| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Pregnancy Complications, Hematologic | D011250 | 11 associated lipids |
| Shock | D012769 | 11 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Learning Disorders | D007859 | 11 associated lipids |
| Aortic Diseases | D001018 | 11 associated lipids |
| Pregnancy Complications, Cardiovascular | D011249 | 11 associated lipids |
| Fatty Liver, Alcoholic | D005235 | 11 associated lipids |
| Acute Coronary Syndrome | D054058 | 11 associated lipids |
| Sepsis | D018805 | 11 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hegarty B and Parker G | Fish oil as a management component for mood disorders - an evolving signal. | 2013 | Curr Opin Psychiatry | pmid:23108232 |
| Ren LJ et al. | Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. | 2013 | Bioprocess Biosyst Eng | pmid:23108442 |
| Bazan NG et al. | Docosahexaenoic acid and its derivative neuroprotectin D1 display neuroprotective properties in the retina, brain and central nervous system. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107502 |
| Fiol-deRoque MA et al. | Cognitive recovery and restoration of cell proliferation in the dentate gyrus in the 5XFAD transgenic mice model of Alzheimer's disease following 2-hydroxy-DHA treatment. | 2013 | Biogerontology | pmid:24114505 |
| MacLean E et al. | n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. | 2013 | Br. J. Nutr. | pmid:22849952 |
| Hajjaji N and Bougnoux P | Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. | 2013 | Cancer Treat. Rev. | pmid:22850619 |
| Kasuya F et al. | Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. | 2013 | J Enzyme Inhib Med Chem | pmid:22299587 |
| Lapillonne A et al. | Lipid needs of preterm infants: updated recommendations. | 2013 | J. Pediatr. | pmid:23445847 |
| West AA et al. | Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. | 2013 | Am. J. Clin. Nutr. | pmid:23446897 |
| Sánchez-MartÃn MJ et al. | Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. | 2013 | Chembiochem | pmid:23447332 |
| Miyata J et al. | Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:23006546 |
| Saha SS and Ghosh M | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. | 2013 | Nutrition | pmid:23422533 |
| Rahman MM et al. | DHA is a more potent inhibitor of breast cancer metastasis to bone and related osteolysis than EPA. | 2013 | Breast Cancer Res. Treat. | pmid:24062211 |
| Xue Z et al. | Production of omega-3 eicosapentaenoic acid by metabolic engineering of Yarrowia lipolytica. | 2013 | Nat. Biotechnol. | pmid:23873085 |
| Pase MP and Stough C | Describing a taxonomy of cognitive processes for clinical trials assessing cognition. | 2013 | Am. J. Clin. Nutr. | pmid:23873682 |
| Fedor DM et al. | The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. | 2013 | Metab Syndr Relat Disord | pmid:23170930 |
| Kuratko CN et al. | The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. | 2013 | Nutrients | pmid:23877090 |
| Vigerust NF et al. | Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. | 2013 | Eur J Nutr | pmid:22923017 |
| Fagan P and Wijesundera C | Rapid isolation of omega-3 long-chain polyunsaturated fatty acids using monolithic high performance liquid chromatography columns. | 2013 | J Sep Sci | pmid:23559561 |
| Jans JJ et al. | Supplementation with a powdered blend of PUFAs normalizes DHA and AA levels in patients with PKU. | 2013 | Mol. Genet. Metab. | pmid:23562298 |
| Faxén-Irving G et al. | Effects on transthyretin in plasma and cerebrospinal fluid by DHA-rich n - 3 fatty acid supplementation in patients with Alzheimer's disease: the OmegAD study. | 2013 | J. Alzheimers Dis. | pmid:23563245 |
| Arnold C et al. | Macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration: a randomized trial. | 2013 | JAMA Ophthalmol | pmid:23519529 |
| Guo B et al. | Identification and heterologous expression of a Δ4-fatty acid desaturase gene from Isochrysis sphaerica. | 2013 | J. Microbiol. Biotechnol. | pmid:23851273 |
| Lohner S et al. | Lower n-3 long-chain polyunsaturated fatty acid values in patients with phenylketonuria: a systematic review and meta-analysis. | 2013 | Nutr Res | pmid:23827125 |
