DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Daak AA et al. Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:24095588
Umhau JC et al. Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. 2013 PLoS ONE pmid:24098376
Renganathan K et al. CEP biomarkers as potential tools for monitoring therapeutics. 2013 PLoS ONE pmid:24098476
Xu J et al. Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. 2013 FEBS J. pmid:24128189
Kimura R et al. DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. 2013 J. Lipid Res. pmid:24133194
Ren LJ et al. Impact of phosphate concentration on docosahexaenoic acid production and related enzyme activities in fermentation of Schizochytrium sp. 2013 Bioprocess Biosyst Eng pmid:23108442
Kautharapu KB et al. Growth condition optimization for docosahexaenoic acid (DHA) production by Moritella marina MP-1. 2013 Appl. Microbiol. Biotechnol. pmid:23111600
Méndez L et al. Reduced protein oxidation in Wistar rats supplemented with marine ω3 PUFAs. 2013 Free Radic. Biol. Med. pmid:23159545
MacLean E et al. n-3 Fatty acids inhibit transcription of human IL-13: implications for development of T helper type 2 immune responses. 2013 Br. J. Nutr. pmid:22849952
Hajjaji N and Bougnoux P Selective sensitization of tumors to chemotherapy by marine-derived lipids: a review. 2013 Cancer Treat. Rev. pmid:22850619
Yang T et al. N-3 PUFAs have antiproliferative and apoptotic effects on human colorectal cancer stem-like cells in vitro. 2013 J. Nutr. Biochem. pmid:22854319
Zong G et al. Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. 2013 Eur J Nutr pmid:23179200
Faizan M et al. Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). 2013 Int J Vitam Nutr Res pmid:25008014
Al-Taan O et al. Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. 2013 Lipids Health Dis pmid:23648075
Nordgren TM et al. Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. 2013 Respir. Res. pmid:23663457
Izquierdo MS et al. Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. 2013 Br. J. Nutr. pmid:23046500
Hara M et al. Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. 2013 Circ. J. pmid:23047296
Kasuya F et al. Effect of the non-steroidal anti-inflammatory drugs on the acyl-CoA synthetase activity toward medium-chain, long-chain and polyunsaturated fatty acids in mitochondria of mouse liver and brain. 2013 J Enzyme Inhib Med Chem pmid:22299587
West AA et al. Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimester. 2013 Am. J. Clin. Nutr. pmid:23446897
Sánchez-Martín MJ et al. Improved conformational stability of the visual G protein-coupled receptor rhodopsin by specific interaction with docosahexaenoic acid phospholipid. 2013 Chembiochem pmid:23447332
Dacks PA et al. Current evidence for the clinical use of long-chain polyunsaturated n-3 fatty acids to prevent age-related cognitive decline and Alzheimer's disease. 2013 J Nutr Health Aging pmid:23459977
Skilton MR et al. High intake of dietary long-chain ω-3 fatty acids is associated with lower blood pressure in children born with low birth weight: NHANES 2003-2008. 2013 Hypertension pmid:23460284
Kurihara T et al. Resolvin D2 restores neutrophil directionality and improves survival after burns. 2013 FASEB J. pmid:23430978
Gustafson KM et al. Effects of docosahexaenoic acid supplementation during pregnancy on fetal heart rate and variability: a randomized clinical trial. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23433688
Kondo T et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. 2013 Cell Stem Cell pmid:23434393
Snodgrass RG et al. Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. 2013 J. Immunol. pmid:24043885
McNamara RK et al. Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. 2013 J Psychiatr Res pmid:23759469
Nielsen G et al. Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. 2013 Basic Clin. Pharmacol. Toxicol. pmid:23724868
Moallem U et al. Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. 2013 Reproduction pmid:24062566
Hudson AG et al. Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. 2013 Nutr Cancer pmid:23530640
Pacetti D et al. Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). 2013 J. Agric. Food Chem. pmid:23531042
Mozurkewich EL et al. The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. 2013 Am. J. Obstet. Gynecol. pmid:23531328
