| MeSH term | MeSH ID | Detail |
|---|---|---|
| Dysbiosis | D064806 | 2 associated lipids |
| Chronic Pain | D059350 | 5 associated lipids |
| Peripheral Nerve Injuries | D059348 | 6 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Plaque, Atherosclerotic | D058226 | 7 associated lipids |
| Plaque, Amyloid | D058225 | 19 associated lipids |
| Acute Kidney Injury | D058186 | 34 associated lipids |
| Geographic Atrophy | D057092 | 1 associated lipids |
| Acute Lung Injury | D055371 | 33 associated lipids |
| Precursor T-Cell Lymphoblastic Leukemia-Lymphoma | D054218 | 5 associated lipids |
DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Minami M and Noguchi M | Effects of low-dose eicosapentaenoic acid, docosahexaenoic acid and dietary fat on the incidence, growth and cell kinetics of mammary carcinomas in rats. | 1996 Sep-Oct | Oncology | pmid:8784475 |
| Noguchi M et al. | The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. | 1995 Jul-Aug | Oncology | pmid:7777237 |
| Li S et al. | The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. | 2014 | Oncotarget | pmid:25004114 |
| Lam SM et al. | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging. | 2016 | Oncotarget | pmid:27517158 |
| Ostroumova TV et al. | [Docosahexaenoyl dopamine in freshwater hydra: effects on regeneration and metabolic changes]. | 2010 May-Jun | Ontogenez | pmid:20583627 |
| Nourooz-Zadeh J and Pereira P | Age-related accumulation of free polyunsaturated fatty acids in human retina. | 1999 | Ophthalmic Res. | pmid:10325542 |
| Miyauchi O et al. | Protective effect of docosahexaenoic acid against retinal ischemic injury: an electroretinographic study. | 2001 Jul-Aug | Ophthalmic Res. | pmid:11464070 |
| Simonelli F et al. | Evaluation of fatty acids in membrane phospholipids of erythrocytes in retinitis pigmentosa patients. | 1996 | Ophthalmic Res. | pmid:8792359 |
| Moriguchi K et al. | Suppression of N-methyl-N-nitrosourea-induced photoreceptor apoptosis in rats by docosahexaenoic acid. | 2004 Mar-Apr | Ophthalmic Res. | pmid:15017106 |
| Schnebelen C et al. | Nutrition for the eye: different susceptibility of the retina and the lacrimal gland to dietary omega-6 and omega-3 polyunsaturated fatty acid incorporation. | 2009 | Ophthalmic Res. | pmid:19451735 |
| Poloschek CM and Jägle H | [Pharmacological concepts to treat hereditary retinal degenerations]. | 2012 | Ophthalmologe | pmid:22350547 |
| Chew EY et al. | The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1). | 2012 | Ophthalmology | pmid:22840421 |
| Chiu CJ et al. | Dietary compound score and risk of age-related macular degeneration in the age-related eye disease study. | 2009 | Ophthalmology | pmid:19410952 |
| Dangour AD et al. | N-3 fatty acids and retinal function. | 2013 | Ophthalmology | pmid:23714605 |
| Kangari H et al. | Short-term consumption of oral omega-3 and dry eye syndrome. | 2013 | Ophthalmology | pmid:23642375 |
| Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |
| Dagnelie G et al. | Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. | 2000 | Optometry | pmid:10970259 |
| Aursnes M et al. | Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. | 2014 | Org. Biomol. Chem. | pmid:24253202 |
| Varga Z | [Omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis]. | 2008 | Orv Hetil | pmid:18375362 |
| Fischer T | [Pharmacological therapy of age-related macular degeneration based on etiopathogenesis]. | 2015 | Orv Hetil | pmid:26548469 |
| Marosvölgyi T et al. | [Fatty acid composition of human milk in mothers of preterm and full-term infants in the first three weeks of lactation]. | 2006 | Orv Hetil | pmid:16981419 |
| Li R et al. | Maresin 1, a Proresolving Lipid Mediator, Mitigates Carbon Tetrachloride-Induced Liver Injury in Mice. | 2016 | Oxid Med Cell Longev | pmid:26881046 |
| Zhang X et al. | Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. | 2013 | Oxid Med Cell Longev | pmid:24381712 |
| Sontrop J et al. | Depressive symptoms during pregnancy in relation to fish consumption and intake of n-3 polyunsaturated fatty acids. | 2008 | Paediatr Perinat Epidemiol | pmid:18578753 |
