Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yu Y et al. | DHA prevents altered 5-HT1A, 5-HT2A, CB1 and GABAA receptor binding densities in the brain of male rats fed a high-saturated-fat diet. | 2013 | J. Nutr. Biochem. | pmid:23337348 |
Chen F et al. | Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways. | 2013 | Innate Immun | pmid:23339927 |
Tikhonenko M et al. | N-3 polyunsaturated Fatty acids prevent diabetic retinopathy by inhibition of retinal vascular damage and enhanced endothelial progenitor cell reparative function. | 2013 | PLoS ONE | pmid:23383097 |
Li H et al. | Production of sophorolipids with eicosapentaenoic acid and docosahexaenoic acid from Wickerhamiella domercqiae var. sophorolipid using fish oil as a hydrophobic carbon source. | 2013 | Biotechnol. Lett. | pmid:23386226 |
Wang TM et al. | Docosahexaenoic acid and eicosapentaenoic acid reduce C-reactive protein expression and STAT3 activation in IL-6-treated HepG2 cells. | 2013 | Mol. Cell. Biochem. | pmid:23361365 |
Suganuma H et al. | Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. | 2013 | Ann. Nutr. Metab. | pmid:23364132 |
Lee HJ et al. | Resolvin D1 inhibits TGF-β1-induced epithelial mesenchymal transition of A549 lung cancer cells via lipoxin A4 receptor/formyl peptide receptor 2 and GPR32. | 2013 | Int. J. Biochem. Cell Biol. | pmid:24120851 |
Offman E et al. | Steady-state bioavailability of prescription omega-3 on a low-fat diet is significantly improved with a free fatty acid formulation compared with an ethyl ester formulation: the ECLIPSE II study. | 2013 | Vasc Health Risk Manag | pmid:24124374 |
Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
Daak AA et al. | Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24095588 |
Larson MK et al. | Exogenous modification of platelet membranes with the omega-3 fatty acids EPA and DHA reduces platelet procoagulant activity and thrombus formation. | 2013 | Am. J. Physiol., Cell Physiol. | pmid:23174566 |
Mussi SV et al. | New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles. | 2013 | Eur J Pharm Sci | pmid:23178339 |
Braga SF and Almgren MM | Complementary therapies in cystic fibrosis: nutritional supplements and herbal products. | 2013 | J Pharm Pract | pmid:23178411 |
Gurzell EA et al. | DHA-enriched fish oil targets B cell lipid microdomains and enhances ex vivo and in vivo B cell function. | 2013 | J. Leukoc. Biol. | pmid:23180828 |
Faber J et al. | Rapid EPA and DHA incorporation and reduced PGE2 levels after one week intervention with a medical food in cancer patients receiving radiotherapy, a randomized trial. | 2013 | Clin Nutr | pmid:23123043 |
Klingler M et al. | Comparison of the incorporation of orally administered DHA into plasma, erythrocyte and cheek cell glycerophospholipids. | 2013 | Br. J. Nutr. | pmid:22874641 |
Robinson DT et al. | Docosahexaenoic and arachidonic acid levels in extremely low birth weight infants with prolonged exposure to intravenous lipids. | 2013 | J. Pediatr. | pmid:22878111 |
Hsiao HM et al. | A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. | 2013 | PLoS ONE | pmid:23484005 |
Hoshi T et al. | Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²âº-dependent K⺠channels. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487785 |
Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
Poudyal H et al. | Effects of ALA, EPA and DHA in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. | 2013 | J. Nutr. Biochem. | pmid:23026492 |
Hu Y et al. | 15-Lipoxygenase-1-mediated metabolism of docosahexaenoic acid is required for syndecan-1 signaling and apoptosis in prostate cancer cells. | 2013 | Carcinogenesis | pmid:23066085 |
Tang Y et al. | Proresolution therapy for the treatment of delayed healing of diabetic wounds. | 2013 | Diabetes | pmid:23043160 |
Cedernaes J et al. | Adipose tissue stearoyl-CoA desaturase 1 index is increased and linoleic acid is decreased in obesity-prone rats fed a high-fat diet. | 2013 | Lipids Health Dis | pmid:23298201 |
Gillingham LG et al. | Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition. | 2013 | Am. J. Clin. Nutr. | pmid:23221573 |