| Kelly OJ et al. | Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. | 2013 | Nutr Res | pmid:23827126 |
| GarcÃa-Sastre A | Lessons from lipids in the fight against influenza. | 2013 | Cell | pmid:23827671 |
| Birch DG et al. | Spectral-domain optical coherence tomography measures of outer segment layer progression in patients with X-linked retinitis pigmentosa. | 2013 | JAMA Ophthalmol | pmid:23828615 |
| Aslan M et al. | LC-MS/MS analysis of plasma polyunsaturated fatty acids in type 2 diabetic patients after insulin analog initiation therapy. | 2013 | Lipids Health Dis | pmid:24195588 |
| Chen HF and Su HM | Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. | 2013 | J. Nutr. Biochem. | pmid:22818715 |
| Zawadzki M et al. | Perna canaliculus lipid complex PCSO-524â„¢ demonstrated pain relief for osteoarthritis patients benchmarked against fish oil, a randomized trial, without placebo control. | 2013 | Mar Drugs | pmid:23739042 |
| Morel PC et al. | Effect of lipid type on growth performance, meat quality and the content of long chain n-3 fatty acids in pork meat. | 2013 | Meat Sci. | pmid:23739265 |
| Flock MR et al. | Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. | 2013 | Diabetes Metab. Res. Rev. | pmid:23592441 |
| Nagachinta S and Akoh CC | Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. | 2013 | J. Agric. Food Chem. | pmid:23597247 |
| Mortensen K and Tawia S | Sustained breastfeeding. | 2013 | Breastfeed Rev | pmid:23600325 |
| Wang Y et al. | DHA inhibits protein degradation more efficiently than EPA by regulating the PPARγ/NFκB pathway in C2C12 myotubes. | 2013 | Biomed Res Int | pmid:23984342 |
| Chien KL et al. | Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort. | 2013 | Atherosclerosis | pmid:23958266 |
| Hashimoto M et al. | Prescription n-3 fatty acids, but not eicosapentaenoic acid alone, improve reference memory-related learning ability by increasing brain-derived neurotrophic factor levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2013 | Neurochem. Res. | pmid:23963508 |
| Betancor MB et al. | Physiological pathways involved in nutritional muscle dystrophy and healing in European sea bass (Dicentrarchus labrax) larvae. | 2013 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:23202658 |
| Crawford MA et al. | A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23206328 |
| Kim K et al. | A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. | 2013 | Bioresour. Technol. | pmid:23206808 |
| Das UN | Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. | 2013 | Nutrition | pmid:23911220 |
| Köhnke T et al. | Acetylsalicylic Acid reduces the severity of dextran sodium sulfate-induced colitis and increases the formation of anti-inflammatory lipid mediators. | 2013 | Biomed Res Int | pmid:24083240 |
| LluÃs L et al. | Protective effect of the omega-3 polyunsaturated fatty acids: Eicosapentaenoic acid/Docosahexaenoic acid 1:1 ratio on cardiovascular disease risk markers in rats. | 2013 | Lipids Health Dis | pmid:24083393 |
| Flock MR et al. | Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial. | 2013 | J Am Heart Assoc | pmid:24252845 |
| McEwen BJ et al. | Effects of omega-3 polyunsaturated fatty acids on platelet function in healthy subjects and subjects with cardiovascular disease. | 2013 | Semin. Thromb. Hemost. | pmid:23329646 |
| Turk HF et al. | Inhibitory effects of omega-3 fatty acids on injury-induced epidermal growth factor receptor transactivation contribute to delayed wound healing. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23426968 |
| Sun SN et al. | Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. | 2013 | Int J Clin Exp Pathol | pmid:23330014 |
| Aliche-Djoudi F et al. | A role for lipid rafts in the protection afforded by docosahexaenoic acid against ethanol toxicity in primary rat hepatocytes. | 2013 | Food Chem. Toxicol. | pmid:23907024 |
| Thom VT et al. | Regulation of ecto-5´-nucleotidase by docosahexaenoic acid in human endothelial cells. | 2013 | Cell. Physiol. Biochem. | pmid:23988425 |
| Gupta A et al. | Pollen baiting facilitates the isolation of marine thraustochytrids with potential in omega-3 and biodiesel production. | 2013 | J. Ind. Microbiol. Biotechnol. | pmid:23990167 |