| MeSH term | MeSH ID | Detail |
|---|---|---|
| Abortion, Habitual | D000026 | 5 associated lipids |
| Acquired Immunodeficiency Syndrome | D000163 | 12 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Adrenoleukodystrophy | D000326 | 29 associated lipids |
| Albinism | D000417 | 3 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kornfeld S et al. | Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. | 2012 | Carcinogenesis | pmid:22114075 |
| Liang W and Chikritzhs T | Does light alcohol consumption during pregnancy improve offspring's cognitive development? | 2012 | Med. Hypotheses | pmid:21985759 |
| Nasiri AH et al. | Combined effect of DHA and α-tocopherol supplementation during bull semen cryopreservation on sperm characteristics and fatty acid composition. | 2012 | Andrologia | pmid:21951061 |
| Luxwolda MF et al. | A maternal erythrocyte DHA content of approximately 6Â g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached. | 2012 | Eur J Nutr | pmid:21952690 |
| Drover JR et al. | A randomized trial of DHA intake during infancy: school readiness and receptive vocabulary at 2-3.5 years of age. | 2012 | Early Hum. Dev. | pmid:22835597 |
| Martinez-Micaelo N et al. | Omega-3 docosahexaenoic acid and procyanidins inhibit cyclo-oxygenase activity and attenuate NF-κB activation through a p105/p50 regulatory mechanism in macrophage inflammation. | 2012 | Biochem. J. | pmid:21954853 |
| Chew EY et al. | The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). | 2012 | Ophthalmology | pmid:22840421 |
| Hong WK et al. | Growth of the oleaginous microalga Aurantiochytrium sp. KRS101 on cellulosic biomass and the production of lipids containing high levels of docosahexaenoic acid. | 2012 | Bioprocess Biosyst Eng | pmid:21959581 |
| Vanlint SJ and Ried K | Efficacy and tolerability of calcium, vitamin D and a plant-based omega-3 oil for osteopenia: a pilot RCT. | 2012 | Maturitas | pmid:22078660 |
| Clà ria J et al. | Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat. | 2012 | J. Immunol. | pmid:22844113 |
| Cruz-Hernandez C et al. | Benefits of structured and free monoacylglycerols to deliver eicosapentaenoic (EPA) in a model of lipid malabsorption. | 2012 | Nutrients | pmid:23201848 |
| Lin DC et al. | Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor. | 2012 | Mol. Pharmacol. | pmid:22859723 |
| Martin CR et al. | The safety and efficacy of oral docosahexaenoic acid supplementation for the treatment of primary sclerosing cholangitis - a pilot study. | 2012 | Aliment. Pharmacol. Ther. | pmid:22129201 |
| Tsushima T et al. | Docosahexaenoic- and eicosapentaenoic acid-bound lysophospholipids are more effective in suppressing angiogenesis than conjugated docosahexaenoic acid. | 2012 | J Oleo Sci | pmid:22864513 |
| Begum G et al. | DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. | 2012 | J. Neurochem. | pmid:22129278 |
| López-Alarcón M et al. | Oral administration of docosahexaenoic acid attenuates interleukin-1β response and clinical course of septic neonates. | 2012 | Nutrition | pmid:22079797 |
| Skulas-Ray AC et al. | Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study. | 2012 | Ann Behav Med | pmid:22865498 |
| Le HD et al. | Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis. | 2012 | JPEN J Parenter Enteral Nutr | pmid:22038210 |
| Towhidi A and Parks JE | Effect of n-3 fatty acids and α-tocopherol on post-thaw parameters and fatty acid composition of bovine sperm. | 2012 | J. Assist. Reprod. Genet. | pmid:22869241 |
| Carvalho-Wells AL et al. | APOE genotype influences triglyceride and C-reactive protein responses to altered dietary fat intake in UK adults. | 2012 | Am. J. Clin. Nutr. | pmid:23134888 |
| Chen J et al. | DPA n-3, DPA n-6 and DHA improve lipoprotein profiles and aortic function in hamsters fed a high cholesterol diet. | 2012 | Atherosclerosis | pmid:22284366 |
