Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Sparreboom A et al. | Disposition of docosahexaenoic acid-paclitaxel, a novel taxane, in blood: in vitro and clinical pharmacokinetic studies. | 2003 | Clin. Cancer Res. | pmid:12538463 |
Kielar ML et al. | Docosahexaenoic acid ameliorates murine ischemic acute renal failure and prevents increases in mRNA abundance for both TNF-alpha and inducible nitric oxide synthase. | 2003 | J. Am. Soc. Nephrol. | pmid:12538739 |
Lemaitre RN et al. | n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study. | 2003 | Am. J. Clin. Nutr. | pmid:12540389 |
Innis SM and Elias SL | Intakes of essential n-6 and n-3 polyunsaturated fatty acids among pregnant Canadian women. | 2003 | Am. J. Clin. Nutr. | pmid:12540410 |
Bakker EC et al. | Long-chain polyunsaturated fatty acids at birth and cognitive function at 7 y of age. | 2003 | Eur J Clin Nutr | pmid:12548302 |
De Vizia B et al. | Effect of an 8-month treatment with omega-3 fatty acids (eicosapentaenoic and docosahexaenoic) in patients with cystic fibrosis. | 2003 Jan-Feb | JPEN J Parenter Enteral Nutr | pmid:12549599 |
Huang H and Bao S | [Studies on production of docosahexaenoic acid by Thraustochytrium aureum]. | 2002 | Wei Sheng Wu Xue Bao | pmid:12557559 |
Howe PR et al. | Tuna fishmeal as a source of DHA for n-3 PUFA enrichment of pork, chicken, and eggs. | 2002 | Lipids | pmid:12558057 |
Kubo K et al. | Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation. | 2003 | Arch. Biochem. Biophys. | pmid:12559986 |
Chiu CC et al. | Omega-3 fatty acids for depression in pregnancy. | 2003 | Am J Psychiatry | pmid:12562593 |
Montine TJ et al. | Antioxidants significantly affect the formation of different classes of isoprostanes and neuroprostanes in rat cerebral synaptosomes. | 2003 | Biochem. Pharmacol. | pmid:12566089 |
Saito M and Kubo K | Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. | 2003 | Br. J. Nutr. | pmid:12568661 |
Ait-Said F et al. | Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. | 2003 | Biochim. Biophys. Acta | pmid:12573452 |
Takeuchi T et al. | Possible regulatory mechanism of DHA-induced anti-stress reaction in rats. | 2003 | Brain Res. | pmid:12573522 |
Berstad P et al. | Supplementation with fish oil affects the association between very long-chain n-3 polyunsaturated fatty acids in serum non-esterified fatty acids and soluble vascular cell adhesion molecule-1. | 2003 | Clin. Sci. | pmid:12589702 |
Hong S et al. | Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation. | 2003 | J. Biol. Chem. | pmid:12590139 |
Kurowska EM et al. | Bioavailability of omega-3 essential fatty acids from perilla seed oil. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591004 |
Usami M et al. | Effect of gamma-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation. | 2003 | Nutrition | pmid:12591548 |
Araseki M et al. | Oxidative stability of polyunsaturated fatty acid in phosphatidylcholine liposomes. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596850 |
Aoki H et al. | Incorporation and accumulation of docosahexaenoic acid from the medium by Pichia methanolica HA-32. | 2002 | Biosci. Biotechnol. Biochem. | pmid:12596859 |
McFadyen M et al. | Maternal and umbilical cord erythrocyte omega-3 and omega-6 fatty acids and haemorheology in singleton and twin pregnancies. | 2003 | Arch. Dis. Child. Fetal Neonatal Ed. | pmid:12598503 |
Terry PD et al. | Intakes of fish and marine fatty acids and the risks of cancers of the breast and prostate and of other hormone-related cancers: a review of the epidemiologic evidence. | 2003 | Am. J. Clin. Nutr. | pmid:12600840 |
Akimoto M et al. | Lipase-catalyzed interesterification of soybean oil with an omega-3 polyunsaturated fatty acid concentrate prepared from sardine oil. | 2003 | Appl. Biochem. Biotechnol. | pmid:12603099 |