| Huang L et al. | Enduring prevention and transient reduction of postoperative pain by intrathecal resolvin D1. | 2011 | Pain | pmid:21255928 |
| Lucena CF et al. | Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies. | 2015 | Pancreas | pmid:25426612 |
| Song KS et al. | Omega-3-polyunsaturated fatty acids suppress pancreatic cancer cell growth in vitro and in vivo via downregulation of Wnt/Beta-catenin signaling. | 2011 | Pancreatology | pmid:22213040 |
| Kuchbaev AE and Bastarbekova GM | [Phospholipid and fatty acid content of the blood of sheep infected with the nematode Dictyocaulus filaria]. | 2001 Sep-Oct | Parazitologia | pmid:11871259 |
| Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
| Weise C et al. | Dietary docosahexaenoic acid in combination with arachidonic acid ameliorates allergen-induced dermatitis in mice. | 2011 | Pediatr Allergy Immunol | pmid:21294775 |
| Furuhjelm C et al. | Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. | 2011 | Pediatr Allergy Immunol | pmid:21332799 |
| Wang L et al. | Comparison of the fatty acid composition of total lipids and phospholipids in breast milk from Japanese women. | 2000 | Pediatr Int | pmid:10703228 |
| Francescato G et al. | Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers. | 2012 | Pediatr Obes | pmid:22991250 |
| Galicia-Connolly EZ et al. | Complementary, holistic, and integrative medicine: therapies for learning disabilities. | 2011 | Pediatr Rev | pmid:21285298 |
| Galicia-Connolly E et al. | Complementary, holistic, and integrative medicine: therapies for neurodevelopment in preterm infants. | 2012 | Pediatr Rev | pmid:22659260 |
| Feucht C and Patel DR | Herbal medicines in pediatric neuropsychiatry. | 2011 | Pediatr. Clin. North Am. | pmid:21281847 |
| Ahmad A et al. | Decrease in neuron size in docosahexaenoic acid-deficient brain. | 2002 | Pediatr. Neurol. | pmid:11955929 |
| Kurlandsky LE et al. | The absorption and effect of dietary supplementation with omega-3 fatty acids on serum leukotriene B4 in patients with cystic fibrosis. | 1994 | Pediatr. Pulmonol. | pmid:7838619 |
| Llanos A et al. | Infants with intrauterine growth restriction have impaired formation of docosahexaenoic acid in early neonatal life: a stable isotope study. | 2005 | Pediatr. Res. | pmid:16189202 |
| Agostoni C and Verduci E | DHA in pregnancy benefits child development. | 2003 | Pediatr. Res. | pmid:12904586 |
| Liu CC et al. | Increase in plasma phospholipid docosahexaenoic and eicosapentaenoic acids as a reflection of their intake and mode of administration. | 1987 | Pediatr. Res. | pmid:2821474 |
| Woods J et al. | Is docosahexaenoic acid necessary in infant formula? Evaluation of high linolenate diets in the neonatal rat. | 1996 | Pediatr. Res. | pmid:8910933 |
| Lauritzen L et al. | Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. | 2005 | Pediatr. Res. | pmid:16006428 |
| Ponder DL et al. | Docosahexaenoic acid status of term infants fed breast milk or infant formula containing soy oil or corn oil. | 1992 | Pediatr. Res. | pmid:1287559 |
| Curatolo N et al. | Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research. | 2011 | Pediatr. Res. | pmid:21857379 |
| Greiner RC et al. | Brain docosahexaenoate accretion in fetal baboons: bioequivalence of dietary alpha-linolenic and docosahexaenoic acids. | 1997 | Pediatr. Res. | pmid:9396565 |
| Salem N | What is the right level of DHA in the infant diet? Commentary on article by Hsieh et al. on page 537. | 2007 | Pediatr. Res. | pmid:17413853 |
| Hsieh AT et al. | The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acids. | 2007 | Pediatr. Res. | pmid:17413857 |
| Lim SY et al. | N-3 fatty acid deficiency induced by a modified artificial rearing method leads to poorer performance in spatial learning tasks. | 2005 | Pediatr. Res. | pmid:16189203 |
| Colombo J et al. | Long-chain polyunsaturated fatty acid supplementation in infancy reduces heart rate and positively affects distribution of attention. | 2011 | Pediatr. Res. | pmid:21705959 |
