Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Innis SM | Polyunsaturated fatty acids in human milk: an essential role in infant development. | 2004 | Adv. Exp. Med. Biol. | pmid:15384565 |
Baumgartner M et al. | Enhancement of arsenic trioxide-mediated apoptosis using docosahexaenoic acid in arsenic trioxide-resistant solid tumor cells. | 2004 | Int. J. Cancer | pmid:15382055 |
Bairati I et al. | Double-blind, randomized, controlled trial of fish oil supplements in prevention of recurrence of stenosis after coronary angioplasty. | 1992 | Circulation | pmid:1537131 |
Raimondi L et al. | n-3 polyunsaturated fatty acids supplementation decreases asymmetric dimethyl arginine and arachidonate accumulation in aging spontaneously hypertensive rats. | 2005 | Eur J Nutr | pmid:15368071 |
Ding WQ et al. | Differential sensitivity of cancer cells to docosahexaenoic acid-induced cytotoxicity: the potential importance of down-regulation of superoxide dismutase 1 expression. | 2004 | Mol. Cancer Ther. | pmid:15367705 |
Calviello G et al. | Docosahexaenoic acid enhances the susceptibility of human colorectal cancer cells to 5-fluorouracil. | 2005 | Cancer Chemother. Pharmacol. | pmid:15365767 |
Berson EL et al. | Further evaluation of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment: subgroup analyses. | 2004 | Arch. Ophthalmol. | pmid:15364709 |
Berson EL et al. | Clinical trial of docosahexaenoic acid in patients with retinitis pigmentosa receiving vitamin A treatment. | 2004 | Arch. Ophthalmol. | pmid:15364708 |
Dennis CL | Preventing postpartum depression part I: a review of biological interventions. | 2004 | Can J Psychiatry | pmid:15362251 |
Calviello G et al. | n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway. | 2004 | Carcinogenesis | pmid:15358633 |
Ghebremeskel K et al. | Type 1 diabetes compromises plasma arachidonic and docosahexaenoic acids in newborn babies. | 2004 | Lipids | pmid:15357021 |
Leaf AA et al. | Factors affecting long-chain polyunsaturated fatty acid composition of plasma choline phosphoglycerides in preterm infants. | 1992 | J. Pediatr. Gastroenterol. Nutr. | pmid:1535657 |
Lindsey S et al. | Low density lipoprotein from humans supplemented with n-3 fatty acids depresses both LDL receptor activity and LDLr mRNA abundance in HepG2 cells. | 1992 | J. Lipid Res. | pmid:1535648 |
Bucci KK | Fish oil supplements. | 1992 | Am Pharm | pmid:1535475 |
Harris WS et al. | Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation. | 2004 | Circulation | pmid:15353491 |
Momchilova S et al. | Resolution of triacylglycerol positional isomers by reversed-phase high-performance liquid chromatography. | 2004 | J Sep Sci | pmid:15352724 |
Giltay EJ et al. | Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. | 2004 | J. Endocrinol. | pmid:15350182 |
Shaikh SR et al. | Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study. | 2004 | Biophys. J. | pmid:15345554 |
Lee SS et al. | Requirement of PPARalpha in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation. | 2004 | J. Lipid Res. | pmid:15342691 |
Bønaa KH et al. | Docosahexaenoic and eicosapentaenoic acids in plasma phospholipids are divergently associated with high density lipoprotein in humans. | 1992 | Arterioscler. Thromb. | pmid:1534256 |
Calon F et al. | Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. | 2004 | Neuron | pmid:15339646 |
Mucke L and Pitas RE | Food for thought: essential fatty acid protects against neuronal deficits in transgenic mouse model of AD. | 2004 | Neuron | pmid:15339638 |
Seal JR and Porter NA | Liquid chromatography coordination ion-spray mass spectrometry (LC-CIS-MS) of docosahexaenoate ester hydroperoxides. | 2004 | Anal Bioanal Chem | pmid:15338093 |
Hoffman DR et al. | Maturation of visual acuity is accelerated in breast-fed term infants fed baby food containing DHA-enriched egg yolk. | 2004 | J. Nutr. | pmid:15333721 |
Baker RR and Chang HY | The hydrolysis of natural phosphatidylethanolamines by phospholipase A2 from rat serum: a degree of selectivity is shown for docosahexaenoate release. | 1992 | Biochim. Biophys. Acta | pmid:1533163 |
