Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Mussi SV et al. | Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced in vitro activity and overcomes drug resistance in MCF-7/Adr cells. | 2014 | Pharm. Res. | pmid:24522814 |
Arnold C et al. | Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids. | 2010 May-Jun | Pharmacol Rep | pmid:20631419 |
Yetimler B et al. | Differential effect of age on the brain fatty acid levels and their correlation with animal cognitive status in mice. | 2012 | Pharmacol. Biochem. Behav. | pmid:22878041 |
Cao DH et al. | Protective effect of chronic ethyl docosahexaenoate administration on brain injury in ischemic gerbils. | 2004 | Pharmacol. Biochem. Behav. | pmid:15582673 |
Minami M et al. | Dietary docosahexaenoic acid increases cerebral acetylcholine levels and improves passive avoidance performance in stroke-prone spontaneously hypertensive rats. | 1997 | Pharmacol. Biochem. Behav. | pmid:9408223 |
Obajimi O et al. | Differential effects of eicosapentaenoic and docosahexaenoic acids upon oxidant-stimulated release and uptake of arachidonic acid in human lymphoma U937 cells. | 2005 | Pharmacol. Res. | pmid:15967385 |
Galli C | Health implications of DHA. | 1999 | Pharmacol. Res. | pmid:10479461 |
Lagarde M | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479462 |
Horrocks LA and Yeo YK | Health benefits of docosahexaenoic acid (DHA) | 1999 | Pharmacol. Res. | pmid:10479465 |
Lopez-Huertas E | Health effects of oleic acid and long chain omega-3 fatty acids (EPA and DHA) enriched milks. A review of intervention studies. | 2010 | Pharmacol. Res. | pmid:19897038 |
Rogers LK et al. | DHA supplementation: current implications in pregnancy and childhood. | 2013 | Pharmacol. Res. | pmid:23266567 |
Gorjão R et al. | Comparative effects of DHA and EPA on cell function. | 2009 | Pharmacol. Ther. | pmid:19318040 |
Schjøtt J et al. | Effects of eicosapentaenoic acid and docosahexaenoic acid diet supplement on tolerance to the cardiotoxicity of epirubicin and to ischaemia reperfusion in the isolated rat heart. | 1996 | Pharmacol. Toxicol. | pmid:8878248 |
Paulsen JE et al. | A fish oil-derived concentrate enriched in eicosapentaenoic and docosahexaenoic acid as ethyl esters inhibits the formation and growth of aberrant crypt foci in rat colon. | 1998 | Pharmacol. Toxicol. | pmid:9527643 |
Sametz W et al. | Influence of polyunsaturated fatty acids on vasoconstrictions induced by 8-iso-PGF(2alpha) and 8-iso-PGE(2). | 2000 | Pharmacology | pmid:10754452 |
Burns T et al. | Effect of omega-3 fatty acid supplementation on the arachidonic acid:eicosapentaenoic acid ratio. | 2007 | Pharmacotherapy | pmid:17461697 |
McKenney JM and Sica D | Role of prescription omega-3 fatty acids in the treatment of hypertriglyceridemia. | 2007 | Pharmacotherapy | pmid:17461707 |
Du J et al. | Palmitic acid and docosahexaenoic acid opposingly regulate the expression of insulin-degrading enzyme in neurons. | 2010 | Pharmazie | pmid:20383947 |
Gederaas OA et al. | Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. | 2005 | Photochem. Photobiol. Sci. | pmid:15803209 |
Kello M et al. | PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT. | 2010 | Photochem. Photobiol. Sci. | pmid:20714672 |
Easley JT et al. | AT-RvD1 combined with DEX is highly effective in treating TNF-α-mediated disruption of the salivary gland epithelium. | 2016 | Physiol Rep | pmid:27694530 |
Kunesová M et al. | The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. | 2006 | Physiol Res | pmid:15857162 |
Levant B et al. | Developmental effects of dietary n-3 fatty acids on activity and response to novelty. | 2010 | Physiol. Behav. | pmid:20457171 |
Correia Bacarin C et al. | Fish oil provides robust and sustained memory recovery after cerebral ischemia: influence of treatment regimen. | 2013 | Physiol. Behav. | pmid:23770426 |
Trofimiuk E and Braszko JJ | Concomitant docosahexaenoic acid administration ameliorates stress-induced cognitive impairment in rats. | 2013 | Physiol. Behav. | pmid:23672853 |