Romero VC et al. Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. 2013 Am. J. Obstet. Gynecol. pmid:23531329
Bagley HN et al. Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. 2013 J Obes pmid:23533720
Dangour AD and Allen E Do omega-3 fats boost brain function in adults? Are we any closer to an answer? 2013 Am. J. Clin. Nutr. pmid:23535110
Pase MP and Stough C Describing a taxonomy of cognitive processes for clinical trials assessing cognition. 2013 Am. J. Clin. Nutr. pmid:23873682
Fedor DM et al. The effect of docosahexaenoic acid on t10, c12-conjugated linoleic acid-induced changes in fatty acid composition of mouse liver, adipose, and muscle. 2013 Metab Syndr Relat Disord pmid:23170930
Kuratko CN et al. The relationship of docosahexaenoic acid (DHA) with learning and behavior in healthy children: a review. 2013 Nutrients pmid:23877090
Vigerust NF et al. Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α. 2013 Eur J Nutr pmid:22923017
Marty-Roix R and Lien E (De-) oiling inflammasomes. 2013 Immunity pmid:23809158
Yan Y et al. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. 2013 Immunity pmid:23809162
Wu A et al. Exercise facilitates the action of dietary DHA on functional recovery after brain trauma. 2013 Neuroscience pmid:23811071
Sugasini D and Lokesh BR Enhanced incorporation of docosahexaenoic acid in serum, heart, and brain of rats given microemulsions of fish oil. 2013 Mol. Cell. Biochem. pmid:23812902
Erken HA et al. Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. 2013 High Alt. Med. Biol. pmid:24377343
Oelrich B et al. Effect of fish oil supplementation on serum triglycerides, LDL cholesterol and LDL subfractions in hypertriglyceridemic adults. 2013 Nutr Metab Cardiovasc Dis pmid:21924882
Tapsell LC et al. Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. 2013 BMC Public Health pmid:24369765
van Valenberg HJ et al. Concentrations of n-3 and n-6 fatty acids in Dutch bovine milk fat and their contribution to human dietary intake. 2013 J. Dairy Sci. pmid:23664339
Ribeiro T et al. Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. 2013 Br. Poult. Sci. pmid:24397512
Rayapudi S et al. Vitamin A and fish oils for retinitis pigmentosa. 2013 Cochrane Database Syst Rev pmid:24357340
Azordegan N et al. Carcinogenesis alters fatty acid profile in breast tissue. 2013 Mol. Cell. Biochem. pmid:23180247
Brouwer IA et al. Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. 2013 PLoS ONE pmid:24349086
Chang G et al. Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. 2013 Bioresour. Technol. pmid:23747449
Zhang L et al. Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. 2013 Bioresour. Technol. pmid:23751810
Janczyk W et al. Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. 2013 BMC Pediatr pmid:23702094
Cortina MS et al. Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23702780
Nyuar KB et al. Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23706881
Terrando N et al. Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 2013 FASEB J. pmid:23709617
Kelly OJ et al. Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis. 2013 Nutr Res pmid:23827126
García-Sastre A Lessons from lipids in the fight against influenza. 2013 Cell pmid:23827671
Birch DG et al. Spectral-domain optical coherence tomography measures of outer segment layer progression in patients with X-linked retinitis pigmentosa. 2013 JAMA Ophthalmol pmid:23828615
Mobraten K et al. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. 2013 Lipids Health Dis pmid:23849180
Martins DA et al. Alternative sources of n-3 long-chain polyunsaturated fatty acids in marine microalgae. 2013 Mar Drugs pmid:23807546
Chen HF and Su HM Exposure to a maternal n-3 fatty acid-deficient diet during brain development provokes excessive hypothalamic-pituitary-adrenal axis responses to stress and behavioral indices of depression and anxiety in male rat offspring later in life. 2013 J. Nutr. Biochem. pmid:22818715
Brahmbhatt V et al. Protective effects of dietary EPA and DHA on ischemia-reperfusion-induced intestinal stress. 2013 J. Nutr. Biochem. pmid:22819560
Benton D et al. Supplementation with DHA and the psychological functioning of young adults. 2013 Br. J. Nutr. pmid:22715808
Alhazzaa R et al. Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. 2013 PLoS ONE pmid:24040040
Kusunoki C et al. Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. 2013 Biochem. Biophys. Res. Commun. pmid:23131562
