| MeSH term | MeSH ID | Detail |
|---|---|---|
| Fibrosis | D005355 | 23 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Lipid Metabolism, Inborn Errors | D008052 | 26 associated lipids |
| Glomerulonephritis | D005921 | 35 associated lipids |
| Sepsis | D018805 | 11 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Pseudomonas Infections | D011552 | 25 associated lipids |
| Brain Infarction | D020520 | 17 associated lipids |
| Infarction, Middle Cerebral Artery | D020244 | 35 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bazan NG et al. | Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6240268 |
| Reddy TS et al. | Long-chain acyl-coenzyme A synthetase from rat brain microsomes. Kinetic studies using [1-14C]docosahexaenoic acid substrate. | 1984 | Eur. J. Biochem. | pmid:6237910 |
| Harris WS et al. | Will dietary omega-3 fatty acids change the composition of human milk? | 1984 | Am. J. Clin. Nutr. | pmid:6237575 |
| Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
| Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
| VanRollins M and Murphy RC | Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. | 1984 | J. Lipid Res. | pmid:6234372 |
| VanRollins M et al. | Oxidation of docosahexaenoic acid by rat liver microsomes. | 1984 | J. Biol. Chem. | pmid:6232277 |
| Goosey JD et al. | A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases. | 1984 | Invest. Ophthalmol. Vis. Sci. | pmid:6232239 |
| Guffy MM et al. | Effect of cellular fatty acid alteration on adriamycin sensitivity in cultured L1210 murine leukemia cells. | 1984 | Cancer Res. | pmid:6231987 |
| Onuma Y et al. | Selective incorporation of docosahexaenoic acid in rat brain. | 1984 | Biochim. Biophys. Acta | pmid:6231055 |
| Fogerty AC et al. | Liver fatty acids and the sudden infant death syndrome. | 1984 | Am. J. Clin. Nutr. | pmid:6230001 |
| Rao GH et al. | Effect of docosahexaenoic acid (DHA) on arachidonic acid metabolism and platelet function. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6229254 |
| Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
| Aveldaño MI and Sprecher H | Synthesis of hydroxy fatty acids from 4, 7, 10, 13, 16, 19-[1-14C] docosahexaenoic acid by human platelets. | 1983 | J. Biol. Chem. | pmid:6223928 |
| Mooibroek J et al. | Comparison of the radiosensitivity of unsaturated fatty acids, structured as micelles or liposomes, under different experimental conditions. | 1982 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6219072 |
| Bazan NG et al. | High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. | 1982 | Biochim. Biophys. Acta | pmid:6215065 |
| Talesnik J and Hsia JC | Coronary flow reactions to arachidonic acid are inhibited by docosahexaenoic acid. | 1982 | Eur. J. Pharmacol. | pmid:6213418 |
| Guffy MM et al. | Effect of cellular fatty acid alteration on hyperthermic sensitivity in cultured L1210 murine leukemia cells. | 1982 | Cancer Res. | pmid:6213296 |
| Nagai M et al. | The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera. | 1982 | Oncodev. Biol. Med. | pmid:6183647 |
| Hsia JC et al. | alpha-fetoprotein binding specificity for arachidonate, bilirubin, docosahexaenoate, and palmitate. A spin label study. | 1980 | J. Biol. Chem. | pmid:6154708 |
| Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
| Iritani N et al. | Identification of shellfish fatty acids and their effects on lipogenic enzymes. | 1980 | Biochim. Biophys. Acta | pmid:6104986 |
| Singer P et al. | Clinical studies on lipid and blood pressure lowering effect of eicosa-pentaenoic acid-rich diet. | 1984 | Biomed. Biochim. Acta | pmid:6097237 |
| Kobatake Y et al. | Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6096527 |
| Lee TH et al. | Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. | 1984 | J. Clin. Invest. | pmid:6096400 |
| Bazan HE et al. | De novo biosynthesis of docosahexaenoyl-phosphatidic acid in bovine retinal microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6091768 |
| Sanders TA | Dietary polyunsaturated fatty acids and health. | 1984 | Br J Clin Pract Suppl | pmid:6091718 |
| Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
| Karmali RA et al. | Effect of omega-3 fatty acids on growth of a rat mammary tumor. | 1984 | J. Natl. Cancer Inst. | pmid:6087007 |
| Cartwright IJ et al. | The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. | 1985 | Atherosclerosis | pmid:4015748 |
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| Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
| Simons LA et al. | On the effects of dietary n-3 fatty acids (Maxepa) on plasma lipids and lipoproteins in patients with hyperlipidaemia. | 1985 | Atherosclerosis | pmid:3888229 |
| Thiery J and Seidel D | Fish oil feeding results in an enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3827970 |
