DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Peritoneal Neoplasms D010534 16 associated lipids
Peritonitis D010538 38 associated lipids
Pneumonia D011014 10 associated lipids
Polycystic Ovary Syndrome D011085 14 associated lipids
Precancerous Conditions D011230 48 associated lipids
Pregnancy Complications D011248 19 associated lipids
Pregnancy Complications, Cardiovascular D011249 11 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Proteinuria D011507 30 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Psoriasis D011565 47 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Pulmonary Valve Stenosis D011666 1 associated lipids
Refsum Disease D012035 19 associated lipids
Retinal Detachment D012163 10 associated lipids
Retinitis Pigmentosa D012174 6 associated lipids
Retinoblastoma D012175 12 associated lipids
Seizures D012640 87 associated lipids
Shock D012769 11 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Shomonov-Wagner L et al. Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. 2015 Lipids Health Dis pmid:25889505
Hsiao HM et al. Resolvin D1 Reduces Emphysema and Chronic Inflammation. 2015 Am. J. Pathol. pmid:26468975
Maekawa T et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. 2015 Nat Commun pmid:26374165
Herrera BS et al. LXA4 actions direct fibroblast function and wound closure. 2015 Biochem. Biophys. Res. Commun. pmid:26188508
Guichardant M et al. Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. 2015 Biochim. Biophys. Acta pmid:25263947
Cox R et al. Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25647402
Gavzan H et al. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. 2015 Naunyn Schmiedebergs Arch. Pharmacol. pmid:26018398
Chiang N et al. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. 2015 J. Exp. Med. pmid:26195725
Wang X et al. Resolution of inflammation is altered in Alzheimer's disease. 2015 Alzheimers Dement pmid:24530025
Kanan Y et al. Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. 2015 Cell. Mol. Neurobiol. pmid:25212825
Orban T et al. Serum levels of lipid metabolites in age-related macular degeneration. 2015 FASEB J. pmid:26187344
Serhan CN et al. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. 2015 Biochim. Biophys. Acta pmid:25139562
Wang CW et al. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. 2015 Infect. Immun. pmid:26667839
Nordgren TM et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. 2015 Transl Res pmid:25655838
Hashim RB et al. Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. 2015 J Oleo Sci pmid:25748380
Tyurina YY et al. LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. 2015 Free Radic. Res. pmid:25740198
Clouard C et al. Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. 2015 J. Nutr. pmid:25644359
Hsieh JC et al. High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. 2015 J. Pediatr. Gastroenterol. Nutr. pmid:25633498
Wang Y et al. Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. 2015 ACS Appl Mater Interfaces pmid:26539742
Ercan S et al. Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. 2015 Lipids Health Dis pmid:25889219
Talvas J et al. Immunonutrition stimulates immune functions and antioxidant defense capacities of leukocytes in radiochemotherapy-treated head & neck and esophageal cancer patients: A double-blind randomized clinical trial. 2015 Clin Nutr pmid:25575640
Sekhon-Loodu S et al. Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. 2015 Int. Immunopharmacol. pmid:25637769
Wang Y et al. Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles. 2015 Colloids Surf B Biointerfaces pmid:26454543
Maciejewska D et al. Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. 2015 World J. Gastroenterol. pmid:25574105
Berge RK et al. Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. 2015 Lipids Health Dis pmid:26666303
Morin C et al. Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. 2015 Arthritis Res. Ther. pmid:26022389
Yoshinaga K et al. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. 2015 J. Nutr. Biochem. pmid:25448607
Cheatham CL and Sheppard KW Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. 2015 Nutrients pmid:26540073
Brigandi SA et al. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. 2015 Int J Mol Sci pmid:25946342
Ossani GP et al. Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. 2015 J Oleo Sci pmid:25948137
Samokhvalov V et al. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. 2015 Toxicol. Lett. pmid:25300478
Wang Y et al. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. 2015 Shock pmid:26196843
Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Wijendran V et al. Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. 2015 Pediatr. Res. pmid:26270575
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Mohajeri S and Newman SA Review of evidence for dietary influences on atopic dermatitis. 2014 Jul-Aug Skin Therapy Lett. pmid:25188523
Akimov MG et al. [The influence of docosahexaenoic acid moiety on cytotoxic activity of 1,2,4-thiadiazole derivatives]. 2014 Jul-Aug Biomed Khim pmid:25249531
Kar S Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. 2014 Jan-Feb Am J Ther pmid:21975796
Casanova E et al. Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. 2014 Jan-Feb Biofactors pmid:23983179
Harris WS and Schmitt TL Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. 2014 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:24393427
Liu J and Ma DW The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. 2014 Nutrients pmid:25412153
Bernhard W et al. Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. 2014 Eur J Nutr pmid:24464176
Ponnampalam EN et al. Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. 2014 Meat Sci. pmid:23643471
Hennebelle M et al. Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. 2014 Proc Nutr Soc pmid:24103099
Schuster GU et al. Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. 2014 Am. J. Respir. Cell Mol. Biol. pmid:24134486