Hong WK et al. | Production of lipids containing high levels of docosahexaenoic acid from empty palm fruit bunches by Aurantiochytrium sp. KRS101. | 2013 | Bioprocess Biosyst Eng | pmid:23053417 |
Hjorth E et al. | Omega-3 fatty acids enhance phagocytosis of Alzheimer's disease-related amyloid-β42 by human microglia and decrease inflammatory markers. | 2013 | J. Alzheimers Dis. | pmid:23481688 |
Lee MS et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid on uncoupling protein 3 gene expression in C(2)C(12) muscle cells. | 2013 | Nutrients | pmid:23698161 |
Snodgrass RG et al. | Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. | 2013 | J. Immunol. | pmid:24043885 |
Kamolrat T and Gray SR | The effect of eicosapentaenoic and docosahexaenoic acid on protein synthesis and breakdown in murine C2C12 myotubes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23438435 |
Cieslik M et al. | Docosahexaenoic acid and tetracyclines as promising neuroprotective compounds with poly(ADP-ribose) polymerase inhibitory activities for oxidative/genotoxic stress treatment. | 2013 | Neurochem. Int. | pmid:23439385 |
Oken E et al. | A pilot randomized controlled trial to promote healthful fish consumption during pregnancy: the Food for Thought Study. | 2013 | Nutr J | pmid:23496848 |
Huang HL et al. | Docosahexaenoic acid in maternal and neonatal plasma phospholipids and milk lipids of Taiwanese women in Kinmen: fatty acid composition of maternal blood, neonatal blood and breast milk. | 2013 | Lipids Health Dis | pmid:23496882 |
Fahrmann JF and Hardman WE | Omega 3 fatty acids increase the chemo-sensitivity of B-CLL-derived cell lines EHEB and MEC-2 and of B-PLL-derived cell line JVM-2 to anti-cancer drugs doxorubicin, vincristine and fludarabine. | 2013 | Lipids Health Dis | pmid:23497075 |
Moate PJ et al. | Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. | 2013 | J. Dairy Sci. | pmid:23498011 |
Kang JX and Gleason ED | Omega-3 Fatty acids and hippocampal neurogenesis in depression. | 2013 | CNS Neurol Disord Drug Targets | pmid:23574158 |
Yamaguchi M et al. | Consumption of seafood, serum liver enzymes, and blood levels of PFOS and PFOA in the Japanese population. | 2013 | J Occup Health | pmid:23574777 |
Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
Weise C et al. | Dietary polyunsaturated fatty acids and non-digestible oligosaccharides reduce dermatitis in mice. | 2013 | Pediatr Allergy Immunol | pmid:23577592 |
De Genaro P et al. | Retinoic acid promotes apoptosis and differentiation in photoreceptors by activating the P38 MAP kinase pathway. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23580485 |
Safarinejad MR et al. | Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial. | 2013 | Br. J. Nutr. | pmid:23199523 |
Montes R et al. | Fatty-acid composition of maternal and umbilical cord plasma and early childhood atopic eczema in a Spanish cohort. | 2013 | Eur J Clin Nutr | pmid:23549201 |
Emmett R et al. | Expanding awareness of docosahexaenoic acid during pregnancy. | 2013 | Nutrients | pmid:23549329 |
Haller MJ et al. | Autologous umbilical cord blood infusion followed by oral docosahexaenoic acid and vitamin D supplementation for C-peptide preservation in children with Type 1 diabetes. | 2013 | Biol. Blood Marrow Transplant. | pmid:23611977 |
Chen J et al. | Docosahexaenoic acid (DHA) ameliorates paraquat-induced pulmonary fibrosis in rats possibly through up-regulation of Smad 7 and SnoN. | 2013 | Food Chem. Toxicol. | pmid:23590892 |
Damsgaard CT et al. | n-3 PUFA status in school children is associated with beneficial lipid profile, reduced physical activity and increased blood pressure in boys. | 2013 | Br. J. Nutr. | pmid:23591057 |
Berman DR et al. | Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model. | 2013 | Neonatology | pmid:23817197 |
Singhal A et al. | Docosahexaenoic acid supplementation, vascular function and risk factors for cardiovascular disease: a randomized controlled trial in young adults. | 2013 | J Am Heart Assoc | pmid:23817470 |
