| MeSH term | MeSH ID | Detail |
|---|---|---|
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ishihara K et al. | Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell. | 1998 | Lipids | pmid:9870906 |
| Yasuda S et al. | Docosahexaenoic acid-rich fish oil does not enhance the elevation of serum transaminase and liver triacylglycerol induced by carbon tetrachloride in mice. | 1997 | Lipids | pmid:9438234 |
| Hansen JB et al. | Lipid peroxidation of isolated chylomicrons and oxidative status in plasma after intake of highly purified eicosapentaenoic or docosahexaenoic acids. | 1998 | Lipids | pmid:9870908 |
| Vaagenes H et al. | Low doses of eicosapentaenoic acid, docosahexaenoic acid, and hypolipidemic eicosapentaenoic acid derivatives have no effect on lipid peroxidation in plasma. | 1998 | Lipids | pmid:9870909 |
| Farkas K et al. | Changes in the size and docosahexaenoic acid content of adipocytes during chick embryo development. | 1996 | Lipids | pmid:8900461 |
| Jeffrey BG et al. | The role of docosahexaenoic acid in retinal function. | 2001 | Lipids | pmid:11724458 |
| Ulven SM et al. | Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. | 2011 | Lipids | pmid:21042875 |
| Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
| Salem N et al. | Mechanisms of action of docosahexaenoic acid in the nervous system. | 2001 | Lipids | pmid:11724467 |
| Kraffe E et al. | Docosahexaenoic acid- and eicosapentaenoic acid-enriched cardiolipin in the Manila clam Ruditapes philippinarum. | 2005 | Lipids | pmid:16149741 |
| Sajiki J and Takahashi K | Free fatty acids inducing mouse lethal toxicity in lipid extracts of Engraulis japonica, the Japanese anchovy. | 1992 | Lipids | pmid:1487961 |
| Paschoal VA et al. | Eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid differentially modulate rat neutrophil function in vitro. | 2013 | Lipids | pmid:23086551 |
| Hamazaki T et al. | Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. | 1999 | Lipids | pmid:10419086 |
| Betancor MB et al. | Vitamin C enhances vitamin E status and reduces oxidative stress indicators in sea bass larvae fed high DHA microdiets. | 2012 | Lipids | pmid:23086553 |
| Crawford MA et al. | Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. | 1999 | Lipids | pmid:10419087 |
| Birbes H et al. | Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. | 1999 | Lipids | pmid:10419092 |
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| Sørensen BM et al. | Storage lipid accumulation and acyltransferase action in developing flaxseed. | 2005 | Lipids | pmid:16382576 |
| Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
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| Ikemoto A et al. | Effect of n-3 fatty acid deficiency on fatty acid composition and metabolism of aminophospholipids in rat brain synaptosomes. | 2000 | Lipids | pmid:11104017 |
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| Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
| Croset M et al. | In vivo compartmental metabolism of 13C-docosahexaenoic acid, studied by gas chromatography-combustion isotope ratio mass spectrometry. | 1996 | Lipids | pmid:8729104 |
| Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
| Martinez M | Docosahexaenoic acid therapy in docosahexaenoic acid-deficient patients with disorders of peroxisomal biogenesis. | 1996 | Lipids | pmid:8729110 |
| Gibson RA et al. | Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. | 1996 | Lipids | pmid:8729115 |
| Connor WE et al. | Increased docosahexaenoic acid levels in human newborn infants by administration of sardines and fish oil during pregnancy. | 1996 | Lipids | pmid:8729116 |
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| Yeh YY et al. | Modification of milk formula to enhance accretion of long-chain n-6 and n-3 polyunsaturated fatty acids in artificially reared infant rats. | 1998 | Lipids | pmid:9625599 |
| Mocellin MC et al. | Fish oil decreases C-reactive protein/albumin ratio improving nutritional prognosis and plasma fatty acid profile in colorectal cancer patients. | 2013 | Lipids | pmid:23888317 |
| Sankaran D et al. | Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat. | 2004 | Lipids | pmid:15233398 |
| Righi V et al. | EPA or DHA supplementation increases triacylglycerol, but not phospholipid, levels in isolated rat cardiomyocytes. | 2011 | Lipids | pmid:21544603 |
| Schnebelen C et al. | Dietary n-3 and n-6 PUFA enhance DHA incorporation in retinal phospholipids without affecting PGE(1) and PGE (2) levels. | 2009 | Lipids | pmid:19242743 |
| Geppert J et al. | Docosahexaenoic acid supplementation in vegetarians effectively increases omega-3 index: a randomized trial. | 2005 | Lipids | pmid:16296399 |
| Hoffman D et al. | Soy-based infant formula supplemented with DHA and ARA supports growth and increases circulating levels of these fatty acids in infants. | 2008 | Lipids | pmid:17912568 |
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| Howe PR et al. | Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. | 2002 | Lipids | pmid:12558057 |
| Peterson LD et al. | Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. | 1998 | Lipids | pmid:9507239 |
| Kao BT et al. | Mice raised on milk transgenically enriched with n-3 PUFA have increased brain docosahexaenoic acid. | 2006 | Lipids | pmid:16981432 |
| Osako K et al. | Docosahexaenoic acid levels in the lipids of spotted mackerel Scomber australasicus. | 2006 | Lipids | pmid:17069355 |
| Yano Y et al. | Production of docosahexaenoic acid by marine bacteria isolated from deep sea fish. | 1994 | Lipids | pmid:7968276 |
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| Nichols PD et al. | Occurrence of high levels of tetracosahexaenoic acid in the jellyfish Aurelia sp. | 2003 | Lipids | pmid:14733367 |
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| Halvorsen DS et al. | The effect of highly purified eicosapentaenoic and docosahexaenoic acids on monocyte phagocytosis in man. | 1997 | Lipids | pmid:9307933 |
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