Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Brockman HL et al. | Packing and electrostatic behavior of sn-2-docosahexaenoyl and -arachidonoyl phosphoglycerides. | 2003 | Biophys. J. | pmid:14507702 |
Diau GY et al. | Docosahexaenoic and arachidonic acid influence on preterm baboon retinal composition and function. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:14507905 |
Tanaka Y et al. | Effects of exercise on platelet and aortic functions in aged rats. | 2003 | Acta Physiol. Scand. | pmid:14510779 |
Moriguchi T and Salem N | Recovery of brain docosahexaenoate leads to recovery of spatial task performance. | 2003 | J. Neurochem. | pmid:14511107 |
Rørvik KA et al. | Synergistic effects of dietary iron and omega-3 fatty acid levels on survival of farmed Atlantic salmon, Salmo salar L., during natural outbreaks of furunculosis and cold water vibriosis. | 2003 | J. Fish Dis. | pmid:14513972 |
Coste TC et al. | Neuroprotective effect of docosahexaenoic acid-enriched phospholipids in experimental diabetic neuropathy. | 2003 | Diabetes | pmid:14514643 |
Ng KF and Innis SM | Behavioral responses are altered in piglets with decreased frontal cortex docosahexaenoic acid. | 2003 | J. Nutr. | pmid:14519814 |
Alessandri JM et al. | Incorporation of docosahexaenoic acid into nerve membrane phospholipids: bridging the gap between animals and cultured cells. | 2003 | Am. J. Clin. Nutr. | pmid:14522727 |
Sarkadi-Nagy E et al. | Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonates. | 2004 | J. Lipid Res. | pmid:14523049 |
GarcÃa-Pelayo MC et al. | Modification of phospholipids fatty acid composition in reuber H35 hepatoma cells: effect on HMG-CoA reductase activity. | 2003 | J. Cell. Biochem. | pmid:14523992 |
Wang Y et al. | Fish consumption, blood docosahexaenoic acid and chronic diseases in Chinese rural populations. | 2003 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:14527635 |
Speake BK et al. | Differential incorporation of docosahexaenoic and arachidonic acids by the yolk sac membrane of the avian embryo. | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:14529761 |
Cherian G and Sim J | Preferential accumulation of n-3 fatty acids in the brain of chicks from eggs enriched with n-3 fatty acids. | 1992 | Poult. Sci. | pmid:1454683 |
Shaikh SR et al. | Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation? | 2003 | Biochemistry | pmid:14556634 |
Obukhova GP et al. | [A neuromorphological analysis of the motor area of the cerebral cortex in rat pups subjected to prenatal exposure to normal and pathological blood serum]. | 1992 Jul-Aug | Zh. Evol. Biokhim. Fiziol. | pmid:1455957 |
Koletzko B et al. | Fatty acid profiles, antioxidant status, and growth of preterm infants fed diets without or with long-chain polyunsaturated fatty acids. A randomized clinical trial. | 2003 | Eur J Nutr | pmid:14569405 |
Sarkadi-Nagy E et al. | Long chain polyunsaturate supplementation does not induce excess lipid peroxidation of piglet tissues. | 2003 | Eur J Nutr | pmid:14569408 |
Tonon T et al. | Identification of a very long chain polyunsaturated fatty acid Delta4-desaturase from the microalga Pavlova lutheri. | 2003 | FEBS Lett. | pmid:14572666 |
Agostoni C et al. | Earlier smoking habits are associated with higher serum lipids and lower milk fat and polyunsaturated fatty acid content in the first 6 months of lactation. | 2003 | Eur J Clin Nutr | pmid:14576760 |
Danchenko OO et al. | [Ontogenic characteristics of changes in fatty acid composition of the liver lipids as a main substrate for peroxidation in geese]. | 2003 May-Jun | Ukr Biokhim Zh (1999) | pmid:14577163 |
Stillwell W and Wassall SR | Docosahexaenoic acid: membrane properties of a unique fatty acid. | 2003 | Chem. Phys. Lipids | pmid:14580707 |
Shimizu T et al. | Effects of highly purified eicosapentaenoic acid on erythrocyte fatty acid composition and leukocyte and colonic mucosa leukotriene B4 production in children with ulcerative colitis. | 2003 | J. Pediatr. Gastroenterol. Nutr. | pmid:14581801 |
Watkins BA et al. | Conjugated linoleic acids alter the fatty acid composition and physical properties of egg yolk and albumen. | 2003 | J. Agric. Food Chem. | pmid:14582988 |
