| MeSH term | MeSH ID | Detail |
|---|---|---|
| Histiocytoma, Malignant Fibrous | D051677 | 1 associated lipids |
| Hydroa Vacciniforme | D006837 | 1 associated lipids |
| Communication Disorders | D003147 | 1 associated lipids |
| Trophoblastic Tumor, Placental Site | D018245 | 1 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Lordosis | D008141 | 1 associated lipids |
| Phenylketonuria, Maternal | D017042 | 1 associated lipids |
| Refsum Disease, Infantile | D052919 | 1 associated lipids |
| Pulmonary Valve Stenosis | D011666 | 1 associated lipids |
| Cerebrovascular Trauma | D020214 | 1 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kageyama K et al. | Cytotoxicity of docosahexaenoic acid and eicosapentaenoic acid in tumor cells and the dependence on binding to serum proteins and incorporation into intracellular lipids. | 2000 Jan-Feb | Oncol. Rep. | pmid:10601596 |
| LeVine SM et al. | Microchemical analysis of retina layers in pigmented and albino rats by Fourier transform infrared microspectroscopy. | 1999 | Biochim. Biophys. Acta | pmid:10594378 |
| Senkal M et al. | Outcome and cost-effectiveness of perioperative enteral immunonutrition in patients undergoing elective upper gastrointestinal tract surgery: a prospective randomized study. | 1999 | Arch Surg | pmid:10593328 |
| Levy R and Herzberg GR | Hydrolysis of long-chain, n-3 fatty acid enriched chylomicrons by cardiac lipoprotein lipase. | 1999 | Can. J. Physiol. Pharmacol. | pmid:10588486 |
| Conquer JA et al. | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects. | 1999 | Thromb. Res. | pmid:10588467 |
| Norrish AE et al. | Prostate cancer risk and consumption of fish oils: a dietary biomarker-based case-control study. | 1999 | Br. J. Cancer | pmid:10584888 |
| Samples BL et al. | Polyunsaturated fatty acids enhance the heat induced stress response in rainbow trout (Oncorhynchus mykiss) leukocytes. | 1999 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:10582313 |
| Jørgensen MH et al. | Does human milk DHA level affect functional outcome in infants? | 1999 | J Hum Lact | pmid:10578769 |
| Bisogno T et al. | Biosynthesis and inactivation of N-arachidonoylethanolamine (anandamide) and N-docosahexaenoylethanolamine in bovine retina. | 1999 | Arch. Biochem. Biophys. | pmid:10577359 |
| Yoshida H et al. | Effect of dietary seal and fish oils on triacylglycerol metabolism in rats. | 1999 | J. Nutr. Sci. Vitaminol. | pmid:10575632 |
| Madsen L et al. | Eicosapentaenoic and docosahexaenoic acid affect mitochondrial and peroxisomal fatty acid oxidation in relation to substrate preference. | 1999 | Lipids | pmid:10574660 |
| Freedman SD et al. | A membrane lipid imbalance plays a role in the phenotypic expression of cystic fibrosis in cftr(-/-) mice. | 1999 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10570187 |
| Agostoni C et al. | Long-chain polyunsaturated fatty acids in human milk. | 1999 | Acta Paediatr Suppl | pmid:10569226 |
| Purepa. | 1999 | Drugs R D | pmid:10566043 | |
| Elmore JS et al. | Effect of the polyunsaturated fatty acid composition of beef muscle on the profile of aroma volatiles. | 1999 | J. Agric. Food Chem. | pmid:10564028 |
| Bakker EC et al. | Early nutrition, essential fatty acid status and visual acuity of term infants at 7 months of age. | 1999 | Eur J Clin Nutr | pmid:10557000 |
| Senanayake SP and Shahidi F | Enzyme-assisted acidolysis of borage (Borago officinalis L.) and evening primrose (Oenothera biennis L.) oils: incorporation of omega-3 polyunsaturated fatty acids. | 1999 | J. Agric. Food Chem. | pmid:10552616 |
| Huang C and Li S | Calorimetric and molecular mechanics studies of the thermotropic phase behavior of membrane phospholipids. | 1999 | Biochim. Biophys. Acta | pmid:10548720 |
| de la Presa Owens S and Innis SM | Docosahexaenoic and arachidonic acid prevent a decrease in dopaminergic and serotoninergic neurotransmitters in frontal cortex caused by a linoleic and alpha-linolenic acid deficient diet in formula-fed piglets. | 1999 | J. Nutr. | pmid:10539789 |
| Zaouali-Ajina M et al. | Dietary docosahexaenoic acid-enriched phospholipids normalize urinary melatonin excretion in adult (n-3) polyunsaturated fatty acid-deficient rats. | 1999 | J. Nutr. | pmid:10539787 |
