DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenocarcinoma D000230 166 associated lipids
Breast Neoplasms D001943 24 associated lipids
Pain D010146 64 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Burns D002056 34 associated lipids
Pancreatic Neoplasms D010190 77 associated lipids
Inflammation D007249 119 associated lipids
Reperfusion Injury D015427 65 associated lipids
Colitis D003092 69 associated lipids
Per page 10 20 50 100 | Total 240

PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

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Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Yang R et al. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. 2011 Curr Protoc Immunol pmid:22048801
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Hamazaki-Fujita N et al. Polyunsaturated fatty acids and blood circulation in the forebrain during a mental arithmetic task. 2011 Brain Res. pmid:21616479
Yui K et al. [Therapeutic effects of larger doses of arachidonic acid added to DHA on social impairment and its relation to alterations of polyunsaturated fatty acids in individuals with autism spectrum disorders]. 2011 Nihon Shinkei Seishin Yakurigaku Zasshi pmid:21800702
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Palmer CD et al. 17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. 2011 J. Leukoc. Biol. pmid:21653234
Brignardello J et al. Increase of plasma fatty acids without changes in n-6/n-3-PUFA ratio in asymptomatic obese subjects. 2011 Arch Latinoam Nutr pmid:22308941
Kim HY et al. A synaptogenic amide N-docosahexaenoylethanolamide promotes hippocampal development. 2011 Prostaglandins Other Lipid Mediat. pmid:21810478
Jing K et al. Docosahexaenoic acid induces autophagy through p53/AMPK/mTOR signaling and promotes apoptosis in human cancer cells harboring wild-type p53. 2011 Autophagy pmid:21811093
German JB Dietary lipids from an evolutionary perspective: sources, structures and functions. 2011 Matern Child Nutr pmid:21366863
Glaser C et al. Genetic variation in polyunsaturated fatty acid metabolism and its potential relevance for human development and health. 2011 Matern Child Nutr pmid:21366865
Fedorova-Dahms I et al. Safety evaluation of DHA-rich Algal Oil from Schizochytrium sp. 2011 Food Chem. Toxicol. pmid:21914458
Lebbadi M et al. Endogenous conversion of omega-6 into omega-3 fatty acids improves neuropathology in an animal model of Alzheimer's disease. 2011 J. Alzheimers Dis. pmid:21914946
Freeman MP and Rapaport MH Omega-3 fatty acids and depression: from cellular mechanisms to clinical care. 2011 J Clin Psychiatry pmid:21382308
Nochera CL et al. Consumption of DHA + EPA by low-income women during pregnancy and lactation. 2011 Nutr Clin Pract pmid:21724916
Shoji H et al. Effects of parenteral soybean oil lipid emulsion on the long-chain polyunsaturated fatty acid profile in very-low-birth-weight infants. 2011 Acta Paediatr. pmid:21366690
Madsen T et al. Marine n-3 polyunsaturated fatty acids in patients with end-stage renal failure and in subjects without kidney disease: a comparative study. 2011 J Ren Nutr pmid:20833075
Meijerink J et al. The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation. 2011 Br. J. Nutr. pmid:21294934
Drover JR et al. Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid. 2011 Early Hum. Dev. pmid:21295417
Zhao J et al. Deposition of docosahexaenoic acid (DHA) is limited in forebrain of young obese fa/fa Zucker rats fed a diet high in α-linolenic acid but devoid of DHA. 2011 J. Nutr. Biochem. pmid:21129946
Stein AD et al. Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravidity in Mexico. 2011 J. Nutr. pmid:21178082
Leon MM et al. [Resolution of inflammation--pharmacological aspects]. 2011 Apr-Jun Rev Med Chir Soc Med Nat Iasi pmid:21870743
Lamaziere A et al. Differential distribution of DHA-phospholipids in rat brain after feeding: A lipidomic approach. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:21109411
