Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Ratnayake WM et al. | Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. | 1997 | Br. J. Nutr. | pmid:9306886 |
Gibson RA et al. | Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. | 1997 | Eur J Clin Nutr | pmid:9306083 |
Carvajal O and Angulo O | Effect of n-3 polyunsaturated fatty acids on the lipidic profile of healthy Mexican volunteers. | 1997 May-Jun | Salud Publica Mex | pmid:9304226 |
Colombo DT et al. | Comparison of hexadecylphosphocholine with fish oil as an antitumor agent. | 1997 | J Lipid Mediat Cell Signal | pmid:9302654 |
Lovegrove JA et al. | Use of manufactured foods enriched with fish oils as a means of increasing long-chain n-3 polyunsaturated fatty acid intake. | 1997 | Br. J. Nutr. | pmid:9301413 |
Brossard N et al. | Human plasma albumin transports [13C]docosahexaenoic acid in two lipid forms to blood cells. | 1997 | J. Lipid Res. | pmid:9300779 |
Van Elswyk ME | Comparison of n-3 fatty acid sources in laying hen rations for improvement of whole egg nutritional quality: a review. | 1997 | Br. J. Nutr. | pmid:9292775 |
Jensen CL et al. | Effect of dietary linoleic/alpha-linolenic acid ratio on growth and visual function of term infants. | 1997 | J. Pediatr. | pmid:9290604 |
Carlson SE | Functional effects of increasing omega-3 fatty acid intake. | 1997 | J. Pediatr. | pmid:9290597 |
Suzuki H et al. | Rapid incorporation of docosahexaenoic acid from dietary sources into brain microsomal, synaptosomal and mitochondrial membranes in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9285258 |
Grimsgaard S et al. | Highly purified eicosapentaenoic acid and docosahexaenoic acid in humans have similar triacylglycerol-lowering effects but divergent effects on serum fatty acids. | 1997 | Am. J. Clin. Nutr. | pmid:9280188 |
Freese R and Mutanen M | Alpha-linolenic acid and marine long-chain n-3 fatty acids differ only slightly in their effects on hemostatic factors in healthy subjects. | 1997 | Am. J. Clin. Nutr. | pmid:9280178 |
Weete JD et al. | Lipids and ultrastructure of Thraustochytrium sp. ATCC 26185. | 1997 | Lipids | pmid:9270975 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte proliferation induced by allogenic cells. | 1997 | Transplant. Proc. | pmid:9270778 |
Hishinuma T et al. | Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. | 1997 | Prostaglandins | pmid:9261859 |
Kanazawa A et al. | Increased hepatic beta-oxidation of docosahexaenoic acid, elongation of eicosapentaenoic acid, and acylation of lysophosphatidate in rats fed a docosahexaenoic acid-enriched diet. | 1997 | Lipids | pmid:9252962 |
Vidgren HM et al. | Incorporation of n-3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid-rich oil among healthy young men. | 1997 | Lipids | pmid:9252957 |
Oliveira FL et al. | Triglyceride hydrolysis of soy oil vs fish oil emulsions. | 1997 Jul-Aug | JPEN J Parenter Enteral Nutr | pmid:9252949 |
Schønberg SA and Skorpen F | Paracetamol counteracts docosahexaenoic acid-induced growth inhibition of A-427 lung carcinoma cells and enhances tumor cell proliferation in vitro. | 1997 Jul-Aug | Anticancer Res. | pmid:9252660 |
Rotstein NP et al. | Apoptosis of retinal photoreceptors during development in vitro: protective effect of docosahexaenoic acid. | 1997 | J. Neurochem. | pmid:9231708 |
Takahashi M et al. | Suppression of azoxymethane-induced rat colon carcinoma development by a fish oil component, docosahexaenoic acid (DHA). | 1997 | Carcinogenesis | pmid:9230276 |
Huang ZH et al. | N-6 and n-3 polyunsaturated fatty acids stimulate translocation of protein kinase Calpha, -betaI, -betaII and -epsilon and enhance agonist-induced NADPH oxidase in macrophages. | 1997 | Biochem. J. | pmid:9230140 |
Panchenko VM et al. | [Effects of eifitol on lipid metabolism in patients with clinically different ischemic heart diseases]. | 1997 | Klin Med (Mosk) | pmid:9229613 |
Peng HW et al. | Urine lipids in patients with a history of filariasis. | 1997 | Urol. Res. | pmid:9228676 |
Hempenius RA et al. | Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data. | 1997 | Food Chem. Toxicol. | pmid:9225015 |
Reynaud D and Pace-Asciak CR | Docosahexaenoic acid causes accumulation of free arachidonic acid in rat pineal gland and hippocampus to form hepoxilins from both substrates. | 1997 | Biochim. Biophys. Acta | pmid:9219915 |
