DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Dysbiosis D064806 2 associated lipids
Chronic Pain D059350 5 associated lipids
Peripheral Nerve Injuries D059348 6 associated lipids
Peripheral Arterial Disease D058729 7 associated lipids
Plaque, Atherosclerotic D058226 7 associated lipids
Plaque, Amyloid D058225 19 associated lipids
Acute Kidney Injury D058186 34 associated lipids
Geographic Atrophy D057092 1 associated lipids
Acute Lung Injury D055371 33 associated lipids
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma D054218 5 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Mussi SV et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. 2014 Pharm. Res. pmid:24522814
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Minami M et al. Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. 1997 Pharmacol. Biochem. Behav. pmid:9408223
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Schjøtt J et al. Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. 1996 Pharmacol. Toxicol. pmid:8878248
Paulsen JE et al. A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. 1998 Pharmacol. Toxicol. pmid:9527643
Sametz W et al. Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). 2000 Pharmacology pmid:10754452
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McKenney JM and Sica D Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. 2007 Pharmacotherapy pmid:17461707
Du J et al. Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. 2010 Pharmazie pmid:20383947
Gederaas OA et al. Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. 2005 Photochem. Photobiol. Sci. pmid:15803209
Kello M et al. PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. 2010 Photochem. Photobiol. Sci. pmid:20714672
Easley JT et al. AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. 2016 Physiol Rep pmid:27694530
Kunesová M et al. The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. 2006 Physiol Res pmid:15857162
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Correia Bacarin C et al. Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. 2013 Physiol. Behav. pmid:23770426
Trofimiuk E and Braszko JJ Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. 2013 Physiol. Behav. pmid:23672853
Bandaru SS et al. Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior. 2010 Physiol. Behav. pmid:19914265
Turner N et al. Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. 2006 May-Jun Physiol. Biochem. Zool. pmid:16691518
Georgiadi A et al. Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. 2012 Physiol. Genomics pmid:22274564
Guihéneuf F et al. Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. 2013 Phytochemistry pmid:23528573
Mansour MP et al. The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. 2003 Phytochemistry pmid:12711135
Zhou XR et al. Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. 2007 Phytochemistry pmid:17291553
Innis SM Essential fatty acid transfer and fetal development. 2005 Placenta pmid:15837071
Johnsen GM et al. Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. 2011 Placenta pmid:21741084
Xu Y et al. Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. 2008 Placenta pmid:18829104
Johnsen GM et al. Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. 2009 Placenta pmid:19880178
Tobin KA et al. Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. 2009 Placenta pmid:19010540
Serna-Saldivar SO et al. Effect of DHA containing oils and powders on baking performance and quality of white pan bread. 2006 Plant Foods Hum Nutr pmid:17031604
Jin F et al. Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. 2012 Plant Foods Hum Nutr pmid:22538527
Metz JG et al. Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: release of the products as free fatty acids. 2009 Plant Physiol. Biochem. pmid:19272783
Andersen MK et al. Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. 2016 PLoS Genet. pmid:27341449
Tikhonenko M et al. N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. 2013 PLoS ONE pmid:23383097
Cox R et al. Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. 2015 PLoS ONE pmid:26317859
Rahman M et al. Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. 2011 PLoS ONE pmid:22140508
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Qin Y et al. Fish Oil Supplements Lower Serum Lipids and Glucose in Correlation with a Reduction in Plasma Fibroblast Growth Factor 21 and Prostaglandin E2 in Nonalcoholic Fatty Liver Disease Associated with Hyperlipidemia: A Randomized Clinical Trial. 2015 PLoS ONE pmid:26226139
Kothapalli KS et al. Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. 2007 PLoS ONE pmid:17426818
Polavarapu S et al. Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. 2014 PLoS ONE pmid:25536345
Wales KM et al. N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. 2014 PLoS ONE pmid:25398022
Jansen D et al. Effects of specific multi-nutrient enriched diets on cerebral metabolism, cognition and neuropathology in AβPPswe-PS1dE9 mice. 2013 PLoS ONE pmid:24086523
Abdelmoaty S et al. Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. 2013 PLoS ONE pmid:24086560
