Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hørby Jørgensen M et al. | Effect of formula supplemented with docosahexaenoic acid and gamma-linolenic acid on fatty acid status and visual acuity in term infants. | 1998 | J. Pediatr. Gastroenterol. Nutr. | pmid:9552137 |
Madsen L et al. | Docosahexaenoic and eicosapentaenoic acids are differently metabolized in rat liver during mitochondria and peroxisome proliferation. | 1998 | J. Lipid Res. | pmid:9548590 |
Sebaldt RJ and Marignani P | Diradylglycerol formation is altered by n-3 highly unsaturated fatty acids, with differences between eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids. | 1997 | Adv. Exp. Med. Biol. | pmid:9547650 |
Rousseau D et al. | Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? | 1998 | Mol. Cell. Biochem. | pmid:9546620 |
Voskuyl RA et al. | Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model. | 1998 | Eur. J. Pharmacol. | pmid:9543232 |
Starkopf J et al. | Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. | 1998 | Cardiovasc. Res. | pmid:9539859 |
Wolk A et al. | Effect of additional questions about fat on the validity of fat estimates from a food frequency questionnaire. Study Group of MRS SWEA. | 1998 | Eur J Clin Nutr | pmid:9537304 |
Rhodes LE and White SI | Dietary fish oil as a photoprotective agent in hydroa vacciniforme. | 1998 | Br. J. Dermatol. | pmid:9536243 |
Paulsen JE et al. | A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. | 1998 | Pharmacol. Toxicol. | pmid:9527643 |
Urano S et al. | Aging and oxidative stress in neurodegeneration. | 1998 | Biofactors | pmid:9523034 |
Ramanadham S et al. | Electrospray ionization mass spectrometric analyses of phospholipids from rat and human pancreatic islets and subcellular membranes: comparison to other tissues and implications for membrane fusion in insulin exocytosis. | 1998 | Biochemistry | pmid:9521776 |
Ward PE et al. | Niacin skin flush in schizophrenia: a preliminary report. | 1998 | Schizophr. Res. | pmid:9516668 |
Larsen LN et al. | Alpha- and beta- alkyl-substituted eicosapentaenoic acids: incorporation into phospholipids and effects on prostaglandin H synthase and 5-lipoxygenase. | 1998 | Biochem. Pharmacol. | pmid:9514074 |
Osmundsen H et al. | Effects of dietary treatment of rats with eicosapentaenoic acid or docosahexaenoic acid on hepatic lipid metabolism. | 1998 | Biochem. J. | pmid:9512474 |
Conquer JA and Holub BJ | Effect of supplementation with different doses of DHA on the levels of circulating DHA as non-esterified fatty acid in subjects of Asian Indian background. | 1998 | J. Lipid Res. | pmid:9507989 |
Peterson LD et al. | Eicosapentaenoic and docosahexaenoic acids alter rat spleen leukocyte fatty acid composition and prostaglandin E2 production but have different effects on lymphocyte functions and cell-mediated immunity. | 1998 | Lipids | pmid:9507239 |
Hansen JB et al. | Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on fatty acid absorption, incorporation into serum phospholipids and postprandial triglyceridemia. | 1998 | Lipids | pmid:9507234 |
Morita N and Shirai J | Effects of microcapsulated docosahexaenoic acid preparation on properties of dough and bread. | 1997 | J. Nutr. Sci. Vitaminol. | pmid:9505244 |
Woltil HA et al. | Long-chain polyunsaturated fatty acid status and early growth of low birth weight infants. | 1998 | Eur. J. Pediatr. | pmid:9504790 |
Hirafuji M et al. | [Specific modulation of vascular smooth muscle cell functions by docosahexaenoic acid]. | 1997 | Nippon Yakurigaku Zasshi | pmid:9503427 |