Murakami T et al. | Suppressive action of docosahexaenoic acid enriched-Euglena on reduction of endothelium-dependent relaxation in stroke-prone spontaneously hypertensive rats (SHRSP). | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9219094 |
Petrukhina GN et al. | [The effect of the chronic internal administration of the new Russian n-3 polyunsaturated fatty acid concentrate--epaden--on blood coagulation system indices in rabbits]. | 1997 Mar-Apr | Eksp Klin Farmakol | pmid:9206567 |
Innis SM and Dyer R | Dietary triacylglycerols with palmitic acid (16:0) in the 2-position increase 16:0 in the 2-position of plasma and chylomicron triacylglycerols, but reduce phospholipid arachidonic and docosahexaenoic acids, and alter cholesteryl ester metabolism in formula-Fed piglets. | 1997 | J. Nutr. | pmid:9202085 |
Terano T et al. | Eicosapentaenoic acid and docosahexaenoic acid inhibit DNA synthesis through inhibiting cdk2 kinase in vascular smooth muscle cells. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9186612 |
Ding ST and Lilburn MS | Changes in fatty acid profiles in different lipid classes during late development of turkey embryos from two genetic lines. | 1997 | Poult. Sci. | pmid:9181615 |
Ikemoto A et al. | Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release. | 1997 | Neurochem. Res. | pmid:9178949 |
Jones CR et al. | Evidence for the involvement of docosahexaenoic acid in cholinergic stimulated signal transduction at the synapse. | 1997 | Neurochem. Res. | pmid:9178948 |
Shimura T et al. | Docosahexanoic acid (DHA) improved glucose and lipid metabolism in KK-Ay mice with genetic non-insulin-dependent diabetes mellitus (NIDDM). | 1997 | Biol. Pharm. Bull. | pmid:9178930 |
Connor WE et al. | Biochemical markers for puberty in the monkey testis: desmosterol and docosahexaenoic acid. | 1997 | J. Clin. Endocrinol. Metab. | pmid:9177405 |
Davidson MH et al. | Effects of docosahexaenoic acid on serum lipoproteins in patients with combined hyperlipidemia: a randomized, double-blind, placebo-controlled trial. | 1997 | J Am Coll Nutr | pmid:9176830 |
Allard JP et al. | Lipid peroxidation during n-3 fatty acid and vitamin E supplementation in humans. | 1997 | Lipids | pmid:9168460 |
Bell JG et al. | The effect of dietary lipid on polyunsaturated fatty acid metabolism in Atlantic salmon (Salmo salar) undergoing parr-smolt transformation. | 1997 | Lipids | pmid:9168458 |
Stillwell W et al. | Effect of docosahexaenoic acid on mouse mitochondrial membrane properties. | 1997 | Lipids | pmid:9168456 |
Jumpsen J et al. | Small changes of dietary (n-6) and (n-3)/fatty acid content ration alter phosphatidylethanolamine and phosphatidylcholine fatty acid composition during development of neuronal and glial cells in rats. | 1997 | J. Nutr. | pmid:9164993 |
Benassayag C et al. | High polyunsaturated fatty acid, thromboxane A2, and alpha-fetoprotein concentrations at the human feto-maternal interface. | 1997 | J. Lipid Res. | pmid:9162747 |
Green P et al. | Replenishment of docosahexaenoic acid in n-3 fatty acid-deficient fetal rats by intraamniotic ethyl-docosahexaenoate administration. | 1997 | J. Neurosci. Res. | pmid:9160249 |
Buzzi M et al. | Biosynthesis of docosahexaenoic acid in trout hepatocytes proceeds via 24-carbon intermediates. | 1997 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:9159889 |
Andreassen AK et al. | Hypertension prophylaxis with omega-3 fatty acids in heart transplant recipients. | 1997 | J. Am. Coll. Cardiol. | pmid:9137231 |
Gordon N | Nutrition and cognitive function. | 1997 | Brain Dev. | pmid:9134186 |
Oski FA | What we eat may determine who we can be. | 1997 | Nutrition | pmid:9131682 |
Harris WS | n-3 fatty acids and serum lipoproteins: human studies. | 1997 | Am. J. Clin. Nutr. | pmid:9129504 |
Tamura M and Suzuki H | Effect of docosahexaenoic acid and linoleic acid diets on the ultrastructure of liver cells in adult mice. | 1997 | Int J Vitam Nutr Res | pmid:9129257 |
Heird WC et al. | Docosahexaenoic acid and the development and function of the infant retina. | 1997 | Curr. Opin. Lipidol. | pmid:9127705 |
Khalfoun B et al. | In vitro effects of docosahexaenoic and eicosapentaenoic acids in association with cyclosporine A on human lymphocyte proliferation. | 1997 Feb-Mar | Transplant. Proc. | pmid:9123309 |