Mori TA et al. | Effect of eicosapentaenoic acid and docosahexaenoic acid on oxidative stress and inflammatory markers in treated-hypertensive type 2 diabetic subjects. | 2003 | Free Radic. Biol. Med. | pmid:14583341 |
Madani S et al. | Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation. | 2004 | J. Biol. Chem. | pmid:14583629 |
Werman MJ et al. | Effects of the marine unicellular alga Nannochloropsis sp. to reduce the plasma and liver cholesterol levels in male rats fed on diets with cholesterol. | 2003 | Biosci. Biotechnol. Biochem. | pmid:14586118 |
Boberg M et al. | Supplementation with n-3 fatty acids reduces triglycerides but increases PAI-1 in non-insulin-dependent diabetes mellitus. | 1992 | Eur. J. Clin. Invest. | pmid:1459169 |
Wang B et al. | Brain ganglioside and glycoprotein sialic acid in breastfed compared with formula-fed infants. | 2003 | Am. J. Clin. Nutr. | pmid:14594791 |
Innis SM | Perinatal biochemistry and physiology of long-chain polyunsaturated fatty acids. | 2003 | J. Pediatr. | pmid:14597908 |
Uauy R et al. | Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. | 2003 | J. Pediatr. | pmid:14597910 |
Rapoport SI | In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism. | 2003 | J. Pediatr. | pmid:14597911 |
Neuringer M and Jeffrey BG | Visual development: Neural basis and new assessment methods. | 2003 | J. Pediatr. | pmid:14597918 |
Ikeda S et al. | Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. | 2003 | J. Nutr. Sci. Vitaminol. | pmid:14598914 |
Burns PD et al. | Effect of fish meal supplementation on plasma and endometrial fatty acid composition in nonlactating beef cows. | 2003 | J. Anim. Sci. | pmid:14601888 |
Ethier I et al. | The transcription factor NGFI-B (Nur77) and retinoids play a critical role in acute neuroleptic-induced extrapyramidal effect and striatal neuropeptide gene expression. | 2004 | Neuropsychopharmacology | pmid:14603264 |
Ovide-Bordeaux S and Grynberg A | Docosahexaenoic acid affects insulin deficiency- and insulin resistance-induced alterations in cardiac mitochondria. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14604840 |
Turner N et al. | Docosahexaenoic acid (DHA) content of membranes determines molecular activity of the sodium pump: implications for disease states and metabolism. | 2003 | Naturwissenschaften | pmid:14610651 |
Semenova EM and Converse CA | Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. | 2003 | Vision Res. | pmid:14611942 |
D'Eufemia P et al. | Fatty acid profile of oesophageal mucosa in children with gastro-oesophageal reflux disease. | 2003 | Dig Liver Dis | pmid:14620617 |
Laurin D et al. | Omega-3 fatty acids and risk of cognitive impairment and dementia. | 2003 | J. Alzheimers Dis. | pmid:14624027 |
Seal JR and Porter NA | Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. | 2004 | Anal Bioanal Chem | pmid:14634702 |
Min Y et al. | Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes. | 2004 | Diabetologia | pmid:14634727 |
Valenzuela A et al. | Supplementation of female rats with alpha-linolenic acid or docosahexaenoic acid leads to the same omega-6/omega-3 LC-PUFA accretion in mother tissues and in fetal and newborn brains. | 2004 | Ann. Nutr. Metab. | pmid:14639043 |
Maki KC et al. | Lipid responses in mildly hypertriglyceridemic men and women to consumption of docosahexaenoic acid-enriched eggs. | 2003 | Int J Vitam Nutr Res | pmid:14639800 |
Kaempf-Rotzoll DE et al. | Influence of long-chain polyunsaturated fatty acid formula feeds on vitamin E status in preterm infants. | 2003 | Int J Vitam Nutr Res | pmid:14639802 |
Kew S et al. | The effect of feeding structured triacylglycerols enriched in eicosapentaenoic or docosahexaenoic acids on murine splenocyte fatty acid composition and leucocyte phagocytosis. | 2003 | Br. J. Nutr. | pmid:14641966 |
Sneddon AA et al. | Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants. | 2003 | Atherosclerosis | pmid:14642406 |
Aires V et al. | Docosahexaenoic acid and other fatty acids induce a decrease in pHi in Jurkat T-cells. | 2003 | Br. J. Pharmacol. | pmid:14645139 |