Maitin V et al. Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. 2014 J. Lipid Res. pmid:24136824
Wang S et al. Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. 2014 Clin Nutr pmid:23672804
Katakura M et al. Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. 2014 Molecules pmid:24642910
Browning LM et al. Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. 2014 J. Nutr. pmid:24647395
Polavarapu S et al. Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. 2014 PLoS ONE pmid:25536345
Tungen JE et al. Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. 2014 J. Nat. Prod. pmid:25247845
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:24834713
[Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. 2014 Ginekol. Pol. pmid:25011224
Skender B et al. DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. 2014 Biochim. Biophys. Acta pmid:24953781
Zhao Z and Zlokovic BV Blood-brain barrier: a dual life of MFSD2A? 2014 Neuron pmid:24853933
Hoffman DR et al. Four-year placebo-controlled trial of docosahexaenoic acid in X-linked retinitis pigmentosa (DHAX trial): a randomized clinical trial. 2014 JAMA Ophthalmol pmid:24805262
Abdulnour RE et al. Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25369934
Shimamoto C et al. Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. 2014 Hum. Mol. Genet. pmid:25027319
White PJ et al. Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. 2014 Nat. Med. pmid:24813250
Balas L et al. Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. 2014 Biochimie pmid:24262603
Evans SJ et al. Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. 2014 J Psychiatr Res pmid:24953860
Siddesha JM et al. Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. 2014 Cell. Signal. pmid:24447911
Shao Z et al. Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. 2014 Arterioscler. Thromb. Vasc. Biol. pmid:24458713
Santos S et al. Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. 2014 Eur J Clin Nutr pmid:24642786
Vandal M et al. Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. 2014 J. Neurochem. pmid:24345162
Prostek A et al. The influence of EPA and DHA on markers of inflammation in 3T3-L1 cells at different stages of cellular maturation. 2014 Lipids Health Dis pmid:24387137
Shaikh NA et al. Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. 2014 Mol. Cell. Biochem. pmid:25185754
Wójcik C et al. Modulation of adipocyte differentiation by omega-3 polyunsaturated fatty acids involves the ubiquitin-proteasome system. 2014 J. Cell. Mol. Med. pmid:24834523
Berasategi I et al. Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. 2014 Meat Sci. pmid:24334039
Wang Q et al. Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. 2014 J. Immunol. pmid:24646745
Pottala JV et al. Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. 2014 Neurology pmid:24453077
Zhao JP et al. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. 2014 PLoS ONE pmid:24454790
Harden CJ et al. Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. 2014 Nutr Res pmid:24418242
Asai M et al. [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. 2014 Nippon Yakurigaku Zasshi pmid:24420133
Jin M et al. Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. 2014 J Med Food pmid:24460246
Chen MY et al. Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. 2014 Food Addit Contam Part A Chem Anal Control Expo Risk Assess pmid:24444393
O'Callaghan N et al. Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. 2014 Nutrition pmid:24342530
Patterson AC et al. The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. 2014 Br. J. Nutr. pmid:23920312
Fredman G et al. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. 2014 Proc. Natl. Acad. Sci. U.S.A. pmid:25246560
Cipollina C et al. Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. 2014 Biochim. Biophys. Acta pmid:24594225
Siddiqui RA et al. Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. 2014 Bioorg. Med. Chem. pmid:24556504
Hashimoto M et al. Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. 2014 J. Pharmacol. Sci. pmid:24561447
Ciaccio CE and Girdhar M Effect of maternal ω3 fatty acid supplementation on infant allergy. 2014 Ann. Allergy Asthma Immunol. pmid:24565593
von Schacky C Omega-3 index and cardiovascular health. 2014 Nutrients pmid:24566438
Bauer I et al. Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. 2014 Hum Psychopharmacol pmid:24285504
Nehra D et al. Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? 2014 J. Surg. Res. pmid:24576779
Abdel-Dayem MA et al. Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. 2014 Drugs R D pmid:24733439
Höper AC et al. Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. 2014 J. Nutr. pmid:24285691
Rutkowsky JM et al. Acylcarnitines activate proinflammatory signaling pathways. 2014 Am. J. Physiol. Endocrinol. Metab. pmid:24760988
DiNicolantonio JJ et al. A higher dietary ratio of long-chain omega-3 to total omega-6 fatty acids for prevention of COX-2-dependent adenocarcinomas. 2014 Nutr Cancer pmid:25356937
Boca SM et al. Testing multiple biological mediators simultaneously. 2014 Bioinformatics pmid:24202540
Sublimi Saponetti M et al. Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. 2014 PLoS ONE pmid:25551704
Cho Y et al. Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. 2014 Exp. Biol. Med. (Maywood) pmid:24495951
Tang H et al. Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. 2014 J. Immunol. pmid:25172497
Montgomery P et al. Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. 2014 J Sleep Res pmid:24605819
Walker CG et al. Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. 2014 Br. J. Nutr. pmid:24063767
Zheng MG et al. Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. 2014 Biotechnol. Lett. pmid:24068506
Bahety P et al. Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. 2014 PLoS ONE pmid:24587236
Kwon B et al. Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. 2014 Biochim. Biophys. Acta pmid:24732014