| Farquharson J et al. | Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. | 1995 | Pediatr. Res. | pmid:7494660 |
| Sauerwald TU et al. | Intermediates in endogenous synthesis of C22:6 omega 3 and C20:4 omega 6 by term and preterm infants. | 1997 | Pediatr. Res. | pmid:9029636 |
| GarcÃa-Calatayud S et al. | Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation. | 2005 | Pediatr. Res. | pmid:15718358 |
| Lefkowitz W et al. | Where does the developing brain obtain its docosahexaenoic acid? Relative contributions of dietary alpha-linolenic acid, docosahexaenoic acid, and body stores in the developing rat. | 2005 | Pediatr. Res. | pmid:15531740 |
| Mollard RC and Weiler HA | Dietary arachidonic acid and docosahexaenoic acid elevate femur calcium and reduce zinc content in piglets. | 2006 | Pediatr. Res. | pmid:16940244 |
| Su HM et al. | Bioequivalence of dietary alpha-linolenic and docosahexaenoic acids as sources of docosahexaenoate accretion in brain and associated organs of neonatal baboons. | 1999 | Pediatr. Res. | pmid:9890614 |
| Bouwstra H et al. | Neurologic condition of healthy term infants at 18 months: positive association with venous umbilical DHA status and negative association with umbilical trans-fatty acids. | 2006 | Pediatr. Res. | pmid:16857765 |
| Damsgaard CT et al. | The effects of n-3 long-chain polyunsaturated fatty acids on bone formation and growth factors in adolescent boys. | 2012 | Pediatr. Res. | pmid:22337227 |
| Anderson GJ et al. | Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. | 1990 | Pediatr. Res. | pmid:2136947 |
| Champoux M et al. | Fatty acid formula supplementation and neuromotor development in rhesus monkey neonates. | 2002 | Pediatr. Res. | pmid:11861930 |
| Lapillonne A et al. | The use of low-EPA fish oil for long-chain polyunsaturated fatty acid supplementation of preterm infants. | 2000 | Pediatr. Res. | pmid:11102555 |
| Larqué E et al. | Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats. | 2000 | Pediatr. Res. | pmid:10674359 |
| Bowen RA et al. | Does increasing dietary linolenic acid content increase the docosahexaenoic acid content of phospholipids in neuronal cells of neonatal rats? | 1999 | Pediatr. Res. | pmid:10367771 |
| Sarkadi-Nagy E et al. | The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. | 2003 | Pediatr. Res. | pmid:12736388 |
| Makrides M et al. | Erythrocyte docosahexaenoic acid correlates with the visual response of healthy, term infants. | 1993 | Pediatr. Res. | pmid:8479826 |
| Birch EE et al. | Visual acuity and the essentiality of docosahexaenoic acid and arachidonic acid in the diet of term infants. | 1998 | Pediatr. Res. | pmid:9702915 |
| Carlson SE et al. | Effect of fish oil supplementation on the n-3 fatty acid content of red blood cell membranes in preterm infants. | 1987 | Pediatr. Res. | pmid:2954026 |
| Dunstan JA et al. | The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. | 2007 | Pediatr. Res. | pmid:17957152 |
| Carlson SE et al. | Long-term feeding of formulas high in linolenic acid and marine oil to very low birth weight infants: phospholipid fatty acids. | 1991 | Pediatr. Res. | pmid:1684416 |
| Carlson SE et al. | Visual acuity and fatty acid status of term infants fed human milk and formulas with and without docosahexaenoate and arachidonate from egg yolk lecithin. | 1996 | Pediatr. Res. | pmid:8726246 |
| Morris SA et al. | Developmental sensitivity of the piglet brain to docosahexanoic acid. | 1999 | Pediatr. Res. | pmid:10509359 |
| Cetin I et al. | Intrauterine growth restriction is associated with changes in polyunsaturated fatty acid fetal-maternal relationships. | 2002 | Pediatr. Res. | pmid:12409524 |
| Clandinin MT et al. | Assessment of the efficacious dose of arachidonic and docosahexaenoic acids in preterm infant formulas: fatty acid composition of erythrocyte membrane lipids. | 1997 | Pediatr. Res. | pmid:9396564 |
| Wijendran V et al. | Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. | 2015 | Pediatr. Res. | pmid:26270575 |
