Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Carlson SJ et al. | The role of the ω-3 fatty acid DHA in the human life cycle. | 2013 | JPEN J Parenter Enteral Nutr | pmid:23192455 |
Le HD et al. | The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model. | 2013 | Metab. Clin. Exp. | pmid:23151438 |
Lecchi C et al. | Effects of EPA and DHA on lipid droplet accumulation and mRNA abundance of PAT proteins in caprine monocytes. | 2013 | Res. Vet. Sci. | pmid:23102647 |
Casey JM et al. | Effect of stearidonic acid-enriched soybean oil on fatty acid profile and metabolic parameters in lean and obese Zucker rats. | 2013 | Lipids Health Dis | pmid:24139088 |
Chang CY et al. | Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats. | 2013 | J. Nutr. Biochem. | pmid:24139673 |
Brenna T et al. | Docosahexaenoic acid in translational medicine: the Tenth Fatty Acids and Cell Signaling meeting (FACS-10). | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23103099 |
Fernández-Iglesias A et al. | DHA sensitizes FaO cells to tert-BHP-induced oxidative effects. Protective role of EGCG. | 2013 | Food Chem. Toxicol. | pmid:24140970 |
Galvao TF et al. | Marine n3 polyunsaturated fatty acids enhance resistance to mitochondrial permeability transition in heart failure but do not improve survival. | 2013 | Am. J. Physiol. Heart Circ. Physiol. | pmid:23103493 |
Song YJ et al. | Regulatory functions of docosahexaenoic acid on ion channels in rat ventricular myocytes. | 2013 | Eur Rev Med Pharmacol Sci | pmid:24142611 |
Tai EK et al. | An update on adding docosahexaenoic acid (DHA) and arachidonic acid (AA) to baby formula. | 2013 | Food Funct | pmid:24150114 |
Lee LK et al. | The role of long chain omega-3 polyunsaturated fatty acids in reducing lipid peroxidation among elderly patients with mild cognitive impairment: a case-control study. | 2013 | J. Nutr. Biochem. | pmid:22898566 |
Yang YC et al. | Docosahexaenoic acid inhibition of inflammation is partially via cross-talk between Nrf2/heme oxygenase 1 and IKK/NF-κB pathways. | 2013 | J. Nutr. Biochem. | pmid:22901690 |
Betancor MB et al. | Oxidative stress in sea bass Dicentrarchus labrax larvae: interaction of high dietary DHA contents and several antioxidant nutrients. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141617 |
Hagemann A et al. | Content of essential fatty acids in cultivated Acartia tonsa nauplii fed a DHA-deficient Tetraselmis sp. concentrate. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141657 |
Lund I et al. | Importance of DHA for first feeding pikeperch larvae--influence on behavioural responses. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141683 |
Mesa-Rodriguez A et al. | Effect of increasing DHA content in new weaning diets for longfin yellowtail (Seriola rivoliana). | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141689 |
Miyashima A et al. | DHA requirement of larval Japanese flounder Paralichthys olivaceus in the rotifer feeding period. | 2013 | Commun. Agric. Appl. Biol. Sci. | pmid:25141691 |
Botelho PB et al. | Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. | 2013 | Lipids Health Dis | pmid:23510369 |
Mocking RJ et al. | Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. | 2013 | Psychoneuroendocrinology | pmid:23465556 |
Gao M et al. | Isolation and characterization of Aurantiochytrium species: high docosahexaenoic acid (DHA) production by the newly isolated microalga, Aurantiochytrium sp. SD116. | 2013 | J Oleo Sci | pmid:23470441 |
Dobson EP et al. | Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. | 2013 | J. Lipid Res. | pmid:23471029 |
Drover JR et al. | Addendum to "Cognitive function in 18-month-old term infants of the DIAMOND study: a randomized, controlled clinical trial with multiple dietary levels of docosahexaenoic acid" [Early Hum. Dev. 87 (2011) 223-230]. | 2013 | Early Hum. Dev. | pmid:23411369 |
Sundrani D et al. | Matrix metalloproteinases-2, -3 and tissue inhibitors of metalloproteinases-1, -2 in placentas from preterm pregnancies and their association with one-carbon metabolites. | 2013 | Reproduction | pmid:23412981 |
