| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Habitual | D000026 | 5 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Albinism | D000417 | 3 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Politi L et al. | Effects of docosahexaenoic acid on retinal development: cellular and molecular aspects. | 2001 | Lipids | pmid:11724465 |
| Salem N et al. | Mechanisms of action of docosahexaenoic acid in the nervous system. | 2001 | Lipids | pmid:11724467 |
| Das UN et al. | Effect of corticosteroids and eicosapentaenoic acid/docosahexaenoic acid on pro-oxidant and anti-oxidant status and metabolism of essential fatty acids in patients with glomerular disorders. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728172 |
| Mizejewski GJ and Pass KA | Fatty acids, alpha-fetoprotein, and cystic fibrosis. | 2001 | Pediatrics | pmid:11731663 |
| Ferdinandusse S et al. | Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. | 2001 | J. Lipid Res. | pmid:11734571 |
| Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase (ERK1/ERK2) signaling in human T cells. | 2001 | J. Lipid Res. | pmid:11734574 |
| Fernández-Real JM et al. | Circulating granulocyte-macrophage colony-stimulating factor and serum fatty acid composition in men and women. | 2001 | Metab. Clin. Exp. | pmid:11735097 |
| Pradalier A et al. | Failure of omega-3 polyunsaturated fatty acids in prevention of migraine: a double-blind study versus placebo. | 2001 | Cephalalgia | pmid:11737007 |
| Contreras MA et al. | Chronic nutritional deprivation of n-3 alpha-linolenic acid does not affect n-6 arachidonic acid recycling within brain phospholipids of awake rats. | 2001 | J. Neurochem. | pmid:11739623 |
| Petrache HI et al. | Structural properties of docosahexaenoyl phospholipid bilayers investigated by solid-state 2H NMR spectroscopy. | 2001 | J. Am. Chem. Soc. | pmid:11741426 |
| Noguchi R et al. | Dietary effects of bitter gourd oil on blood and liver lipids of rats. | 2001 | Arch. Biochem. Biophys. | pmid:11747298 |
| Siddiqui RA et al. | Prevention of docosahexaenoic acid-induced cytotoxicity by phosphatidic acid in Jurkat leukemic cells: the role of protein phosphatase-1. | 2001 | Biochim. Biophys. Acta | pmid:11755213 |
| de Swaaf ME et al. | Characterisation of extracellular polysaccharides produced by Crypthecodinium cohnii. | 2001 | Appl. Microbiol. Biotechnol. | pmid:11759692 |
| Reich EE et al. | Quantification of F-ring and D-/E-ring isoprostanes and neuroprostanes in Alzheimer's disease. | 2001 | Adv. Exp. Med. Biol. | pmid:11764949 |
| Bell MV et al. | Biosynthesis and tissue deposition of docosahexaenoic acid (22:6n-3) in rainbow trout (Oncorhynchus mykiss). | 2001 | Lipids | pmid:11768160 |
| Hawkes JS et al. | Transforming growth factor beta in human milk does not change in response to modest intakes of docosahexaenoic acid. | 2001 | Lipids | pmid:11768164 |
| Wu FC et al. | Docosahexaenoic acid is superior to eicosapentaenoic acid as the essential fatty acid for growth of grouper, Epinephelus malabaricus. | 2002 | J. Nutr. | pmid:11773511 |
| Valenzuela A and Nieto MS | [Docosahexaenoic acid (DHA) in fetal development and in infant nutrition]. | 2001 | Rev Med Chil | pmid:11775350 |
| Pawlosky RJ et al. | Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. | 2001 | Alcohol. Clin. Exp. Res. | pmid:11781509 |
| Huber T et al. | Structure of docosahexaenoic acid-containing phospholipid bilayers as studied by (2)H NMR and molecular dynamics simulations. | 2002 | J. Am. Chem. Soc. | pmid:11782182 |
| Agostoni C et al. | Prolonged breast-feeding (six months or more) and milk fat content at six months are associated with higher developmental scores at one year of age within a breast-fed population. | 2001 | Adv. Exp. Med. Biol. | pmid:11787675 |
| Gibson RA and Makrides M | Long-chain polyunsaturated fatty acids in breast milk: are they essential? | 2001 | Adv. Exp. Med. Biol. | pmid:11787705 |
| Neschen S et al. | Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content. | 2002 | Am. J. Physiol. Endocrinol. Metab. | pmid:11788372 |
| Whelan J | Targeted taxane therapy for cancer. | 2002 | Drug Discov. Today | pmid:11790612 |