Eady TN et al. Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats. 2012 PLoS ONE pmid:23118851
Musto AE et al. Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. 2015 PLoS ONE pmid:25617763
Villalpando DM et al. Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. 2017 PLoS ONE pmid:28968462
Hsiao HM et al. A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. 2013 PLoS ONE pmid:23484005
Chatterjee A et al. The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. 2014 PLoS ONE pmid:25409514
Abe E et al. Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. 2014 PLoS ONE pmid:25090090
Mulder KA et al. Omega-3 fatty acid deficiency in infants before birth identified using a randomized trial of maternal DHA supplementation in pregnancy. 2014 PLoS ONE pmid:24427279
Shulse CN and Allen EE Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. 2011 PLoS ONE pmid:21629834
Sundrani DP et al. Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. 2012 PLoS ONE pmid:22253805
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Williams JJ et al. N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. 2013 PLoS ONE pmid:23437099
Suzuki-Kemuriyama N et al. Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. 2016 PLoS ONE pmid:27333187
Joseph MS et al. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. 2012 PLoS ONE pmid:22911773
Bonilla DL et al. Incorporation of a dietary omega 3 fatty acid impairs murine macrophage responses to Mycobacterium tuberculosis. 2010 PLoS ONE pmid:20526363
Martin N et al. Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. 2012 PLoS ONE pmid:22970103
Richardson AJ et al. Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). 2012 PLoS ONE pmid:22970149
Kulkarni A et al. Effects of altered maternal folic acid, vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. 2011 PLoS ONE pmid:21423696
Zhang X et al. Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. 2013 PLoS ONE pmid:23840712
Haas-Stapleton EJ et al. Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. 2007 PLoS ONE pmid:18091990
Markhus MW et al. Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. 2013 PLoS ONE pmid:23844041
Amtul Z et al. DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? 2011 PLoS ONE pmid:21931647
Bhatia HS et al. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. 2011 PLoS ONE pmid:22163304
Singh A et al. Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. 2013 PLoS ONE pmid:23844124
Zúñiga J et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. 2011 PLoS ONE pmid:22174823
Santos-Soto IJ et al. Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. 2013 PLoS ONE pmid:24349072
Nakamoto K et al. Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. 2013 PLoS ONE pmid:24349089
Sun YB et al. Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. 2013 PLoS ONE pmid:24391884
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Katakura M et al. Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats. 2015 PLoS ONE pmid:26485038
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Motter AL and Ahern GP TRPA1 is a polyunsaturated fatty acid sensor in mammals. 2012 PLoS ONE pmid:22723860
Zhao JP et al. Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. 2014 PLoS ONE pmid:24454790
Baselga-Escudero L et al. Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. 2013 PLoS ONE pmid:23922812
de Goede J et al. Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. 2012 PLoS ONE pmid:22496770
Jeckel KM et al. Docosahexaenoic acid supplementation does not improve Western diet-induced cardiomyopathy in rats. 2012 PLoS ONE pmid:23300587
Candelario J et al. PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. 2012 PLoS ONE pmid:23300710
Kjær MA et al. Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. 2016 PLoS ONE pmid:27973547
Derogis PB et al. The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. 2013 PLoS ONE pmid:24204871
Sublimi Saponetti M et al. Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. 2014 PLoS ONE pmid:25551704
Zhao Y et al. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer's disease models. 2011 PLoS ONE pmid:21246057
Zhao Z et al. The Association of Fatty Acid Levels and Gleason Grade among Men Undergoing Radical Prostatectomy. 2016 PLoS ONE pmid:27880795
Rossmeisl M et al. Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. 2012 PLoS ONE pmid:22701720
Vedin I et al. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study. 2012 PLoS ONE pmid:22545106
Gronroos NN et al. Fish, fish-derived n-3 fatty acids, and risk of incident atrial fibrillation in the Atherosclerosis Risk in Communities (ARIC) study. 2012 PLoS ONE pmid:22570739
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Bahety P et al. Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. 2014 PLoS ONE pmid:24587236
Labrousse VF et al. Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. 2012 PLoS ONE pmid:22662127
de Waal H et al. The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. 2014 PLoS ONE pmid:24475144
Desai A et al. Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. 2014 PLoS ONE pmid:24475126