Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hirayama S et al. | Effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder - a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:14985685 |
Jiang Y et al. | Fatty acid composition and squalene content of the marine microalga Schizochytrium mangrovei. | 2004 | J. Agric. Food Chem. | pmid:14995120 |
Liu JD et al. | Thiol antioxidant and thiol-reducing agents attenuate 15-deoxy-delta 12,14-prostaglandin J2-induced heme oxygenase-1 expression. | 2004 | Life Sci. | pmid:14998722 |
Chiu CC et al. | Omega-3 polyunsaturated fatty acids for postpartum depression. | 2004 | Am. J. Obstet. Gynecol. | pmid:15002412 |
Moriguchi K et al. | Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. | 2004 Mar-Apr | Ophthalmic Res. | pmid:15017106 |
Gohlke H | [Prevention of coronary disease and sudden death by nutrition]. | 2004 | Z Kardiol | pmid:15021992 |
Hsu JM et al. | The effect of dietary docosahexaenoic acid on the expression of porcine lipid metabolism-related genes. | 2004 | J. Anim. Sci. | pmid:15032424 |
Gorson DM | Fish oil supplementation and ulcerative colitis. | 1992 | Ann. Intern. Med. | pmid:1503361 |
Merendino N et al. | Induction of apoptosis in human pancreatic cancer cells by docosahexaenoic acid. | 2003 | Ann. N. Y. Acad. Sci. | pmid:15033753 |
Hejazi MA and Wijffels RH | Milking of microalgae. | 2004 | Trends Biotechnol. | pmid:15038924 |
Horrocks LA and Farooqui AA | Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15041028 |
Hogg RJ and Wyatt RJ | A randomized controlled trial of mycophenolate mofetil in patients with IgA nephropathy [ISRCTN62574616]. | 2004 | BMC Nephrol | pmid:15043759 |
Ota Y et al. | Vitamin E supplementation increases polyunsaturated fatty acids of RBC membrane in HCV-infected patients. | 2004 | Nutrition | pmid:15043851 |
Shahdat H et al. | Synaptic plasma membrane-bound acetylcholinesterase activity is not affected by docosahexaenoic acid-induced decrease in membrane order. | 2004 | Life Sci. | pmid:15051424 |
Theobald HE et al. | LDL cholesterol-raising effect of low-dose docosahexaenoic acid in middle-aged men and women. | 2004 | Am. J. Clin. Nutr. | pmid:15051597 |
Kew S et al. | Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans. | 2004 | Am. J. Clin. Nutr. | pmid:15051614 |
Marszalek JR et al. | Acyl-CoA synthetase 2 overexpression enhances fatty acid internalization and neurite outgrowth. | 2004 | J. Biol. Chem. | pmid:15051725 |
Sala-Vila A et al. | The source of long-chain PUFA in formula supplements does not affect the fatty acid composition of plasma lipids in full-term infants. | 2004 | J. Nutr. | pmid:15051839 |
Nkondjock A and Ghadirian P | Dietary carotenoids and risk of colon cancer: case-control study. | 2004 | Int. J. Cancer | pmid:15054875 |
Murata Y et al. | Degradation of ethyl docosahexaenoate by gamma-ray irradiation and suppression of this degradation by antioxidants. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15056911 |
Hoffman DR et al. | A randomized, placebo-controlled clinical trial of docosahexaenoic acid supplementation for X-linked retinitis pigmentosa. | 2004 | Am. J. Ophthalmol. | pmid:15059710 |
Parinyasiri U et al. | Effect of fish oil on oxidative stress, lipid profile and renal function in IgA nephropathy. | 2004 | J Med Assoc Thai | pmid:15061297 |
Blanco PG et al. | Induction of colitis in cftr-/- mice results in bile duct injury. | 2004 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15064232 |
Fewtrell MS et al. | Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infants. | 2004 | J. Pediatr. | pmid:15069395 |
Di Stasi D et al. | Early modifications of fatty acid composition in plasma phospholipids, platelets and mononucleates of healthy volunteers after low doses of n-3 polyunsaturated fatty acids. | 2004 | Eur. J. Clin. Pharmacol. | pmid:15069592 |
Yaqoob P | Fatty acids and the immune system: from basic science to clinical applications. | 2004 | Proc Nutr Soc | pmid:15070442 |
Lengqvist J et al. | Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain. | 2004 | Mol. Cell Proteomics | pmid:15073272 |
Speake BK et al. | Comparison of the fatty-acid compositions of prey items and yolks of Australian insectivorous scincid lizards. | 2004 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:15085383 |
Sanjurjo P et al. | Supplementation with docosahexaenoic acid in the last trimester of pregnancy: maternal-fetal biochemical findings. | 2004 | J Perinat Med | pmid:15085888 |
Denys A et al. | Thapsigargin-stimulated MAP kinase phosphorylation via CRAC channels and PLD activation: inhibitory action of docosahexaenoic acid. | 2004 | FEBS Lett. | pmid:15094063 |