Li C et al. High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. 2013 Bioresour. Technol. pmid:23131649
Nicholson T et al. The role of marine n-3 fatty acids in improving cardiovascular health: a review. 2013 Food Funct pmid:23325431
Hamaoka N et al. Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. 2013 J. Food Sci. pmid:23915081
Jing K et al. Omega-3 polyunsaturated fatty acids and cancer. 2013 Anticancer Agents Med Chem pmid:23919748
Nagachinta S and Akoh CC Synthesis of structured lipid enriched with omega fatty acids and sn-2 palmitic acid by enzymatic esterification and its incorporation in powdered infant formula. 2013 J. Agric. Food Chem. pmid:23597247
Mortensen K and Tawia S Sustained breastfeeding. 2013 Breastfeed Rev pmid:23600325
Harsløf LB et al. FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants. 2013 Am. J. Clin. Nutr. pmid:23636240
Kangari H et al. Short-term consumption of oral omega-3 and dry eye syndrome. 2013 Ophthalmology pmid:23642375
Tanghe S et al. Echium oil and linseed oil as alternatives for fish oil in the maternal diet: Blood fatty acid profiles and oxidative status of sows and piglets. 2013 J. Anim. Sci. pmid:23658328
Gow RV et al. Omega-3 fatty acids are inversely related to callous and unemotional traits in adolescent boys with attention deficit hyperactivity disorder. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23664595
Reinders I et al. Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. 2013 Eur J Clin Nutr pmid:24084512
Hoshi T et al. Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23940844
Sadli N et al. Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. 2013 Cell. Physiol. Biochem. pmid:23942088
Rajasagi NK et al. Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23942967
Mühlroth A et al. Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. 2013 Mar Drugs pmid:24284429
Harris WS et al. Omega-3 fatty acids and cardiovascular disease: new developments and applications. 2013 Postgrad Med pmid:24200766
Crawford MA et al. A quantum theory for the irreplaceable role of docosahexaenoic acid in neural cell signalling throughout evolution. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23206328
Kim K et al. A novel fed-batch process based on the biology of Aurantiochytrium sp. KRS101 for the production of biodiesel and docosahexaenoic acid. 2013 Bioresour. Technol. pmid:23206808
Pomponi M et al. Plasma levels of n-3 fatty acids in bipolar patients: deficit restricted to DHA. 2013 J Psychiatr Res pmid:23207113
Valentine CJ et al. Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors. 2013 Breastfeed Med pmid:22568471
Tomita T et al. High concentrations of omega-3 fatty acids are associated with the development of atrial fibrillation in the Japanese population. 2013 Heart Vessels pmid:22696184
Makrides M DHA supplementation during the perinatal period and neurodevelopment: Do some babies benefit more than others? 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22698951
Tam VC Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. 2013 Semin. Immunol. pmid:24084369
Orr SK et al. Unesterified docosahexaenoic acid is protective in neuroinflammation. 2013 J. Neurochem. pmid:23919613
Yusof HM et al. Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. 2013 Mar Drugs pmid:24065166
Stanley WC et al. Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. 2013 J Cardiovasc Transl Res pmid:24065618
Xiao G et al. Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. 2013 PLoS ONE pmid:24066055
Andrade-Vieira R et al. Omega-3 polyunsaturated fatty acid promotes the inhibition of glycolytic enzymes and mTOR signaling by regulating the tumor suppressor LKB1. 2013 Cancer Biol. Ther. pmid:24025358
Lachance C et al. Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. 2013 PLoS ONE pmid:24069363
Leggieri E et al. Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. 2013 Minerva Pediatr. pmid:24051972
Sun SN et al. Docosahexaenoic acid (DHA) induces apoptosis in human hepatocellular carcinoma cells. 2013 Int J Clin Exp Pathol pmid:23330014
Bogl LH et al. Association between habitual dietary intake and lipoprotein subclass profile in healthy young adults. 2013 Nutr Metab Cardiovasc Dis pmid:23333726
Depner CM et al. Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis. 2013 J. Nutr. pmid:23303872