DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with DHA?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
| Widgerow AD | Cellular resolution of inflammation--catabasis. | 2012 Jan-Feb | Wound Repair Regen | pmid:22276585 |
| McDaniel JC et al. | Omega-3 fatty acids effect on wound healing. | 2008 May-Jun | Wound Repair Regen | pmid:18471252 |
| McDaniel JC et al. | Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. | 2011 Mar-Apr | Wound Repair Regen | pmid:21362086 |
| Legrand P et al. | Update of French nutritional recommendations for fatty acids. | 2011 | World Rev Nutr Diet | pmid:21865827 |
| Kyle DJ and Arterburn LM | Single cell oil sources of docosahexaenoic acid: clinical studies. | 1998 | World Rev Nutr Diet | pmid:9648509 |
| Wright T et al. | Docosahexaenoic acid-enriched milk. | 1998 | World Rev Nutr Diet | pmid:9648512 |
| Bazan NG et al. | Docosahexaenoic acid supply to the retina and its conservation in photoreceptor cells by active retinal pigment epithelium-mediated recycling. | 1994 | World Rev Nutr Diet | pmid:7871812 |
| Anderson RE et al. | The accretion of docosahexaenoic acid in the retina. | 1994 | World Rev Nutr Diet | pmid:7871813 |
| von Houwelingen AC and Hornstra G | Trans fatty acids in early human development. | 1994 | World Rev Nutr Diet | pmid:7871822 |
| Martinez M | Polyunsaturated fatty acids in the developing human brain, red cells and plasma: influence of nutrition and peroxisomal disease. | 1994 | World Rev Nutr Diet | pmid:7871835 |
| Martinez M | Developmental profiles of polyunsaturated fatty acids in the brain of normal infants and patients with peroxisomal diseases: severe deficiency of docosahexaenoic acid in Zellweger's and pseudo-Zellweger's syndromes. | 1991 | World Rev Nutr Diet | pmid:1828923 |
| Simopoulos AP | Omega-6/omega-3 essential fatty acids: biological effects. | 2009 | World Rev Nutr Diet | pmid:19136835 |
| Hibbeln JR | Depression, suicide and deficiencies of omega-3 essential fatty acids in modern diets. | 2009 | World Rev Nutr Diet | pmid:19136836 |
| Niemoller TD et al. | Omega-3 fatty acid docosahexaenoic acid is the precursor of neuroprotectin D1 in the nervous system. | 2009 | World Rev Nutr Diet | pmid:19136838 |
| Lukiw WJ | Docosahexaenoic acid and amyloid-beta peptide signaling in Alzheimer's disease. | 2009 | World Rev Nutr Diet | pmid:19136839 |
| Wurtman RJ et al. | Administration of docosahexaenoic acid, uridine and choline increases levels of synaptic membranes and dendritic spines in rodent brain. | 2009 | World Rev Nutr Diet | pmid:19136840 |
| Hadley KB et al. | An assessment of dietary docosahexaenoic acid requirements for brain accretion and turnover during early childhood. | 2009 | World Rev Nutr Diet | pmid:19136841 |
| SanGiovanni JP et al. | Variation in lipid-associated genes as they relate to risk of advanced age-related macular degeneration. | 2009 | World Rev Nutr Diet | pmid:19136842 |
| Gruszfeld D and Socha P | Early nutrition and health: short- and long-term outcomes. | 2013 | World Rev Nutr Diet | pmid:24029784 |