Grønn M et al. | Effects of dietary purified eicosapentaenoic acid (20:5 (n-3)) and docosahexaenoic acid (22:6(n-3)) on fatty acid desaturation and oxidation in isolated rat liver cells. | 1992 | Biochim. Biophys. Acta | pmid:1533162 |
Treen M et al. | Effect of docosahexaenoic acid on membrane fluidity and function in intact cultured Y-79 retinoblastoma cells. | 1992 | Arch. Biochem. Biophys. | pmid:1533110 |
Innis SM | Plasma and red blood cell fatty acid values as indexes of essential fatty acids in the developing organs of infants fed with milk or formulas. | 1992 | J. Pediatr. | pmid:1532829 |
Gordon WC et al. | Retinal pigment epithelial cells play a central role in the conservation of docosahexaenoic acid by photoreceptor cells after shedding and phagocytosis. | 1992 | Curr. Eye Res. | pmid:1532774 |
Van Anholt RD et al. | Arachidonic acid reduces the stress response of gilthead seabream Sparus aurata L. | 2004 | J. Exp. Biol. | pmid:15326218 |
Speake BK and Deans EA | Biosynthesis of oleic, arachidonic and docosahexaenoic acids from their C18 precursors in the yolk sac membrane of the avian embryo. | 2004 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15325342 |
Parent CA et al. | Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes. | 1992 | J. Biol. Chem. | pmid:1532390 |
Innis SM et al. | n-6 Docosapentaenoic acid is not a predictor of low docosahexaenoic acid status in Canadian preschool children. | 2004 | Am. J. Clin. Nutr. | pmid:15321820 |
Irie M and Sakimoto M | Fat characteristics of pigs fed fish oil containing eicosapentaenoic and docosahexaenoic acids. | 1992 | J. Anim. Sci. | pmid:1532172 |
Nenseter MS et al. | Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans. | 1992 | Arterioscler. Thromb. | pmid:1532127 |
Herzberg GR et al. | Intestinal absorption of fish oil in rats previously adapted to diets containing fish oil or corn oil. | 1992 | Biochim. Biophys. Acta | pmid:1531932 |
Croset M et al. | Incorporation and turnover of eicosapentaenoic and docosahexaenoic acids in human blood platelets in vitro. | 1992 | Biochem. J. | pmid:1531291 |
Harris JI et al. | Statin treatment alters serum n-3 and n-6 fatty acids in hypercholesterolemic patients. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15310527 |
Muderhwa JM and Brockman HL | Regulation of fatty acid 18O exchange catalyzed by pancreatic carboxylester lipase. 2. Effects of lateral lipid distribution in mixtures with phosphatidylcholine. | 1992 | Biochemistry | pmid:1531021 |
Hofmanová J et al. | Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. | 2005 | Eur J Nutr | pmid:15309463 |
Zhao A et al. | Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. | 2004 | DNA Cell Biol. | pmid:15307955 |
Pereira SL et al. | Identification of two novel microalgal enzymes involved in the conversion of the omega3-fatty acid, eicosapentaenoic acid, into docosahexaenoic acid. | 2004 | Biochem. J. | pmid:15307817 |
Takahashi M et al. | Effect of omega 3 and omega 6 fatty acids on transformation of cultured cells by irradiation and transfection. | 1992 | Cancer Res. | pmid:1530767 |
Chen JR et al. | Dietary patterns and blood fatty acid composition in children with attention-deficit hyperactivity disorder in Taiwan. | 2004 | J. Nutr. Biochem. | pmid:15302081 |
Sung M et al. | Differential effects of dietary fatty acids on the regulation of CYP2E1 and protein kinase C in human hepatoma HepG2 cells. | 2004 | J Med Food | pmid:15298768 |
Broadfield EC et al. | A case-control study of dietary and erythrocyte membrane fatty acids in asthma. | 2004 | Clin. Exp. Allergy | pmid:15298563 |
Narayanan BA et al. | Effects of a combination of docosahexaenoic acid and 1,4-phenylene bis(methylene) selenocyanate on cyclooxygenase 2, inducible nitric oxide synthase and beta-catenin pathways in colon cancer cells. | 2004 | Carcinogenesis | pmid:15297372 |
Meyer A et al. | Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis. | 2004 | J. Lipid Res. | pmid:15292371 |
Serhan CN et al. | Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15290791 |