Vilaseca MA et al. Long-chain polyunsaturated fatty acid concentration in patients with inborn errors of metabolism. 2011 Jan-Feb Nutr Hosp pmid:21519739
Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
Lam YY et al. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: the effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21570480
Mason CM et al. Prescription omega-3s: an overview for nurse practitioners. 2011 Jul-Aug J Cardiovasc Nurs pmid:21666421
Gao F et al. Liver conversion of docosahexaenoic and arachidonic acids from their 18-carbon precursors in rats on a DHA-free but α-LNA-containing n-3 PUFA adequate diet. 2011 Jul-Aug Biochim. Biophys. Acta pmid:21651989
Trimarco B et al. [The Alpha Omega study]. 2011 Jul-Aug G Ital Cardiol (Rome) pmid:21779112
Gladyshev MI et al. Effect of water temperature on the content of essential polyunsaturated fatty acids in freshwater zooplankton. 2011 Mar-Apr Dokl. Biochem. Biophys. pmid:21590375
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
McDaniel JC et al. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds. 2011 Mar-Apr Wound Repair Regen pmid:21362086
Kawabata T et al. Age-related changes of dietary intake and blood eicosapentaenoic acid, docosahexaenoic acid, and arachidonic acid levels in Japanese men and women. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21420843
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
Kilari A et al. Associations of long-chain polyunsaturated fatty acid concentrations with birth outcome in term Indian mothers and their neonates. 2011 May-Jun Am. J. Hum. Biol. pmid:21484911
Jones JL et al. A Mediterranean-style low-glycemic-load diet improves variables of metabolic syndrome in women, and addition of a phytochemical-rich medical food enhances benefits on lipoprotein metabolism. 2011 May-Jun J Clin Lipidol pmid:21600524
Maki KC et al. Effects of prescription omega-3-acid ethyl esters, coadministered with atorvastatin, on circulating levels of lipoprotein particles, apolipoprotein CIII, and lipoprotein-associated phospholipase A2 mass in men and women with mixed dyslipidemia. 2011 Nov-Dec J Clin Lipidol pmid:22108152
Siddiqui RA et al. Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects. 2011 Nov-Dec Biofactors pmid:22038684
Opperman M et al. Analysis of omega-3 fatty acid content of South African fish oil supplements. 2011 Nov-Dec Cardiovasc J Afr pmid:22159321
Kim Y and Ilich JZ Implications of dietary α-linolenic acid in bone health. 2011 Nov-Dec Nutrition pmid:21726979
Maki KC et al. Prescription omega-3-acid ethyl esters reduce fasting and postprandial triglycerides and modestly reduce pancreatic β-cell response in subjects with primary hypertriglyceridemia. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21775113
Luxwolda MF et al. The relation between the omega-3 index and arachidonic acid is bell shaped: synergistic at low EPA+DHA status and antagonistic at high EPA+DHA status. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21715149
Fabelo N et al. Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. 2011 Sep-Oct Mol. Med. pmid:21717034
Shilina NM et al. [Changes in the fatty acid composition of blood cell membranes in children with inflammatory diseases]. 2011 Sep-Oct Biomed Khim pmid:22629608
Dhobale MV et al. Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. 2011 Sep-Oct Prostaglandins Leukot. Essent. Fatty Acids pmid:21816593
Figueroa JD et al. Docosahexaenoic acid pretreatment confers protection and functional improvements after acute spinal cord injury in adult rats. 2012 J. Neurotrauma pmid:21970623
Sørensen IM et al. Serum long chain n-3 fatty acids (EPA and DHA) in the pregnant mother are independent of risk of type 1 diabetes in the offspring. 2012 Diabetes Metab. Res. Rev. pmid:22396195