Sturlan S et al. | Docosahexaenoic acid enhances arsenic trioxide-mediated apoptosis in arsenic trioxide-resistant HL-60 cells. | 2003 | Blood | pmid:12609832 |
Hibbeln JR et al. | Smoking, gender, and dietary influences on erythrocyte essential fatty acid composition among patients with schizophrenia or schizoaffective disorder. | 2003 | Biol. Psychiatry | pmid:12614996 |
Mayer K et al. | Parenteral nutrition with fish oil modulates cytokine response in patients with sepsis. | 2003 | Am. J. Respir. Crit. Care Med. | pmid:12615625 |
Narayanan BA et al. | Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega-3 fatty acid docosahexaenoic acid in human colon cancer cells. | 2003 | Cancer Res. | pmid:12615711 |
[Sudden cardiac death. Targets every 2nd person without warning]. | 2003 | MMW Fortschr Med | pmid:12619216 | |
Suresh Y and Das UN | Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. | 2003 | Nutrition | pmid:12620523 |
Chen WJ and Yeh SL | Effects of fish oil in parenteral nutrition. | 2003 | Nutrition | pmid:12620534 |
Engler MM et al. | Effects of docosahexaenoic acid on vascular pathology and reactivity in hypertension. | 2003 | Exp. Biol. Med. (Maywood) | pmid:12626775 |
Itoh Y et al. | Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. | 2003 | Nature | pmid:12629551 |
Smuts CM et al. | A randomized trial of docosahexaenoic acid supplementation during the third trimester of pregnancy. | 2003 | Obstet Gynecol | pmid:12636950 |
Houston KD et al. | Inhibition of proliferation and estrogen receptor signaling by peroxisome proliferator-activated receptor gamma ligands in uterine leiomyoma. | 2003 | Cancer Res. | pmid:12649180 |
Fischler L et al. | Influence of a parenteral fish-oil preparation (Omegaven) on erythrocyte morphology and blood viscosity in vitro. | 2003 | Clin. Hemorheol. Microcirc. | pmid:12652013 |
Tanaka T et al. | Mechanisms of accumulation of arachidonate in phosphatidylinositol in yellowtail. A comparative study of acylation systems of phospholipids in rat and the fish species Seriola quinqueradiata. | 2003 | Eur. J. Biochem. | pmid:12654002 |
Tully AM et al. | Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study. | 2003 | Br. J. Nutr. | pmid:12654166 |
Okada M et al. | How does prolonged caloric restriction ameliorate age-related impairment of long-term potentiation in the hippocampus? | 2003 | Brain Res. Mol. Brain Res. | pmid:12654517 |
de Swaaf ME et al. | Fed-batch cultivation of the docosahexaenoic-acid-producing marine alga Crypthecodinium cohnii on ethanol. | 2003 | Appl. Microbiol. Biotechnol. | pmid:12658513 |
Nesbitt GH et al. | Effect of n-3 fatty acid ratio and dose on clinical manifestations, plasma fatty acids and inflammatory mediators in dogs with pruritus. | 2003 | Vet. Dermatol. | pmid:12662263 |
Abril R et al. | Safety assessment of DHA-rich microalgae from Schizochytrium sp. Part V: target animal safety/toxicity study in growing swine. | 2003 | Regul. Toxicol. Pharmacol. | pmid:12662911 |
Finnegan YE et al. | Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. | 2003 | Am. J. Clin. Nutr. | pmid:12663273 |
Djoussé L et al. | Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. | 2003 | Am. J. Clin. Nutr. | pmid:12663278 |
Reich EE et al. | Formation of novel D-ring and E-ring isoprostane-like compounds (D4/E4-neuroprostanes) in vivo from docosahexaenoic acid. | 2002 | Adv. Exp. Med. Biol. | pmid:12664634 |
Youssef J et al. | Pantothenic acid: an organ-specific pro-oxidant vitamin. Brain and liver neuroprostane levels in rats fed a pantothenic acid-deficient diet. | 2002 | Adv. Exp. Med. Biol. | pmid:12664639 |
Meireles LA et al. | Lipid class composition of the microalga Pavlova lutheri: eicosapentaenoic and docosahexaenoic acids. | 2003 | J. Agric. Food Chem. | pmid:12670163 |
Koo WW | Efficacy and safety of docosahexaenoic acid and arachidonic acid addition to infant formulas: can one buy better vision and intelligence? | 2003 | J Am Coll Nutr | pmid:12672705 |
