| MeSH term | MeSH ID | Detail |
|---|---|---|
| Body Weight | D001835 | 333 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Cell Transformation, Neoplastic | D002471 | 126 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Green P and Yavin E | Modulation of fetal rat brain and liver phospholipid content by intraamniotic ethyl docosahexaenoate administration. | 1995 | J. Neurochem. | pmid:7595551 |
| Schaefer EJ et al. | Red blood cell membrane phosphatidylethanolamine fatty acid content in various forms of retinitis pigmentosa. | 1995 | J. Lipid Res. | pmid:7595066 |
| Romans JR et al. | Effects of ground flaxseed in swine diets on pig performance and on physical and sensory characteristics and omega-3 fatty acid content of pork: II. Duration of 15% dietary flaxseed. | 1995 | J. Anim. Sci. | pmid:7592083 |
| Fujita T et al. | Effects of fatty acids and fatty acyl CoA esters on Cu(2+)-induced conversion of xanthine dehydrogenase to oxidase in rabbit liver. | 1995 | Free Radic. Biol. Med. | pmid:7590398 |
| Oshima M et al. | Effects of docosahexaenoic acid (DHA) on intestinal polyp development in Apc delta 716 knockout mice. | 1995 | Carcinogenesis | pmid:7586174 |
| Burdon RH et al. | Hydrogen peroxide and the proliferation of BHK-21 cells. | 1995 | Free Radic. Res. | pmid:7581830 |
| Marckmann P et al. | Biomarkers of habitual fish intake in adipose tissue. | 1995 | Am. J. Clin. Nutr. | pmid:7572741 |
| Mantzioris E et al. | Nutritional attributes of dietary flaxseed oil. | 1995 | Am. J. Clin. Nutr. | pmid:7572718 |
| Clark RM and She L | Lymphatic fatty acids from rats fed human milk and formula supplemented with fish oil. | 1995 | Lipids | pmid:7564923 |
| Siscovick DS et al. | Dietary intake and cell membrane levels of long-chain n-3 polyunsaturated fatty acids and the risk of primary cardiac arrest. | 1995 | JAMA | pmid:7563561 |
| Rapoport SI | Docosahexaenoate turnover in brain phospholipids. | 1995 | J. Neurochem. | pmid:7561892 |
| Rhodes LE et al. | Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption. | 1995 | J. Invest. Dermatol. | pmid:7561154 |
| Pietsch A et al. | N-3 but not N-6 fatty acids reduce the expression of the combined adhesion and scavenger receptor CD36 in human monocytic cells. | 1995 | Cell Biochem. Funct. | pmid:7554100 |
| Maldjian A et al. | The transfer of docosahexaenoic acid from the yolk to the tissues of the chick embryo. | 1995 | Biochim. Biophys. Acta | pmid:7548187 |
| Al MD et al. | Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. | 1995 | Br. J. Nutr. | pmid:7547829 |
| De Caterina R et al. | Omega-3 fatty acids and endothelial leukocyte adhesion molecules. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7540306 |
| Weber C et al. | Docosahexaenoic acid selectively attenuates induction of vascular cell adhesion molecule-1 and subsequent monocytic cell adhesion to human endothelial cells stimulated by tumor necrosis factor-alpha. | 1995 | Arterioscler. Thromb. Vasc. Biol. | pmid:7538427 |
| De Caterina R et al. | The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells. | 1994 | Arterioscler. Thromb. | pmid:7524649 |
| Pepe S et al. | Omega 3 polyunsaturated fatty acid modulates dihydropyridine effects on L-type Ca2+ channels, cytosolic Ca2+, and contraction in adult rat cardiac myocytes. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:7522322 |
| Nishikawa M et al. | Facilitatory effect of docosahexaenoic acid on N-methyl-D-aspartate response in pyramidal neurones of rat cerebral cortex. | 1994 | J. Physiol. (Lond.) | pmid:7514666 |
| Sasaki YF et al. | Bio-anticlastogenic effects of unsaturated fatty acids included in fish oil--docosahexaenoic acid, docosapentaenoic acid, and eicosapentaenoic acid--in cultured Chinese hamster cells. | 1994 | Mutat. Res. | pmid:7506391 |
| Ruan C et al. | Milk composition in women from five different regions of China: the great diversity of milk fatty acids. | 1995 | J. Nutr. | pmid:7500177 |
| Farquharson J et al. | Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. | 1995 | Pediatr. Res. | pmid:7494660 |
