DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Glaucoma, Open-Angle D005902 3 associated lipids
Glioma D005910 112 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Failure D006333 36 associated lipids
Hemolysis D006461 131 associated lipids
Hepatitis C D006526 7 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Agren JJ et al. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430389
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Zhang J et al. Characteristics of fatty acid distribution is associated with colorectal cancer prognosis. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23465412
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Kuipers RS et al. Intrauterine, postpartum and adult relationships between arachidonic acid (AA) and docosahexaenoic acid (DHA). 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21561751
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Marín MC et al. Dietary long-chain fatty acids and visual response in malnourished nursing infants. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11133176
Hashimoto M et al. Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16165346
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Kruger MC and Schollum LM Is docosahexaenoic acid more effective than eicosapentaenoic acid for increasing calcium bioavailability? 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16154334
Whelan J et al. Docosahexaenoic acid: measurements in food and dietary exposure. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19493663
Fritsche KL and Cassity NA Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981628
Fokkema MR et al. Short-term supplementation of low-dose gamma-linolenic acid (GLA), alpha-linolenic acid (ALA), or GLA plus ALA does not augment LCP omega 3 status of Dutch vegans to an appreciable extent. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090255
Makrides M Is there a dietary requirement for DHA in pregnancy? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500960
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
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Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
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Kuratko CN and Salem N Biomarkers of DHA status. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545987
Holub BJ Docosahexaenoic acid (DHA) and cardiovascular disease risk factors. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545988
McNamara RK Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22521863
Hanssens L et al. The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27154364
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Bazan NG The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23022417
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Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Rapoport SI et al. Quantitative contributions of diet and liver synthesis to docosahexaenoic acid homeostasis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20226642
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Harris WS et al. Erythrocyte omega-3 fatty acids increase and linoleic acid decreases with age: observations from 160,000 patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23375840
Gramer G et al. Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27269713
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
Chen ZY and Istfan NW Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:11090257
Bell JG et al. Growth, mortality, tissue histopathology and fatty acid compositions, eicosanoid production and response to stress, in juvenile turbot fed diets rich in gamma-linolenic acid in combination with eicosapentaenoic acid or docosahexaenoic acid. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9690713
Brenna T Tissue-specific LCPUFA accretion in fetal humans. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22078006
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Horrocks LA and Farooqui AA Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041028
Wijendran V et al. Dietary arachidonic acid and docosahexaenoic acid regulate liver fatty acid desaturase (FADS) alternative transcript expression in suckling piglets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24075244
Harris MA et al. Effects of conjugated linoleic acids and docosahexaenoic acid on rat liver and reproductive tissue fatty acids, prostaglandins and matrix metalloproteinase production. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11487304
Harris WS and Schmitt TL Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. 2014 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:24393427
Calderon F and Kim HY Role of RXR in neurite outgrowth induced by docosahexaenoic acid. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036800
Rousseau-Ralliard D et al. Docosahexaenoic acid, but not eicosapentaenoic acid, lowers ambulatory blood pressure and shortens interval QT in spontaneously hypertensive rats in vivo. 2009 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:19428232
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Plourde M et al. Unresolved issues in the link between docosahexaenoic acid and Alzheimer's disease. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036804
Erdogan H et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253883
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Krabbendam L et al. Relationship between DHA status at birth and child problem behaviour at 7 years of age. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17074476
Pregnolato P et al. Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8981629
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Kikuchi S et al. Modulation of eosinophil chemotactic activities to leukotriene B4 by n-3 polyunsaturated fatty acids. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9610849
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Brenner RR Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538079
Qiu X Biosynthesis of docosahexaenoic acid (DHA, 22:6-4, 7,10,13,16,19): two distinct pathways. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538082
Kim HY et al. Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207120
Minns LM et al. Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207123
Sarri KO et al. Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18258421
Levy BD Resolvins and protectins: natural pharmacophores for resolution biology. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20227865
McPhee S et al. Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20074924
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Block RC et al. The effects of EPA, DHA, and aspirin ingestion on plasma lysophospholipids and autotaxin. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20106646
Parletta N et al. Effects of fish oil supplementation on learning and behaviour of children from Australian Indigenous remote community schools: a randomised controlled trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23756346
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Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
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