Chien KL et al. | A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers. | 2013 | BMC Med Res Methodol | pmid:23414574 |
Rai AK et al. | Bioefficacy of EPA-DHA from lipids recovered from fish processing wastes through biotechnological approaches. | 2013 | Food Chem | pmid:23017395 |
van den Elsen LW et al. | n-3 Long-chain PUFA reduce allergy-related mediator release by human mast cells in vitro via inhibition of reactive oxygen species. | 2013 | Br. J. Nutr. | pmid:23021516 |
Bazan NG | The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23022417 |
Del Bó C et al. | Horse meat consumption affects iron status, lipid profile and fatty acid composition of red blood cells in healthy volunteers. | 2013 | Int J Food Sci Nutr | pmid:23025273 |
Scholtz SA et al. | Clinical overview of effects of dietary long-chain polyunsaturated fatty acids during the perinatal period. | 2013 | Nestle Nutr Inst Workshop Ser | pmid:24107504 |
Kim HY and Spector AA | Synaptamide, endocannabinoid-like derivative of docosahexaenoic acid with cannabinoid-independent function. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22959887 |
Minihane AM | Fish oil omega-3 fatty acids and cardio-metabolic health, alone or with statins. | 2013 | Eur J Clin Nutr | pmid:23403872 |
Miyahara T et al. | D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury. | 2013 | FASEB J. | pmid:23407709 |
Huang LL et al. | Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23474173 |
Morita M et al. | The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. | 2013 | Cell | pmid:23477864 |
Lee LK et al. | Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. | 2013 | Psychopharmacology (Berl.) | pmid:22932777 |
Berberovic E et al. | Arachidonic and docosahexaenoic acid in the blood of a mother and umbilical vein in diabetic pregnant women. | 2013 | J. Matern. Fetal. Neonatal. Med. | pmid:23480524 |
Mischoulon D and Freeman MP | Omega-3 fatty acids in psychiatry. | 2013 | Psychiatr. Clin. North Am. | pmid:23538073 |
Koltsida O et al. | Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. | 2013 | EMBO Mol Med | pmid:23584892 |
Li J et al. | Comparative metabolomics analysis of docosahexaenoic acid fermentation processes by Schizochytrium sp. under different oxygen availability conditions. | 2013 | OMICS | pmid:23586678 |
Barros KV et al. | Fatty acids in plasma, white and red blood cells, and tissues after oral or intravenous administration of fish oil in rats. | 2013 | Clin Nutr | pmid:23541913 |
Bruins MJ et al. | Plasma oxylipin profiling identifies polyunsaturated vicinal diols as responsive to arachidonic acid and docosahexaenoic acid intake in growing piglets. | 2013 | J. Lipid Res. | pmid:23543770 |
Calder PC | Editorial: Fat chance to enhance B cell function. | 2013 | J. Leukoc. Biol. | pmid:23547174 |
Mozaffarian D et al. | Plasma phospholipid long-chain ω-3 fatty acids and total and cause-specific mortality in older adults: a cohort study. | 2013 | Ann. Intern. Med. | pmid:23546563 |
Zhang G et al. | Epoxy metabolites of docosahexaenoic acid (DHA) inhibit angiogenesis, tumor growth, and metastasis. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23553837 |
Zhang J et al. | Different intakes of n-3 fatty acids among pregnant women in 3 regions of China with contrasting dietary patterns are reflected in maternal but not in umbilical erythrocyte phosphatidylcholine fatty acid composition. | 2013 | Nutr Res | pmid:23890350 |
Yao C et al. | Neuroprotectin D1 attenuates brain damage induced by transient middle cerebral artery occlusion in rats through TRPC6/CREB pathways. | 2013 | Mol Med Rep | pmid:23799606 |
Al-Farsi YM et al. | Impact of nutrition on serum levels of docosahexaenoic acid among Omani children with autism. | 2013 | Nutrition | pmid:23800562 |
Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
Samieri C et al. | Relationship between diet and plasma long-chain n-3 PUFAs in older people: impact of apolipoprotein E genotype. | 2013 | J. Lipid Res. | pmid:23801662 |
Végran F et al. | Socs3 induction by PPARγ restrains cancer-promoting inflammation. | 2013 | Cell Cycle | pmid:23803735 |
