Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Suganuma H et al. | Effect of hypoxic-ischemic insults on the composition of fatty acids in the brain of neonatal rats. | 2013 | Ann. Nutr. Metab. | pmid:23364132 |
Lee HN et al. | Resolution of inflammation as a novel chemopreventive strategy. | 2013 | Semin Immunopathol | pmid:23370700 |
Schantz MM et al. | Development of botanical and fish oil standard reference materials for fatty acids. | 2013 | Anal Bioanal Chem | pmid:23371533 |
Teague H et al. | Dendritic cell activation, phagocytosis and CD69 expression on cognate T cells are suppressed by n-3 long-chain polyunsaturated fatty acids. | 2013 | Immunology | pmid:23373457 |
Soubias O and Gawrisch K | Rhodopsin-lipid interactions studied by NMR. | 2013 | Meth. Enzymol. | pmid:23374188 |
Daak AA et al. | Docosahexaenoic and eicosapentaenoic acid supplementation does not exacerbate oxidative stress or intravascular haemolysis in homozygous sickle cell patients. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24095588 |
Ishida T et al. | Distinct regulation of plasma LDL cholesterol by eicosapentaenoic acid and docosahexaenoic acid in high fat diet-fed hamsters: participation of cholesterol ester transfer protein and LDL receptor. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23375839 |
Umhau JC et al. | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. | 2013 | PLoS ONE | pmid:24098376 |
Renganathan K et al. | CEP biomarkers as potential tools for monitoring therapeutics. | 2013 | PLoS ONE | pmid:24098476 |
Xu J et al. | Expression of a type 2 diacylglycerol acyltransferase from Thalassiosira pseudonana in yeast leads to incorporation of docosahexaenoic acid β-oxidation intermediates into triacylglycerol. | 2013 | FEBS J. | pmid:24128189 |
Kimura R et al. | DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells. | 2013 | J. Lipid Res. | pmid:24133194 |
Teague H et al. | DHA-fluorescent probe is sensitive to membrane order and reveals molecular adaptation of DHA in ordered lipid microdomains. | 2013 | J. Nutr. Biochem. | pmid:22841541 |
Zong G et al. | Effects of flaxseed supplementation on erythrocyte fatty acids and multiple cardiometabolic biomarkers among Chinese with risk factors of metabolic syndrome. | 2013 | Eur J Nutr | pmid:23179200 |
Meher AP et al. | Preconceptional omega-3 fatty acid supplementation on a micronutrient-deficient diet improves the reproductive cycle in Wistar rats. | 2013 | Reprod. Fertil. Dev. | pmid:23137932 |
Betancor MB et al. | Oxidative status and histological changes in sea bass larvae muscle in response to high dietary content of docosahexaenoic acid DHA. | 2013 | J. Fish Dis. | pmid:23167568 |
Herba CM et al. | Breastfeeding and early brain development: the Generation R study. | 2013 | Matern Child Nutr | pmid:23167730 |
Rovito D et al. | Omega-3 PUFA ethanolamides DHEA and EPEA induce autophagy through PPARγ activation in MCF-7 breast cancer cells. | 2013 | J. Cell. Physiol. | pmid:23168911 |
Sato SB et al. | Inhibition of constitutive Akt (PKB) phosphorylation by docosahexaenoic acid in the human breast cancer cell line MDA-MB-453. | 2013 | Biochim. Biophys. Acta | pmid:23085420 |
Faizan M et al. | Dietary alpha-tocopherol affects tissue vitamin e and malondialdehyde levels but does not change antioxidant enzymes and fatty acid composition in farmed Atlantic salmon (Salmo salar L.). | 2013 | Int J Vitam Nutr Res | pmid:25008014 |
Al-Taan O et al. | Changes in plasma and erythrocyte omega-6 and omega-3 fatty acids in response to intravenous supply of omega-3 fatty acids in patients with hepatic colorectal metastases. | 2013 | Lipids Health Dis | pmid:23648075 |
Marze S et al. | In vitro digestion of fish oils rich in n-3 polyunsaturated fatty acids studied in emulsion and at the oil-water interface. | 2013 | Food Funct | pmid:23086175 |
Hoshi T et al. | Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23487786 |
Gerstenblith AT et al. | Electroretinographic effects of omega-3 Fatty Acid supplementation on dry age-related macular degeneration. | 2013 | JAMA Ophthalmol | pmid:23494041 |