Gómez de Segura IA et al. | Protective effects of dietary enrichment with docosahexaenoic acid plus protein in 5-fluorouracil-induced intestinal injury in the rat. | 2004 | Eur J Gastroenterol Hepatol | pmid:15097041 |
Leu GZ et al. | Anti-HCV activities of selective polyunsaturated fatty acids. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15110784 |
Stark KD and Holub BJ | Differential eicosapentaenoic acid elevations and altered cardiovascular disease risk factor responses after supplementation with docosahexaenoic acid in postmenopausal women receiving and not receiving hormone replacement therapy. | 2004 | Am. J. Clin. Nutr. | pmid:15113713 |
Nkondjock A and Ghadirian P | Intake of specific carotenoids and essential fatty acids and breast cancer risk in Montreal, Canada. | 2004 | Am. J. Clin. Nutr. | pmid:15113726 |
Weisman D et al. | Efficacy of omega-3 fatty acid supplementation in primary and secondary prevention of coronary heart disease. | 2004 | Isr. Med. Assoc. J. | pmid:15115262 |
Hamazaki T and Hirayama S | The effect of docosahexaenoic acid-containing food administration on symptoms of attention-deficit/hyperactivity disorder-a placebo-controlled double-blind study. | 2004 | Eur J Clin Nutr | pmid:15116088 |
Onodera K et al. | Zooxanthellactone, a novel gamma-lactone-type oxylipine from dinoflagellates of Symbiodinium sp.: structure, distribution, and biological activity. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15118313 |
Pan M et al. | Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. | 2004 | J. Clin. Invest. | pmid:15124019 |
Kida Y | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15128902 |
Agaba M et al. | Zebrafish cDNA encoding multifunctional Fatty Acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. | 2004 May-Jun | Mar. Biotechnol. | pmid:15129327 |
Steger B and Colvin HP | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15131835 |
Young GS et al. | Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. | 2004 | Lipids | pmid:15134138 |
Du C et al. | Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease. | 2004 | J. Nutr. Biochem. | pmid:15135151 |
Levant B et al. | Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. | 2004 | Behav. Brain Res. | pmid:15135968 |
Yazawa K | [Importance of "health foods", EPA and DHA, for preventive medicine]. | 2004 | Rinsho Byori | pmid:15137325 |
Hamam F and Shahidi F | Synthesis of structured lipids via acidolysis of docosahexaenoic acid single cell oil (DHASCO) with capric acid. | 2004 | J. Agric. Food Chem. | pmid:15137833 |
Zhang M and Fritsche KL | Fatty acid-mediated inhibition of IL-12 production by murine macrophages is independent of PPARgamma. | 2004 | Br. J. Nutr. | pmid:15137925 |
Payet M et al. | Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients. | 2004 | Br. J. Nutr. | pmid:15137931 |
Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
Niu SL et al. | Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. | 2004 | J. Biol. Chem. | pmid:15145938 |
Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
Mukherjee PK et al. | Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15152078 |
Thomas B et al. | Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women. | 2004 | Eur J Clin Nutr | pmid:15162132 |
Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
Thomas TR et al. | Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions. | 2004 | Metab. Clin. Exp. | pmid:15164323 |
Blanco PG et al. | Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses. | 2004 | Am. J. Obstet. Gynecol. | pmid:15167843 |
Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
Roig-Pérez S et al. | Lipid peroxidation induced by DHA enrichment modifies paracellular permeability in Caco-2 cells: protective role of taurine. | 2004 | J. Lipid Res. | pmid:15175351 |
Moriguchi T et al. | Effects of an n-3-deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats. | 2004 | J. Lipid Res. | pmid:15175358 |
Green AG | From alpha to omega-producing essential fatty acids in plants. | 2004 | Nat. Biotechnol. | pmid:15175687 |
Miles EA et al. | The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. | 2004 | Br. J. Nutr. | pmid:15182393 |
Wijendran V and Hayes KC | Dietary n-6 and n-3 fatty acid balance and cardiovascular health. | 2004 | Annu. Rev. Nutr. | pmid:15189133 |
Nguyen LQ et al. | Influence of dietary linseed, fish and coconut oil on growth performance of growing pigs kept on small holdings in central Vietnam. | 2004 | J Anim Physiol Anim Nutr (Berl) | pmid:15189425 |
Stoknes IS et al. | Fatty acid and lipid class composition in eyes and brain from teleosts and elasmobranchs. | 2004 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15193274 |
AbuGhazaleh AA and Jenkins TC | Disappearance of docosahexaenoic and eicosapentaenoic acids from cultures of mixed ruminal microorganisms. | 2004 | J. Dairy Sci. | pmid:15202649 |