Kiernan M et al. | The effect of the in vitro supplementation of exogenous long-chain fatty acids on bovine sperm cell function. | 2013 | Reprod. Fertil. Dev. | pmid:23036717 |
Hoss E et al. | Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin. | 2013 | Arch. Dermatol. Res. | pmid:23839497 |
Zhang X et al. | Resolvin D1 protects podocytes in adriamycin-induced nephropathy through modulation of 14-3-3β acetylation. | 2013 | PLoS ONE | pmid:23840712 |
Shin S et al. | The omega-3 polyunsaturated fatty acid DHA induces simultaneous apoptosis and autophagy via mitochondrial ROS-mediated Akt-mTOR signaling in prostate cancer cells expressing mutant p53. | 2013 | Biomed Res Int | pmid:23841076 |
Dalli J et al. | Novel n-3 immunoresolvents: structures and actions. | 2013 | Sci Rep | pmid:23736886 |
Devaraj S et al. | Modulation of endothelial progenitor cell number and function with n-3 polyunsaturated fatty acids. | 2013 | Atherosclerosis | pmid:23528830 |
Finlin BS et al. | Regulation of thrombospondin-1 expression in alternatively activated macrophages and adipocytes: role of cellular cross talk and omega-3 fatty acids. | 2013 | J. Nutr. Biochem. | pmid:23528972 |
Rashid MA et al. | N-Docosahexaenoylethanolamine is a potent neurogenic factor for neural stem cell differentiation. | 2013 | J. Neurochem. | pmid:23570577 |
Shiraishi M et al. | Estimation of eicosapentaenoic acid and docosahexaenoic acid intakes in pregnant Japanese women without nausea by using a self-administered diet history questionnaire. | 2013 | Nutr Res | pmid:23746563 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Vaezi R et al. | Identification and functional characterization of genes encoding omega-3 polyunsaturated fatty acid biosynthetic activities from unicellular microalgae. | 2013 | Mar Drugs | pmid:24351909 |
Thomas J et al. | Dietary supplementation with resveratrol and/or docosahexaenoic acid alters hippocampal gene expression in adult C57Bl/6 mice. | 2013 | J. Nutr. Biochem. | pmid:23746933 |
Chang G et al. | Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. | 2013 | Bioresour. Technol. | pmid:23747449 |
Wu JH et al. | Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial. | 2013 | J Am Heart Assoc | pmid:24145742 |
Xie W et al. | Resolvin D1 reduces deterioration of tight junction proteins by upregulating HO-1 in LPS-induced mice. | 2013 | Lab. Invest. | pmid:23857007 |
Li Q et al. | A comparative study: In vitro effects of EPA and DHA on immune functions of head-kidney macrophages isolated from large yellow croaker (Larmichthys crocea). | 2013 | Fish Shellfish Immunol. | pmid:23859878 |
Chen S and Subbaiah PV | Regioisomers of phosphatidylcholine containing DHA and their potential to deliver DHA to the brain: role of phospholipase specificities. | 2013 | Lipids | pmid:23604781 |
Long SJ and Benton D | A double-blind trial of the effect of docosahexaenoic acid and vitamin and mineral supplementation on aggression, impulsivity, and stress. | 2013 | Hum Psychopharmacol | pmid:23625531 |
Das UN | Polyunsaturated fatty acids in heart failure. | 2013 | Circ. J. | pmid:23628915 |
Titova OE et al. | Dietary intake of eicosapentaenoic and docosahexaenoic acids is linked to gray matter volume and cognitive function in elderly. | 2013 | Age (Dordr) | pmid:22791395 |
Klek S et al. | Four-week parenteral nutrition using a third generation lipid emulsion (SMOFlipid)--a double-blind, randomised, multicentre study in adults. | 2013 | Clin Nutr | pmid:22796064 |
Schuchardt JP and Hahn A | Bioavailability of long-chain omega-3 fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23676322 |
Kitson AP et al. | Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23764042 |
Taha AY et al. | A minimum of 3 months of dietary fish oil supplementation is required to raise amygdaloid afterdischarge seizure thresholds in rats--implications for treating complex partial seizures. | 2013 | Epilepsy Behav | pmid:23376336 |
Collins MA et al. | Docosahexaenoic acid (DHA) prevents binge ethanol-dependent aquaporin-4 elevations while inhibiting neurodegeneration: experiments in rat adult-age entorhino-hippocampal slice cultures. | 2013 | Neurotox Res | pmid:23184649 |
