DHA
Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
Cross Reference
Introduction
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with DHA?
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with DHA
PubChem Associated disorders and diseases
What pathways are associated with DHA
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with DHA?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with DHA?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with DHA?
Related references are published most in these journals:
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What genes are associated with DHA?
Related references are published most in these journals:
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What common seen animal models are associated with DHA?
Mouse Model
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with DHA
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Fernández-González R et al. | Decontamination solutions for polychlorinated biphenyls (PCBs) in raw fish oils from environmentally contaminated sea fishes. | 2014 | Sci. Total Environ. | pmid:24095964 |
| Currais A et al. | Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. | 2014 | Aging Cell | pmid:24341874 |
| Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
| Hennebelle M et al. | Ageing and apoE change DHA homeostasis: relevance to age-related cognitive decline. | 2014 | Proc Nutr Soc | pmid:24103099 |
| Jilkova ZM et al. | Adipose tissue-related proteins locally associated with resolution of inflammation in obese mice. | 2014 | Int J Obes (Lond) | pmid:23756677 |
| Wang S et al. | Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. | 2014 | Clin Nutr | pmid:23672804 |
| De Mel D and Suphioglu C | Fishy business: effect of omega-3 fatty acids on zinc transporters and free zinc availability in human neuronal cells. | 2014 | Nutrients | pmid:25195602 |
| Katakura M et al. | Omega-3 fatty acids protect renal functions by increasing docosahexaenoic acid-derived metabolite levels in SHR.Cg-Lepr(cp)/NDmcr rats, a metabolic syndrome model. | 2014 | Molecules | pmid:24642910 |
| Tungen JE et al. | Synthesis and anti-inflammatory and pro-resolving activities of 22-OH-PD1, a monohydroxylated metabolite of protectin D1. | 2014 | J. Nat. Prod. | pmid:25247845 |
| McCauley LK et al. | Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. | 2014 | J. Immunol. | pmid:24890726 |
| Serhan CN | Pro-resolving lipid mediators are leads for resolution physiology. | 2014 | Nature | pmid:24899309 |
| [Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:24834713 | |
| [Recommendations of the Polish Gynecological Society concerning docosahexaenoic acid supplementation in the prevention of preterm birth]. | 2014 | Ginekol. Pol. | pmid:25011224 | |
| Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
| Chan SS et al. | Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease. | 2014 | Aliment. Pharmacol. Ther. | pmid:24611981 |
| Aursnes M et al. | Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. | 2014 | Org. Biomol. Chem. | pmid:24253202 |
| Shimamoto C et al. | Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder and mouse behavioral studies. | 2014 | Hum. Mol. Genet. | pmid:25027319 |
| White PJ et al. | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. | 2014 | Nat. Med. | pmid:24813250 |
| Balas L et al. | Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. | 2014 | Biochimie | pmid:24262603 |
| Evans SJ et al. | Dietary intake and plasma metabolomic analysis of polyunsaturated fatty acids in bipolar subjects reveal dysregulation of linoleic acid metabolism. | 2014 | J Psychiatr Res | pmid:24953860 |
| Santos S et al. | Fatty acids derived from a food frequency questionnaire and measured in the erythrocyte membrane in relation to adiponectin and leptin concentrations. | 2014 | Eur J Clin Nutr | pmid:24642786 |
| Liu X et al. | Amide-type adduct of dopamine - plausible cause of Parkinson diseases. | 2014 | Subcell. Biochem. | pmid:24374917 |
| Vandal M et al. | Reduction in DHA transport to the brain of mice expressing human APOE4 compared to APOE2. | 2014 | J. Neurochem. | pmid:24345162 |