Bandaru SS et al. | Effects of PI3K inhibition and low docosahexaenoic acid on cognition and behavior. | 2010 | Physiol. Behav. | pmid:19914265 |
Turner N et al. | Scaling of Na+,K+-ATPase molecular activity and membrane fatty acid composition in mammalian and avian hearts. | 2006 May-Jun | Physiol. Biochem. Zool. | pmid:16691518 |
Georgiadi A et al. | Detailed transcriptomics analysis of the effect of dietary fatty acids on gene expression in the heart. | 2012 | Physiol. Genomics | pmid:22274564 |
Guihéneuf F et al. | Use of radiolabeled substrates to determine the desaturase and elongase activities involved in eicosapentaenoic acid and docosahexaenoic acid biosynthesis in the marine microalga Pavlova lutheri. | 2013 | Phytochemistry | pmid:23528573 |
Mansour MP et al. | The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. | 2003 | Phytochemistry | pmid:12711135 |
Zhou XR et al. | Isolation and characterization of genes from the marine microalga Pavlova salina encoding three front-end desaturases involved in docosahexaenoic acid biosynthesis. | 2007 | Phytochemistry | pmid:17291553 |
Innis SM | Essential fatty acid transfer and fetal development. | 2005 | Placenta | pmid:15837071 |
Johnsen GM et al. | Docosahexaenoic acid stimulates tube formation in first trimester trophoblast cells, HTR8/SVneo. | 2011 | Placenta | pmid:21741084 |
Xu Y et al. | Maternal di-(2-ethylhexyl)-phthalate exposure influences essential fatty acid homeostasis in rat placenta. | 2008 | Placenta | pmid:18829104 |
Johnsen GM et al. | Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells. | 2009 | Placenta | pmid:19880178 |
Tobin KA et al. | Long-chain polyunsaturated fatty acid transport across human placental choriocarcinoma (BeWo) cells. | 2009 | Placenta | pmid:19010540 |
Serna-Saldivar SO et al. | Effect of DHA containing oils and powders on baking performance and quality of white pan bread. | 2006 | Plant Foods Hum Nutr | pmid:17031604 |
Jin F et al. | Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women. | 2012 | Plant Foods Hum Nutr | pmid:22538527 |
Metz JG et al. | Biochemical characterization of polyunsaturated fatty acid synthesis in Schizochytrium: release of the products as free fatty acids. | 2009 | Plant Physiol. Biochem. | pmid:19272783 |
Andersen MK et al. | Identification of Novel Genetic Determinants of Erythrocyte Membrane Fatty Acid Composition among Greenlanders. | 2016 | PLoS Genet. | pmid:27341449 |
Cox R et al. | Resolvins Decrease Oxidative Stress Mediated Macrophage and Epithelial Cell Interaction through Decreased Cytokine Secretion. | 2015 | PLoS ONE | pmid:26317859 |
Mirza M et al. | Progressive retinal degeneration and glial activation in the CLN6 (nclf) mouse model of neuronal ceroid lipofuscinosis: a beneficial effect of DHA and curcumin supplementation. | 2013 | PLoS ONE | pmid:24124525 |
Umhau JC et al. | Brain docosahexaenoic acid [DHA] incorporation and blood flow are increased in chronic alcoholics: a positron emission tomography study corrected for cerebral atrophy. | 2013 | PLoS ONE | pmid:24098376 |
Rahman M et al. | Docosahexaenoic acid inhibits UVB-induced activation of NF-κB and expression of COX-2 and NOX-4 in HR-1 hairless mouse skin by blocking MSK1 signaling. | 2011 | PLoS ONE | pmid:22140508 |
Renganathan K et al. | CEP biomarkers as potential tools for monitoring therapeutics. | 2013 | PLoS ONE | pmid:24098476 |
Kothapalli KS et al. | Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas. | 2007 | PLoS ONE | pmid:17426818 |
Petrie JR et al. | Metabolic engineering plant seeds with fish oil-like levels of DHA. | 2012 | PLoS ONE | pmid:23145108 |
Polavarapu S et al. | Effect of polyunsaturated fatty acids and their metabolites on bleomycin-induced cytotoxic action on human neuroblastoma cells in vitro. | 2014 | PLoS ONE | pmid:25536345 |
Wales KM et al. | N-3 PUFAs protect against aortic inflammation and oxidative stress in angiotensin II-infused apolipoprotein E-/- mice. | 2014 | PLoS ONE | pmid:25398022 |
