DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Keim SA et al. Breastfeeding and long-chain polyunsaturated fatty acid intake in the first 4 post-natal months and infant cognitive development: an observational study. 2012 Matern Child Nutr pmid:21615865
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An WS et al. Omega-3 fatty acid supplementation increases 1,25-dihydroxyvitamin D and fetuin-A levels in dialysis patients. 2012 Nutr Res pmid:22901557
Pineda-Peña EA et al. Docosahexaenoic acid, an omega-3 polyunsaturated acid protects against indomethacin-induced gastric injury. 2012 Eur. J. Pharmacol. pmid:23063544
Liu RZ et al. A fatty acid-binding protein 7/RXRβ pathway enhances survival and proliferation in triple-negative breast cancer. 2012 J. Pathol. pmid:22322885
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Kisos H et al. Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. 2012 PLoS ONE pmid:23077527
König K et al. Supplementation in acute lung injury. 2012 JAMA pmid:22235080
Cortina MS et al. Recovery of corneal sensitivity, calcitonin gene-related peptide-positive nerves, and increased wound healing induced by pigment epithelial-derived factor plus docosahexaenoic acid after experimental surgery. 2012 Arch. Ophthalmol. pmid:21911652
Maqbool A et al. Relation between dietary fat intake type and serum fatty acid status in children with cystic fibrosis. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22699835
Trikalinos TA et al. Concordance of randomized and nonrandomized studies was unrelated to translational patterns of two nutrient-disease associations. 2012 J Clin Epidemiol pmid:22047889
Zhou SJ et al. Fish-oil supplementation in pregnancy does not reduce the risk of gestational diabetes or preeclampsia. 2012 Am. J. Clin. Nutr. pmid:22552037
Finocchiaro C et al. Effect of n-3 fatty acids on patients with advanced lung cancer: a double-blind, placebo-controlled study. 2012 Br. J. Nutr. pmid:22114792
An WS et al. Effect of omega-3 fatty acids on the modification of erythrocyte membrane fatty acid content including oleic acid in peritoneal dialysis patients. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22071008
Jacobson TA et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a review. 2012 Jan-Feb J Clin Lipidol pmid:22264569
Widgerow AD Cellular resolution of inflammation--catabasis. 2012 Jan-Feb Wound Repair Regen pmid:22276585
Kuipers RS et al. Fetal intrauterine whole body linoleic, arachidonic and docosahexaenoic acid contents and accretion rates. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22115845
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Abad S and Turon X Valorization of biodiesel derived glycerol as a carbon source to obtain added-value metabolites: Focus on polyunsaturated fatty acids. 2012 May-Jun Biotechnol. Adv. pmid:22261015
Ma L et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuate hyperoxia-induced lung injury in neonatal mice. 2012 Nov-Dec Nutrition pmid:23044165
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Davidson MH et al. A novel omega-3 free fatty acid formulation has dramatically improved bioavailability during a low-fat diet compared with omega-3-acid ethyl esters: the ECLIPSE (Epanova(®) compared to Lovaza(®) in a pharmacokinetic single-dose evaluation) study. 2012 Nov-Dec J Clin Lipidol pmid:23312053
Block RC et al. The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:23017325
Kartikasari LR et al. Dietary alpha-linolenic acid enhances omega-3 long chain polyunsaturated fatty acid levels in chicken tissues. 2012 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:22925778
Dalal JJ et al. Role of omega-3 ethyl ester concentrate in reducing sudden cardiac death following myocardial infarction and in management of hypertriglyceridemia: an Indian consensus statement. 2012 Sep-Oct Indian Heart J pmid:23102390
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Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Lee HJ et al. Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. 2013 Int. J. Biochem. Cell Biol. pmid:24120851
Offman E et al. Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. 2013 Vasc Health Risk Manag pmid:24124374
Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Galvao TF et al. Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. 2013 Am. J. Physiol. Heart Circ. Physiol. pmid:23103493
Yang YC et al. Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. 2013 J. Nutr. Biochem. pmid:22901690
Tsuboi H et al. Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population--a preliminary study. 2013 Clin Nutr pmid:22901744
Lindberg M et al. Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. 2013 Br. J. Nutr. pmid:22846205
Hu Y et al. 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. 2013 Carcinogenesis pmid:23066085
Tang Y et al. Proresolution therapy for the treatment of delayed healing of diabetic wounds. 2013 Diabetes pmid:23043160
Cedernaes J et al. Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. 2013 Lipids Health Dis pmid:23298201
Gillingham LG et al. Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. 2013 Am. J. Clin. Nutr. pmid:23221573
Sundrani D et al. Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. 2013 Reproduction pmid:23412981
Chien KL et al. A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. 2013 BMC Med Res Methodol pmid:23414574
Maskrey BH et al. Emerging importance of omega-3 fatty acids in the innate immune response: molecular mechanisms and lipidomic strategies for their analysis. 2013 Mol Nutr Food Res pmid:23417926
Lapillonne A et al. Lipid needs of preterm infants: updated recommendations. 2013 J. Pediatr. pmid:23445847
Hong WK et al. Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. 2013 Bioprocess Biosyst Eng pmid:23053417
Hjorth E et al. Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. 2013 J. Alzheimers Dis. pmid:23481688