Broadhurst CL et al. | (13)C nuclear magnetic resonance spectra of natural undiluted lipids: docosahexaenoic-rich phospholipid and triacylglycerol from fish. | 2004 | J. Agric. Food Chem. | pmid:15212476 |
Park Y et al. | Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids. | 2004 | Am. J. Clin. Nutr. | pmid:15213026 |
Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
Cockeran R et al. | Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. | 2004 | Infect. Immun. | pmid:15213185 |
Tsujita-Kyutoku M et al. | Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo: potential mechanisms of action. | 2004 | Breast Cancer Res. | pmid:15217495 |
Menoyo D et al. | Adaptation of lipid metabolism, tissue composition and flesh quality in gilthead sea bream (Sparus aurata) to the replacement of dietary fish oil by linseed and soyabean oils. | 2004 | Br. J. Nutr. | pmid:15230986 |
Mishra A et al. | Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15231516 |
Sankaran D et al. | Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat. | 2004 | Lipids | pmid:15233398 |
Designer eggs: best way to get your omega-3 fatty acids? | 2004 | Consum Rep | pmid:15243993 | |
Khedr EM et al. | Neural maturation of breastfed and formula-fed infants. | 2004 | Acta Paediatr. | pmid:15244219 |
Erdogan H et al. | Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15253883 |
Siddiqui RA et al. | Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid. | 2004 | J. Cell. Biochem. | pmid:15258898 |
Mattos R et al. | The effects of feeding fish oil on uterine secretion of PGF2alpha, milk composition, and metabolic status of periparturient Holstein cows. | 2004 | J. Dairy Sci. | pmid:15259226 |
AbuGhazaleh AA and Jenkins TC | Short communication: docosahexaenoic acid promotes vaccenic acid accumulation in mixed ruminal cultures when incubated with linoleic acid. | 2004 | J. Dairy Sci. | pmid:15259240 |
Colombo J et al. | Maternal DHA and the development of attention in infancy and toddlerhood. | 2004 Jul-Aug | Child Dev | pmid:15260876 |
Mesa MD et al. | Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein. | 2004 | Atherosclerosis | pmid:15262190 |
Haggarty P | Effect of placental function on fatty acid requirements during pregnancy. | 2004 | Eur J Clin Nutr | pmid:15266306 |
Fish oil: staging a comeback. | 2004 | Harv Mens Health Watch | pmid:15273065 | |
Naliwaiko K et al. | Effects of fish oil on the central nervous system: a new potential antidepressant? | 2004 | Nutr Neurosci | pmid:15279495 |
Bauer JE et al. | Maternal diet alpha-linolenic acid during gestation and lactation does not increase docosahexaenoic acid in canine milk. | 2004 | J. Nutr. | pmid:15284396 |
Calderon F and Kim HY | Docosahexaenoic acid promotes neurite growth in hippocampal neurons. | 2004 | J. Neurochem. | pmid:15287904 |
Chiu LC et al. | Docosahexaenoic acid modulates different genes in cell cycle and apoptosis to control growth of human leukemia HL-60 cells. | 2004 | Int. J. Oncol. | pmid:15289877 |
Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15290791 |
Meyer A et al. | Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis. | 2004 | J. Lipid Res. | pmid:15292371 |
Narayanan BA et al. | Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. | 2004 | Carcinogenesis | pmid:15297372 |
Broadfield EC et al. | A case-control study of dietary and erythrocyte membrane fatty acids in asthma. | 2004 | Clin. Exp. Allergy | pmid:15298563 |
Sung M et al. | Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells. | 2004 | J Med Food | pmid:15298768 |
Chen JR et al. | Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. | 2004 | J. Nutr. Biochem. | pmid:15302081 |
Takahashi M et al. | Effect of omega 3 and omega 6 fatty acids on transformation of cultured cells by irradiation and transfection. | 1992 | Cancer Res. | pmid:1530767 |
Pereira SL et al. | Identification of two novel microalgal enzymes involved in the conversion of the omega3-fatty acid, eicosapentaenoic acid, into docosahexaenoic acid. | 2004 | Biochem. J. | pmid:15307817 |
Zhao A et al. | Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 | DNA Cell Biol. | pmid:15307955 |
Hofmanová J et al. | Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. | 2005 | Eur J Nutr | pmid:15309463 |
Muderhwa JM and Brockman HL | Regulation of fatty acid 18O exchange catalyzed by pancreatic carboxylester lipase. 2. Effects of lateral lipid distribution in mixtures with phosphatidylcholine. | 1992 | Biochemistry | pmid:1531021 |
Harris JI et al. | Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15310527 |
Croset M et al. | Incorporation and turnover of eicosapentaenoic and docosahexaenoic acids in human blood platelets in vitro. | 1992 | Biochem. J. | pmid:1531291 |