| Sullivan DR et al. | Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil. | 1986 | Atherosclerosis | pmid:3753548 |
| Rylance PB et al. | Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients. | 1986 | Nephron | pmid:3724927 |
| Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
| Maurice PD et al. | The effects of dietary supplementation with fish oil in patients with psoriasis. | 1987 | Br. J. Dermatol. | pmid:3689678 |
| Chamberlain JG and Belton C | Effects of long term consumption of fish oil (Maxepa) on serum lipids and arterial ultrastructure in Japanese quail (Coturnix coturnix japonica). | 1987 | Atherosclerosis | pmid:3689486 |
| Sanders TA | Re: Fish oil feeding results in enhancement of cholesterol-induced atherosclerosis in rabbits. | 1987 | Atherosclerosis | pmid:3675708 |
| Codde JP et al. | The effect of dietary fish oil and salt on blood pressure and eicosanoid metabolism of spontaneously hypertensive rats. | 1987 | J. Hypertens. | pmid:3611764 |
| Cendrowski W | Multiple sclerosis and MaxEPA. | 1986 | Br J Clin Pract | pmid:3542002 |
| Gibney MJ and Bolton-Smith C | The effect of a dietary supplement of n-3 polyunsaturated fat on platelet lipid composition, platelet function and platelet plasma membrane fluidity in healthy volunteers. | 1988 | Br. J. Nutr. | pmid:3408705 |
| Whittle JC | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. | 1988 | Am. J. Med. | pmid:3376983 |
| Demke DM et al. | Effects of a fish oil concentrate in patients with hypercholesterolemia. | 1988 | Atherosclerosis | pmid:3355619 |
| Picado C et al. | Effects of a fish oil enriched diet on aspirin intolerant asthmatic patients: a pilot study. | 1988 | Thorax | pmid:3353894 |
| Arm JP et al. | Effect of dietary supplementation with fish oil lipids on mild asthma. | 1988 | Thorax | pmid:3353893 |
| Vandongen R et al. | Hypercholesterolaemic effect of fish oil in insulin-dependent diabetic patients. | 1988 | Med. J. Aust. | pmid:3340028 |
| Cahill PD et al. | Inhibition of vein graft intimal thickening by eicosapentanoic acid: reduced thromboxane production without change in lipoprotein levels or low-density lipoprotein receptor density. | 1988 | J. Vasc. Surg. | pmid:3336117 |
| Glauber H et al. | Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. | 1988 | Ann. Intern. Med. | pmid:3282462 |
| Mehta JL et al. | Dietary supplementation with omega-3 polyunsaturated fatty acids in patients with stable coronary heart disease. Effects on indices of platelet and neutrophil function and exercise performance. | 1988 | Am. J. Med. | pmid:3276185 |
| Zucker ML et al. | Effects of dietary fish oil on platelet function and plasma lipids in hyperlipoproteinemic and normal subjects. | 1988 | Atherosclerosis | pmid:3178928 |
| Schmidt EB et al. | The effect of fish oil on lipids, coagulation and fibrinolysis in patients with angina pectoris. | 1988 | Artery | pmid:3178506 |
| Ferretti A et al. | Occurrence of prostaglandin E3 in human urine as a result of marine oil ingestion: gas chromatographic-mass spectrometric evidence. | 1988 | Biochim. Biophys. Acta | pmid:3162687 |
| Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
| Parks JE and Hammerstedt RH | Development changes occurring in the lipids of ram epididymal spermatozoa plasma membrane. | 1985 | Biol. Reprod. | pmid:3158356 |
| Mehta J et al. | Reduction in plasminogen activator inhibitor-1 (PAI-1) with omega-3 polyunsaturated fatty acid (PUFA) intake. | 1988 | Am. Heart J. | pmid:3142242 |
| Norris PG et al. | Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. | 1986 | Br Med J (Clin Res Ed) | pmid:3089408 |
| Miller JP et al. | Triglyceride lowering effect of MaxEPA fish lipid concentrate: a multicentre placebo controlled double blind study. | 1988 | Clin. Chim. Acta | pmid:3071435 |
| Maxepa--Eskimos, fish oils and ischaemic heart disease. | 1988 | Drug Ther Bull | pmid:3053081 | |
| Koletzko B | Omega-3 fatty acid requirement. | 1987 | Am. J. Clin. Nutr. | pmid:3039827 |
| Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
| Fish oil for the heart. | 1987 | Med Lett Drugs Ther | pmid:3025574 | |
| Ziboh VA et al. | Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Modulation of clinical course of psoriatic subjects. | 1986 | Arch Dermatol | pmid:3022655 |
| Croset M and Lagarde M | In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. | 1986 | Thromb. Haemost. | pmid:3022414 |
| Haines AP et al. | Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. | 1986 | Thromb. Res. | pmid:3020732 |
| Lee TH et al. | Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. | 1986 | J. Immunol. | pmid:3005414 |
| von Schacky C and Weber PC | Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. | 1985 | J. Clin. Invest. | pmid:3001149 |
