DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Vreugdenhil M et al. Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. 1996 Proc. Natl. Acad. Sci. U.S.A. pmid:8901621
Hoshi T et al. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487785
Hoshi T et al. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. 2013 Proc. Natl. Acad. Sci. U.S.A. pmid:23487786
Mukherjee PK et al. Photoreceptor outer segment phagocytosis attenuates oxidative stress-induced apoptosis with concomitant neuroprotectin D1 synthesis. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17670935
Scott BL and Bazan NG Membrane docosahexaenoate is supplied to the developing brain and retina by the liver. 1989 Proc. Natl. Acad. Sci. U.S.A. pmid:2523075
Krishnamoorthy S et al. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. 2010 Proc. Natl. Acad. Sci. U.S.A. pmid:20080636
Mukherjee PK et al. Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15152078
Berger A et al. Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets. 2001 Proc. Natl. Acad. Sci. U.S.A. pmid:11353819
Corey EJ et al. Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. 1983 Proc. Natl. Acad. Sci. U.S.A. pmid:6304720
Kang JX et al. Free, long-chain, polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. 1995 Proc. Natl. Acad. Sci. U.S.A. pmid:7732020
Akbar M et al. Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival. 2005 Proc. Natl. Acad. Sci. U.S.A. pmid:16040805
Ruyle M et al. Placental transfer of essential fatty acids in humans: venous-arterial difference for docosahexaenoic acid in fetal umbilical erythrocytes. 1990 Proc. Natl. Acad. Sci. U.S.A. pmid:2146677
Honoré E et al. External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. 1994 Proc. Natl. Acad. Sci. U.S.A. pmid:8127910
Bruno MJ et al. Docosahexaenoic acid alters bilayer elastic properties. 2007 Proc. Natl. Acad. Sci. U.S.A. pmid:17535898
Nishio K et al. Novel water-soluble derivatives of docosahexaenoic acid increase diacylglycerol production mediated by phosphatidylcholine-specific phospholipase C. 1993 Proc. Soc. Exp. Biol. Med. pmid:8389049
Engler MM et al. Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. 1999 Proc. Soc. Exp. Biol. Med. pmid:10320629
Jenski LJ et al. Omega-3 fatty acid-containing liposomes in cancer therapy. 1995 Proc. Soc. Exp. Biol. Med. pmid:8539260
Uauy-Dagach R and Valenzuela A Marine oils as a source of omega-3 fatty acids in the diet: how to optimize the health benefits. 1992 Prog Food Nutr Sci pmid:1438808
Judé S et al. Dietary long-chain omega-3 fatty acids of marine origin: a comparison of their protective effects on coronary heart disease and breast cancers. 2006 Jan-Apr Prog. Biophys. Mol. Biol. pmid:16005051
Wetzel MG et al. Fatty acid metabolism in normal miniature poodles and those affected with progressive rod-cone degeneration (prcd). 1989 Prog. Clin. Biol. Res. pmid:2532748
Karanian JW et al. Cardiovascular properties of hydroxylated docosahexaenoates. 1989 Prog. Clin. Biol. Res. pmid:2529554
Bazan NG The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. 1989 Prog. Clin. Biol. Res. pmid:2529559
Martinez M Treatment with docosahexaenoic acid favorably modifies the fatty acid composition of erythrocytes in peroxisomal patients. 1992 Prog. Clin. Biol. Res. pmid:1438383
Huang WH et al. Control of the sodium pump by liponucleotides and unsaturated fatty acids: side-dependent effects in red cells. 1988 Prog. Clin. Biol. Res. pmid:2851818
Organisciak DT et al. Aspects of the ascorbate protective mechanism in retinal light damage of rats with normal and reduced ROS docosahexaenoic acid. 1987 Prog. Clin. Biol. Res. pmid:2960984
Barceló-Coblijn G and Murphy EJ Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels. 2009 Prog. Lipid Res. pmid:19619583
Frisardi V et al. Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. 2011 Prog. Lipid Res. pmid:21703303
Cunnane SC et al. Fish, docosahexaenoic acid and Alzheimer's disease. 2009 Prog. Lipid Res. pmid:19362576
Bougnoux P et al. Fatty acids and breast cancer: sensitization to treatments and prevention of metastatic re-growth. 2010 Prog. Lipid Res. pmid:19715726
Valentine RC and Valentine DL Omega-3 fatty acids in cellular membranes: a unified concept. 2004 Prog. Lipid Res. pmid:15458813
Giusto NM et al. Lipid metabolism in vertebrate retinal rod outer segments. 2000 Prog. Lipid Res. pmid:10856601
Elsherbiny ME et al. Interaction of brain fatty acid-binding protein with the polyunsaturated fatty acid environment as a potential determinant of poor prognosis in malignant glioma. 2013 Prog. Lipid Res. pmid:23981365
Poudyal H et al. Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action. 2011 Prog. Lipid Res. pmid:21762726
Lauritzen L et al. The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. 2001 Jan-Mar Prog. Lipid Res. pmid:11137568
Venegas-Calerón M et al. An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids. 2010 Prog. Lipid Res. pmid:19857520
Domenichiello AF et al. Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain? 2015 Prog. Lipid Res. pmid:25920364
Ramos-Loyo J et al. Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia. 2013 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:23421976
Doornbos B et al. The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:19625011
Buydens-Branchey L et al. Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. 2008 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18060675
Blanchet J et al. Resveratrol, a red wine polyphenol, protects dopaminergic neurons in MPTP-treated mice. 2008 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18471948
Doornbos B et al. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. 2009 Prog. Neuropsychopharmacol. Biol. Psychiatry pmid:18955102
Blachier F et al. Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis. 1988 Prostaglandins pmid:2834771
Kim HY and Salem N Preparation and the structural determination of hydroperoxy derivatives of docosahexaenoic acid and other polyunsaturates by thermospray LC/MS. 1989 Prostaglandins pmid:2541468
Mai J et al. A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. 1981 Prostaglandins pmid:6280241
Kim HY et al. Stereochemical analysis of hydroxylated docosahexaenoates produced by human platelets and rat brain homogenate. 1990 Prostaglandins pmid:2147773
Kim HY et al. Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets. 1990 Prostaglandins pmid:2147774
Fischer S et al. Dietary docosahexaenoic acid is retroconverted in man to eicosapentaenoic acid, which can be quickly transformed to prostaglandin I3. 1987 Prostaglandins pmid:2829279
Hishinuma T et al. Microdetermination of the thromboxane B3 gas chromatography-selected-ion monitoring using [18O]thromboxane B3 as an internal standard. 1997 Prostaglandins pmid:9261859