Hutchins-Wiese HL et al. Hind limb suspension and long-chain omega-3 PUFA increase mRNA endocannabinoid system levels in skeletal muscle. 2012 J. Nutr. Biochem. pmid:22051448
Rontoyanni VG et al. A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA. 2012 Br. J. Nutr. pmid:22348439
Jayashankar S et al. Cerebral gene expression and neurobehavioural responses in mice pups exposed to methylmercury and docosahexaenoic acid through the maternal diet. 2012 Environ. Toxicol. Pharmacol. pmid:22056564
Meldrum SJ et al. Effects of high-dose fish oil supplementation during early infancy on neurodevelopment and language: a randomised controlled trial. 2012 Br. J. Nutr. pmid:22348468
Kariv-Inbal Z et al. The isoform-specific pathological effects of apoE4 in vivo are prevented by a fish oil (DHA) diet and are modified by cholesterol. 2012 J. Alzheimers Dis. pmid:22057027
Cheon Y et al. Disturbed brain phospholipid and docosahexaenoic acid metabolism in calcium-independent phospholipase A(2)-VIA (iPLA(2)β)-knockout mice. 2012 Biochim. Biophys. Acta pmid:22349267
Antonietta Ajmone-Cat M et al. Docosahexaenoic acid modulates inflammatory and antineurogenic functions of activated microglial cells. 2012 J. Neurosci. Res. pmid:22057807
Noreen EE and Brandauer J The effects of supplemental fish oil on blood pressure and morning cortisol in normotensive adults: a pilot study. 2012 J Complement Integr Med pmid:23104856
Kautharapu KB and Jarboe LR Genome sequence of the psychrophilic deep-sea bacterium Moritella marina MP-1 (ATCC 15381). 2012 J. Bacteriol. pmid:23105048
Wang X et al. The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). 2012 PLoS ONE pmid:23110176
Li N et al. Arginyl-glutamine dipeptide or docosahexaenoic acid attenuates hyperoxia-induced small intestinal injury in neonatal mice. 2012 J. Pediatr. Gastroenterol. Nutr. pmid:22020559
Samaee SM and Estévez A Embryo and larva development in Dentex dentex, a marine pelagophil teleost: an endeavor to find a series of new fatty acid interrelations. 2012 J Exp Zool A Ecol Genet Physiol pmid:22021057
Yang ZH et al. Ingestion of a single serving of saury alters postprandial levels of plasma n-3 polyunsaturated fatty acids and long-chain monounsaturated fatty acids in healthy human adults. 2012 Lipids Health Dis pmid:22846384
Jackson PA et al. No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18-35 years. 2012 Br. J. Nutr. pmid:21864417
Harden CJ et al. Effect of different long-chain fatty acids on cholecystokinin release in vitro and energy intake in free-living healthy males. 2012 Br. J. Nutr. pmid:22313587
Komatsuzaki N and Shima J Effects of live Lactobacillus paracasei on plasma lipid concentration in rats fed an ethanol-containing diet. 2012 Biosci. Biotechnol. Biochem. pmid:22313752
Silva Jde A et al. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. 2012 Nutr Cancer pmid:22295891
Mackay I et al. Effect of Omega-3 fatty acid supplementation on markers of platelet and endothelial function in patients with peripheral arterial disease. 2012 Atherosclerosis pmid:22296885
Tan Z et al. Enzymatic synthesis of phytosteryl docosahexaneates and evaluation of their anti-atherogenic effects in apo-E deficient mice. 2012 Food Chem pmid:23442661
Kirkegaard E et al. Marine n-3 fatty acids, atrial fibrillation and QT interval in haemodialysis patients. 2012 Br. J. Nutr. pmid:21791142
O'Flaherty JT et al. 15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival. 2012 PLoS ONE pmid:23029040
Cazzola R et al. Effects of DHA-phospholipids, melatonin and tryptophan supplementation on erythrocyte membrane physico-chemical properties in elderly patients suffering from mild cognitive impairment. 2012 Exp. Gerontol. pmid:23000875
Hajjaji N et al. DHA effect on chemotherapy-induced body weight loss: an exploratory study in a rodent model of mammary tumors. 2012 Nutr Cancer pmid:23035949
Norris PC and Dennis EA Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. 2012 Proc. Natl. Acad. Sci. U.S.A. pmid:22586114