| Brown SP et al. | Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist. | 2012 | ACS Med Chem Lett | pmid:24900539 |
| Whelan J et al. | Effects of dietary stearidonic acid on biomarkers of lipid metabolism. | 2012 | J. Nutr. | pmid:22279143 |
| Wu JH et al. | Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study. | 2012 | Circulation | pmid:22282329 |
| Weylandt KH et al. | Omega-3 fatty acids and their lipid mediators: towards an understanding of resolvin and protectin formation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22326554 |
| Harlioglu AG et al. | Fatty acid, cholesterol and fat-soluble vitamin composition of wild and captive freshwater crayfish (Astacus leptodactylus). | 2012 | Food Sci Technol Int | pmid:22328124 |
| Dawson K et al. | Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. | 2012 | J. Nutr. Biochem. | pmid:21775114 |
| Swanson D et al. | Omega-3 fatty acids EPA and DHA: health benefits throughout life. | 2012 | Adv Nutr | pmid:22332096 |
| Hofmanová J et al. | Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids. | 2012 | J. Nutr. Biochem. | pmid:21775115 |
| Berson EL et al. | ω-3 intake and visual acuity in patients with retinitis pigmentosa receiving vitamin A. | 2012 | Arch. Ophthalmol. | pmid:22332205 |
| Beezhold BL and Johnston CS | Restriction of meat, fish, and poultry in omnivores improves mood: a pilot randomized controlled trial. | 2012 | Nutr J | pmid:22333737 |
| Kitson AP et al. | Tissue-specific sex differences in docosahexaenoic acid and Δ6-desaturase in rats fed a standard chow diet. | 2012 | Appl Physiol Nutr Metab | pmid:23050796 |
| Quan-Xin F et al. | Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia, phosphorylation of NMDA receptors, and cytokines expression in the thoracic spinal dorsal horn. | 2012 | BMC Gastroenterol | pmid:23092159 |
| Ritter JC and Budge SM | Key lipid oxidation products can be used to predict sensory quality of fish oils with different levels of EPA and DHA. | 2012 | Lipids | pmid:23096224 |
| Jackson KG et al. | Dietary fat manipulation has a greater impact on postprandial lipid metabolism than the apolipoprotein E (epsilon) genotype-insights from the SATgenε study. | 2012 | Mol Nutr Food Res | pmid:23097177 |
| Liu Y et al. | Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. | 2012 | J. Nutr. | pmid:23014495 |
| D'Vaz N et al. | Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. | 2012 | Pediatrics | pmid:22945403 |
| Francescato G et al. | Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. | 2012 | Pediatr Obes | pmid:22991250 |
| Bistrian BR | Supplementation in acute lung injury. | 2012 | JAMA | pmid:22235079 |
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| Joseph MS et al. | Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. | 2012 | PLoS ONE | pmid:22911773 |
| Mas E et al. | Resolvins D1, D2, and other mediators of self-limited resolution of inflammation in human blood following n-3 fatty acid supplementation. | 2012 | Clin. Chem. | pmid:22912397 |
| Schmitt D et al. | Toxicologic evaluations of DHA-rich algal oil in rats: developmental toxicity study and 3-month dietary toxicity study with an in utero exposure phase. | 2012 | Food Chem. Toxicol. | pmid:22960629 |
| Waldron MK et al. | Plasma phospholipid fatty acid and ex vivo neutrophil responses are differentially altered in dogs fed fish- and linseed-oil containing diets at the same n-6:n-3 fatty acid ratio. | 2012 | Lipids | pmid:22252853 |
| Feng Z et al. | Maternal docosahexaenoic acid feeding protects against impairment of learning and memory and oxidative stress in prenatally stressed rats: possible role of neuronal mitochondria metabolism. | 2012 | Antioxid. Redox Signal. | pmid:21905985 |
| Moreno-Indias I et al. | The effect of diet and DHA addition on the sensory quality of goat kid meat. | 2012 | Meat Sci. | pmid:21907501 |
