DHA

Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.

Cross Reference

Introduction

To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with DHA?

DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with DHA

MeSH term MeSH ID Detail
Abortion, Habitual D000026 5 associated lipids
Acquired Immunodeficiency Syndrome D000163 12 associated lipids
Adenocarcinoma D000230 166 associated lipids
Adrenoleukodystrophy D000326 29 associated lipids
Albinism D000417 3 associated lipids
Alzheimer Disease D000544 76 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia D000740 21 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Aortic Diseases D001018 11 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arthus Reaction D001183 8 associated lipids
Asthma D001249 52 associated lipids
Asthma, Exercise-Induced D001250 10 associated lipids
Atrial Fibrillation D001281 16 associated lipids
Autoimmune Diseases D001327 27 associated lipids
Basal Ganglia Diseases D001480 8 associated lipids
Biliary Atresia D001656 4 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Body Weight D001835 333 associated lipids
Bone Diseases, Metabolic D001851 9 associated lipids
Brain Neoplasms D001932 15 associated lipids
Breast Neoplasms D001943 24 associated lipids
Burns D002056 34 associated lipids
Cachexia D002100 21 associated lipids
Carcinoma D002277 18 associated lipids
Carcinoma 256, Walker D002279 22 associated lipids
Cardiomyopathy, Dilated D002311 15 associated lipids
Catalepsy D002375 30 associated lipids
Cataract D002386 34 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Intracranial Arteriosclerosis D002537 4 associated lipids
Brain Ischemia D002545 89 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholestasis D002779 23 associated lipids
Choline Deficiency D002796 16 associated lipids
Colitis D003092 69 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Communication Disorders D003147 1 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Deficiency Diseases D003677 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with DHA

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with DHA?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with DHA?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with DHA?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with DHA?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with DHA?

Mouse Model

Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).

Transgenic Model

Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).