Chiu LC et al. | Docosahexaenoic acid modulates different genes in cell cycle and apoptosis to control growth of human leukemia HL-60 cells. | 2004 | Int. J. Oncol. | pmid:15289877 |
Calderon F and Kim HY | Docosahexaenoic acid promotes neurite growth in hippocampal neurons. | 2004 | J. Neurochem. | pmid:15287904 |
Bauer JE et al. | Maternal diet alpha-linolenic acid during gestation and lactation does not increase docosahexaenoic acid in canine milk. | 2004 | J. Nutr. | pmid:15284396 |
Naliwaiko K et al. | Effects of fish oil on the central nervous system: a new potential antidepressant? | 2004 | Nutr Neurosci | pmid:15279495 |
Fish oil: staging a comeback. | 2004 | Harv Mens Health Watch | pmid:15273065 | |
Haggarty P | Effect of placental function on fatty acid requirements during pregnancy. | 2004 | Eur J Clin Nutr | pmid:15266306 |
Mesa MD et al. | Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on the oxidizability and thrombogenicity of low-density lipoprotein. | 2004 | Atherosclerosis | pmid:15262190 |
Colombo J et al. | Maternal DHA and the development of attention in infancy and toddlerhood. | 2004 Jul-Aug | Child Dev | pmid:15260876 |
AbuGhazaleh AA and Jenkins TC | Short communication: docosahexaenoic acid promotes vaccenic acid accumulation in mixed ruminal cultures when incubated with linoleic acid. | 2004 | J. Dairy Sci. | pmid:15259240 |
Mattos R et al. | The effects of feeding fish oil on uterine secretion of PGF2alpha, milk composition, and metabolic status of periparturient Holstein cows. | 2004 | J. Dairy Sci. | pmid:15259226 |
Siddiqui RA et al. | Inhibition of phenylephrine-induced cardiac hypertrophy by docosahexaenoic acid. | 2004 | J. Cell. Biochem. | pmid:15258898 |
Erdogan H et al. | Effect of fish oil supplementation on plasma oxidant/antioxidant status in rats. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15253883 |
Khedr EM et al. | Neural maturation of breastfed and formula-fed infants. | 2004 | Acta Paediatr. | pmid:15244219 |
Designer eggs: best way to get your omega-3 fatty acids? | 2004 | Consum Rep | pmid:15243993 | |
Sankaran D et al. | Modulation of renal injury in pcy mice by dietary fat containing n-3 fatty acids depends on the level and type of fat. | 2004 | Lipids | pmid:15233398 |
Mishra A et al. | Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway. | 2004 | Arterioscler. Thromb. Vasc. Biol. | pmid:15231516 |
Menoyo D et al. | Adaptation of lipid metabolism, tissue composition and flesh quality in gilthead sea bream (Sparus aurata) to the replacement of dietary fish oil by linseed and soyabean oils. | 2004 | Br. J. Nutr. | pmid:15230986 |
Tsujita-Kyutoku M et al. | Conjugated docosahexaenoic acid suppresses KPL-1 human breast cancer cell growth in vitro and in vivo: potential mechanisms of action. | 2004 | Breast Cancer Res. | pmid:15217495 |
Cockeran R et al. | Docosahexaenoic acid and eicosapentaenoic acid antagonize the proinflammatory interactions of pneumolysin with human neutrophils. | 2004 | Infect. Immun. | pmid:15213185 |
Leitzmann MF et al. | Dietary intake of n-3 and n-6 fatty acids and the risk of prostate cancer. | 2004 | Am. J. Clin. Nutr. | pmid:15213050 |
Park Y et al. | Triacylglycerol-rich lipoprotein margination: a potential surrogate for whole-body lipoprotein lipase activity and effects of eicosapentaenoic and docosahexaenoic acids. | 2004 | Am. J. Clin. Nutr. | pmid:15213026 |
Broadhurst CL et al. | (13)C nuclear magnetic resonance spectra of natural undiluted lipids: docosahexaenoic-rich phospholipid and triacylglycerol from fish. | 2004 | J. Agric. Food Chem. | pmid:15212476 |
AbuGhazaleh AA and Jenkins TC | Disappearance of docosahexaenoic and eicosapentaenoic acids from cultures of mixed ruminal microorganisms. | 2004 | J. Dairy Sci. | pmid:15202649 |
Stoknes IS et al. | Fatty acid and lipid class composition in eyes and brain from teleosts and elasmobranchs. | 2004 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:15193274 |
Nguyen LQ et al. | Influence of dietary linseed, fish and coconut oil on growth performance of growing pigs kept on small holdings in central Vietnam. | 2004 | J Anim Physiol Anim Nutr (Berl) | pmid:15189425 |