Lee MS et al. Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. 2013 Nutrients pmid:23698161
Kang JX and Gleason ED Omega-3 Fatty acids and hippocampal neurogenesis in depression. 2013 CNS Neurol Disord Drug Targets pmid:23574158
Yamaguchi M et al. Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. 2013 J Occup Health pmid:23574777
Correia M et al. Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. 2013 PLoS ONE pmid:23577140
Weise C et al. Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. 2013 Pediatr Allergy Immunol pmid:23577592
De Genaro P et al. Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. 2013 Invest. Ophthalmol. Vis. Sci. pmid:23580485
Berberovic E et al. Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. 2013 J. Matern. Fetal. Neonatal. Med. pmid:23480524
Lee HN et al. Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression. 2013 J. Cell. Sci. pmid:23788426
Araújo JR et al. Gestational diabetes mellitus decreases placental uptake of long-chain polyunsaturated fatty acids: involvement of long-chain acyl-CoA synthetase. 2013 J. Nutr. Biochem. pmid:23790250
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Montes R et al. Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. 2013 Eur J Clin Nutr pmid:23549201
Emmett R et al. Expanding awareness of docosahexaenoic acid during pregnancy. 2013 Nutrients pmid:23549329
Haller MJ et al. Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. 2013 Biol. Blood Marrow Transplant. pmid:23611977
Chen J et al. Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. 2013 Food Chem. Toxicol. pmid:23590892
Damsgaard CT et al. n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. 2013 Br. J. Nutr. pmid:23591057
Dalli J et al. Novel n-3 immunoresolvents: structures and actions. 2013 Sci Rep pmid:23736886
Devaraj S et al. Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. 2013 Atherosclerosis pmid:23528830
Finlin BS et al. Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. 2013 J. Nutr. Biochem. pmid:23528972
Rashid MA et al. N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. 2013 J. Neurochem. pmid:23570577
Shiraishi M et al. Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. 2013 Nutr Res pmid:23746563
Vaezi R et al. Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. 2013 Mar Drugs pmid:24351909
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Jung SB et al. Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. 2013 Biochem. Biophys. Res. Commun. pmid:23806688
Decsi T and Boehm G trans Isomeric fatty acids are inversely related to the availability of long-chain PUFAs in the perinatal period. 2013 Am. J. Clin. Nutr. pmid:23824720
Lundström SL et al. Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids. 2013 Mol Nutr Food Res pmid:23824870
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
Kitson AP et al. Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23764042
Taha AY et al. A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. 2013 Epilepsy Behav pmid:23376336
Ostapchenko VG et al. Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. 2013 J. Neurochem. pmid:23651058
Ramkumar HL et al. Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. 2013 J. Nutr. pmid:23677863
Nobre ME et al. Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and antinociceptive effects in rodents at low doses. 2013 Nutr Res pmid:23684444
Xu ZZ et al. Neuroprotectin/protectin D1 protects against neuropathic pain in mice after nerve trauma. 2013 Ann. Neurol. pmid:23686636
Flock MR et al. Immunometabolic role of long-chain omega-3 fatty acids in obesity-induced inflammation. 2013 Diabetes Metab. Res. Rev. pmid:23592441
Opperman M and Benade S Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. 2013 Cardiovasc J Afr pmid:24240381
Begum G et al. ER stress and effects of DHA as an ER stress inhibitor. 2013 Transl Stroke Res pmid:24323417
Rosa A et al. Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. 2013 Food Chem. Toxicol. pmid:23948356
Bjorgvinsdottir L et al. Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? 2013 Cardiology pmid:23948862
Lee AL and Park Y The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. 2013 Ann. Nutr. Metab. pmid:23949659
Metherel AH et al. EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. 2013 Lipids pmid:23949919
Ishikado A et al. 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. 2013 PLoS ONE pmid:23936010
Nobili V et al. Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. 2013 Nutr Metab Cardiovasc Dis pmid:23220074
Chung ML et al. Profiling of oxidized lipid products of marine fish under acute oxidative stress. 2013 Food Chem. Toxicol. pmid:23220612
van der Merwe LF et al. Long-chain PUFA supplementation in rural African infants: a randomized controlled trial of effects on gut integrity, growth, and cognitive development. 2013 Am. J. Clin. Nutr. pmid:23221579
Zeilmaker MJ et al. Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. 2013 Food Chem. Toxicol. pmid:22079313
Wu BT et al. Low fish intake is associated with low blood concentrations of vitamin D, choline and n-3 DHA in pregnant women. 2013 Br. J. Nutr. pmid:22691303
Marcon R et al. Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. 2013 J. Immunol. pmid:24038091
Fontes-Villalba M et al. African hominin stable isotopic data do not necessarily indicate grass consumption. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:24062471
Yan Y et al. Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. 2013 Bioresour. Technol. pmid:23347925
Jaudszus A et al. Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. 2013 J. Lipid Res. pmid:23349208
Neuhofer A et al. Impaired local production of proresolving lipid mediators in obesity and 17-HDHA as a potential treatment for obesity-associated inflammation. 2013 Diabetes pmid:23349501
Sofi F et al. The atherosclerotic risk profile is affected differently by fish flesh with a similar EPA and DHA content but different n-6/n-3 ratio. 2013 Asia Pac J Clin Nutr pmid:23353608