DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Body Weight D001835 333 associated lipids
Lung Neoplasms D008175 171 associated lipids
Adenocarcinoma D000230 166 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Edema D004487 152 associated lipids
Carcinoma, Hepatocellular D006528 140 associated lipids
Hemolysis D006461 131 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Inflammation D007249 119 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Gu Z et al. Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes. 2016 Innate Immun pmid:26878867
Liu Y et al. Resolvin D1 protects against inflammation in experimental acute pancreatitis and associated lung injury. 2016 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:26702138
Crandell JR et al. Lipid effects of switching from prescription EPA+DHA (omega-3-acid ethyl esters) to prescription EPA only (icosapent ethyl) in dyslipidemic patients. 2016 Postgrad Med pmid:27684412
Visentin S et al. Red blood cell membrane fatty acid composition in infants fed formulas with different lipid profiles. 2016 Early Hum. Dev. pmid:27391868
Zhang MJ et al. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. 2016 Circulation pmid:27507404
Stein K et al. A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation. 2016 J. Leukoc. Biol. pmid:26292977
McManus S et al. Differential effects of EPA versus DHA on postprandial vascular function and the plasma oxylipin profile in men. 2016 J. Lipid Res. pmid:27170732
Graciano MF et al. Omega-3 fatty acids control productions of superoxide and nitrogen oxide and insulin content in INS-1E cells. 2016 J. Physiol. Biochem. pmid:27474043
Li R et al. Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. 2016 Oxid Med Cell Longev pmid:26881046
Hanssens L et al. The clinical benefits of long-term supplementation with omega-3 fatty acids in cystic fibrosis patients - A pilot study. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27154364
Ghosh S et al. Epigenomic maintenance through dietary intervention can facilitate DNA repair process to slow down the progress of premature aging. 2016 IUBMB Life pmid:27364681
Subbaiah PV et al. Enhanced incorporation of dietary DHA into lymph phospholipids by altering its molecular carrier. 2016 Biochim. Biophys. Acta pmid:27178174
Bassuk SS et al. Baseline characteristics of participants in the VITamin D and OmegA-3 TriaL (VITAL). 2016 Contemp Clin Trials pmid:26767629
Allaire J et al. A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: the Comparing EPA to DHA (ComparED) Study. 2016 Am. J. Clin. Nutr. pmid:27281302
Gramer G et al. Long-chain polyunsaturated fatty acid status in children, adolescents and adults with phenylketonuria. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:27269713
Wang H et al. Potential serum biomarkers from a metabolomics study of autism. 2016 J Psychiatry Neurosci pmid:26395811
Si TL et al. Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation. 2016 Mol Med Rep pmid:27176922
Primdahl KG et al. Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins. 2016 J. Nat. Prod. pmid:27704804
Jeyanathan J et al. Biohydrogenation of 22:6n-3 by Butyrivibrio proteoclasticus P18. 2016 BMC Microbiol. pmid:27283157
Khaire A et al. Vitamin B Deficiency Across Three Generations Adversely Influences Long-chain Polyunsaturated Fatty Acid Status and Cardiometabolic Markers in Rats. 2016 Arch. Med. Res. pmid:27986122
Meesawatsom P et al. Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. 2016 J Neuroinflammation pmid:27589850
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Arnold WR et al. Asymmetric Binding and Metabolism of Polyunsaturated Fatty Acids (PUFAs) by CYP2J2 Epoxygenase. 2016 Biochemistry pmid:27992998
Zhao Z et al. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. 2016 PLoS ONE pmid:27880795
Lo Van A et al. Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases. 2016 Biochimie pmid:27496085
Easley JT et al. AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. 2016 Physiol Rep pmid:27694530
McNamara RK and Welge JA Meta-analysis of erythrocyte polyunsaturated fatty acid biostatus in bipolar disorder. 2016 Bipolar Disord pmid:27087497
Bascoul-Colombo C et al. Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease. 2016 Biochim. Biophys. Acta pmid:26968097