Kikugawa K et al. | beta-Carotene effectively scavenges toxic nitrogen oxides: nitrogen dioxide and peroxynitrous acid. | 1997 | FEBS Lett. | pmid:9119059 |
Ndiaye J and Hayashi S | Effect of docosahexaenoic acid on lipoprotein synthesis and secretion by cultured eel hepatocytes. | 1996 | Cell Struct. Funct. | pmid:9118236 |
Mandell IB et al. | Effects of fish meal in beef cattle diets on growth performance, carcass characteristics, and fatty acid composition of longissimus muscle. | 1997 | J. Anim. Sci. | pmid:9110201 |
McKeone BJ et al. | Alterations in serum phosphatidylcholine fatty acyl species by eicosapentaenoic and docosahexaenoic ethyl esters in patients with severe hypertriglyceridemia. | 1997 | J. Lipid Res. | pmid:9101424 |
Rodriguez de Turco EB et al. | Post-Golgi vesicles cotransport docosahexaenoyl-phospholipids and rhodopsin during frog photoreceptor membrane biogenesis. | 1997 | J. Biol. Chem. | pmid:9099692 |
Mohan IK and Das UN | Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9089797 |
Bouglé D et al. | Relationships between red blood cell vitamin E and polyunsaturated fatty acid in the premature infant. | 1996 | Ann. Nutr. Metab. | pmid:9087310 |
Conquer JA and Holub BJ | Dietary docosahexaenoic acid as a source of eicosapentaenoic acid in vegetarians and omnivores. | 1997 | Lipids | pmid:9076673 |
Atkinson TG et al. | Incorporation of long-chain n-3 fatty acids in tissues and enhanced bone marrow cellularity with docosahexaenoic acid feeding in post-weanling Fischer 344 rats. | 1997 | Lipids | pmid:9076666 |
Kimura S et al. | Dietary docosahexaenoic acid (22: 6n-3) prevents the development of hypertension in SHRSP. | 1995 | Clin Exp Pharmacol Physiol Suppl | pmid:9072405 |
Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
Kelso KA et al. | Lipid and antioxidant changes in spermatozoa and seminal plasma throughout the reproductive period of bulls. | 1997 | J. Reprod. Fertil. | pmid:9068407 |
Yamane M and Abe A | Properties of the omega-hydroxylation system of docosahexaenoic or arachidonic acid in brain or liver homogenate of rat. | 1995 | Neurosci. Lett. | pmid:9064612 |
Infante JP and Huszagh VA | On the molecular etiology of decreased arachidonic (20:4n-6), docosapentaenoic (22:5n-6) and docosahexaenoic (22:6n-3) acids in Zellweger syndrome and other peroxisomal disorders. | 1997 | Mol. Cell. Biochem. | pmid:9062899 |
Orth M and Luley C | Diagnostic pitfalls during therapy for extreme hypertriglyceridaemia. | 1997 | Eur J Clin Chem Clin Biochem | pmid:9056751 |
Dacremont G and Vincent G | Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. | 1995 | J. Inherit. Metab. Dis. | pmid:9053558 |
Iigo M et al. | Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung. | 1997 | Br. J. Cancer | pmid:9043019 |
Wainwright PE et al. | Arachidonic acid offsets the effects on mouse brain and behavior of a diet with a low (n-6):(n-3) ratio and very high levels of docosahexaenoic acid. | 1997 | J. Nutr. | pmid:9040564 |
Kresiun VI et al. | [The membrane-protective action of a new preparation of n-3 polyenic acids in the adrenaline-damaged myocardium]. | 1996 Mar-Apr | Lik. Sprava | pmid:9035880 |
Delton-Vandenbroucke I et al. | Polyunsaturated fatty acid metabolism in retinal and cerebral microvascular endothelial cells. | 1997 | J. Lipid Res. | pmid:9034209 |
Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
Badalamenti S et al. | Lack of renal effects of fish oil administration in patients with advanced cirrhosis and impaired glomerular filtration. | 1997 | Hepatology | pmid:9021940 |
Noguchi M et al. | Chemoprevention of DMBA-induced mammary carcinogenesis in rats by low-dose EPA and DHA. | 1997 | Br. J. Cancer | pmid:9020478 |
Sheaff Greiner RC et al. | Linoleate, alpha-linolenate, and docosahexaenoate recycling into saturated and monounsaturated fatty acids is a major pathway in pregnant or lactating adults and fetal or infant rhesus monkeys. | 1996 | J. Lipid Res. | pmid:9017518 |
Tamura M and Suzuki H | Effects of docosahexaenoic acid and sardine oil diets on the ultrastructure of jejunal absorptive cells in adult mice. | 1996 | Ann. Nutr. Metab. | pmid:9001686 |
Conquer JA and Holub BJ | Supplementation with an algae source of docosahexaenoic acid increases (n-3) fatty acid status and alters selected risk factors for heart disease in vegetarian subjects. | 1996 | J. Nutr. | pmid:9001371 |