Cheng R et al. | Cloning and functional analysis of putative malonyl-CoA:acyl-carrier protein transacylase gene from the docosahexaenoic acid-producer Schizochytrium sp. TIO1101. | 2013 | World J. Microbiol. Biotechnol. | pmid:23292648 |
Chen J et al. | Docosahexaenoic acid (DHA) attenuated paraquat induced lung damage in mice. | 2013 | Inhal Toxicol | pmid:23293968 |
Figueroa JD et al. | Dietary omega-3 polyunsaturated fatty acids improve the neurolipidome and restore the DHA status while promoting functional recovery after experimental spinal cord injury. | 2013 | J. Neurotrauma | pmid:23294084 |
Opperman M and Benade S | Analysis of the omega-3 fatty acid content of South African fish oil supplements: a follow-up study. | 2013 | Cardiovasc J Afr | pmid:24240381 |
Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
Lang JE et al. | Nutrigenetic response to omega-3 fatty acids in obese asthmatics (NOOA): rationale and methods. | 2013 | Contemp Clin Trials | pmid:23298524 |
Begum G et al. | ER stress and effects of DHA as an ER stress inhibitor. | 2013 | Transl Stroke Res | pmid:24323417 |
Hutchins-Wiese HL et al. | The impact of supplemental n-3 long chain polyunsaturated fatty acids and dietary antioxidants on physical performance in postmenopausal women. | 2013 | J Nutr Health Aging | pmid:23299384 |
Takayama M et al. | Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. | 2013 | J Nutr Health Aging | pmid:23299385 |
Akiyama M et al. | Impact of docosahexaenoic acid on gene expression during osteoclastogenesis in vitro--a comprehensive analysis. | 2013 | Nutrients | pmid:23945674 |
Rosa A et al. | Potential anti-tumor effects of Mugil cephalus processed roe extracts on colon cancer cells. | 2013 | Food Chem. Toxicol. | pmid:23948356 |
Bjorgvinsdottir L et al. | Do high levels of n-3 polyunsaturated fatty acids in cell membranes increase the risk of postoperative atrial fibrillation? | 2013 | Cardiology | pmid:23948862 |
Lee AL and Park Y | The association between n-3 polyunsaturated fatty acid levels in erythrocytes and the risk of rheumatoid arthritis in Korean women. | 2013 | Ann. Nutr. Metab. | pmid:23949659 |
Metherel AH et al. | EPA and DHA levels in whole blood decrease more rapidly when stored at -20 °C as compared with room temperature, 4 and -75 °C. | 2013 | Lipids | pmid:23949919 |
Ishikado A et al. | 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. | 2013 | PLoS ONE | pmid:23936010 |
de Oliveira Otto MC et al. | Circulating and dietary omega-3 and omega-6 polyunsaturated fatty acids and incidence of CVD in the Multi-Ethnic Study of Atherosclerosis. | 2013 | J Am Heart Assoc | pmid:24351702 |
Kilpinen L et al. | Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality. | 2013 | J. Lipid Res. | pmid:23271708 |
Storck Lindholm E et al. | Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23273824 |
Atwell K et al. | Respiratory hospitalisation of infants supplemented with docosahexaenoic acid as preterm neonates. | 2013 | J Paediatr Child Health | pmid:23279074 |
Barros KV et al. | Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. | 2013 | Clin Nutr | pmid:23260750 |
Spite M | Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. | 2013 | Proc Nutr Soc | pmid:23991833 |
Ryu BG et al. | Use of organic waste from the brewery industry for high-density cultivation of the docosahexaenoic acid-rich microalga, Aurantiochytrium sp. KRS101. | 2013 | Bioresour. Technol. | pmid:23262011 |
Marcon R et al. | Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis. | 2013 | J. Immunol. | pmid:24038091 |
Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
Fontes-Villalba M et al. | African hominin stable isotopic data do not necessarily indicate grass consumption. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24062471 |
Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |
Engel S et al. | Docosahexaenoic acid status at 9 months is inversely associated with communicative skills in 3-year-old girls. | 2013 | Matern Child Nutr | pmid:22642227 |