| Schiefermeier M and Yavin E | n-3 Deficient and docosahexaenoic acid-enriched diets during critical periods of the developing prenatal rat brain. | 2002 | J. Lipid Res. | pmid:11792731 |
| Ratledge C et al. | Production of docosahexaenoic acid by Crypthecodinium cohnii grown in a pH-auxostat culture with acetic acid as principal carbon source. | 2001 | Lipids | pmid:11795857 |
| Qi B et al. | Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana. | 2002 | FEBS Lett. | pmid:11801246 |
| Buznikov GA et al. | [Cholinergic regulation of the sea urchin embryonic and larval development]. | 2001 | Ross Fiziol Zh Im I M Sechenova | pmid:11822358 |
| Bell JG et al. | Substituting fish oil with crude palm oil in the diet of Atlantic salmon (Salmo salar) affects muscle fatty acid composition and hepatic fatty acid metabolism. | 2002 | J. Nutr. | pmid:11823582 |
| McLennan PL | Myocardial membrane fatty acids and the antiarrhythmic actions of dietary fish oil in animal models. | 2001 | Lipids | pmid:11837983 |
| Marchioli R et al. | Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: results of GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. | 2001 | Lipids | pmid:11837985 |
| Takeuchi T et al. | Influence of a dietary n-3 fatty acid deficiency on the cerebral catecholamine contents, EEG and learning ability in rat. | 2002 | Behav. Brain Res. | pmid:11844586 |
| Qi K et al. | Long-chain polyunsaturated fatty acid accretion in brain. | 2002 | Curr Opin Clin Nutr Metab Care | pmid:11844978 |
| Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
| Birch EE et al. | A randomized controlled trial of long-chain polyunsaturated fatty acid supplementation of formula in term infants after weaning at 6 wk of age. | 2002 | Am. J. Clin. Nutr. | pmid:11864865 |
| Brouwer IA et al. | Association between n-3 fatty acid status in blood and electrocardiographic predictors of arrhythmia risk in healthy volunteers. | 2002 | Am. J. Cardiol. | pmid:11867059 |
| Kuchbaev AE and Bastarbekova GM | [Phospholipid and fatty acid content of the blood of sheep infected with the nematode Dictyocaulus filaria]. | 2001 Sep-Oct | Parazitologia | pmid:11871259 |
| Urquhart P et al. | The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. | 2002 | Biochim. Biophys. Acta | pmid:11880240 |
| Kitajka K et al. | The role of n-3 polyunsaturated fatty acids in brain: modulation of rat brain gene expression by dietary n-3 fatty acids. | 2002 | Proc. Natl. Acad. Sci. U.S.A. | pmid:11880617 |
| Lyzogub VG et al. | [Role of the skin in destabilization of coronary circulation]. | 2001 Sep-Dec | Lik. Sprava | pmid:11881380 |
| Pan J and Chung FL | Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. | 2002 | Chem. Res. Toxicol. | pmid:11896684 |
| Igbavboa U et al. | A new role for apolipoprotein E: modulating transport of polyunsaturated phospholipid molecular species in synaptic plasma membranes. | 2002 | J. Neurochem. | pmid:11902115 |
| Hawkes JS et al. | A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. | 2002 | Am. J. Clin. Nutr. | pmid:11916764 |
| Revajová V et al. | Influencing the immune parameters in germ-free piglets by administration of seal oil with increased content of omega-3 PUFA. | 2001 | Arch Tierernahr | pmid:11921854 |
| Hamazaki T et al. | The effect of docosahexaenoic acid on aggression in elderly Thai subjects--a placebo-controlled double-blind study. | 2002 | Nutr Neurosci | pmid:11929196 |
| Lagarde M et al. | Lysophosphatidylcholine as a carrier of docosahexaenoic acid to target tissues. | 2001 | World Rev Nutr Diet | pmid:11935951 |
| Sato M et al. | Cloning of rat delta 6-desaturase and its regulation by dietary eicosapentaenoic or docosahexaenoic acid. | 2001 | World Rev Nutr Diet | pmid:11935956 |
| Hamazaki T et al. | Effect of docosahexaenoic acid on hostility. | 2001 | World Rev Nutr Diet | pmid:11935969 |
| Crawford MA et al. | Docosahexaenoic acid and cerebral evolution. | 2001 | World Rev Nutr Diet | pmid:11935972 |
| Suzuki H et al. | Effect of DHA oil supplementation on intelligence and visual acuity in the elderly. | 2001 | World Rev Nutr Diet | pmid:11935973 |
| Nestel P | Fish oil fatty acids beneficially modulate vascular function. | 2001 | World Rev Nutr Diet | pmid:11935976 |