Herber SM and Van Elswyk ME | Dietary marine algae promotes efficient deposition of n-3 fatty acids for the production of enriched shell eggs. | 1996 | Poult. Sci. | pmid:9000275 |
Liutova LV et al. | [Effect of docanol on the status of hemostasis and fibrinolysis systems, as well as lipid spectrum in patients with ischemic heart disease depending on the initial level of fibrinolytic activity]. | 1996 Jan-Mar | Vopr. Med. Khim. | pmid:8999661 |
Taugbøl O et al. | An experimental study on transcutaneous absorption of ethylesters of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) in pigs. | 1996 | Acta Vet. Scand. | pmid:8996873 |
Pregnolato P et al. | Effect of diets containing different amounts of precursor and derivative fatty acids on serum TXB2. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981629 |
Fritsche KL and Cassity NA | Metabolism of [3H]arachidonic acid by n-3 polyunsaturated fatty acid-enriched piglet alveolar macrophages. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8981628 |
Martin DD et al. | The fatty acid composition of human gliomas differs from that found in nonmalignant brain tissue. | 1996 | Lipids | pmid:8972462 |
Khalfoun B et al. | Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human lymphocyte-endothelial cell adhesion. | 1996 | Transplantation | pmid:8970622 |
Brossard N et al. | Metabolic fate of an oral tracer dose of [13C]docosahexaenoic acid triglycerides in the rat. | 1996 | Am. J. Physiol. | pmid:8967415 |
Futamura Y | Toxicity of amiodarone on mouse pulmonary endothelial cells cultured with or without alveolar macrophages. | 1996 | J Toxicol Sci | pmid:8959650 |
Foreman-van Drongelen MM et al. | Influence of feeding artificial-formula milks containing docosahexaenoic and arachidonic acids on the postnatal long-chain polyunsaturated fatty acid status of healthy preterm infants. | 1996 | Br. J. Nutr. | pmid:8958000 |
Garratt JC et al. | Blockade of two voltage-dependent potassium channels, mKv1.1 and mKv1.2, by docosahexaenoic acid. | 1996 | Eur. J. Pharmacol. | pmid:8957264 |
Ohira T et al. | Improvement by eicosanoids in cancer cachexia induced by LLC-IL6 transplantation. | 1996 | J. Cancer Res. Clin. Oncol. | pmid:8954167 |
Awad AB et al. | The effect of unsaturated fatty acids on membrane composition and signal transduction in HT-29 human colon cancer cells. | 1996 | Cancer Lett. | pmid:8950205 |
Reinboth JJ et al. | Light elicits the release of docosahexaenoic acid from membrane phospholipids in the rat retina in vitro. | 1996 | Exp. Eye Res. | pmid:8943700 |
Katoku Y et al. | Effect of the cholesterol content of a formula on the lipid compositions of plasma lipoproteins and red blood cell membranes in early infancy. | 1996 | Am. J. Clin. Nutr. | pmid:8942411 |
Suzuki Y et al. | Trial of docosahexaenoic acid supplementation on a Japanese patient with a peroxisome biogenesis defect. | 1996 | Acta Paediatr Jpn | pmid:8942014 |
Poling JS et al. | Docosahexaenoic acid block of neuronal voltage-gated K+ channels: subunit selective antagonism by zinc. | 1996 | Neuropharmacology | pmid:8938727 |
Krämer HJ et al. | Fish oil fatty acids and human platelets: dose-dependent decrease in dienoic and increase in trienoic thromboxane generation. | 1996 | Biochem. Pharmacol. | pmid:8937428 |
De Craemer D et al. | Dietary docosahexaenoic acid has little effect on peroxisomes in healthy mice. | 1996 | Lipids | pmid:8934448 |
Santos GA and Silversides FG | Utilization of the sex-linked gene for imperfect albinism (S*ALS). 1. Effect of early weight loss on chick metabolism. | 1996 | Poult. Sci. | pmid:8933584 |
Agren JJ et al. | Fish diet, fish oil and docosahexaenoic acid rich oil lower fasting and postprandial plasma lipid levels. | 1996 | Eur J Clin Nutr | pmid:8933125 |
Santos FF et al. | Alterations in rabbit retina lipid metabolism induced by detachment. Decreased incorporation of [3H]DHA into phospholipids. | 1995-1996 | Int Ophthalmol | pmid:8926126 |
Carballeira NM et al. | Phospholipid fatty acid composition of gorgonians of the genus Pseudopterogorgia: identification of tetracosapolyenoic acids. | 1996 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:8925444 |
Zerouga M et al. | Phospholipid class as a determinant in docosahexaenoic acid's effect on tumor cell viability. | 1996 Sep-Oct | Anticancer Res. | pmid:8917399 |