Ramos-Loyo J et al. | Sex differences in lipid peroxidation and fatty acid levels in recent onset schizophrenia. | 2013 | Prog. Neuropsychopharmacol. Biol. Psychiatry | pmid:23421976 |
Dallaire R et al. | Exposure to organochlorines and mercury through fish and marine mammal consumption: associations with growth and duration of gestation among Inuit newborns. | 2013 | Environ Int | pmid:23422685 |
Liu J et al. | Screening and characterization of Isochrysis strains and optimization of culture conditions for docosahexaenoic acid production. | 2013 | Appl. Microbiol. Biotechnol. | pmid:23423326 |
Metherel AH et al. | Butylated hydroxytoluene can protect polyunsaturated fatty acids in dried blood spots from degradation for up to 8 weeks at room temperature. | 2013 | Lipids Health Dis | pmid:23425563 |
Nordgren TM et al. | Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. | 2013 | Respir. Res. | pmid:23663457 |
Izquierdo MS et al. | Effects of dietary DHA and α-tocopherol on bone development, early mineralisation and oxidative stress in Sparus aurata (Linnaeus, 1758) larvae. | 2013 | Br. J. Nutr. | pmid:23046500 |
Hara M et al. | Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction. | 2013 | Circ. J. | pmid:23047296 |
McNamara RK et al. | Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease. | 2013 | J Psychiatr Res | pmid:23759469 |
Nielsen G et al. | Alterations of N-3 polyunsaturated fatty acid-activated K2P channels in hypoxia-induced pulmonary hypertension. | 2013 | Basic Clin. Pharmacol. Toxicol. | pmid:23724868 |
Moate PJ et al. | Effects of feeding algal meal high in docosahexaenoic acid on feed intake, milk production, and methane emissions in dairy cows. | 2013 | J. Dairy Sci. | pmid:23498011 |
Ajami M et al. | Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. | 2013 | Fundam Clin Pharmacol | pmid:22943605 |
Ruiz-Lopez N et al. | Reconstitution of EPA and DHA biosynthesis in arabidopsis: iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. | 2013 | Metab. Eng. | pmid:23500000 |
Recchiuti A | Resolvin D1 and its GPCRs in resolution circuits of inflammation. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500003 |
Gladyshev MI et al. | Production of EPA and DHA in aquatic ecosystems and their transfer to the land. | 2013 | Prostaglandins Other Lipid Mediat. | pmid:23500063 |
Zhuang W et al. | Omega-3 polyunsaturated fatty acids reduce vascular endothelial growth factor production and suppress endothelial wound repair. | 2013 | J Cardiovasc Transl Res | pmid:22993129 |
Lu Y et al. | Spinal injection of docosahexaenoic acid attenuates carrageenan-induced inflammatory pain through inhibition of microglia-mediated neuroinflammation in the spinal cord. | 2013 | Neuroscience | pmid:23500096 |
Mozaffari-Khosravi H et al. | Eicosapentaenoic acid versus docosahexaenoic acid in mild-to-moderate depression: a randomized, double-blind, placebo-controlled trial. | 2013 | Eur Neuropsychopharmacol | pmid:22910528 |
Cardenia V et al. | Health-related lipids components of sardine muscle as affected by photooxidation. | 2013 | Food Chem. Toxicol. | pmid:23500769 |
Moallem U et al. | Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. | 2013 | Reproduction | pmid:24062566 |
Hudson AG et al. | Erythrocyte omega-6 and omega-3 fatty acids and mammographic breast density. | 2013 | Nutr Cancer | pmid:23530640 |
Pacetti D et al. | Effect of spawning on furan fatty acid profile of edible muscle and organ tissues from sardine (Sardina pilchardus) and anchovy (Engraulis encrasicolus). | 2013 | J. Agric. Food Chem. | pmid:23531042 |
Mozurkewich EL et al. | The Mothers, Omega-3, and Mental Health Study: a double-blind, randomized controlled trial. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531328 |
Romero VC et al. | Developmental programming for allergy: a secondary analysis of the Mothers, Omega-3, and Mental Health Study. | 2013 | Am. J. Obstet. Gynecol. | pmid:23531329 |
Bagley HN et al. | Maternal docosahexaenoic acid increases adiponectin and normalizes IUGR-induced changes in rat adipose deposition. | 2013 | J Obes | pmid:23533720 |