| Franklin ST et al. | Dietary marine algae (Schizochytrium sp.) increases concentrations of conjugated linoleic, docosahexaenoic and transvaccenic acids in milk of dairy cows. | 1999 | J. Nutr. | pmid:10539783 |
| Xiao Y and Li X | Polyunsaturated fatty acids modify mouse hippocampal neuronal excitability during excitotoxic or convulsant stimulation. | 1999 | Brain Res. | pmid:10536218 |
| Rose DP and Connolly JM | Antiangiogenicity of docosahexaenoic acid and its role in the suppression of breast cancer cell growth in nude mice. | 1999 | Int. J. Oncol. | pmid:10536186 |
| Ku K et al. | Beneficial effects of omega-3 fatty acid treatment on the recovery of cardiac function after cold storage of hyperlipidemic rats. | 1999 | Metab. Clin. Exp. | pmid:10535379 |
| Desvergne B and Wahli W | Peroxisome proliferator-activated receptors: nuclear control of metabolism. | 1999 | Endocr. Rev. | pmid:10529898 |
| Conquer JA et al. | Fatty acid analysis of blood serum, seminal plasma, and spermatozoa of normozoospermic vs. asthenozoospermic males. | 1999 | Lipids | pmid:10529089 |
| Véricel E et al. | The influence of low intake of n-3 fatty acids on platelets in elderly people. | 1999 | Atherosclerosis | pmid:10525140 |
| Nguyen KA et al. | The PPAR activator docosahexaenoic acid prevents acetaminophen hepatotoxicity in male CD-1 mice. | 1999 | J. Toxicol. Environ. Health Part A | pmid:10522648 |
| Pakala R et al. | Eicosapentaenoic acid and docosahexaenoic acid block serotonin-induced smooth muscle cell proliferation. | 1999 | Arterioscler. Thromb. Vasc. Biol. | pmid:10521359 |
| Morris SA et al. | Developmental sensitivity of the piglet brain to docosahexanoic acid. | 1999 | Pediatr. Res. | pmid:10509359 |
| Lemaitre-Delaunay D et al. | Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [(13)C]DHA in phosphatidylcholine. | 1999 | J. Lipid Res. | pmid:10508206 |
| Jørgensen MH et al. | The role of long-chain polyunsaturated fatty acids in neonatal nutrition. | 1999 | Acta Paediatr. | pmid:10503696 |
| Clandinin MT et al. | Assessment of feeding different amounts of arachidonic and docosahexaenoic acids in preterm infant formulas on the fatty acid content of lipoprotein lipids. | 1999 | Acta Paediatr. | pmid:10503691 |
| Cunnane SC et al. | Docosahexaenoate requirement and infant development. | 1999 | Nutrition | pmid:10501301 |
| Gee JM et al. | Consumption of fish oil leads to prompt incorporation of eicosapentaenoic acid into colonic mucosa of patients prior to surgery for colorectal cancer, but has no detectable effect on epithelial cytokinetics. | 1999 | J. Nutr. | pmid:10498759 |
| Berge RK et al. | In contrast with docosahexaenoic acid, eicosapentaenoic acid and hypolipidaemic derivatives decrease hepatic synthesis and secretion of triacylglycerol by decreased diacylglycerol acyltransferase activity and stimulation of fatty acid oxidation. | 1999 | Biochem. J. | pmid:10493929 |
| Barber MD et al. | The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. | 1999 | Br. J. Cancer | pmid:10487616 |
| Hishinuma T et al. | Effects of long-term supplementation of eicosapentanoic and docosahexanoic acid on the 2-, 3-series prostacyclin production by endothelial cells. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10480487 |
| Horrocks LA and Yeo YK | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479465 |
| Lagarde M | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479462 |
| Galli C | Health implications of DHA. | 1999 | Pharmacol. Res. | pmid:10479461 |
| Chen H et al. | Synthesis and release of docosahexaenoic acid by the RPE cells of prcd-affected dogs. | 1999 | Invest. Ophthalmol. Vis. Sci. | pmid:10476811 |
| Risé P and Galli C | Arachidonic and docosahexaenoic acids differentially affect the expression of fatty acyl-CoA oxidase, protein kinase C and lipid peroxidation in HepG2 cells. | 1999 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10471123 |
| Gilbert M et al. | Differential effects of long chain n-3 fatty acids on the expression of PGH synthase isoforms in bovine aortic endothelial cells. | 1999 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10471122 |
| Makrides M et al. | Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: A randomized clinical trial. | 1999 | Pediatrics | pmid:10469771 |
| Foulon T et al. | Effects of fish oil fatty acids on plasma lipids and lipoproteins and oxidant-antioxidant imbalance in healthy subjects. | 1999 | Scand. J. Clin. Lab. Invest. | pmid:10463462 |