Wijendran V and Hayes KC | Dietary n-6 and n-3 fatty acid balance and cardiovascular health. | 2004 | Annu. Rev. Nutr. | pmid:15189133 |
Miles EA et al. | The influence of different combinations of gamma-linolenic acid, stearidonic acid and EPA on immune function in healthy young male subjects. | 2004 | Br. J. Nutr. | pmid:15182393 |
Green AG | From alpha to omega-producing essential fatty acids in plants. | 2004 | Nat. Biotechnol. | pmid:15175687 |
Moriguchi T et al. | Effects of an n-3-deficient diet on brain, retina, and liver fatty acyl composition in artificially reared rats. | 2004 | J. Lipid Res. | pmid:15175358 |
Roig-Pérez S et al. | Lipid peroxidation induced by DHA enrichment modifies paracellular permeability in Caco-2 cells: protective role of taurine. | 2004 | J. Lipid Res. | pmid:15175351 |
Jia Q et al. | Docosahexaenoic acid and eicosapentaenoic acid, but not alpha-linolenic acid, suppress deoxynivalenol-induced experimental IgA nephropathy in mice. | 2004 | J. Nutr. | pmid:15173396 |
Blanco PG et al. | Oral docosahexaenoic acid given to pregnant mice increases the amount of surfactant in lung and amniotic fluid in preterm fetuses. | 2004 | Am. J. Obstet. Gynecol. | pmid:15167843 |
Thomas TR et al. | Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions. | 2004 | Metab. Clin. Exp. | pmid:15164323 |
Remans PH et al. | Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. | 2004 | Eur J Clin Nutr | pmid:15164103 |
Thomas B et al. | Plasma AA and DHA levels are not compromised in newly diagnosed gestational diabetic women. | 2004 | Eur J Clin Nutr | pmid:15162132 |
Mukherjee PK et al. | Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15152078 |
Bertrandt J et al. | Influence of vitamin B6 supplementation on polyunsaturated fatty acids concentration in serum and liver of rats fed a diet restricted in protein. | 2004 | Nahrung | pmid:15146965 |
Niu SL et al. | Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency. | 2004 | J. Biol. Chem. | pmid:15145938 |
Astorg P | Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence. | 2004 | Cancer Causes Control | pmid:15141138 |
Payet M et al. | Docosahexaenoic acid-enriched egg consumption induces accretion of arachidonic acid in erythrocytes of elderly patients. | 2004 | Br. J. Nutr. | pmid:15137931 |
Zhang M and Fritsche KL | Fatty acid-mediated inhibition of IL-12 production by murine macrophages is independent of PPARgamma. | 2004 | Br. J. Nutr. | pmid:15137925 |
Hamam F and Shahidi F | Synthesis of structured lipids via acidolysis of docosahexaenoic acid single cell oil (DHASCO) with capric acid. | 2004 | J. Agric. Food Chem. | pmid:15137833 |
Yazawa K | [Importance of "health foods", EPA and DHA, for preventive medicine]. | 2004 | Rinsho Byori | pmid:15137325 |
Levant B et al. | Decreased brain docosahexaenoic acid during development alters dopamine-related behaviors in adult rats that are differentially affected by dietary remediation. | 2004 | Behav. Brain Res. | pmid:15135968 |
Du C et al. | Dietary polyunsaturated fatty acids suppress acute hepatitis, alter gene expression and prolong survival of female Long-Evans Cinnamon rats, a model of Wilson disease. | 2004 | J. Nutr. Biochem. | pmid:15135151 |
Young GS et al. | Blood phospholipid fatty acid analysis of adults with and without attention deficit/hyperactivity disorder. | 2004 | Lipids | pmid:15134138 |
Steger B and Colvin HP | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15131835 |
Agaba M et al. | Zebrafish cDNA encoding multifunctional Fatty Acid elongase involved in production of eicosapentaenoic (20:5n-3) and docosahexaenoic (22:6n-3) acids. | 2004 May-Jun | Mar. Biotechnol. | pmid:15129327 |
Kida Y | Eicosanoids in cystic fibrosis. | 2004 | N. Engl. J. Med. | pmid:15128902 |
Pan M et al. | Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. | 2004 | J. Clin. Invest. | pmid:15124019 |
Onodera K et al. | Zooxanthellactone, a novel gamma-lactone-type oxylipine from dinoflagellates of Symbiodinium sp.: structure, distribution, and biological activity. | 2004 | Biosci. Biotechnol. Biochem. | pmid:15118313 |