Wang X et al. | The effect of insulin, TNFα and DHA on the proliferation, differentiation and lipolysis of preadipocytes isolated from large yellow croaker (Pseudosciaena Crocea R.). | 2012 | PLoS ONE | pmid:23110176 |
Sugasini D and Subbaiah PV | Rate of acyl migration in lysophosphatidylcholine (LPC) is dependent upon the nature of the acyl group. Greater stability of sn-2 docosahexaenoyl LPC compared to the more saturated LPC species. | 2017 | PLoS ONE | pmid:29117232 |
Eady TN et al. | Docosahexaenoic acid signaling modulates cell survival in experimental ischemic stroke penumbra and initiates long-term repair in young and aged rats. | 2012 | PLoS ONE | pmid:23118851 |
Zhu G et al. | Enhanced production of docosahexaenoic acid in mammalian cells. | 2014 | PLoS ONE | pmid:24788769 |
Martin CR et al. | Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. | 2014 | PLoS ONE | pmid:24892762 |
Nakamoto K et al. | Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice. | 2017 | PLoS ONE | pmid:28723961 |
Musto AE et al. | Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin d1. | 2015 | PLoS ONE | pmid:25617763 |
Villalpando DM et al. | Dietary docosahexaenoic acid supplementation prevents the formation of cholesterol oxidation products in arteries from orchidectomized rats. | 2017 | PLoS ONE | pmid:28968462 |
Nagai T et al. | Circulating Omega-6, But Not Omega-3 Polyunsaturated Fatty Acids, Are Associated with Clinical Outcomes in Patients with Acute Decompensated Heart Failure. | 2016 | PLoS ONE | pmid:27824904 |
Sundrani DP et al. | Matrix metalloproteinase-1 and -9 in human placenta during spontaneous vaginal delivery and caesarean sectioning in preterm pregnancy. | 2012 | PLoS ONE | pmid:22253805 |
Williams JJ et al. | N-3 fatty acid rich triglyceride emulsions are neuroprotective after cerebral hypoxic-ischemic injury in neonatal mice. | 2013 | PLoS ONE | pmid:23437099 |
Suzuki-Kemuriyama N et al. | Different Effects of Eicosapentaenoic and Docosahexaenoic Acids on Atherogenic High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice. | 2016 | PLoS ONE | pmid:27333187 |
Xue B et al. | Omega-3 polyunsaturated fatty acids antagonize macrophage inflammation via activation of AMPK/SIRT1 pathway. | 2012 | PLoS ONE | pmid:23071533 |
Kisos H et al. | Increased neuronal α-synuclein pathology associates with its accumulation in oligodendrocytes in mice modeling α-synucleinopathies. | 2012 | PLoS ONE | pmid:23077527 |
Correia M et al. | Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid. | 2013 | PLoS ONE | pmid:23577140 |
Martin N et al. | Primary human airway epithelial cell-dependent inhibition of human lung mast cell degranulation. | 2012 | PLoS ONE | pmid:22970103 |
Richardson AJ et al. | Docosahexaenoic acid for reading, cognition and behavior in children aged 7-9 years: a randomized, controlled trial (the DOLAB Study). | 2012 | PLoS ONE | pmid:22970149 |
Haas-Stapleton EJ et al. | Candida albicans modulates host defense by biosynthesizing the pro-resolving mediator resolvin E1. | 2007 | PLoS ONE | pmid:18091990 |
Amtul Z et al. | DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? | 2011 | PLoS ONE | pmid:21931647 |
Arsenault D et al. | DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice. | 2011 | PLoS ONE | pmid:21383850 |
Santos-Soto IJ et al. | Voluntary running in young adult mice reduces anxiety-like behavior and increases the accumulation of bioactive lipids in the cerebral cortex. | 2013 | PLoS ONE | pmid:24349072 |
Nakamoto K et al. | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | 2013 | PLoS ONE | pmid:24349089 |
Brouwer IA et al. | Effect of alpha linolenic acid supplementation on serum prostate specific antigen (PSA): results from the alpha omega trial. | 2013 | PLoS ONE | pmid:24349086 |
Virtanen JK et al. | Serum long-chain n-3 polyunsaturated fatty acids, mercury, and risk of sudden cardiac death in men: a prospective population-based study. | 2012 | PLoS ONE | pmid:22815906 |