| Petryk L and Weiler HA | Sows' milk attenuates dexamethasone-induced reductions in liver docosahexaenoic acid. | 2002 | Biol. Neonate | pmid:11937725 |
| Radominska-Pandya A and Chen G | Photoaffinity labeling of human retinoid X receptor beta (RXRbeta) with 9-cis-retinoic acid: identification of phytanic acid, docosahexaenoic acid, and lithocholic acid as ligands for RXRbeta. | 2002 | Biochemistry | pmid:11939783 |
| Gutiérrez AM et al. | Fatty acid profiles and lipid peroxidation of microsomes and mitochondria from liver, heart and brain of Cairina moschata. | 2002 | Int. J. Biochem. Cell Biol. | pmid:11943591 |
| Lim SY and Suzuki H | Dose-response effect of docosahexaenoic acid ethyl ester on maze behavior and brain fatty acid composition in adult mice. | 2002 | Int J Vitam Nutr Res | pmid:11944198 |
| Little JM et al. | Glucuronidation of the dietary fatty acids, phytanic acid and docosahexaenoic acid, by human UDP-glucuronosyltransferases. | 2002 | Drug Metab. Dispos. | pmid:11950783 |
| Ahmad A et al. | Decrease in neuron size in docosahexaenoic acid-deficient brain. | 2002 | Pediatr. Neurol. | pmid:11955929 |
| Freedman SD et al. | Characterization of LPS-induced lung inflammation in cftr-/- mice and the effect of docosahexaenoic acid. | 2002 | J. Appl. Physiol. | pmid:11960971 |
| Duplus E et al. | Evidence for selective induction of phosphoenolpyruvate carboxykinase gene expression by unsaturated and nonmetabolized fatty acids in adipocytes. | 2002 | J. Cell. Biochem. | pmid:11968005 |
| Voigt RG et al. | Relationship between omega3 long-chain polyunsaturated fatty acid status during early infancy and neurodevelopmental status at 1 year of age. | 2002 | J Hum Nutr Diet | pmid:11972740 |
| Egea PF et al. | Molecular recognition of agonist ligands by RXRs. | 2002 | Mol. Endocrinol. | pmid:11981034 |
| Zerouga M et al. | Synthesis of a novel phosphatidylcholine conjugated to docosahexaenoic acid and methotrexate that inhibits cell proliferation. | 2002 | Anticancer Drugs | pmid:11984074 |
| Carlson SE | Docosahexaenoic acid and arachidonic acid in infant development. | 2001 | Semin Neonatol | pmid:11988033 |
| Cha MC and Meckling-Gill KA | Modifications of deoxycytidine kinase and deaminase activities by docosahexaenoic acid in normal and transformed rat fibroblasts. | 2002 | Biochem. Pharmacol. | pmid:11992640 |
| Moseley K et al. | Lipid status and long-chain polyunsaturated fatty acid concentrations in adults and adolescents with phenylketonuria on phenylalanine-restricted diet. | 2002 | J. Inherit. Metab. Dis. | pmid:11999981 |
| Wainwright PE | Dietary essential fatty acids and brain function: a developmental perspective on mechanisms. | 2002 | Proc Nutr Soc | pmid:12002796 |
| Yavin E et al. | Docosahexaenoic acid sources for the developing brain during intrauterine life. | 2001 | Nutr Health | pmid:12003088 |
| Leigh-Firbank EC et al. | Eicosapentaenoic acid and docosahexaenoic acid from fish oils: differential associations with lipid responses. | 2002 | Br. J. Nutr. | pmid:12010583 |
| Wu GS and Rao NA | Detection of docosahexaenoic acid hydroperoxides in retina by gas chromatography/mass spectrometry. | 2002 | Methods Mol. Biol. | pmid:12013778 |
| Mattos R et al. | Uterine, ovarian, and production responses of lactating dairy cows to increasing dietary concentrations of menhaden fish meal. | 2002 | J. Dairy Sci. | pmid:12018420 |
| Guajardo MH et al. | Retinal fatty acid binding protein reduce lipid peroxidation stimulated by long-chain fatty acid hydroperoxides on rod outer segments. | 2002 | Biochim. Biophys. Acta | pmid:12020634 |
| Banno F et al. | Lymphatic absorption of docosahexaenoic acid given as monoglyceride, diglyceride, triglyceride, and ethyl ester in rats. | 2002 | J. Nutr. Sci. Vitaminol. | pmid:12026185 |
| Denys A et al. | Eicosapentaenoic acid and docosahexaenoic acid modulate MAP kinase enzyme activity in human T-cells. | 2002 | Mol. Cell. Biochem. | pmid:12030372 |
| Ferrier GR et al. | Differential effects of docosahexaenoic acid on contractions and L-type Ca2+ current in adult cardiac myocytes. | 2002 | Cardiovasc. Res. | pmid:12031706 |
| Innis SM et al. | Docosahexaenoic acid and arachidonic acid enhance growth with no adverse effects in preterm infants fed formula. | 2002 | J. Pediatr. | pmid:12032520 |