Gao F et al. | Aging decreases rate of docosahexaenoic acid synthesis-secretion from circulating unesterified α-linolenic acid by rat liver. | 2013 | Age (Dordr) | pmid:22388930 |
Erken HA et al. | Exercise and DHA prevent the negative effects of hypoxia on EEG and nerve conduction velocity. | 2013 | High Alt. Med. Biol. | pmid:24377343 |
Tapsell LC et al. | Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial. | 2013 | BMC Public Health | pmid:24369765 |
van Valenberg HJ et al. | Concentrations of n-3 and n-6 fatty acids in Dutch bovine milk fat and their contribution to human dietary intake. | 2013 | J. Dairy Sci. | pmid:23664339 |
Baillie JK and Digard P | Influenza--time to target the host? | 2013 | N. Engl. J. Med. | pmid:23841736 |
Markhus MW et al. | Low omega-3 index in pregnancy is a possible biological risk factor for postpartum depression. | 2013 | PLoS ONE | pmid:23844041 |
Ribeiro T et al. | Direct supplementation of diet is the most efficient way of enriching broiler meat with n-3 long-chain polyunsaturated fatty acids. | 2013 | Br. Poult. Sci. | pmid:24397512 |
Singh A et al. | Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses. | 2013 | PLoS ONE | pmid:23844124 |
Muldoon MF et al. | Concurrent physical activity modifies the association between n3 long-chain fatty acids and cardiometabolic risk in midlife adults. | 2013 | J. Nutr. | pmid:23884386 |
Watson AM et al. | Taurine supplementation of plant derived protein and n-3 fatty acids are critical for optimal growth and development of cobia, Rachycentron canadum. | 2013 | Lipids | pmid:23884630 |
Rayapudi S et al. | Vitamin A and fish oils for retinitis pigmentosa. | 2013 | Cochrane Database Syst Rev | pmid:24357340 |
Azordegan N et al. | Carcinogenesis alters fatty acid profile in breast tissue. | 2013 | Mol. Cell. Biochem. | pmid:23180247 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Chang G et al. | Improvement of docosahexaenoic acid production on glycerol by Schizochytrium sp. S31 with constantly high oxygen transfer coefficient. | 2013 | Bioresour. Technol. | pmid:23747449 |
Zhang L et al. | Improving docosahexaenoic acid productivity of Schizochytrium sp. by a two-stage AEMR/shake mixed culture mode. | 2013 | Bioresour. Technol. | pmid:23751810 |
Janczyk W et al. | Omega-3 fatty acids for treatment of non-alcoholic fatty liver disease: design and rationale of randomized controlled trial. | 2013 | BMC Pediatr | pmid:23702094 |
Cortina MS et al. | Neuroprotectin D1 restores corneal nerve integrity and function after damage from experimental surgery. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23702780 |
Nyuar KB et al. | Regular consumption of Nile river fish could ameliorate the low milk DHA of Southern Sudanese women living in Khartoum City area. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23706881 |
Terrando N et al. | Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. | 2013 | FASEB J. | pmid:23709617 |
Das UN | Polyunsaturated fatty acids in heart failure. | 2013 | Circ. J. | pmid:23628915 |
Hara M and Sakata Y | Polyunsaturated fatty acids in heart failure: reply. | 2013 | Circ. J. | pmid:23628916 |
Chouinard-Watkins R et al. | Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE ε4 allele. | 2013 | Br. J. Nutr. | pmid:23631810 |
Laird BD et al. | Dietary advice on Inuit traditional food use needs to balance benefits and risks of mercury, selenium, and n3 fatty acids. | 2013 | J. Nutr. | pmid:23616502 |
Sala-Vila A et al. | Eicosapentaenoic acid in serum phospholipids relates to a less atherogenic lipoprotein profile in subjects with familial hypercholesterolemia. | 2013 | J. Nutr. Biochem. | pmid:23618530 |
Meyer BJ et al. | Assessing long-chain ω-3 polyunsaturated fatty acids: a tailored food-frequency questionnaire is better. | 2013 | Nutrition | pmid:22929186 |
Johnston DT et al. | Red blood cell omega-3 fatty acid levels and neurocognitive performance in deployed U.S. Servicemembers. | 2013 | Nutr Neurosci | pmid:22748167 |
Kusunoki C et al. | Omega-3 polyunsaturated fatty acid has an anti-oxidant effect via the Nrf-2/HO-1 pathway in 3T3-L1 adipocytes. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23131562 |