Animal Disease Models

Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with DHA

Download all related citations
Per page 10 20 50 100 | Total 7336
Authors Title Published Journal PubMed Link
Chen ZY and Istfan NW Docosahexaenoic acid, a major constituent of fish oil diets, prevents activation of cyclin-dependent kinases and S-phase entry by serum stimulation in HT-29 cells. 2001 Prostaglandins Leukot. Essent. Fatty Acids pmid:11161587
van de Lagemaat M et al. Post term dietary-induced changes in DHA and AA status relate to gains in weight, length, and head circumference in preterm infants. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:21995887
Yi SH et al. A randomized, placebo-controlled, double-blind trial of supplemental docosahexaenoic acid on cognitive processing speed and executive function in females of reproductive age with phenylketonuria: A pilot study. 2011 Prostaglandins Leukot. Essent. Fatty Acids pmid:22000478
Smithers LG et al. Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20417081
Cunnane SC Commentary on the workshop statement. Essentiality of and recommended dietary intakes for Omega-6 and Omega-3 fatty acids. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10991770
Glew RH et al. The fatty acid composition of the serum phospholipids of children with sickle cell disease in Nigeria. 2002 Prostaglandins Leukot. Essent. Fatty Acids pmid:12401435
Dalton A et al. A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. 2009 Feb-Mar Prostaglandins Leukot. Essent. Fatty Acids pmid:19201180
Dijck-Brouwer DA et al. Lower fetal status of docosahexaenoic acid, arachidonic acid and essential fatty acids is associated with less favorable neonatal neurological condition. 2005 Prostaglandins Leukot. Essent. Fatty Acids pmid:15589396
Kris-Etherton PM et al. Dietary reference intakes for DHA and EPA. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19525100
Sanders TA DHA status of vegetarians. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19500961
Lapillonne A and Jensen CL Reevaluation of the DHA requirement for the premature infant. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19577914
Rapoport SI and Igarashi M Can the rat liver maintain normal brain DHA metabolism in the absence of dietary DHA? 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19540098
Brenna JT and Salem N Workshop proceedings: DHA as a required nutrient. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19604681
Yavin E Versatile roles of docosahexaenoic acid in the prenatal brain: from pro- and anti-oxidant features to regulation of gene expression. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16839753
Lagarde M et al. Dose-effect and metabolism of docosahexaenoic acid: pathophysiological relevance in blood platelets. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22520055
Peltier S et al. Preferential enrichment of liver phospholipids in docosahexaenoate relative to eicosapentaenoate in omega-3-depleted rats injected with a medium-chain triglyceride: fish oil emulsion. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18083359
Saldanha LG et al. Workshop on DHA as a required nutrient: overview. 2009 Aug-Sep Prostaglandins Leukot. Essent. Fatty Acids pmid:19643589
Brenna JT and Diau GY The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid composition. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18023566
Bonham MP et al. Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study). 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18585023
Rapoport SI Brain arachidonic and docosahexaenoic acid cascades are selectively altered by drugs, diet and disease. 2008 Sep-Nov Prostaglandins Leukot. Essent. Fatty Acids pmid:18973997
Ye S et al. Polyunsaturated docosahexaenoic acid suppresses oxidative stress induced endothelial cell calcium influx by altering lipid composition in membrane caveolar rafts. 2010 Prostaglandins Leukot. Essent. Fatty Acids pmid:20206488
Calon F and Cole G Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18037281
Pifferi F et al. n-3 Fatty acids modulate brain glucose transport in endothelial cells of the blood-brain barrier. 2007 Nov-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:18042368
van Goor SA et al. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. 2011 May-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:21316208
Childs CE et al. Maternal diet during pregnancy has tissue-specific effects upon fetal fatty acid composition and alters fetal immune parameters. 2010 Oct-Dec Prostaglandins Leukot. Essent. Fatty Acids pmid:20817424
Jolly CA et al. Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes. 1998 Prostaglandins Leukot. Essent. Fatty Acids pmid:9654402
Hurst S et al. Dietary fatty acids and arthritis. 2010 Apr-Jun Prostaglandins Leukot. Essent. Fatty Acids pmid:20189789
Ren H et al. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16410047
Wittwer J and Hersberger M The two faces of the 15-lipoxygenase in atherosclerosis. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17869078
Manna S et al. Dietary fish oil associated with increased apoptosis and modulated expression of Bax and Bcl-2 during 7,12-dimethylbenz(alpha)anthracene-induced mammary carcinogenesis in rats. 2008 Jul-Aug Prostaglandins Leukot. Essent. Fatty Acids pmid:18614344
Watanabe S et al. Dietary docosahexaenoic acid but not eicosapentaenoic acid suppresses lipopolysaccharide-induced interleukin-1 beta mRNA induction in mouse spleen leukocytes. 2000 Prostaglandins Leukot. Essent. Fatty Acids pmid:10841036
Puri BK et al. A 31-phosphorus neurospectroscopy study of omega-3 long-chain polyunsaturated fatty acid intervention with eicosapentaenoic acid and docosahexaenoic acid in patients with chronic refractory epilepsy. 2007 Prostaglandins Leukot. Essent. Fatty Acids pmid:17761409
Schuchardt JP and Hahn A Bioavailability of long-chain omega-3 fatty acids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23676322
Kitson AP et al. Treatment of ovariectomized rats with 17β-estradiol increases hepatic delta-6 desaturase enzyme expression and docosahexaenoic acid levels in hepatic and plasma phospholipids. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23764042
Sato SB et al. Differential roles of internal and terminal double bonds in docosahexaenoic acid: Comparative study of cytotoxicity of polyunsaturated fatty acids to HT-29 human colorectal tumor cell line. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20952172
Kulkarni AV et al. Reduced placental docosahexaenoic acid levels associated with increased levels of sFlt-1 in preeclampsia. 2011 Jan-Feb Prostaglandins Leukot. Essent. Fatty Acids pmid:20956072
Murali G et al. Differential effects of eicosapentaenoic acid and docosahexaenoic acid in promoting the differentiation of 3T3-L1 preadipocytes. 2014 Prostaglandins Leukot. Essent. Fatty Acids pmid:24332315
Qin Q et al. Neuroprotectin D1 inhibits retinal ganglion cell death following axotomy. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:19019647
Das UN Beneficial effect of eicosapentaenoic and docosahexaenoic acids in the management of systemic lupus erythematosus and its relationship to the cytokine network. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:7824535
Alnajjar A et al. Effect of n-3 and n-6 polyunsaturated fatty acids on lymphocyte proliferation, interleukin production and phospholipid fatty acids composition in type 2 diabetic and healthy subjects in Jordan people. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16650969
Storck Lindholm E et al. Different fatty acid pattern in breast milk of obese compared to normal-weight mothers. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:23273824
Taha AY et al. Threshold changes in rat brain docosahexaenoic acid incorporation and concentration following graded reductions in dietary alpha-linolenic acid. 2016 Prostaglandins Leukot. Essent. Fatty Acids pmid:26869088
Van Biervliet S et al. Oral DHA supplementation in DeltaF508 homozygous cystic fibrosis patients. 2008 Prostaglandins Leukot. Essent. Fatty Acids pmid:18276127
Larson MK et al. Omega-3 fatty acids modulate collagen signaling in human platelets. 2011 Mar-Apr Prostaglandins Leukot. Essent. Fatty Acids pmid:21177087
Innis SM et al. Long chain omega-3 fatty acids: micronutrients in disguise. 2013 Prostaglandins Leukot. Essent. Fatty Acids pmid:22709913
van Goor SA et al. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. 2009 Prostaglandins Leukot. Essent. Fatty Acids pmid:19118992
Karanian JW et al. Lipoxygenase stimulating effects of hydroxylated docosahexaenoates produced by human platelets. 1994 Prostaglandins Leukot. Essent. Fatty Acids pmid:8066103
Horrobin DF Schizophrenia as a membrane lipid disorder which is expressed throughout the body. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888116
Abbate R et al. n-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. 1996 Prostaglandins Leukot. Essent. Fatty Acids pmid:8888356
Bryhn M et al. The bioavailability and pharmacodynamics of different concentrations of omega-3 acid ethyl esters. 2006 Prostaglandins Leukot. Essent. Fatty Acids pmid:16806871