Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
Liu J and Ma DW | The role of n-3 polyunsaturated fatty acids in the prevention and treatment of breast cancer. | 2014 | Nutrients | pmid:25412153 |
Bernhard W et al. | Plasma phospholipids indicate impaired fatty acid homeostasis in preterm infants. | 2014 | Eur J Nutr | pmid:24464176 |
Schuster GU et al. | Dietary long-chain omega-3 fatty acids do not diminish eosinophilic pulmonary inflammation in mice. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24134486 |
Maitin V et al. | Docosahexaenoic acid impairs the maturation of very low density lipoproteins in rat hepatic cells. | 2014 | J. Lipid Res. | pmid:24136824 |
Browning LM et al. | Compared with daily, weekly n-3 PUFA intake affects the incorporation of eicosapentaenoic acid and docosahexaenoic acid into platelets and mononuclear cells in humans. | 2014 | J. Nutr. | pmid:24647395 |
Skender B et al. | DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism. | 2014 | Biochim. Biophys. Acta | pmid:24953781 |
Zhao Z and Zlokovic BV | Blood-brain barrier: a dual life of MFSD2A? | 2014 | Neuron | pmid:24853933 |
Siddesha JM et al. | Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration. | 2014 | Cell. Signal. | pmid:24447911 |
Shao Z et al. | Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. | 2014 | Arterioscler. Thromb. Vasc. Biol. | pmid:24458713 |
Shaikh NA et al. | Efficacy of a unique omega-3 formulation on the correction of nutritional deficiency and its effects on cardiovascular disease risk factors in a randomized controlled VASCAZEN(®) REVEAL Trial. | 2014 | Mol. Cell. Biochem. | pmid:25185754 |
Asai M et al. | [Cellular models for individualized medicine in Alzheimer's disease using patient-derived induced pluripotent stem cells]. | 2014 | Nippon Yakurigaku Zasshi | pmid:24420133 |
Jin M et al. | Eicosapentaenoic acid and docosahexaenoic acid suppress Th2 cytokine expression in RBL-2H3 basophilic leukemia cells. | 2014 | J Med Food | pmid:24460246 |
Chen MY et al. | Quantitative risk-benefit analysis of fish consumption for women of child-bearing age in Hong Kong. | 2014 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:24444393 |
Patterson AC et al. | The percentage of DHA in erythrocytes can detect non-adherence to advice to increase EPA and DHA intakes. | 2014 | Br. J. Nutr. | pmid:23920312 |
von Schacky C | Omega-3 index and cardiovascular health. | 2014 | Nutrients | pmid:24566438 |
Nehra D et al. | Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target? | 2014 | J. Surg. Res. | pmid:24576779 |
Boca SM et al. | Testing multiple biological mediators simultaneously. | 2014 | Bioinformatics | pmid:24202540 |
Bahety P et al. | Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. | 2014 | PLoS ONE | pmid:24587236 |
Kwon B et al. | Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells. | 2014 | Biochim. Biophys. Acta | pmid:24732014 |