| Groh-Wargo S et al. | Body composition in preterm infants who are fed long-chain polyunsaturated fatty acids: a prospective, randomized, controlled trial. | 2005 | Pediatr. Res. | pmid:15718356 |
| Mayes C et al. | Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. | 2006 | Pediatr. Res. | pmid:16439591 |
| de la Presa Owens S and Innis SM | Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and alpha-linolenic acids on piglet brain monoaminergic neurotransmitters. | 2000 | Pediatr. Res. | pmid:10879811 |
| Carnielli VP et al. | The very low birth weight premature infant is capable of synthesizing arachidonic and docosahexaenoic acids from linoleic and linolenic acids. | 1996 | Pediatr. Res. | pmid:8798265 |
| Sweeney B et al. | Polyunsaturated fatty acids influence neonatal monocyte survival. | 2001 | Pediatr. Surg. Int. | pmid:11409157 |
| Makrides M et al. | A critical appraisal of the role of dietary long-chain polyunsaturated fatty acids on neural indices of term infants: a randomized, controlled trial. | 2000 | Pediatrics | pmid:10617701 |
| Scott DT et al. | Formula supplementation with long-chain polyunsaturated fatty acids: are there developmental benefits? | 1998 | Pediatrics | pmid:9794989 |
| Mizejewski GJ and Pass KA | Fatty acids, alpha-fetoprotein, and cystic fibrosis. | 2001 | Pediatrics | pmid:11731663 |
| O'Connor DL et al. | Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial. | 2001 | Pediatrics | pmid:11483801 |
| Auestad N et al. | Growth and development in term infants fed long-chain polyunsaturated fatty acids: a double-masked, randomized, parallel, prospective, multivariate study. | 2001 | Pediatrics | pmid:11483802 |
| Manley BJ et al. | High-dose docosahexaenoic acid supplementation of preterm infants: respiratory and allergy outcomes. | 2011 | Pediatrics | pmid:21708809 |
| Imhoff-Kunsch B et al. | Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial. | 2011 | Pediatrics | pmid:21807696 |
| Clandinin MT and VanAerde J | Formula supplementation and growth. | 2003 | Pediatrics | pmid:14654632 |
| Auestad N et al. | Visual, cognitive, and language assessments at 39 months: a follow-up study of children fed formulas containing long-chain polyunsaturated fatty acids to 1 year of age. | 2003 | Pediatrics | pmid:12949309 |
| D'Vaz N et al. | Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. | 2012 | Pediatrics | pmid:22945403 |
| Isaacs EB et al. | 10-year cognition in preterms after random assignment to fatty acid supplementation in infancy. | 2011 | Pediatrics | pmid:21930549 |
| Henriksen C et al. | Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. | 2008 | Pediatrics | pmid:18519483 |
| Makrides M et al. | Dietary long-chain polyunsaturated fatty acids do not influence growth of term infants: A randomized clinical trial. | 1999 | Pediatrics | pmid:10469771 |
| Helland IB et al. | Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. | 2001 | Pediatrics | pmid:11694666 |
| Murakami K et al. | Fish and n-3 polyunsaturated fatty acid intake and depressive symptoms: Ryukyus Child Health Study. | 2010 | Pediatrics | pmid:20713476 |
| Beblo S et al. | Effects of alcohol intake during pregnancy on docosahexaenoic acid and arachidonic acid in umbilical cord vessels of black women. | 2005 | Pediatrics | pmid:15687427 |
| Krugman S and Law P | Breastfeeding and IQ. | 1999 | Pediatrics | pmid:9988628 |
| Pawlik D et al. | Fish-oil fat emulsion supplementation may reduce the risk of severe retinopathy in VLBW infants. | 2011 | Pediatrics | pmid:21199856 |
| Bueno AA et al. | Effects of different fatty acids and dietary lipids on adiponectin gene expression in 3T3-L1 cells and C57BL/6J mice adipose tissue. | 2008 | Pflugers Arch. | pmid:17717684 |
| Jiang LH et al. | Oral administration of docosahexaenoic acid activates the GDNF-MAPK-CERB pathway in hippocampus of natural aged rat. | 2013 | Pharm Biol | pmid:23767459 |
| Hörcher U | [Omega-3-fatty acids from fish oil for the prevention of myocardial infarct]. | 1988 | Pharm Unserer Zeit | pmid:2840674 |