DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Glaucoma, Open-Angle D005902 3 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Hepatitis C D006526 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mocking RJ et al. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. 2013 Psychoneuroendocrinology pmid:23465556
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Parker GB et al. Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. 2006 Psychiatry Res pmid:16499974
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McNamara RK et al. Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. 2008 Psychiatry Res pmid:18715653
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Nadalin S et al. Niacin skin flush test: a research tool for studying schizophrenia. 2010 Psychiatr Danub pmid:20305586
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Shaikh IA et al. Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. 2008 Prostate pmid:18668525
Cavazos DA et al. Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. 2011 Prostate pmid:21360560
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Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Recchiuti A Resolvin D1 and its GPCRs in resolution circuits of inflammation. 2013 Prostaglandins Other Lipid Mediat. pmid:23500003
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Serhan CN et al. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. 2004 Prostaglandins Other Lipid Mediat. pmid:15290791
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Yuan J et al. The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro. 2010 Prostaglandins Other Lipid Mediat. pmid:20394833
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Shi H et al. VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. 2016 Prostaglandins Other Lipid Mediat. pmid:27026343
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van de Lagemaat M et al. Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21995887
Yi SH et al. A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22000478
Williard DE et al. Comparison of 20-, 22-, and 24-carbon n-3 and n-6 polyunsaturated fatty acid utilization in differentiated rat brain astrocytes. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324227
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Martin RE et al. Docosahexaenoic, arachidonic, palmitic, and oleic acids are differentially esterified into phospholipids of frog retina. 2002 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:12324228
Sayanova O and Napier JA Transgenic oilseed crops as an alternative to fish oils. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21596549
Smithers LG et al. Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20417081
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Gow RV et al. Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19230637
Das UN et al. Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11728172
Dijck-Brouwer DA et al. Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589396
Du Plooy WJ et al. The cumulative dose response effect of eicosapentaenoic and docosahexaenoic acid on blood pressure, plasma lipid profile and diet pattern in mild to moderate essential hypertensive black patients. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1409770
Lapillonne A and Jensen CL Reevaluation of the DHA requirement for the premature infant. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19577914
Pakala R et al. Serotonin-induced endothelial cell proliferation is blocked by omega-3 fatty acids. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10328332
Graf BA et al. Age dependent incorporation of 14C-DHA into rat brain and body tissues after dosing various 14C-DHA-esters. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20580213
Brenna JT and Salem N Workshop proceedings: DHA as a required nutrient. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19604681
Shinto L et al. Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19171471
Yavin E Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16839753
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Peltier S et al. Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18083359
Saldanha LG et al. Workshop on DHA as a required nutrient: overview. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19643589
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Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
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Agostoni C et al. Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11237478
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Manna S et al. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. 2008 Jul-Aug Prostaglandins Leukot. Essent. Fatty Acids pmid:18614344
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Barber E et al. Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24012207
Mueller MJ Isoprostane nomenclature: inherent problems may cause setbacks for the development of the isoprostanoid field. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20034775
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Baskaya MK et al. Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860103
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Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
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Qin Q et al. Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:19019647
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Van Biervliet S et al. Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18276127
Matsumoto K et al. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. 1993 Prostaglandins Leukot. Essent. Fatty Acids pmid:8302921
Innis SM et al. Long chain omega-3 fatty acids: micronutrients in disguise. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22709913
Brenna JT et al. alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19269799
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Das UN et al. Can tumour cell drug resistance be reversed by essential fatty acids and their metabolites? 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9482165
van Goor SA et al. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19118992
Bryhn M et al. The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16806871
Attar-Bashi NM et al. Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17275274