Bruno MJ et al. | Interactions of drugs and amphiphiles with membranes: modulation of lipid bilayer elastic properties by changes in acyl chain unsaturation and protonation. | 2013 | Faraday Discuss. | pmid:23805753 |
Jung SB et al. | Docosahexaenoic acid improves vascular function via up-regulation of SIRT1 expression in endothelial cells. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23806688 |
Sun YB et al. | Endothelial dysfunction exacerbates renal interstitial fibrosis through enhancing fibroblast Smad3 linker phosphorylation in the mouse obstructed kidney. | 2013 | PLoS ONE | pmid:24391884 |
Zhang X et al. | Resolvin D1 reverts lipopolysaccharide-induced TJ proteins disruption and the increase of cellular permeability by regulating IκBα signaling in human vascular endothelial cells. | 2013 | Oxid Med Cell Longev | pmid:24381712 |
Weiss GA et al. | High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation. | 2013 | Lipids Health Dis | pmid:23767972 |
Codabaccus MB et al. | Restoration of EPA and DHA in rainbow trout (Oncorhynchus mykiss) using a finishing fish oil diet at two different water temperatures. | 2013 | Food Chem | pmid:23768353 |
Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
Leino O et al. | Effects of docosahexaenoic acid and methylmercury on child's brain development due to consumption of fish by Finnish mother during pregnancy: a probabilistic modeling approach. | 2013 | Food Chem. Toxicol. | pmid:21723361 |
Jones ML et al. | Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta. | 2013 | J. Lipid Res. | pmid:23723388 |
German OL et al. | Retinoid X receptor activation is essential for docosahexaenoic acid protection of retina photoreceptors. | 2013 | J. Lipid Res. | pmid:23723389 |
Hiratsuka S et al. | Effects of dietary sialic acid in n-3 fatty acid-deficient dams during pregnancy and lactation on the learning abilities of their pups after weaning. | 2013 | J. Nutr. Sci. Vitaminol. | pmid:23727644 |
Barber E et al. | Comparative actions of omega-3 fatty acids on in-vitro lipid droplet formation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24012207 |
Veszelka S et al. | Docosahexaenoic acid reduces amyloid-β induced toxicity in cells of the neurovascular unit. | 2013 | J. Alzheimers Dis. | pmid:23645098 |
Stephenson JA et al. | Unsaturated fatty acids differ between hepatic colorectal metastases and liver tissue without tumour in humans: results from a randomised controlled trial of intravenous eicosapentaenoic and docosahexaenoic acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23647811 |
Nishinaka T et al. | [Elucidation of mechanisms underlying docosahexaenoic acid-induced antinociception]. | 2013 | Yakugaku Zasshi | pmid:23649389 |
Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
Ostapchenko VG et al. | Increased prion protein processing and expression of metabotropic glutamate receptor 1 in a mouse model of Alzheimer's disease. | 2013 | J. Neurochem. | pmid:23651058 |
Ramkumar HL et al. | Nutrient supplementation with n3 polyunsaturated fatty acids, lutein, and zeaxanthin decrease A2E accumulation and VEGF expression in the retinas of Ccl2/Cx3cr1-deficient mice on Crb1rd8 background. | 2013 | J. Nutr. | pmid:23677863 |
Pagán A et al. | Materno-fetal transfer of docosahexaenoic acid is impaired by gestational diabetes mellitus. | 2013 | Am. J. Physiol. Endocrinol. Metab. | pmid:23921142 |
Sheets KG et al. | Microglial ramification and redistribution concomitant with the attenuation of choroidal neovascularization by neuroprotectin D1. | 2013 | Mol. Vis. | pmid:23922492 |
Rapoport SI | Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22766388 |
Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
Bjorgvinsdottir L et al. | Inflammatory response following heart surgery and association with n-3 and n-6 long-chain polyunsaturated fatty acids in plasma and red blood cell membrane lipids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23999253 |
Iwasaka H et al. | Utilization of waste syrup for production of polyunsaturated fatty acids and xanthophylls by Aurantiochytrium. | 2013 | J Oleo Sci | pmid:24005017 |