| Helge JW et al. | Regular exercise modulates muscle membrane phospholipid profile in rats. | 1999 | J. Nutr. | pmid:10460197 |
| Mori TA et al. | Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. | 1999 | Hypertension | pmid:10454450 |
| Matsuyama N et al. | Polyunsaturated fatty acid anilides as inhibitors of acyl-coA: cholesterol acyltransferase (ACAT). | 1999 | Bioorg. Med. Chem. Lett. | pmid:10450977 |
| Smuts CM et al. | Smoking and alcohol use during pregnancy affects preterm infants' docosahexaenoic acid (DHA) status. | 1999 | Acta Paediatr. | pmid:10447136 |
| Hoffman DR et al. | Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. | 1999 | Lipids | pmid:10443966 |
| Kelley DS et al. | Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men. | 1999 | Lipids | pmid:10443964 |
| de Deckere EA | Possible beneficial effect of fish and fish n-3 polyunsaturated fatty acids in breast and colorectal cancer. | 1999 | Eur. J. Cancer Prev. | pmid:10443950 |
| Rodriguez de Turco EB et al. | Selective retinal pigment epithelial cell lipid metabolism and remodeling conserves photoreceptor docosahexaenoic acid following phagocytosis. | 1999 | J. Neurosci. Res. | pmid:10440897 |
| Singleton CB et al. | Blockade by N-3 polyunsaturated fatty acid of the Kv4.3 current stably expressed in Chinese hamster ovary cells. | 1999 | Br. J. Pharmacol. | pmid:10433502 |
| Gamoh S et al. | Chronic administration of docosahexaenoic acid improves reference memory-related learning ability in young rats. | 1999 | Neuroscience | pmid:10430487 |
| Pakala R et al. | Serotonin fails to induce proliferation of endothelial cells preloaded with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Atherosclerosis | pmid:10428304 |
| Guesnet P et al. | Blood lipid concentrations of docosahexaenoic and arachidonic acids at birth determine their relative postnatal changes in term infants fed breast milk or formula. | 1999 | Am. J. Clin. Nutr. | pmid:10426708 |
| Terano T et al. | Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. | 1999 | Lipids | pmid:10419198 |
| Horrocks LA and Yeo YK | Docosahexaenoic acid-enriched foods: production and effects on blood lipids. | 1999 | Lipids | pmid:10419189 |
| Howe PR et al. | Equal antithrombotic and triglyceride-lowering effectiveness of eicosapentaenoic acid-rich and docosahexaenoic acid-rich fish oil supplements. | 1999 | Lipids | pmid:10419186 |
| Harris WS | n-3 fatty acids and human lipoprotein metabolism: an update. | 1999 | Lipids | pmid:10419172 |
| Kim HY and Edsall L | The role of docosahexaenoic acid (22:6n-3) in neuronal signaling. | 1999 | Lipids | pmid:10419168 |
| Glozman S et al. | Ethyl docosahexaenoic acid administration during intrauterine life enhances prostanoid production and reduces free radicals generation in the fetal rat brain. | 1999 | Lipids | pmid:10419167 |
| Kyle DJ et al. | Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. | 1999 | Lipids | pmid:10419166 |
| Greiner RS et al. | Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. | 1999 | Lipids | pmid:10419165 |
| Anderson RE et al. | A hypothesis to explain the reduced blood levels of docosahexaenoic acid in inherited retinal degenerations caused by mutations in genes encoding retina-specific proteins. | 1999 | Lipids | pmid:10419164 |
| Borod E et al. | Effects of third trimester consumption of eggs high in docosahexaenoic acid on docosahexaenoic acid status and pregnancy. | 1999 | Lipids | pmid:10419162 |
| van Houwelingen AC et al. | The female docosahexaenoic acid status related to the number of completed pregnancies. | 1999 | Lipids | pmid:10419161 |
| Otto SJ et al. | The postpartum docosahexaenoic acid status of lactating and nonlactating mothers. | 1999 | Lipids | pmid:10419160 |
| Jensen CL et al. | Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. | 1999 | Lipids | pmid:10419159 |
| Løchsen T et al. | Effects of fish oil and n-3 fatty acids on the regulation of delta9-fatty acid desaturase mRNA and -activity in rat liver. | 1999 | Lipids | pmid:10419157 |
| Gilbert M et al. | Opposite regulation of prostaglandin H synthase isoforms by eicosapentaenoic and docosahexaenoic acids. | 1999 | Lipids | pmid:10419156 |
| Rotstein NP et al. | Essentiality of docosahexaenoic acid in retina photoreceptor cell development. | 1999 | Lipids | pmid:10419114 |
