DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Fibrosis D005355 23 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Lipid Metabolism, Inborn Errors D008052 26 associated lipids
Glomerulonephritis D005921 35 associated lipids
Sepsis D018805 11 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Psoriasis D011565 47 associated lipids
Pseudomonas Infections D011552 25 associated lipids
Brain Infarction D020520 17 associated lipids
Infarction, Middle Cerebral Artery D020244 35 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Granot E et al. DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. 2011 Mediators Inflamm. pmid:21941411
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Park CK et al. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 2011 J. Neurosci. pmid:22016541
Morin C et al. Docosahexaenoic acid derivative prevents inflammation and hyperreactivity in lung: implication of PKC-Potentiated inhibitory protein for heterotrimeric myosin light chain phosphatase of 17 kD in asthma. 2011 Am. J. Respir. Cell Mol. Biol. pmid:21057106
Keithly JI et al. Thermogenesis, blood metabolites and hormones, and growth of lambs born to ewes supplemented with algae-derived docosahexaenoic acid. 2011 J. Anim. Sci. pmid:21742943
Sun H et al. Omega-3 fatty acids induce apoptosis in human breast cancer cells and mouse mammary tissue through syndecan-1 inhibition of the MEK-Erk pathway. 2011 Carcinogenesis pmid:21771724
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Beck G et al. Neuroaxonal dystrophy in calcium-independent phospholipase A2β deficiency results from insufficient remodeling and degeneration of mitochondrial and presynaptic membranes. 2011 J. Neurosci. pmid:21813701
Konrad M et al. The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners. 2011 Int J Sport Nutr Exerc Metab pmid:21813917
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Guesnet P et al. α-Linolenate reduces the dietary requirement for linoleate in the growing rat. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21880475
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Harper KN et al. Maternal serum docosahexaenoic acid and schizophrenia spectrum disorders in adult offspring. 2011 Schizophr. Res. pmid:21324652
Pawlik D et al. Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. 2011 Pediatrics pmid:21199856
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Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
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Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
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Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
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Kilari A et al. Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. 2011 May-Jun Am. J. Hum. Biol. pmid:21484911
Jones JL et al. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. 2011 May-Jun J Clin Lipidol pmid:21600524
Maki KC et al. Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. 2011 Nov-Dec J Clin Lipidol pmid:22108152
Siddiqui RA et al. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. 2011 Nov-Dec Biofactors pmid:22038684
Opperman M et al. Analysis of omega-3 fatty acid content of South African fish oil supplements. 2011 Nov-Dec Cardiovasc J Afr pmid:22159321
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Maki KC et al. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21775113
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Fabelo N et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. 2011 Sep-Oct Mol. Med. pmid:21717034
Shilina NM et al. [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. 2011 Sep-Oct Biomed Khim pmid:22629608
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Kornfeld S et al. Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. 2012 Carcinogenesis pmid:22114075
Liang W and Chikritzhs T Does light alcohol consumption during pregnancy improve offspring's cognitive development? 2012 Med. Hypotheses pmid:21985759
Nasiri AH et al. Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. 2012 Andrologia pmid:21951061
Luxwolda MF et al. A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. 2012 Eur J Nutr pmid:21952690
Chew EY et al. The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). 2012 Ophthalmology pmid:22840421
Vanlint SJ and Ried K Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. 2012 Maturitas pmid:22078660
Clària J et al. Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. 2012 J. Immunol. pmid:22844113
Lin DC et al. Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. 2012 Mol. Pharmacol. pmid:22859723
Martin CR et al. The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. 2012 Aliment. Pharmacol. Ther. pmid:22129201
Tsushima T et al. Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. 2012 J Oleo Sci pmid:22864513
Chen J et al. DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. 2012 Atherosclerosis pmid:22284366
Brown SP et al. Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. 2012 ACS Med Chem Lett pmid:24900539
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Wu JH et al. Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. 2012 Circulation pmid:22282329
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Harlioglu AG et al. Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). 2012 Food Sci Technol Int pmid:22328124
Dawson K et al. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. 2012 J. Nutr. Biochem. pmid:21775114
Hofmanová J et al. Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. 2012 J. Nutr. Biochem. pmid:21775115
Kitson AP et al. Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet. 2012 Appl Physiol Nutr Metab pmid:23050796
Quan-Xin F et al. Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn. 2012 BMC Gastroenterol pmid:23092159
Ritter JC and Budge SM Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. 2012 Lipids pmid:23096224
Chang YL et al. Docosahexaenoic acid promotes dopaminergic differentiation in induced pluripotent stem cells and inhibits teratoma formation in rats with Parkinson-like pathology. 2012 Cell Transplant pmid:21669041
D'Vaz N et al. Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. 2012 Pediatrics pmid:22945403
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Bonatto SJ et al. Fish oil supplementation improves neutrophil function during cancer chemotherapy. 2012 Lipids pmid:22160495
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Park Y et al. Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. 2012 Ann. Nutr. Metab. pmid:22776859
Rogerio AP et al. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. 2012 J. Immunol. pmid:22802419
Quiroga AD et al. Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. 2012 Hepatology pmid:22806626
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Ewaschuk JB et al. Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. 2012 Lipids pmid:23054549
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Egert S et al. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. 2012 J. Nutr. pmid:22810989
Sirot V et al. A restricted cubic spline approach to assess the association between high fat fish intake and red blood cell EPA + DHA content. 2012 Nutr Metab Cardiovasc Dis pmid:20875947
Garneau V et al. Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. 2012 Nutr J pmid:22775977
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
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Gladyshev MI et al. Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. 2012 J. Food Sci. pmid:23240970
Chen YJ et al. Docosahexaenoic acid suppresses the expression of FoxO and its target genes. 2012 J. Nutr. Biochem. pmid:22444500
Krishnamoorthy S et al. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. 2012 Am. J. Pathol. pmid:22449948
Gil-Sánchez A et al. Current understanding of placental fatty acid transport. 2012 Curr Opin Clin Nutr Metab Care pmid:22450774
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Crawford MA and Broadhurst CL The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. 2012 Nutr Health pmid:22544773
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Novak EM et al. Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22365109
Meldrum SJ et al. Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22572105
Chiang N et al. Infection regulates pro-resolving mediators that lower antibiotic requirements. 2012 Nature pmid:22538616
Gil-Campos M and Sanjurjo Crespo P Omega 3 fatty acids and inborn errors of metabolism. 2012 Br. J. Nutr. pmid:22591887
Lopez-Huertas E The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. 2012 Br. J. Nutr. pmid:22591892
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