Li C et al. | High efficient treatment of citric acid effluent by Chlorella vulgaris and potential biomass utilization. | 2013 | Bioresour. Technol. | pmid:23131649 |
Nicholson T et al. | The role of marine n-3 fatty acids in improving cardiovascular health: a review. | 2013 | Food Funct | pmid:23325431 |
Hamaoka N et al. | Oxidative stability of lipids rich in EPA and DHA extracted from fermented scallop ovary. | 2013 | J. Food Sci. | pmid:23915081 |
Reinders I et al. | Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. | 2013 | Eur J Clin Nutr | pmid:24084512 |
Takayama M et al. | Association of marine-origin n-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. | 2013 | J Nutr Health Aging | pmid:23299385 |
Lovegrove JA and Griffin BA | The acute and long-term effects of dietary fatty acids on vascular function in health and disease. | 2013 | Curr Opin Clin Nutr Metab Care | pmid:23299700 |
Santos VC et al. | Effects of DHA-rich fish oil supplementation on lymphocyte function before and after a marathon race. | 2013 | Int J Sport Nutr Exerc Metab | pmid:23239683 |
Raza Shaikh S and Brown DA | Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22464052 |
Hoshi T et al. | Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23940844 |
Sadli N et al. | Effect of DHA and coenzymeQ10 against Aβ- and zinc-induced mitochondrial dysfunction in human neuronal cells. | 2013 | Cell. Physiol. Biochem. | pmid:23942088 |
Rajasagi NK et al. | Neuroprotectin D1 reduces the severity of herpes simplex virus-induced corneal immunopathology. | 2013 | Invest. Ophthalmol. Vis. Sci. | pmid:23942967 |
Mühlroth A et al. | Pathways of lipid metabolism in marine algae, co-expression network, bottlenecks and candidate genes for enhanced production of EPA and DHA in species of Chromista. | 2013 | Mar Drugs | pmid:24284429 |
Chaung HC et al. | Docosahexaenoic acid and phosphatidylserine improves the antioxidant activities in vitro and in vivo and cognitive functions of the developing brain. | 2013 | Food Chem | pmid:23265497 |
Akanbi TO et al. | Selective concentration of EPA and DHA using Thermomyces lanuginosus lipase is due to fatty acid selectivity and not regioselectivity. | 2013 | Food Chem | pmid:23265531 |
Alicandro G et al. | A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266209 |
Fenton JI and McCaskey SJ | Curcumin and docosahexaenoic acid block insulin-induced colon carcinoma cell proliferation. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23266210 |
Tam VC | Lipidomic profiling of bioactive lipids by mass spectrometry during microbial infections. | 2013 | Semin. Immunol. | pmid:24084369 |
Rogers LK et al. | DHA supplementation: current implications in pregnancy and childhood. | 2013 | Pharmacol. Res. | pmid:23266567 |
Orr SK et al. | Unesterified docosahexaenoic acid is protective in neuroinflammation. | 2013 | J. Neurochem. | pmid:23919613 |
Yusof HM et al. | Limited impact of 2 g/day omega-3 fatty acid ethyl esters (Omacor®) on plasma lipids and inflammatory markers in patients awaiting carotid endarterectomy. | 2013 | Mar Drugs | pmid:24065166 |
Stanley WC et al. | Evaluation of docosahexaenoic acid in a dog model of hypertension induced left ventricular hypertrophy. | 2013 | J Cardiovasc Transl Res | pmid:24065618 |
Xiao G et al. | Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. | 2013 | PLoS ONE | pmid:24066055 |
Lachance C et al. | Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. | 2013 | PLoS ONE | pmid:24069363 |
Leggieri E et al. | Clinical effects of diet supplementation with DHA in pediatric patients suffering from cystic fibrosis. | 2013 | Minerva Pediatr. | pmid:24051972 |
Cunnane SC et al. | Docosahexaenoic acid homeostasis, brain aging and Alzheimer's disease: Can we reconcile the evidence? | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22575581 |
Delplanque B et al. | A dairy fat matrix providing alpha-linolenic acid (ALA) is better than a vegetable fat mixture to increase brain DHA accretion in young rats. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:22884780 |