| Mitchell DC et al. | Quantifying the differential effects of DHA and DPA on the early events in visual signal transduction. | 2012 | Chem. Phys. Lipids | pmid:22405878 |
| Bonatto SJ et al. | Fish oil supplementation improves neutrophil function during cancer chemotherapy. | 2012 | Lipids | pmid:22160495 |
| Yan J et al. | Improving stability and activity of cross-linked enzyme aggregates based on polyethylenimine in hydrolysis of fish oil for enrichment of polyunsaturated fatty acids. | 2012 | Appl. Biochem. Biotechnol. | pmid:22167690 |
| Mil-Homens D et al. | The antibacterial properties of docosahexaenoic omega-3 fatty acid against the cystic fibrosis multiresistant pathogen Burkholderia cenocepacia. | 2012 | FEMS Microbiol. Lett. | pmid:22150831 |
| Rupp H et al. | Mechanisms involved in the differential reduction of omega-3 and omega-6 highly unsaturated fatty acids by structural heart disease resulting in "HUFA deficiency". | 2012 | Can. J. Physiol. Pharmacol. | pmid:22188440 |
| Peters BS et al. | The effect of a 12-week course of omega-3 polyunsaturated fatty acids on lipid parameters in hypertriglyceridemic adult HIV-infected patients undergoing HAART: a randomized, placebo-controlled pilot trial. | 2012 | Clin Ther | pmid:22212377 |
| Chen WY et al. | Beneficial effect of docosahexaenoic acid on cholestatic liver injury in rats. | 2012 | J. Nutr. Biochem. | pmid:21497498 |
| Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
| Bang S et al. | 17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. | 2012 | Br. J. Pharmacol. | pmid:21718307 |
| Huang T et al. | Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism. | 2012 | Nutr J | pmid:22260268 |
| Park Y et al. | Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea. | 2012 | Ann. Nutr. Metab. | pmid:22776859 |
| Rogerio AP et al. | Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. | 2012 | J. Immunol. | pmid:22802419 |
| Quiroga AD et al. | Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia. | 2012 | Hepatology | pmid:22806626 |
| Jones CN et al. | Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23185003 |
| Gruber JF et al. | Associations between toenail arsenic concentration and dietary factors in a New Hampshire population. | 2012 | Nutr J | pmid:22747713 |
| Ewaschuk JB et al. | Docosahexanoic acid improves chemotherapy efficacy by inducing CD95 translocation to lipid rafts in ER(-) breast cancer cells. | 2012 | Lipids | pmid:23054549 |
| Kitson AP et al. | Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749739 |
| Johnson M et al. | Fatty acids in ADHD: plasma profiles in a placebo-controlled study of Omega 3/6 fatty acids in children and adolescents. | 2012 | Atten Defic Hyperact Disord | pmid:22753087 |
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| Egert S et al. | Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. | 2012 | J. Nutr. | pmid:22810989 |
| Moallem U and Zachut M | Short communication: the effects of supplementation of various n-3 fatty acids to late-pregnant dairy cows on plasma fatty acid composition of the newborn calves. | 2012 | J. Dairy Sci. | pmid:22720961 |
| Garneau V et al. | Omega-3 fatty acids status in human subjects estimated using a food frequency questionnaire and plasma phospholipids levels. | 2012 | Nutr J | pmid:22775977 |
| Jeckel KM et al. | Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. | 2012 | PLoS ONE | pmid:23300587 |
| Candelario J et al. | PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. | 2012 | PLoS ONE | pmid:23300710 |
| Gladyshev MI et al. | Comparison of polyunsaturated fatty acids content in filets of anadromous and landlocked sockeye salmon Oncorhynchus nerka. | 2012 | J. Food Sci. | pmid:23240970 |
| Maqbool A et al. | Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. | 2012 | J. Pediatr. Gastroenterol. Nutr. | pmid:22699835 |