| Berasategi I et al. | Healthy reduced-fat Bologna sausages enriched in ALA and DHA and stabilized with Melissa officinalis extract. | 2014 | Meat Sci. | pmid:24334039 |
| Wang Q et al. | Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury. | 2014 | J. Immunol. | pmid:24646745 |
| Pottala JV et al. | Higher RBC EPA + DHA corresponds with larger total brain and hippocampal volumes: WHIMS-MRI study. | 2014 | Neurology | pmid:24453077 |
| Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
| Harden CJ et al. | Long-chain polyunsaturated fatty acid supplementation had no effect on body weight but reduced energy intake in overweight and obese women. | 2014 | Nutr Res | pmid:24418242 |
| O'Callaghan N et al. | Telomere shortening in elderly individuals with mild cognitive impairment may be attenuated with ω-3 fatty acid supplementation: a randomized controlled pilot study. | 2014 | Nutrition | pmid:24342530 |
| Martorell M et al. | Effect of DHA on plasma fatty acid availability and oxidative stress during training season and football exercise. | 2014 | Food Funct | pmid:24955731 |
| Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
| Kitessa SM et al. | DHA-containing oilseed: a timely solution for the sustainability issues surrounding fish oil sources of the health-benefitting long-chain omega-3 oils. | 2014 | Nutrients | pmid:24858407 |
| Eto M et al. | A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with a possible role for incorporating docosahexaenoic acid into brain glycerophospholipids. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24333445 |
| Nelson JW et al. | ALX/FPR2 receptor for RvD1 is expressed and functional in salivary glands. | 2014 | Am. J. Physiol., Cell Physiol. | pmid:24259417 |
| O'Sullivan A et al. | Habitual diets rich in dark-green vegetables are associated with an increased response to ω-3 fatty acid supplementation in Americans of African ancestry. | 2014 | J. Nutr. | pmid:24259553 |
| Cipollina C et al. | Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-induced inflammation. | 2014 | Biochim. Biophys. Acta | pmid:24594225 |
| Siddiqui RA et al. | Characterization of lovastatin-docosahexaenoate anticancer properties against breast cancer cells. | 2014 | Bioorg. Med. Chem. | pmid:24556504 |
| Hashimoto M et al. | Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. | 2014 | J. Pharmacol. Sci. | pmid:24561447 |
| Ciaccio CE and Girdhar M | Effect of maternal ω3 fatty acid supplementation on infant allergy. | 2014 | Ann. Allergy Asthma Immunol. | pmid:24565593 |
| Bauer I et al. | Does omega-3 fatty acid supplementation enhance neural efficiency? A review of the literature. | 2014 | Hum Psychopharmacol | pmid:24285504 |
| Abdel-Dayem MA et al. | Valproate-induced liver injury: modulation by the omega-3 fatty acid DHA proposes a novel anticonvulsant regimen. | 2014 | Drugs R D | pmid:24733439 |
| Höper AC et al. | Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. | 2014 | J. Nutr. | pmid:24285691 |
| Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
| Hong S et al. | Maresin-like lipid mediators are produced by leukocytes and platelets and rescue reparative function of diabetes-impaired macrophages. | 2014 | Chem. Biol. | pmid:25200603 |
| Cho Y et al. | Colon cancer cell apoptosis is induced by combined exposure to the n-3 fatty acid docosahexaenoic acid and butyrate through promoter methylation. | 2014 | Exp. Biol. Med. (Maywood) | pmid:24495951 |
| Park J et al. | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. | 2014 | PLoS ONE | pmid:24465474 |
| Tang H et al. | Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. | 2014 | J. Immunol. | pmid:25172497 |
| Montgomery P et al. | Fatty acids and sleep in UK children: subjective and pilot objective sleep results from the DOLAB study--a randomized controlled trial. | 2014 | J Sleep Res | pmid:24605819 |
| Walker CG et al. | Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. | 2014 | Br. J. Nutr. | pmid:24063767 |
| Zheng MG et al. | Cloning, expression and stress-respondent transcription of long-chain acyl-coenzyme A synthetase cDNA gene of Nannochloropsis gaditana and its involvement in the biosynthesis of eicosapentaenoic and decosahexaenoic acids. | 2014 | Biotechnol. Lett. | pmid:24068506 |