Zhao YL et al. Resolvin D1 Protects Lipopolysaccharide-induced Acute Kidney Injury by Down-regulating Nuclear Factor-kappa B Signal and Inhibiting Apoptosis. 2016 Chin. Med. J. pmid:27098797
Shi H et al. VIP protects human retinal microvascular endothelial cells against high glucose-induced increases in TNF-α and enhances RvD1. 2016 Prostaglandins Other Lipid Mediat. pmid:27026343
Schmid M et al. Resolvin D1 Polarizes Primary Human Macrophages toward a Proresolution Phenotype through GPR32. 2016 J. Immunol. pmid:26969756
Shomonov-Wagner L et al. Alpha linolenic acid in maternal diet halts the lipid disarray due to saturated fatty acids in the liver of mice offspring at weaning. 2015 Lipids Health Dis pmid:25889505
Prieto P et al. Activation of autophagy in macrophages by pro-resolving lipid mediators. 2015 Autophagy pmid:26506892
Wu A et al. Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. 2015 Biochim. Biophys. Acta pmid:25550171
Hsiao HM et al. Resolvin D1 Reduces Emphysema and Chronic Inflammation. 2015 Am. J. Pathol. pmid:26468975
Maekawa T et al. Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. 2015 Nat Commun pmid:26374165
Cox R et al. Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. 2015 PLoS ONE pmid:26317859
Herrera BS et al. LXA4 actions direct fibroblast function and wound closure. 2015 Biochem. Biophys. Res. Commun. pmid:26188508
Rossi S et al. Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats. 2015 Mediators Inflamm. pmid:26180376
de Oliveira JR et al. AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4. 2015 Biomed Res Int pmid:26075216
Shevalye H et al. Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. 2015 J. Neurophysiol. pmid:25925322
Kain V et al. Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function. 2015 J. Mol. Cell. Cardiol. pmid:25870158
Fiala M et al. ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. 2015 FASEB J. pmid:25805829
Dalli J et al. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. 2015 FASEB J. pmid:25713027
Guichardant M et al. Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. 2015 Biochim. Biophys. Acta pmid:25263947
Cox R et al. Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. 2015 Am. J. Respir. Cell Mol. Biol. pmid:25647402
Saito H et al. Variation of Lipids and Fatty Acids of the Japanese Freshwater Eel, Anguilla japonica, during Spawning Migration. 2015 J Oleo Sci pmid:26028326
Cespedes E et al. Adipose tissue n-3 fatty acids and metabolic syndrome. 2015 Eur J Clin Nutr pmid:25097001
Ting HC et al. Polyunsaturated fatty acids incorporation into cardiolipin in H9c2 cardiac myoblast. 2015 J. Nutr. Biochem. pmid:25866137
Valenzuela R et al. Modification of Docosahexaenoic Acid Composition of Milk from Nursing Women Who Received Alpha Linolenic Acid from Chia Oil during Gestation and Nursing. 2015 Nutrients pmid:26247968
Gavzan H et al. Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. 2015 Naunyn Schmiedebergs Arch. Pharmacol. pmid:26018398
Chiang N et al. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. 2015 J. Exp. Med. pmid:26195725
Wang H et al. 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids. 2015 Chem. Res. Toxicol. pmid:25793308
Marinho GS et al. Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. 2015 Mar Drugs pmid:26184241
Koh AS et al. The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. 2015 Eur J Prev Cardiol pmid:24343844
Wang X et al. Resolution of inflammation is altered in Alzheimer's disease. 2015 Alzheimers Dement pmid:24530025
Aursnes M et al. Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. 2015 J. Nat. Prod. pmid:26580578
Keim SA and Branum AM Dietary intake of polyunsaturated fatty acids and fish among US children 12-60 months of age. 2015 Matern Child Nutr pmid:24034437
Calandria JM et al. NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. 2015 Cell Death Differ. pmid:25633199
Musto AE et al. Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. 2015 PLoS ONE pmid:25617763
Kanan Y et al. Neuroprotectin D1 is synthesized in the cone photoreceptor cell line 661W and elicits protection against light-induced stress. 2015 Cell. Mol. Neurobiol. pmid:25212825
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Serhan CN et al. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. 2015 Biochim. Biophys. Acta pmid:25139562