Shirai N and Suzuki H | Effect of dietary docosahexaenoic acid and catechins on maze behavior in mice. | 2004 | Ann. Nutr. Metab. | pmid:14646341 |
Metcalf RG et al. | A practical approach to increasing intakes of n-3 polyunsaturated fatty acids: use of novel foods enriched with n-3 fats. | 2003 | Eur J Clin Nutr | pmid:14647226 |
Kjeldsen-Kragh J et al. | Dietary omega-3 fatty acid supplementation and naproxen treatment in patients with rheumatoid arthritis. | 1992 | J. Rheumatol. | pmid:1464864 |
Phillips T et al. | A dietary supplement attenuates IL-6 and CRP after eccentric exercise in untrained males. | 2003 | Med Sci Sports Exerc | pmid:14652498 |
Logan AC | Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression. | 2003 | Altern Med Rev | pmid:14653768 |
Clandinin MT and VanAerde J | Formula supplementation and growth. | 2003 | Pediatrics | pmid:14654632 |
Lin DS et al. | Selective changes of docosahexaenoic acid-containing phospholipid molecular species in monkey testis during puberty. | 2004 | J. Lipid Res. | pmid:14657201 |
Musiek ES et al. | Quantification of F-ring isoprostane-like compounds (F4-neuroprostanes) derived from docosahexaenoic acid in vivo in humans by a stable isotope dilution mass spectrometric assay. | 2004 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:14659440 |
Wang X et al. | Neuroprotective effect of docosahexaenoic acid on glutamate-induced cytotoxicity in rat hippocampal cultures. | 2003 | Neuroreport | pmid:14663210 |
Barbir M et al. | Maxepa versus bezafibrate in hyperlipidemic cardiac transplant recipients. | 1992 | Am. J. Cardiol. | pmid:1466329 |
Pawlosky R et al. | n-3 fatty acid metabolism in women. | 2003 | Br. J. Nutr. | pmid:14667193 |
Stene LC and Joner G | Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. | 2003 | Am. J. Clin. Nutr. | pmid:14668274 |
Iribarren C et al. | Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults--the CARDIA study. | 2004 | Eur J Clin Nutr | pmid:14679363 |
Mawatari S et al. | Absence of correlation between glycated hemoglobin and lipid composition of erythrocyte membrane in type 2 diabetic patients. | 2004 | Metab. Clin. Exp. | pmid:14681853 |
Blanaru JL et al. | Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula. | 2004 | Am. J. Clin. Nutr. | pmid:14684410 |
Nilsen DW and Harris WS | n-3 Fatty acids and cardiovascular disease. | 2004 | Am. J. Clin. Nutr. | pmid:14684413 |
Champeil-Potokar G et al. | Astrocytes in culture require docosahexaenoic acid to restore the n-3/n-6 polyunsaturated fatty acid balance in their membrane phospholipids. | 2004 | J. Neurosci. Res. | pmid:14689452 |
Spiekerkoetter U et al. | Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. | 2004 | Muscle Nerve | pmid:14694500 |
Muskiet FA et al. | Is docosahexaenoic acid (DHA) essential? Lessons from DHA status regulation, our ancient diet, epidemiology and randomized controlled trials. | 2004 | J. Nutr. | pmid:14704315 |
Barbarich NC et al. | Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa. | 2004 | Int J Eat Disord | pmid:14705152 |
Farooqui AA et al. | Plasmalogens, docosahexaenoic acid and neurological disorders. | 2003 | Adv. Exp. Med. Biol. | pmid:14713251 |
Milatovic D et al. | Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. | 2003 | J. Neurochem. | pmid:14713307 |
Bakken AM and Farstad M | The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets. | 1992 | Biochem. J. | pmid:1471991 |
Boroda AM et al. | [Specificity of endometrium phospholipids and their fatty acids changes in the development of hyperplasia]. | 2003 Oct-Nov | Lik. Sprava | pmid:14723136 |
Honen BN et al. | Suppression of calcium sparks in rat ventricular myocytes and direct inhibition of sheep cardiac RyR channels by EPA, DHA and oleic acid. | 2003 | J. Membr. Biol. | pmid:14724746 |
Huang J et al. | Grouping newly isolated docosahexaenoic acid-producing thraustochytrids based on their polyunsaturated fatty acid profiles and comparative analysis of 18S rRNA genes. | 2003 Sep-Oct | Mar. Biotechnol. | pmid:14730428 |