| Hu PC and Chen BH | Effects of riboflavin and fatty acid methyl esters on cholesterol oxidation during illumination. | 2002 | J. Agric. Food Chem. | pmid:12033831 |
| Yoshii H et al. | Autoxidation kinetic analysis of docosahexaenoic acid ethyl ester and docosahexaenoic triglyceride with oxygen sensor. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12036046 |
| Makrides M et al. | Nutritional effect of including egg yolk in the weaning diet of breast-fed and formula-fed infants: a randomized controlled trial. | 2002 | Am. J. Clin. Nutr. | pmid:12036817 |
| Yavin E et al. | Docosahexaenoic acid abundance in the brain: a biodevice to combat oxidative stress. | 2002 | Nutr Neurosci | pmid:12041873 |
| Irvine AJ et al. | Dietary supplementation with (n-3) polyunsaturated fatty acids does not affect insulin sensitivity in healthy Labrador retriever dogs. | 2002 | J. Nutr. | pmid:12042502 |
| Contreras MA and Rapoport SI | Recent studies on interactions between n-3 and n-6 polyunsaturated fatty acids in brain and other tissues. | 2002 | Curr. Opin. Lipidol. | pmid:12045396 |
| Dunbar BL and Bauer JE | Metabolism of dietary essential fatty acids and their conversion to long-chain polyunsaturated metabolites. | 2002 | J. Am. Vet. Med. Assoc. | pmid:12051499 |
| Hammond BG et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. | 2002 | Regul. Toxicol. Pharmacol. | pmid:12052009 |
| Suzuki R et al. | Effects of n-3 polyunsaturated fatty acids on dermatitis in NC/Nga mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12054914 |
| Hirafuji M et al. | Docosahexaenoic acid potentiates interleukin-1beta induction of nitric oxide synthase through mechanism involving p44/42 MAPK activation in rat vascular smooth muscle cells. | 2002 | Br. J. Pharmacol. | pmid:12055140 |
| Chambrier C et al. | Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma. | 2002 | Obes. Res. | pmid:12055328 |
| Kraffe E et al. | Evidence of a tetradocosahexaenoic cardiolipin in some marine bivalves. | 2002 | Lipids | pmid:12056594 |
| Haggarty P et al. | The effect of maternal smoking and ethanol on fatty acid transport by the human placenta. | 2002 | Br. J. Nutr. | pmid:12064333 |
| Bernard-Gallon DJ et al. | Differential effects of n-3 and n-6 polyunsaturated fatty acids on BRCA1 and BRCA2 gene expression in breast cell lines. | 2002 | Br. J. Nutr. | pmid:12064337 |
| Gibson RA et al. | Essential role of fats throughout the lifecycle: summary and recommendations. | 2002 | Med. J. Aust. | pmid:12064967 |
| Makrides M and Gibson RA | The role of fats in the lifecycle stages: pregnancy and the first year of life. | 2002 | Med. J. Aust. | pmid:12064969 |
| Hashimoto M et al. | Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats. | 2002 | J. Neurochem. | pmid:12065621 |
| Leaden P et al. | The protection of long chain polyunsaturated fatty acids by melatonin during nonenzymatic lipid peroxidation of rat liver microsomes. | 2002 | J. Pineal Res. | pmid:12074095 |
| Larque E et al. | Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system. | 2002 | Ann. N. Y. Acad. Sci. | pmid:12079857 |
| Dewailly E et al. | Cardiovascular disease risk factors and n-3 fatty acid status in the adult population of James Bay Cree. | 2002 | Am. J. Clin. Nutr. | pmid:12081820 |
| Saugstad LF | Human nature is unique in the mismatch between the usual diet and the need for "food for the brain" (marine fat, DHA). Adding marine fat is beneficial in schizophrenia and manic-depressive psychosis. This underlines brain dysfunction in these neurological disorders is associated with deficient intake of marine fat(DHA). | 2002 | Nutr Health | pmid:12083411 |
| MacDonald IM | What are your patients reading? | 2002 | Can. J. Ophthalmol. | pmid:12083472 |
| Rinaldi B et al. | Effects of docosahexaenoic acid on calcium pathway in adult rat cardiomyocytes. | 2002 | Life Sci. | pmid:12088759 |
| Rapoport SI and Bosetti F | Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? | 2002 | Arch. Gen. Psychiatry | pmid:12090811 |
| Stark KD et al. | Fatty acid compositions of serum phospholipids of postmenopausal women: a comparison between Greenland Inuit and Canadians before and after supplementation with fish oil. | 2002 Jul-Aug | Nutrition | pmid:12093443 |