| Calviello G et al. | Effects of eicosapentaenoic and docosahexaenoic acids dietary supplementation on cell proliferation and apoptosis in rat colonic mucosa. | 1999 | Lipids | pmid:10419112 |
| Bougnoux P et al. | Cytotoxic drug efficacy correlates with adipose tissue docosahexaenoic acid level in locally advanced breast carcinoma. | 1999 | Lipids | pmid:10419111 |
| Finstad HS et al. | Proliferation and types of killing of leukemia cell lines by very long chain polyunsaturated fatty acids. | 1999 | Lipids | pmid:10419110 |
| Takahata K et al. | Protection from chemotherapy-induced alopecia by docosahexaenoic acid. | 1999 | Lipids | pmid:10419109 |
| McLennan PL and Raederstorff D | Diabetes puts myocardial n-3 fatty acid status at risk in the absence of supplementation in the rat. | 1999 | Lipids | pmid:10419102 |
| Birbes H et al. | Inhibition of Ca2+-independent phospholipase A2 affects arachidonate-, not docosahexaenoate-, phospholipid remodeling in U(III) cells. | 1999 | Lipids | pmid:10419092 |
| Crawford MA et al. | Evidence for the unique function of docosahexaenoic acid during the evolution of the modern hominid brain. | 1999 | Lipids | pmid:10419087 |
| Hamazaki T et al. | Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. | 1999 | Lipids | pmid:10419086 |
| Calviello G et al. | Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. | 1999 | Lipids | pmid:10405974 |
| Andersen LF et al. | Evaluation of a food frequency questionnaire with weighed records, fatty acids, and alpha-tocopherol in adipose tissue and serum. | 1999 | Am. J. Epidemiol. | pmid:10400557 |
| Kafrawy O et al. | Docosahexaenoic acid in phosphatidylcholine mediates cytotoxicity more effectively than other omega-3 and omega-6 fatty acids. | 1998 | Cancer Lett. | pmid:10397449 |
| Pakala R et al. | Thromboxane A2 fails to induce proliferation of smooth muscle cells enriched with eicosapentaenoic acid and docosahexaenoic acid. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10397410 |
| Wijendran V et al. | Maternal plasma phospholipid polyunsaturated fatty acids in pregnancy with and without gestational diabetes mellitus: relations with maternal factors. | 1999 | Am. J. Clin. Nutr. | pmid:10393139 |
| Harding CO et al. | Docosahexaenoic acid and retinal function in children with long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency. | 1999 | J. Inherit. Metab. Dis. | pmid:10384386 |
| Yeh YY et al. | Dietary supplementation with arachidonic and docosahexaenoic acids has no effect on pulmonary surfactant in artificially reared infant rats. | 1999 | Lipids | pmid:10380120 |
| Smit EN et al. | Low erythrocyte docosahexaenoic acid in malnourished, often breast-fed, Pakistani infants: a matter of concern? | 1999 | Eur. J. Pediatr. | pmid:10378406 |
| Flock S et al. | Syntheses of some polyunsaturated sulfur- and oxygen-containing fatty acids related to eicosapentaenoic and docosahexaenoic acids. | 1999 | Acta Chem. Scand. | pmid:10377950 |
| Higgins S et al. | Effects of oleic acid, docosahexaenoic acid and eicosapentaenoic acid on background and genotoxin-induced frequencies of SCEs in Indian muntjac fibroblasts. | 1999 | Mutagenesis | pmid:10375002 |
| Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
| Barichello JM et al. | Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids. | 1999 | Int J Pharm | pmid:10361163 |
| Kotkat HM et al. | Effect of dietary fish oil (active EPA-30) on liver phospholipids in young and aged rats. | 1999 | Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. | pmid:10356759 |
| Marckmann P | Footprint of fish: docosahexaenoic acid (DHA) in adipose tissue. | 1999 | Nutrition | pmid:10355858 |
| Shahar E et al. | Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10351918 |
| Roberts LJ et al. | Novel eicosanoids. Isoprostanes and related compounds. | 1999 | Methods Mol. Biol. | pmid:10343322 |
| Masuda R et al. | Incorporation of dietary docosahexaenoic acid into the central nervous system of the yellowtail Seriola quinqueradiata. | 1999 | Brain Behav. Evol. | pmid:10343083 |
| Hun CS et al. | Increased uncoupling protein2 mRNA in white adipose tissue, and decrease in leptin, visceral fat, blood glucose, and cholesterol in KK-Ay mice fed with eicosapentaenoic and docosahexaenoic acids in addition to linolenic acid. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10334920 |