Nichols PD et al. | Occurrence of high levels of tetracosahexaenoic acid in the jellyfish Aurelia sp. | 2003 | Lipids | pmid:14733367 |
MacDonald IM et al. | Effect of docosahexaenoic acid supplementation on retinal function in a patient with autosomal dominant Stargardt-like retinal dystrophy. | 2004 | Br J Ophthalmol | pmid:14736799 |
Sijtsma L and de Swaaf ME | Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid. | 2004 | Appl. Microbiol. Biotechnol. | pmid:14740186 |
Auestad N et al. | Auditory brainstem evoked response in juvenile rats fed rat milk formulas with high docosahexaenoic acid. | 2003 | Nutr Neurosci | pmid:14744037 |
Liu Z et al. | Determination of fatty acid levels in erythrocyte membranes of patients with chronic fatigue syndrome. | 2003 | Nutr Neurosci | pmid:14744043 |
Kim HY et al. | Substrate preference in phosphatidylserine biosynthesis for docosahexaenoic acid containing species. | 2004 | Biochemistry | pmid:14744148 |
de Groot RH et al. | Effect of alpha-linolenic acid supplementation during pregnancy on maternal and neonatal polyunsaturated fatty acid status and pregnancy outcome. | 2004 | Am. J. Clin. Nutr. | pmid:14749231 |
Hansen HS and Olsen SF | Sleep patterns, docosahexaenoic acid, and gestational length. | 2004 | Am. J. Clin. Nutr. | pmid:14749243 |
Das UN | Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension. | 2004 | Eur J Clin Nutr | pmid:14749737 |
Freedman SD et al. | Association of cystic fibrosis with abnormalities in fatty acid metabolism. | 2004 | N. Engl. J. Med. | pmid:14762183 |
Strandvik B | Fatty acid metabolism in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:14762189 |
Calabresi L et al. | An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. | 2004 | Metab. Clin. Exp. | pmid:14767865 |
Appel MJ and Woutersen RA | Effects of a diet high in fish oil (MaxEPA) on the formation of micronucleated erythrocytes in blood and on the number of atypical acinar cell foci Induced in rat pancreas by azaserine. | 2003 | Nutr Cancer | pmid:14769538 |
Bordoni A et al. | Diacylglycerol fatty acid composition is related to activation of protein kinase C in cultured cardiomyocytes. | 1992 | Cardioscience | pmid:1477293 |
Grynberg A et al. | Eicosapentaenoic and docosahexaenoic acids in cultured rat ventricular myocytes and hypoxia-induced alterations of phospholipase-A activity. | 1992 | Mol. Cell. Biochem. | pmid:1480156 |
Mehta VR | 'Side effects of eicosapentaenoic acid and docosahexaenoic acid (maxepa)'. | 1992 | J Assoc Physicians India | pmid:1484043 |
Sajiki J and Takahashi K | Free fatty acids inducing mouse lethal toxicity in lipid extracts of Engraulis japonica, the Japanese anchovy. | 1992 | Lipids | pmid:1487961 |
Baumstark MW et al. | Influence of n-3 fatty acids from fish oils on concentration of high- and low-density lipoprotein subfractions and their lipid and apolipoprotein composition. | 1992 | Clin. Biochem. | pmid:1490295 |
Ackman RG | The absorption of fish oils and concentrates. | 1992 | Lipids | pmid:1491603 |
Innis SM | n-3 fatty acid requirements of the newborn. | 1992 | Lipids | pmid:1491606 |
D'Almeida A et al. | Effects of a combination of evening primrose oil (gamma linolenic acid) and fish oil (eicosapentaenoic + docahexaenoic acid) versus magnesium, and versus placebo in preventing pre-eclampsia. | 1992 | Women Health | pmid:1492408 |
Colas S et al. | Enhanced radiosensitivity of rat autochthonous mammary tumors by dietary docosahexaenoic acid. | 2004 | Int. J. Cancer | pmid:14961586 |
van Heeckeren AM et al. | Nutritional effects on host response to lung infections with mucoid Pseudomonas aeruginosa in mice. | 2004 | Infect. Immun. | pmid:14977953 |
Marangell LB et al. | Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. | 2004 | Depress Anxiety | pmid:14978781 |
Swamy MV et al. | Modulation of cyclooxygenase-2 activities by the combined action of celecoxib and decosahexaenoic acid: novel strategies for colon cancer prevention and treatment. | 2004 | Mol. Cancer Ther. | pmid:14985462 |
Dunstan JA et al. | Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition. | 2004 | Eur J Clin Nutr | pmid:14985680 |