Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
Salem N et al. | Mechanisms of action of docosahexaenoic acid in the nervous system. | 2001 | Lipids | pmid:11724467 |
Das UN et al. | Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728172 |
Mizejewski GJ and Pass KA | Fatty acids, alpha-fetoprotein, and cystic fibrosis. | 2001 | Pediatrics | pmid:11731663 |
Ferdinandusse S et al. | Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. | 2001 | J. Lipid Res. | pmid:11734571 |
Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. | 2001 | J. Lipid Res. | pmid:11734574 |
Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
Pradalier A et al. | Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. | 2001 | Cephalalgia | pmid:11737007 |
Contreras MA et al. | Chronic nutritional deprivation of n-3 alpha-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats. | 2001 | J. Neurochem. | pmid:11739623 |
Petrache HI et al. | Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy. | 2001 | J. Am. Chem. Soc. | pmid:11741426 |
Noguchi R et al. | Dietary effects of bitter gourd oil on blood and liver lipids of rats. | 2001 | Arch. Biochem. Biophys. | pmid:11747298 |
Siddiqui RA et al. | Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. | 2001 | Biochim. Biophys. Acta | pmid:11755213 |
de Swaaf ME et al. | Characterisation of extracellular polysaccharides produced by Crypthecodinium cohnii. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11759692 |
Reich EE et al. | Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Adv. Exp. Med. Biol. | pmid:11764949 |
Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
Wu FC et al. | Docosahexaenoic acid is superior to eicosapentaenoic acid as the essential fatty acid for growth of grouper, Epinephelus malabaricus. | 2002 | J. Nutr. | pmid:11773511 |
Valenzuela A and Nieto MS | [Docosahexaenoic acid (DHA) in fetal development and in infant nutrition]. | 2001 | Rev Med Chil | pmid:11775350 |
Pawlosky RJ et al. | Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. | 2001 | Alcohol. Clin. Exp. Res. | pmid:11781509 |
Huber T et al. | Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. | 2002 | J. Am. Chem. Soc. | pmid:11782182 |
Agostoni C et al. | Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. | 2001 | Adv. Exp. Med. Biol. | pmid:11787675 |
Gibson RA and Makrides M | Long-chain polyunsaturated fatty acids in breast milk: are they essential? | 2001 | Adv. Exp. Med. Biol. | pmid:11787705 |
Neschen S et al. | Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11788372 |
Whelan J | Targeted taxane therapy for cancer. | 2002 | Drug Discov. Today | pmid:11790612 |
Schiefermeier M and Yavin E | n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain. | 2002 | J. Lipid Res. | pmid:11792731 |
Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
Qi B et al. | Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. | 2002 | FEBS Lett. | pmid:11801246 |
Buznikov GA et al. | [Cholinergic regulation of the sea urchin embryonic and larval development]. | 2001 | Ross Fiziol Zh Im I M Sechenova | pmid:11822358 |
Bell JG et al. | Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism. | 2002 | J. Nutr. | pmid:11823582 |
McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
Marchioli R et al. | Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. | 2001 | Lipids | pmid:11837985 |
Takeuchi T et al. | Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. | 2002 | Behav. Brain Res. | pmid:11844586 |
Qi K et al. | Long-chain polyunsaturated fatty acid accretion in brain. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844978 |
Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
Birch EE et al. | A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. | 2002 | Am. J. Clin. Nutr. | pmid:11864865 |
Brouwer IA et al. | Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. | 2002 | Am. J. Cardiol. | pmid:11867059 |
Kuchbaev AE and Bastarbekova GM | [Phospholipid and fatty acid content of the blood of sheep infected with the nematode Dictyocaulus filaria]. | 2001 Sep-Oct | Parazitologia | pmid:11871259 |
Urquhart P et al. | The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:11880240 |
Kitajka K et al. | The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11880617 |
Lyzogub VG et al. | [Role of the skin in destabilization of coronary circulation]. | 2001 Sep-Dec | Lik. Sprava | pmid:11881380 |
Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |
Igbavboa U et al. | A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. | 2002 | J. Neurochem. | pmid:11902115 |
Hawkes JS et al. | A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. | 2002 | Am. J. Clin. Nutr. | pmid:11916764 |
Revajová V et al. | Influencing the immune parameters in germ-free piglets by administration of seal oil with increased content of omega-3 PUFA. | 2001 | Arch Tierernahr | pmid:11921854 |
Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind study. | 2002 | Nutr Neurosci | pmid:11929196 |
Lagarde M et al. | Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. | 2001 | World Rev Nutr Diet | pmid:11935951 |
Sato M et al. | Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid. | 2001 | World Rev Nutr Diet | pmid:11935956 |
Hamazaki T et al. | Effect of docosahexaenoic acid on hostility. | 2001 | World Rev Nutr Diet | pmid:11935969 |
Crawford MA et al. | Docosahexaenoic acid and cerebral evolution. | 2001 | World Rev Nutr Diet | pmid:11935972 |
Suzuki H et al. | Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. | 2001 | World Rev Nutr Diet | pmid:11935973 |