Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Agren JJ et al. | Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430389 |
Chen ZY and Istfan NW | Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11161587 |
Bégin ME et al. | Plasma fatty acid levels in patients with acquired immune deficiency syndrome and in controls. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550969 |
Al-Turkmani MR et al. | Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18036797 |
Aoki N et al. | Acute effects of unsaturated fatty acids in splanchnic artery occlusion shock. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2550971 |
von Schacky C | Cardiovascular disease prevention and treatment. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520557 |
Lii CK et al. | Effect of dietary lipid on gamma-glutamyl transferase-positive foci during hepatocarcinogenesis in rats. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9774170 |
Bazan NG | Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19520558 |
Hsieh AT and Brenna JT | Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonates. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19524425 |
Dalton A et al. | A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. | 2009 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19201180 |
Le HD et al. | The essentiality of arachidonic acid and docosahexaenoic acid. | 2009 Aug-Sep | Prostaglandins Leukot. Essent. Fatty Acids | pmid:19540099 |
Marsen TA et al. | Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1387231 |
Dyerberg J et al. | Bioavailability of marine n-3 fatty acid formulations. | 2010 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20638827 |
Block RC et al. | The combination of EPA+DHA and low-dose aspirin ingestion reduces platelet function acutely whereas each alone may not in healthy humans. | 2012 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23017325 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Rapoport SI et al. | Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060754 |
Mukherjee PK et al. | Docosanoids are multifunctional regulators of neural cell integrity and fate: significance in aging and disease. | 2007 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18060755 |
Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
Kuipers RS et al. | Differences in preterm and term milk fatty acid compositions may be caused by the different hormonal milieu of early parturition. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21903369 |
Rapoport SI | Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. | 2008 Sep-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18973997 |
Tyburczy C et al. | Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets. | 2011 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21885269 |
Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
van Goor SA et al. | The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. | 2011 May-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21316208 |
Ly LH et al. | Dietary eicosapentaenoic acid modulates CTLA-4 expression in murine CD4+ T-cells. | 2006 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:16221546 |
He J and Bazan HE | Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20202804 |
Fortier M et al. | Higher plasma n-3 fatty acid status in the moderately healthy elderly in southern Québec: higher fish intake or aging-related change in n-3 fatty acid metabolism? | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20206489 |
Jolly CA et al. | Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9654402 |
Raza Shaikh S | Diet-induced docosahexaenoic acid non-raft domains and lymphocyte function. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207118 |
Kim HY et al. | Phosphatidylserine-dependent neuroprotective signaling promoted by docosahexaenoic acid. | 2010 Apr-Jun | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20207120 |
Agostoni C et al. | Biochemical effects of supplemented long-chain polyunsaturated fatty acids in hyperphenylalaninemia. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11237478 |
Zhou D et al. | Vitamin A deficiency reduces liver and colon docosahexaenoic acid levels in rats fed high linoleic and low alpha-linolenic acid diet. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15519497 |
Watanabe S et al. | Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10841036 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
Kitson AP et al. | Enzymes in brain phospholipid docosahexaenoic acid accretion: a PL-ethora of potential PL-ayers. | 2012 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22749739 |
Baskaya MK et al. | Enhanced accumulation of free fatty acids in experimental focal cerebral ischemia. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8860103 |
Sato SB et al. | Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20952172 |
Kulkarni AV et al. | Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. | 2011 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:20956072 |
Das UN | Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7824535 |
Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
Leaf A | Omega-3 fatty acids and prevention of ventricular fibrillation. | 1995 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784457 |
van Goor SA et al. | Maternal and fetal brain contents of docosahexaenoic acid (DHA) and arachidonic acid (AA) at various essential fatty acid (EFA), DHA and AA dietary intakes during pregnancy in mice. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18343099 |
Dhobale MV et al. | Reduced levels of placental long chain polyunsaturated fatty acids in preterm deliveries. | 2011 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:21816593 |
Brown AJ et al. | Erythrocyte eicosapentaenoic acid versus docosahexaenoic acid as a marker for fish and fish oil consumption. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1836062 |
Samman S | The effect of Max Epa on low density lipoprotein metabolism: perspectives from an animal model. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1886911 |
Horrobin DF | Schizophrenia as a membrane lipid disorder which is expressed throughout the body. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888116 |
Abbate R et al. | n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8888356 |
Kuipers RS et al. | Gestational age dependent content, composition and intrauterine accretion rates of fatty acids in fetal white adipose tissue. | 2012 Jan-Feb | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22093549 |
Attar-Bashi NM et al. | Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from alpha-linolenic acid in healthy human volunteers. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17275274 |
Frøyland L et al. | Hypotriacylglycerolemic component of fish oil. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9430383 |