Wang CW et al. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. 2015 Infect. Immun. pmid:26667839
Nordgren TM et al. Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. 2015 Transl Res pmid:25655838
Krishnamoorthy N et al. Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. 2015 J. Immunol. pmid:25539814
Hashim RB et al. Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. 2015 J Oleo Sci pmid:25748380
Askari M et al. Tissue fatty acid composition and secretory phospholipase-A2 activity in oral squamous cell carcinoma. 2015 Clin Transl Oncol pmid:25351172
Tyurina YY et al. LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. 2015 Free Radic. Res. pmid:25740198
Clouard C et al. Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. 2015 J. Nutr. pmid:25644359
Hsieh JC et al. High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. 2015 J. Pediatr. Gastroenterol. Nutr. pmid:25633498
Wang Y et al. Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. 2015 ACS Appl Mater Interfaces pmid:26539742
Ercan S et al. Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. 2015 Lipids Health Dis pmid:25889219
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Wang Y et al. Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles. 2015 Colloids Surf B Biointerfaces pmid:26454543
Maciejewska D et al. Fatty acid changes help to better understand regression of nonalcoholic fatty liver disease. 2015 World J. Gastroenterol. pmid:25574105
Chen CT et al. Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain. 2015 Sci Rep pmid:26511533
Berge RK et al. Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. 2015 Lipids Health Dis pmid:26666303
Holen E et al. Combining eicosapentaenoic acid, decosahexaenoic acid and arachidonic acid, using a fully crossed design, affect gene expression and eicosanoid secretion in salmon head kidney cells in vitro. 2015 Fish Shellfish Immunol. pmid:26003739
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Yoshinaga K et al. Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. 2015 J. Nutr. Biochem. pmid:25448607
Hiram R et al. Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries. 2015 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:26320154
Cheatham CL and Sheppard KW Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. 2015 Nutrients pmid:26540073
Lucena CF et al. Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies. 2015 Pancreas pmid:25426612
Brigandi SA et al. Autistic children exhibit decreased levels of essential Fatty acids in red blood cells. 2015 Int J Mol Sci pmid:25946342
Chew EY et al. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. 2015 JAMA pmid:26305649
Ossani GP et al. Short-term menhaden oil rich diet changes renal lipid profile in acute kidney injury. 2015 J Oleo Sci pmid:25948137
Samokhvalov V et al. PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. 2015 Toxicol. Lett. pmid:25300478
Honda KL et al. Docosahexaenoic acid differentially affects TNFα and IL-6 expression in LPS-stimulated RAW 264.7 murine macrophages. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25921297
Wang Y et al. Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. 2015 Shock pmid:26196843
Block RC et al. The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. 2015 Prostaglandins Leukot. Essent. Fatty Acids pmid:25555354
Yang S et al. Effect of thermal processing on astaxanthin and astaxanthin esters in pacific white shrimp Litopenaeus vannamei. 2015 J Oleo Sci pmid:25757428
Véricel E et al. Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. 2015 Thromb. Haemost. pmid:25832443
Wijendran V et al. Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. 2015 Pediatr. Res. pmid:26270575
Bobiński R and Mikulska M The ins and outs of maternal-fetal fatty acid metabolism. 2015 Acta Biochim. Pol. pmid:26345097
Hieda K et al. Pharmacological effect of functional foods with a hypotensive action. 2015 Nippon Yakurigaku Zasshi pmid:26165340
Mansara PP et al. Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. 2015 PLoS ONE pmid:26325577
Mason JK et al. α-linolenic acid and docosahexaenoic acid, alone and combined with trastuzumab, reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways. 2015 Lipids Health Dis pmid:26282560
Domenichiello AF et al. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? 2015 Prog. Lipid Res. pmid:25920364