Alhazzaa R et al. | Bioconversion of α-linolenic acid into n-3 long-chain polyunsaturated fatty acid in hepatocytes and ad hoc cell culture optimisation. | 2013 | PLoS ONE | pmid:24040040 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
Astarita G et al. | Deficient liver biosynthesis of docosahexaenoic acid correlates with cognitive impairment in Alzheimer's disease. | 2010 | PLoS ONE | pmid:20838618 |
Giroud S et al. | Membrane phospholipid fatty acid composition regulates cardiac SERCA activity in a hibernator, the Syrian hamster (Mesocricetus auratus). | 2013 | PLoS ONE | pmid:23650545 |
Turk HF et al. | Alteration of EGFR spatiotemporal dynamics suppresses signal transduction. | 2012 | PLoS ONE | pmid:22761867 |
Baselga-Escudero L et al. | Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats. | 2013 | PLoS ONE | pmid:23922812 |
Khairallah RJ et al. | Improved mitochondrial function with diet-induced increase in either docosahexaenoic acid or arachidonic acid in membrane phospholipids. | 2012 | PLoS ONE | pmid:22479624 |
Fecchio C et al. | α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. | 2013 | PLoS ONE | pmid:24312431 |
Kang KS et al. | Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. | 2010 | PLoS ONE | pmid:20421971 |
de Goede J et al. | Gender-specific associations of marine n-3 fatty acids and fish consumption with 10-year incidence of stroke. | 2012 | PLoS ONE | pmid:22496770 |
Kjær MA et al. | Regulation of the Omega-3 Fatty Acid Biosynthetic Pathway in Atlantic Salmon Hepatocytes. | 2016 | PLoS ONE | pmid:27973547 |
Ishikado A et al. | 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation. | 2013 | PLoS ONE | pmid:23936010 |
Nuez-OrtÃn WG et al. | Preliminary Validation of a High Docosahexaenoic Acid (DHA) and -Linolenic Acid (ALA) Dietary Oil Blend: Tissue Fatty Acid Composition and Liver Proteome Response in Atlantic Salmon (Salmo salar) Smolts. | 2016 | PLoS ONE | pmid:27556399 |
Derogis PB et al. | The development of a specific and sensitive LC-MS-based method for the detection and quantification of hydroperoxy- and hydroxydocosahexaenoic acids as a tool for lipidomic analysis. | 2013 | PLoS ONE | pmid:24204871 |
Sublimi Saponetti M et al. | Aggregation of Aß(25-35) on DOPC and DOPC/DHA bilayers: an atomic force microscopy study. | 2014 | PLoS ONE | pmid:25551704 |
Alsharari ZD et al. | Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women. | 2017 | PLoS ONE | pmid:28125662 |
Khaddaj-Mallat R et al. | Pro-Resolving Effects of Resolvin D2 in LTD4 and TNF-α Pre-Treated Human Bronchi. | 2016 | PLoS ONE | pmid:27935998 |
Gladine C et al. | Lipid profiling following intake of the omega 3 fatty acid DHA identifies the peroxidized metabolites F4-neuroprostanes as the best predictors of atherosclerosis prevention. | 2014 | PLoS ONE | pmid:24558496 |
Rossmeisl M et al. | Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids. | 2012 | PLoS ONE | pmid:22701720 |
Park J et al. | Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. | 2014 | PLoS ONE | pmid:24465474 |
Xiao G et al. | Eicosapentaenoic acid enhances heat stress-impaired intestinal epithelial barrier function in Caco-2 cells. | 2013 | PLoS ONE | pmid:24066055 |
Lachance C et al. | Fenretinide corrects the imbalance between omega-6 to omega-3 polyunsaturated fatty acids and inhibits macrophage inflammatory mediators via the ERK pathway. | 2013 | PLoS ONE | pmid:24069363 |
Bahety P et al. | Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. | 2014 | PLoS ONE | pmid:24587236 |
Mansara PP et al. | Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. | 2015 | PLoS ONE | pmid:26325577 |
Mottola G et al. | Aspirin-triggered resolvin D1 attenuates PDGF-induced vascular smooth muscle cell migration via the cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) pathway. | 2017 | PLoS ONE | pmid:28362840 |
Eickmeier O et al. | Pro-resolving lipid mediator Resolvin D1 serves as a marker of lung disease in cystic fibrosis. | 2017 | PLoS ONE | pmid:28158236 |
Correia M et al. | Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization. | 2012 | PLoS ONE | pmid:22529974 |