Liu Y et al. | Fish oil alleviates activation of the hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaned piglets after a lipopolysaccharide challenge. | 2013 | J. Nutr. | pmid:24005609 |
Chen HW et al. | Inhibition of matrix metalloproteinase-9 expression by docosahexaenoic acid mediated by heme oxygenase 1 in 12-O-tetradecanoylphorbol-13-acetate-induced MCF-7 human breast cancer cells. | 2013 | Arch. Toxicol. | pmid:23288142 |
Matsuoka Y et al. | Tachikawa project for prevention of posttraumatic stress disorder with polyunsaturated fatty acid (TPOP): study protocol for a randomized controlled trial. | 2013 | BMC Psychiatry | pmid:23289548 |
Ritter JC et al. | Quality analysis of commercial fish oil preparations. | 2013 | J. Sci. Food Agric. | pmid:23255124 |
Fogagnolo Mauricio A et al. | Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice. | 2013 | Clin Nutr | pmid:23218947 |
Nobili V et al. | Docosahexaenoic acid for the treatment of fatty liver: randomised controlled trial in children. | 2013 | Nutr Metab Cardiovasc Dis | pmid:23220074 |
Steffen BT et al. | n-3 and n-6 Fatty acids are independently associated with lipoprotein-associated phospholipase A2 in the Multi-Ethnic Study of Atherosclerosis. | 2013 | Br. J. Nutr. | pmid:23551952 |
Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
Wang D et al. | Organochlorine pesticides in fish from Taihu Lake, China, and associated human health risk assessment. | 2013 | Ecotoxicol. Environ. Saf. | pmid:24125867 |
Hoshi T et al. | A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. | 2013 | J. Gen. Physiol. | pmid:24127525 |
Nagai T et al. | Actual ratios of triacylglycerol positional isomers and enantiomers comprising saturated fatty acids and highly unsaturated fatty acids in fishes and marine mammals. | 2013 | J Oleo Sci | pmid:24292353 |
Zeilmaker MJ et al. | Fish consumption during child bearing age: a quantitative risk-benefit analysis on neurodevelopment. | 2013 | Food Chem. Toxicol. | pmid:22079313 |
Sato K et al. | Selective and potent inhibitory effect of docosahexaenoic acid (DHA) on U46619-induced contraction in rat aorta. | 2013 | J Smooth Muscle Res | pmid:24304639 |
Nikolakopoulou Z et al. | The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. | 2013 | Toxicol. Lett. | pmid:23391486 |
Souied EH et al. | Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: the Nutritional AMD Treatment 2 study. | 2013 | Ophthalmology | pmid:23395546 |
Denis I et al. | Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. | 2013 | Ageing Res. Rev. | pmid:23395782 |
Yan Y et al. | Enhanced catalysis of Yarrowia lipolytica lipase LIP2 immobilized on macroporous resin and its application in enrichment of polyunsaturated fatty acids. | 2013 | Bioresour. Technol. | pmid:23347925 |
Jaudszus A et al. | Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells. | 2013 | J. Lipid Res. | pmid:23349208 |
Nobili V et al. | The I148M variant of PNPLA3 reduces the response to docosahexaenoic acid in children with non-alcoholic fatty liver disease. | 2013 | J Med Food | pmid:24074360 |
Gadaria-Rathod N et al. | Red blood cell fatty acid analysis for determining compliance with omega3 supplements in dry eye disease trials. | 2013 | J Ocul Pharmacol Ther | pmid:23971620 |
Weintraub H | Update on marine omega-3 fatty acids: management of dyslipidemia and current omega-3 treatment options. | 2013 | Atherosclerosis | pmid:24075771 |
Stulnig G et al. | Docosahexaenoic acid (DHA)-induced heme oxygenase-1 attenuates cytotoxic effects of DHA in vascular smooth muscle cells. | 2013 | Atherosclerosis | pmid:24075775 |
Nagachinta S and Akoh CC | Spray-dried structured lipid containing long-chain polyunsaturated fatty acids for use in infant formulas. | 2013 | J. Food Sci. | pmid:24024870 |
Kennedy DO | Reply to MP Pase and C Stough. | 2013 | Am. J. Clin. Nutr. | pmid:24027792 |
Gruszfeld D and Socha P | Early nutrition and health: short- and long-term outcomes. | 2013 | World Rev Nutr Diet | pmid:24029784 |
Przyrembel H and Agostoni C | Growing-up milk: a necessity or marketing? | 2013 | World Rev Nutr Diet | pmid:24029786 |