Wu FC et al. | Dietary docosahexaenoic acid is more optimal than eicosapentaenoic acid affecting the level of cellular defence responses of the juvenile grouper Epinephelus malabaricus. | 2003 | Fish Shellfish Immunol. | pmid:12681278 |
Komatsu W et al. | Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress. | 2003 | Free Radic. Biol. Med. | pmid:12684085 |
[Additional omega-3-fatty acids. Infarct mortality gets reduced]. | 2003 | MMW Fortschr Med | pmid:12688033 | |
Wright TC et al. | Effect of combinations of fish meal and feather meal on milk fatty acid content and nitrogen utilization in dairy cows. | 2003 | J. Dairy Sci. | pmid:12703623 |
Mansour MP et al. | The effect of growth phase on the lipid class, fatty acid and sterol composition in the marine dinoflagellate, Gymnodinium sp. in batch culture. | 2003 | Phytochemistry | pmid:12711135 |
Horrobin D et al. | The effects on plasma, red cell and platelet fatty acids of taking 12 g/day of ethyl-eicosapentaenoate for 16 months: dihomogammalinolenic, arachidonic and docosahexaenoic acids and relevance to Inuit metabolism. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12711245 |
Pass the fish (oil capsules), please. Following the latest recommendations from the American Heart Association may mean reaching for fish oil supplements. | 2003 | Harv Heart Lett | pmid:12711572 | |
Insua MF et al. | Cell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714666 |
Rotstein NP et al. | Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12714668 |
James MJ et al. | Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids. | 2003 | Am. J. Clin. Nutr. | pmid:12716664 |
Kew S et al. | Lack of effect of foods enriched with plant- or marine-derived n-3 fatty acids on human immune function. | 2003 | Am. J. Clin. Nutr. | pmid:12716684 |
Wallace FA et al. | Comparison of the effects of linseed oil and different doses of fish oil on mononuclear cell function in healthy human subjects. | 2003 | Br. J. Nutr. | pmid:12720588 |
Mattos R et al. | Polyunsaturated fatty acids and bovine interferon-tau modify phorbol ester-induced secretion of prostaglandin F2 alpha and expression of prostaglandin endoperoxide synthase-2 and phospholipase-A2 in bovine endometrial cells. | 2003 | Biol. Reprod. | pmid:12724278 |
Li H et al. | [Effect of fish oil supplementation on fatty acid composition and neurotransmitters of growing rats]. | 2000 | Wei Sheng Yan Jiu | pmid:12725043 |
Marangell LB et al. | A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression. | 2003 | Am J Psychiatry | pmid:12727707 |
Inagaki K et al. | Evidence of isozymes for delta6 fatty acid desaturase in rat hepatocytes. | 2003 | Biosci. Biotechnol. Biochem. | pmid:12729021 |
Berry CB and McBean GJ | An investigation into the role of calcium in the modulation of rat synaptosomal D-[3H]aspartate transport by docosahexaenoic acid. | 2003 | Brain Res. | pmid:12729959 |
Thorpe M | Infant formula supplemented with DHA: are there benefits? | 2003 | J Am Diet Assoc | pmid:12733531 |
Sumino H et al. | Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. | 2003 | Endocr. J. | pmid:12733709 |
Cha MC et al. | Dietary docosahexaenoic acid levels influence the outcome of arabinosylcytosine chemotherapy in L1210 leukemic mice. | 2002 | Nutr Cancer | pmid:12734065 |
Sarkadi-Nagy E et al. | The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissues. | 2003 | Pediatr. Res. | pmid:12736388 |
Gu X et al. | Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and Peptide adduction chemistry. | 2003 | J. Org. Chem. | pmid:12737551 |
Merritt RJ et al. | Safety evaluation of sources of docosahexaenoic acid and arachidonic acid for use in infant formulas in newborn piglets. | 2003 | Food Chem. Toxicol. | pmid:12738195 |