Claeys M et al. Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. 1986 Prostaglandins pmid:2951768
Agren JJ et al. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430389
Reardon HT et al. Dietary long-chain polyunsaturated fatty acids upregulate expression of FADS3 transcripts. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22398025
Chen ZY and Istfan NW Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161587
Ott J et al. Lipids in critical care medicine. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21546231
Al-Turkmani MR et al. Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18036797
Brenna T et al. Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23103099
Hashimoto M et al. Effects of aging on the relation of adenyl purine release with plasma membrane fluidity of arterial endothelial cells. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:16165346
Lii CK et al. Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9774170
Hsieh AT and Brenna JT Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19524425
Whelan J et al. Docosahexaenoic acid: measurements in food and dietary exposure. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19493663
Makrides M Is there a dietary requirement for DHA in pregnancy? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500960
Schuchardt JP et al. Moderate doses of EPA and DHA from re-esterified triacylglycerols but not from ethyl-esters lower fasting serum triacylglycerols in statin-treated dyslipidemic subjects: Results from a six month randomized controlled trial. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21862301
Lien EL Toxicology and safety of DHA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19501496
Chen CT et al. Rapid beta-oxidation of eicosapentaenoic acid in mouse brain: an in situ study. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19237271
Nieminen LR et al. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls. 2006 Oct-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:16959481
Marsen TA et al. Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. 1992 Prostaglandins Leukot. Essent. Fatty Acids pmid:1387231
Kuratko CN and Salem N Biomarkers of DHA status. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545987
Holub BJ Docosahexaenoic acid (DHA) and cardiovascular disease risk factors. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19545988
Lagarde M et al. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22520055
Mohan IK and Das UN Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9089797
Russell KL et al. Low brain DHA content worsens sensorimotor outcomes after TBI and decreases TBI-induced Timp1 expression in juvenile rats. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23796971
Horrocks LA and Farooqui AA Docosahexaenoic acid in the diet: its importance in maintenance and restoration of neural membrane function. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15041028
Kurowska EM et al. Bioavailability of omega-3 essential fatty acids from perilla seed oil. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12591004
Erdogan H et al. Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15253883
Krabbendam L et al. Relationship between DHA status at birth and child problem behaviour at 7 years of age. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17074476
Qin X et al. Brown but not white adipose cells synthesize omega-3 docosahexaenoic acid in culture. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26802938
Brenner RR Hormonal modulation of delta6 and delta5 desaturases: case of diabetes. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12538079
Kim HY et al. Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207120
Minns LM et al. Toddler formula supplemented with docosahexaenoic acid (DHA) improves DHA status and respiratory health in a randomized, double-blind, controlled trial of US children less than 3 years of age. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20207123
Sarri KO et al. Adipose DHA inversely associated with depression as measured by the Beck Depression Inventory. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18258421
McPhee S et al. Prophylactic and therapeutic effects of Mytilus edulis fatty acids on adjuvant-induced arthritis in male Wistar rats. 2010 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:20074924
Agostoni C et al. Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11237478
Zhou D et al. Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. 2004 Prostaglandins Leukot. Essent. Fatty Acids pmid:15519497
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
Kitson AP et al. Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23764042
Baskaya MK et al. Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8860103
Rapoport SI Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22766388
Burdge GC et al. The effect of altering the 20:5n-3 and 22:6n-3 content of a meal on the postprandial incorporation of n-3 polyunsaturated fatty acids into plasma triacylglycerol and non-esterified fatty acids in humans. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17693069
Murali G et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24332315
Engler MM et al. The effects of a diet rich in docosahexaenoic acid on organ and vascular fatty acid composition in spontaneously hypertensive rats. 1999 Prostaglandins Leukot. Essent. Fatty Acids pmid:10670690
Calder PC Immunomodulation by omega-3 fatty acids. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18032006
Leaf A Omega-3 fatty acids and prevention of ventricular fibrillation. 1995 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:7784457
van Goor SA et al. Maternal and fetal brain contents of docosahexaenoic acid (DHA) and arachidonic acid (AA) at various essential fatty acid (EFA), DHA and AA dietary intakes during pregnancy in mice. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18343099
Helmersson-Karlqvist J et al. Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study. 2012 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:22047909
Taha AY et al. Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26869088
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Harmon SD et al. Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16820285
Marzo I et al. Loss of delta6-desaturase activity leads to impaired docosahexaenoic acid synthesis in Y-79 retinoblastoma cells. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9888202
Yusof HM et al. Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18403189
Frøyland L et al. Hypotriacylglycerolemic component of fish oil. 1997 Prostaglandins Leukot. Essent. Fatty Acids pmid:9430383