| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peritoneal Neoplasms | D010534 | 16 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Pneumonia | D011014 | 10 associated lipids |
| Polycystic Ovary Syndrome | D011085 | 14 associated lipids |
| Precancerous Conditions | D011230 | 48 associated lipids |
| Pregnancy Complications | D011248 | 19 associated lipids |
| Pregnancy Complications, Cardiovascular | D011249 | 11 associated lipids |
| Pregnancy Complications, Hematologic | D011250 | 11 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Refsum Disease | D012035 | 19 associated lipids |
| Retinal Detachment | D012163 | 10 associated lipids |
| Retinitis Pigmentosa | D012174 | 6 associated lipids |
| Retinoblastoma | D012175 | 12 associated lipids |
| Seizures | D012640 | 87 associated lipids |
| Shock | D012769 | 11 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
| Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
| Rees AM et al. | Omega-3 deficiency associated with perinatal depression: case control study. | 2009 | Psychiatry Res | pmid:19268372 |
| Parker GB et al. | Low levels of docosahexaenoic acid identified in acute coronary syndrome patients with depression. | 2006 | Psychiatry Res | pmid:16499974 |
| Lucas M et al. | Plasma omega-3 and psychological distress among Nunavik Inuit (Canada). | 2009 | Psychiatry Res | pmid:19394089 |
| Kale A et al. | Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. | 2010 | Psychiatry Res | pmid:19969375 |
| Buydens-Branchey L and Branchey M | Long-chain n-3 polyunsaturated fatty acids decrease feelings of anger in substance abusers. | 2008 | Psychiatry Res | pmid:17900705 |
| McNamara RK et al. | Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. | 2008 | Psychiatry Res | pmid:18715653 |
| Conklin SM et al. | Serum omega-3 fatty acids are associated with variation in mood, personality and behavior in hypercholesterolemic community volunteers. | 2007 | Psychiatry Res | pmid:17383013 |
| Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
| Nadalin S et al. | Niacin skin flush test: a research tool for studying schizophrenia. | 2010 | Psychiatr Danub | pmid:20305586 |
| Buretić-Tomljanović A et al. | Phospholipid membrane abnormalities and reduced niacin skin flush response in schizophrenia. | 2008 | Psychiatr Danub | pmid:18827766 |
| Shaikh IA et al. | Docosahexaenoic acid enhances the efficacy of docetaxel in prostate cancer cells by modulation of apoptosis: the role of genes associated with the NF-kappaB pathway. | 2008 | Prostate | pmid:18668525 |
| Cavazos DA et al. | Docosahexaenoic acid selectively induces human prostate cancer cell sensitivity to oxidative stress through modulation of NF-κB. | 2011 | Prostate | pmid:21360560 |
| Westphal C et al. | CYP-eicosanoids--a new link between omega-3 fatty acids and cardiac disease? | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21945326 |
| Weylandt KH et al. | Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22326554 |
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| Kim HY et al. | A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21810478 |
| Recchiuti A | Resolvin D1 and its GPCRs in resolution circuits of inflammation. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500003 |
| Gladyshev MI et al. | Production of EPA and DHA in aquatic ecosystems and their transfer to the land. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500063 |
| Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15290791 |
| Wagner K et al. | Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21854866 |
| von Schacky C | The Omega-3 Index as a risk factor for cardiovascular diseases. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21726658 |
| Monia ZA et al. | Docosahexaenoic acid reduces both cyclic nucleotide and melatonin synthesis in rat pinealocytes. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9653768 |
| Rapoport SI et al. | Docosahexaenoic acid (DHA) incorporation into the brain from plasma, as an in vivo biomarker of brain DHA metabolism and neurotransmission. | 2011 | Prostaglandins Other Lipid Mediat. | pmid:21704722 |
| Taber DF and Jackson Roberts L | Nomenclature systems for the neuroprostanes and for the neurofurans. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303600 |
| Hong S et al. | Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303609 |
| Yuan J et al. | The effects of polyunsaturated fatty acids and their metabolites on osteoclastogenesis in vitro. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20394833 |
| Seki H et al. | Omega-3 PUFA derived anti-inflammatory lipid mediator resolvin E1. | 2009 | Prostaglandins Other Lipid Mediat. | pmid:19737659 |
| Hishinuma T et al. | Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10480487 |
| Shi H et al. | VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. | 2016 | Prostaglandins Other Lipid Mediat. | pmid:27026343 |
| Niemoller TD and Bazan NG | Docosahexaenoic acid neurolipidomics. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:19804838 |
| Yi SH et al. | A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22000478 |
| Smithers LG et al. | Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20417081 |
| Gow RV et al. | Total red blood cell concentrations of omega-3 fatty acids are associated with emotion-elicited neural activity in adolescent boys with attention-deficit hyperactivity disorder. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19230637 |
| Rapoport SI and Igarashi M | Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540098 |
| Yavin E | Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16839753 |
| Saldanha LG et al. | Workshop on DHA as a required nutrient: overview. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19643589 |
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| Ren H et al. | Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16410047 |
| Manna S et al. | Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. | 2008 Jul-Aug | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18614344 |
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| Gibson RA et al. | Docosahexaenoic acid synthesis from alpha-linolenic acid is inhibited by diets high in polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22515943 |
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| van Goor SA et al. | Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. | 2009 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19118992 |
| Louw L and Dannhauser A | Keloids in rural black South Africans. Part 2: dietary fatty acid intake and total phospholipid fatty acid profile in the blood of keloid patients. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11090250 |