Chiu CY et al. Omega-6 docosapentaenoic acid-derived resolvins and 17-hydroxydocosahexaenoic acid modulate macrophage function and alleviate experimental colitis. 2012 Inflamm. Res. pmid:22618200
Bazan NG Neuroinflammation and proteostasis are modulated by endogenously biosynthesized neuroprotectin D1. 2012 Mol. Neurobiol. pmid:22956271
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Muldoon MF Discerning whether and how long-chain, n-3 fatty acids lower blood pressure: a comment on Skulas-Ray et al. 2012 Ann Behav Med pmid:22918613
Zou XQ et al. Preparation of human milk fat substitutes from palm stearin with arachidonic and docosahexaenoic acid: combination of enzymatic and physical methods. 2012 J. Agric. Food Chem. pmid:22920386
Valentine CJ Maternal dietary DHA supplementation to improve inflammatory outcomes in the preterm infant. 2012 Adv Nutr pmid:22585914
Ribeiro P et al. Effect of fish oil supplementation in pregnancy on the fatty acid composition of erythrocyte phospholipids and breast milk lipids. 2012 Int J Food Sci Nutr pmid:21707451
Stein AD et al. Auditory- and visual-evoked potentials in Mexican infants are not affected by maternal supplementation with 400 mg/d docosahexaenoic acid in the second half of pregnancy. 2012 J. Nutr. pmid:22739364
Virtanen JK et al. Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. 2012 PLoS ONE pmid:22815906
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Khairallah RJ et al. Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. 2012 PLoS ONE pmid:22479624
Baracos VE et al. Survival: the relevant primary outcome for nutrition therapy in cancer patients. 2012 Curr Opin Clin Nutr Metab Care pmid:22466928
Hoffmire CA et al. Associations between omega-3 poly-unsaturated fatty acids from fish consumption and severity of depressive symptoms: an analysis of the 2005-2008 National Health and Nutrition Examination Survey. 2012 Prostaglandins Leukot. Essent. Fatty Acids pmid:22472486
Roy S et al. Maternal micronutrients (folic acid and vitamin B(12)) and omega 3 fatty acids: implications for neurodevelopmental risk in the rat offspring. 2012 Brain Dev. pmid:21300490
Liao Z et al. Resolvin D1 attenuates inflammation in lipopolysaccharide-induced acute lung injury through a process involving the PPARγ/NF-κB pathway. 2012 Respir. Res. pmid:23199346
Russell FD and Bürgin-Maunder CS Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids. 2012 Mar Drugs pmid:23203276
Calder PC and Yaqoob P Marine omega-3 fatty acids and coronary heart disease. 2012 Curr. Opin. Cardiol. pmid:22565141
Sciotto C and Mjøs SA Trans isomers of EPA and DHA in omega-3 products on the European market. 2012 Lipids pmid:22566205
Bianchini F et al. 22 : 6n-3 DHA inhibits differentiation of prostate fibroblasts into myofibroblasts and tumorigenesis. 2012 Br. J. Nutr. pmid:22390897
Sparvero LJ et al. Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations. 2012 Chem. Phys. Lipids pmid:22692104
Szabó A et al. Negative allometry of docosahexaenoic acid in the fowl lung and pulmonary surfactant phospholipids. 2012 Acta. Biol. Hung. pmid:22695520
Tu WC et al. An alternative n-3 fatty acid elongation pathway utilising 18:3n-3 in barramundi (Lates calcarifer). 2012 Biochem. Biophys. Res. Commun. pmid:22640739
Phang M et al. Gender-specific inhibition of platelet aggregation following omega-3 fatty acid supplementation. 2012 Nutr Metab Cardiovasc Dis pmid:20708391
Daud ZA et al. Effects of protein and omega-3 supplementation, provided during regular dialysis sessions, on nutritional and inflammatory indices in hemodialysis patients. 2012 Vasc Health Risk Manag pmid:22536073
Ginty AT and Conklin SM Preliminary evidence that acute long-chain omega-3 supplementation reduces cardiovascular reactivity to mental stress: a randomized and placebo controlled trial. 2012 Biol Psychol pmid:21967854