| Bankey P et al. | Liposomes modulate Kupffer cell endotoxin response. | 1995 | Arch Surg | pmid:7492273 |
| Decsi T et al. | Long-chain polyunsaturated fatty acids in children with severe protein-energy malnutrition with and without human immunodeficiency virus-1 infection. | 1995 | Am. J. Clin. Nutr. | pmid:7491893 |
| Sadou H et al. | Differential incorporation of fish-oil eicosapentaenoate and docosahexaenoate into lipids of lipoprotein fractions as related to their glyceryl esterification: a short-term (postprandial) and long-term study in healthy humans. | 1995 | Am. J. Clin. Nutr. | pmid:7491879 |
| Hrelia S et al. | Essential fatty acid metabolism in cultured rat cardiomyocytes in response to either N-6 or N-3 fatty acid supplementation. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7488075 |
| Toft I et al. | Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension. A randomized, controlled trial. | 1995 | Ann. Intern. Med. | pmid:7486485 |
| Noguchi M et al. | Effects of eicosapentaenoic and docosahexaenoic acid on cell growth and prostaglandin E and leukotriene B production by a human breast cancer cell line (MDA-MB-231). | 1995 Nov-Dec | Oncology | pmid:7478431 |
| Van den Branden C et al. | Peroxisomes in mice fed a diet supplemented with low doses of fish oil. | 1995 | Lipids | pmid:7475984 |
| Peet M et al. | Depleted red cell membrane essential fatty acids in drug-treated schizophrenic patients. | 1995 May-Jun | J Psychiatr Res | pmid:7473298 |
| Koletzko B et al. | Effects of a low birthweight infant formula containing human milk levels of docosahexaenoic and arachidonic acids. | 1995 | J. Pediatr. Gastroenterol. Nutr. | pmid:7472907 |
| Okita M et al. | n-3 and n-6 fatty acid intake and serum phospholipid fatty acid composition in middle-aged women living in rural and urban areas in Okayama Prefecture. | 1995 | J. Nutr. Sci. Vitaminol. | pmid:7472676 |
| Armstrong D et al. | Studies on experimentally induced retinal degeneration. 1. Effect of lipid peroxides on electroretinographic activity in the albino rabbit. | 1982 | Exp. Eye Res. | pmid:7151884 |
| Organisciak DT et al. | Rod outer segment lipid--opsin ratios in the developing normal and retinal dystrophic rat. | 1982 | Exp. Eye Res. | pmid:6461559 |
| Nissen HP et al. | [Significance of bound fatty acids in human sperm in fertility disorders]. | 1981 Sep-Oct | Andrologia | pmid:6459043 |
| Sanders TA and Naismith DJ | The metabolism of alpha-linolenic acid by the foetal rat. | 1980 | Br. J. Nutr. | pmid:6448628 |
| Giesing M and Zilliken F | Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter. | 1980 | Neurochem. Res. | pmid:6445512 |
| Castledine AJ and Buckley JT | Distribution and mobility of omega 3 fatty acids in rainbow trout fed varying levels and types of dietary lipid. | 1980 | J. Nutr. | pmid:6445002 |
| Bruckner GG et al. | Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. | 1984 | Thromb. Res. | pmid:6330927 |
| Fischer S et al. | Uptake, release and metabolism of docosahexaenoic acid (DHA, c22:6 omega 3) in human platelets and neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329189 |
| Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
| Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
| Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
| Corey EJ et al. | Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6304720 |
| Sanders TA and Roshanai F | The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. | 1983 | Clin. Sci. | pmid:6295686 |
| Studies of docosahexaenoic and eicosapentaenoic acids in trout and frogs. | 1982 | Nutr. Rev. | pmid:6289203 | |
| Mai J et al. | A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. | 1981 | Prostaglandins | pmid:6280241 |
| De Schrijver R and Privett OS | Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | 1982 | J. Nutr. | pmid:6279803 |
| Sanders TA et al. | Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. | 1981 | Clin. Sci. | pmid:6266735 |