| Arsenault D et al. | Chronic dietary intake of α-linolenic acid does not replicate the effects of DHA on passive properties of entorhinal cortex neurons. | 2012 | Br. J. Nutr. | pmid:21851757 |
| Chen YJ et al. | Docosahexaenoic acid suppresses the expression of FoxO and its target genes. | 2012 | J. Nutr. Biochem. | pmid:22444500 |
| Roy S et al. | Maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids: implications for neurodevelopmental risk in the rat offspring. | 2012 | Brain Dev. | pmid:21300490 |
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| Moon HJ et al. | Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis. | 2012 | Ann. Nutr. Metab. | pmid:22507833 |
| Calandria JM et al. | Ataxin-1 poly(Q)-induced proteotoxic stress and apoptosis are attenuated in neural cells by docosahexaenoic acid-derived neuroprotectin D1. | 2012 | J. Biol. Chem. | pmid:22511762 |
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| Kwak SM et al. | Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. | 2012 | Arch. Intern. Med. | pmid:22493407 |
| Liu SH et al. | Docosahexaenoic acid and phosphatidylserine supplementations improve antioxidant activities and cognitive functions of the developing brain on pentylenetetrazol-induced seizure model. | 2012 | Brain Res. | pmid:22440676 |
| Phang M et al. | Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. | 2012 | Nutr Metab Cardiovasc Dis | pmid:20708391 |
| Bazan NG et al. | Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke. | 2012 | Exp. Neurol. | pmid:22542947 |
| Crawford MA and Broadhurst CL | The role of docosahexaenoic and the marine food web as determinants of evolution and hominid brain development: the challenge for human sustainability. | 2012 | Nutr Health | pmid:22544773 |
| Vedin I et al. | Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. | 2012 | PLoS ONE | pmid:22545106 |
| Gronroos NN et al. | Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. | 2012 | PLoS ONE | pmid:22570739 |
| Novak EM et al. | Low linoleic acid may facilitate Δ6 desaturase activity and docosahexaenoic acid accretion in human fetal development. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22365109 |
| Meldrum SJ et al. | Determinants of DHA levels in early infancy: differential effects of breast milk and direct fish oil supplementation. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22572105 |
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| Gil-Campos M and Sanjurjo Crespo P | Omega 3 fatty acids and inborn errors of metabolism. | 2012 | Br. J. Nutr. | pmid:22591887 |
| Glover KE et al. | Effect of feeding fresh forage and marine algae on the fatty acid composition and oxidation of milk and butter. | 2012 | J. Dairy Sci. | pmid:22612917 |
| Lopez-Huertas E | The effect of EPA and DHA on metabolic syndrome patients: a systematic review of randomised controlled trials. | 2012 | Br. J. Nutr. | pmid:22591892 |
| Delgado-Lista J et al. | Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. | 2012 | Br. J. Nutr. | pmid:22591894 |
| Corsetto PA et al. | Chemical-physical changes in cell membrane microdomains of breast cancer cells after omega-3 PUFA incorporation. | 2012 | Cell Biochem. Biophys. | pmid:22622660 |
| Serra-Majem L et al. | Dietary methods and biomarkers of omega 3 fatty acids: a systematic review. | 2012 | Br. J. Nutr. | pmid:22591904 |
| Larqué E et al. | Omega 3 fatty acids, gestation and pregnancy outcomes. | 2012 | Br. J. Nutr. | pmid:22591905 |
| Campoy C et al. | Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. | 2012 | Br. J. Nutr. | pmid:22591907 |
| Njoroge SW et al. | DHA and EPA reverse cystic fibrosis-related FA abnormalities by suppressing FA desaturase expression and activity. | 2012 | J. Lipid Res. | pmid:22095831 |
| Wielinga PY et al. | Arachidonic acid/docosahexaenoic acid-supplemented diet in early life reduces body weight gain, plasma lipids, and adiposity in later life in ApoE*3Leiden mice. | 2012 | Mol Nutr Food Res | pmid:22611002 |