stec K et al. N-3 polyunsaturated fatty acids do not influence the efficacy of dual antiplatelet therapy in stable angina pectoris patients after percutaneous coronary intervention. 2013 Cardiol J pmid:24469870
Morel PC et al. Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. 2013 Meat Sci. pmid:23739265
Liu Y et al. Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge. 2013 J. Nutr. pmid:23739309
Parletta N et al. Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23756346
Juman S et al. Effects of long-term oral administration of arachidonic acid and docosahexaenoic acid on the immune functions of young rats. 2013 Nutrients pmid:23760060
Merendino N et al. Dietary ω -3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. 2013 Biomed Res Int pmid:23762838
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Sala-Vila A et al. Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. 2013 J. Nutr. Biochem. pmid:23618530
Shida T et al. Colonic delivery of docosahexaenoic acid improves impaired glucose tolerance via GLP-1 secretion and suppresses pancreatic islet hyperplasia in diabetic KK-A(y) mice. 2013 Int J Pharm pmid:23618969
Berger H et al. SOCS3 transactivation by PPARγ prevents IL-17-driven cancer growth. 2013 Cancer Res. pmid:23619236
Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. 2013 JAMA pmid:23644932
Veszelka S et al. Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. 2013 J. Alzheimers Dis. pmid:23645098
Ravacci GR et al. Lipid raft disruption by docosahexaenoic acid induces apoptosis in transformed human mammary luminal epithelial cells harboring HER-2 overexpression. 2013 J. Nutr. Biochem. pmid:22749134
Adler EM Of fish oil, rafts, and scrambling things up. 2013 J. Gen. Physiol. pmid:24277599
Ramprasath VR et al. Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil. 2013 Lipids Health Dis pmid:24304605
Fecchio C et al. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. 2013 PLoS ONE pmid:24312431
Hashimoto M et al. Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2013 Neurochem. Res. pmid:23963508
Tabbaa M et al. Docosahexaenoic acid, inflammation, and bacterial dysbiosis in relation to periodontal disease, inflammatory bowel disease, and the metabolic syndrome. 2013 Nutrients pmid:23966110
Szklenar M et al. Eicosanoids and docosanoids in plasma and aorta of healthy and atherosclerotic rabbits. 2013 J. Vasc. Res. pmid:23969947
Dabkowski ER et al. Docosahexaenoic acid supplementation alters key properties of cardiac mitochondria and modestly attenuates development of left ventricular dysfunction in pressure overload-induced heart failure. 2013 Cardiovasc Drugs Ther pmid:24013804
O'Sullivan BP et al. Evolution of pancreatic function during the first year in infants with cystic fibrosis. 2013 J. Pediatr. pmid:23245194
Rincón Cervera MÁ et al. Acyl migration evaluation in monoacylglycerols from Echium plantagineum seed oil and Marinol. 2013 J. Biosci. Bioeng. pmid:23287502
Chen HW et al. Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. 2013 Arch. Toxicol. pmid:23288142
Matsuoka Y et al. Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. 2013 BMC Psychiatry pmid:23289548
Köhnke T et al. Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. 2013 Biomed Res Int pmid:24083240
Lluís L et al. Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. 2013 Lipids Health Dis pmid:24083393
Nikolakopoulou Z et al. Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. 2013 Carcinogenesis pmid:23892603
Takkunen M et al. Dietary fat in relation to erythrocyte fatty acid composition in men. 2013 Lipids pmid:23975575
Qu L et al. Biomass composition, lipid characterization, and metabolic profile analysis of the fed-batch fermentation process of two different docosahexanoic acid producing Schizochytrium sp. strains. 2013 Appl. Biochem. Biotechnol. pmid:24061873
D'Souza V et al. Counteracting oxidative stress in pregnancy through modulation of maternal micronutrients and omega-3 fatty acids. 2013 Curr. Med. Chem. pmid:24274816
Wu D et al. Novel biphasic role of resolvin D1 on expression of cyclooxygenase-2 in lipopolysaccharide-stimulated lung fibroblasts is partly through PI3K/AKT and ERK2 pathways. 2013 Mediators Inflamm. pmid:24174713
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Otsuka R et al. Higher serum EPA or DHA, and lower ARA compositions with age independent fatty acid intake in Japanese aged 40 to 79. 2013 Lipids pmid:23389403
Barbadoro P et al. Fish oil supplementation reduces cortisol basal levels and perceived stress: a randomized, placebo-controlled trial in abstinent alcoholics. 2013 Mol Nutr Food Res pmid:23390041
Phang M et al. Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women. 2013 J. Nutr. pmid:23390192
Nikolakopoulou Z et al. The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. 2013 Toxicol. Lett. pmid:23391486
Cunnane SC et al. Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22575581
Kenchegowda S et al. Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22579364
Delplanque B et al. A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22884780
Gupta A et al. Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. 2013 J. Ind. Microbiol. Biotechnol. pmid:23990167
Satkunendrarajah K and Fehlings MG Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27. 2013 Exp. Neurol. pmid:23994716
Li Y et al. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. 2013 Immunity pmid:24238341