| German JB et al. | Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids. | 1986 | Biochim. Biophys. Acta | pmid:3000452 |
| Singer P et al. | Blood pressure- and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension. | 1985 | Atherosclerosis | pmid:3000395 |
| von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
| Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
| Singer P et al. | Influence on serum lipids, lipoproteins and blood pressure of mackerel and herring diet in patients with type IV and V hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:2992534 |
| Lee TH et al. | Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. | 1985 | N. Engl. J. Med. | pmid:2985986 |
| Karanian JW et al. | Smooth muscle effects of hydroxylated docosahexaenoates produced from human platelet. | 1988 | Biomed. Biochim. Acta | pmid:2977725 |
| Takahashi R et al. | Plasma, platelet, and aorta fatty acids composition in response to dietary n-6 and n-3 fats supplementation in a rat model of non-insulin-dependent diabetes. | 1988 | J. Nutr. Sci. Vitaminol. | pmid:2976815 |
| Masuzawa Y | [The mysteries of docosahexaenoic acid--possible functions of C22 polyenoic fatty acids]. | 1988 | Seikagaku | pmid:2976795 |
| Louie K et al. | Docosahexaenoate-containing molecular species of glycerophospholipids from frog retinal rod outer segments show different rates of biosynthesis and turnover. | 1988 | Biochemistry | pmid:2976602 |
| Shingu T et al. | Discovery of novel brain lipoxygenase products formed from docosahexaenoic acid (22:6w3). | 1988 | Adv Alcohol Subst Abuse | pmid:2975919 |
| Tesoriere L et al. | Modulation by docosahexaenoic acid of the epinephrine-stimulated adenylate cyclase activity of the bovine retina. | 1988 | J. Neurochem. | pmid:2970525 |
| Hruby K | [Is retinitis pigmentosa absolutely incurable?]. | 1988 | Klin Monbl Augenheilkd | pmid:2969995 |
| Ansari KA and Shoeman D | Rapid separation of free fatty acids from neutral lipids in brain extracts. | 1988 | J. Chromatogr. | pmid:2969915 |
| Weissmann G et al. | Stimulus-response coupling in marine sponge cell aggregation: lipid metabolism and the function of exogenously added arachidonic and docosahexaenoic acids. | 1988 | Biochim. Biophys. Acta | pmid:2968121 |
| Croset M et al. | Inhibition by lipoxygenase products of TXA2-like responses of platelets and vascular smooth muscle. 14-Hydroxy from 22:6n-3 is more potent than 12-HETE. | 1988 | Biochem. Pharmacol. | pmid:2965590 |
| Specker BL et al. | Differences in fatty acid composition of human milk in vegetarian and nonvegetarian women: long-term effect of diet. | 1987 Sep-Oct | J. Pediatr. Gastroenterol. Nutr. | pmid:2961862 |
| Organisciak DT et al. | Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. | 1987 | Prog. Clin. Biol. Res. | pmid:2960984 |
| Kobayashi S et al. | Changes of hemorrheological properties by highly purified DHA in normal subjects. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960200 |
| Codde JP et al. | Effects of fish oil "Max EPA" on blood pressures and prostanoid metabolism of spontaneously hypertensive rats during salt loading. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2960180 |
| del Nido PJ et al. | Evidence of myocardial free radical injury during elective repair of tetralogy of Fallot. | 1987 | Circulation | pmid:2959398 |
| Frank H et al. | Fatty acids in liver microsomal lipids of rats exposed to hypoxia, tetrachloromethane, or both. | 1987 | Biochim. Biophys. Acta | pmid:2959325 |
| Virkkunen ME et al. | Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. | 1987 | Biol. Psychiatry | pmid:2958095 |
| Rotstein NP and Aveldaño MI | Labeling of phosphatidylcholines of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)), docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958090 |
| Rotstein NP and Aveldaño MI | Labeling of lipids of retina subcellular fractions by [1-14C]eicosatetraenoate (20:4(n-6)) docosapentaenoate (22:5(n-3)) and docosahexaenoate (22:6(n-3)). | 1987 | Biochim. Biophys. Acta | pmid:2958089 |
| Mitsuhashi N and Kato J | Modulation of steroid hormone receptors in the brain--inhibitory effect of fatty acids on the binding between cytosol progestin receptors in the rat cortex and R5020. | 1987 | Psychoneuroendocrinology | pmid:2955444 |
| Infante JP | Docosahexaenoate-containing phospholipids in sarcoplasmic reticulum and retinal photoreceptors. A proposal for a role in Ca2+-ATPase calcium transport. | 1987 | Mol. Cell. Biochem. | pmid:2955214 |
| Rotstein NP et al. | Effects of aging on the composition and metabolism of docosahexaenoate-containing lipids of retina. | 1987 | Lipids | pmid:2955190 |
| Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
| pmid:29536298 | ||||
| Claeys M et al. | Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. | 1986 | Prostaglandins | pmid:2951768 |