Mashek DG and Grummer RR | Short communication: Net uptake of nonesterified long chain fatty acids by the perfused caudate lobe of the caprine liver. | 2003 | J. Dairy Sci. | pmid:12741546 |
Almansa E et al. | Temperature-activity relationship for the intestinal Na+-K+-ATPase of Sparus aurata. A role for the phospholipid microenvironment? | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12743726 |
Armstrong VT et al. | Rapid flip-flop in polyunsaturated (docosahexaenoate) phospholipid membranes. | 2003 | Arch. Biochem. Biophys. | pmid:12745257 |
Llorente AM et al. | Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. | 2003 | Am. J. Obstet. Gynecol. | pmid:12748510 |
Sano Y et al. | A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. | 2003 | J. Biol. Chem. | pmid:12754259 |
Yusufi AN et al. | Differential effects of low-dose docosahexaenoic acid and eicosapentaenoic acid on the regulation of mitogenic signaling pathways in mesangial cells. | 2003 | J. Lab. Clin. Med. | pmid:12761475 |
de Swaaf ME et al. | Analysis of docosahexaenoic acid biosynthesis in Crypthecodinium cohnii by 13C labelling and desaturase inhibitor experiments. | 2003 | J. Biotechnol. | pmid:12770501 |
Harel M and Place AR | Tissue essential fatty acid composition and competitive response to dietary manipulations in white bass (Morone chrysops), striped bass (M. saxatilis) and hybrid striped bass (M. chrysopsxM. saxatilis). | 2003 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:12781976 |
Barceló-Coblijn G et al. | Gene expression and molecular composition of phospholipids in rat brain in relation to dietary n-6 to n-3 fatty acid ratio. | 2003 | Biochim. Biophys. Acta | pmid:12782153 |
Beck S et al. | Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | 2003 | J. Biol. Chem. | pmid:12782627 |
Torres CF et al. | Lipase-catalyzed ethanolysis of fish oils: multi-response kinetics. | 2003 | Biotechnol. Bioeng. | pmid:12783483 |
Eldho NV et al. | Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond. | 2003 | J. Am. Chem. Soc. | pmid:12785780 |
Youssef JA et al. | Age-independent, gray matter-localized, brain-enhanced oxidative stress in male fischer 344 rats: brain levels of F(2)-isoprostanes and F(4)-neuroprostanes. | 2003 | Free Radic. Biol. Med. | pmid:12788483 |
Del Castillo IC et al. | Docosahexaenoic acid selectively augments muscarinic stimulation of epithelial Cl- secretion. | 2003 | J. Surg. Res. | pmid:12788663 |
Rodriguez A et al. | Preterm infant formula supplementation with alpha linolenic acid and docosahexaenoic acid. | 2003 | Eur J Clin Nutr | pmid:12792656 |
pmid:12794672 | ||||
Clements KM et al. | Spontaneously hypertensive and Wistar Kyoto rats differ in delayed matching-to-place performance and response to dietary long-chain polyunsaturated fatty acids. | 2003 | Dev Psychobiol | pmid:12794779 |
Hulbert AJ | Life, death and membrane bilayers. | 2003 | J. Exp. Biol. | pmid:12796449 |
Ng R | Fish oil therapy in recurrent IgA nephropathy. | 2003 | Ann. Intern. Med. | pmid:12809474 |
Wang Z | Role of redox state in modulation of ion channel function by fatty acids and phospholipids. | 2003 | Br. J. Pharmacol. | pmid:12812990 |
Judé S et al. | Peroxidation of docosahexaenoic acid is responsible for its effects on I TO and I SS in rat ventricular myocytes. | 2003 | Br. J. Pharmacol. | pmid:12813005 |
Erkkilä AT et al. | n-3 Fatty acids and 5-y risks of death and cardiovascular disease events in patients with coronary artery disease. | 2003 | Am. J. Clin. Nutr. | pmid:12816772 |
Chen H et al. | EPA and DHA attenuate ox-LDL-induced expression of adhesion molecules in human coronary artery endothelial cells via protein kinase B pathway. | 2003 | J. Mol. Cell. Cardiol. | pmid:12818567 |
Rojas CV et al. | Gene expression analysis in human fetal retinal explants treated with docosahexaenoic acid. | 2003 | Invest. Ophthalmol. Vis. Sci. | pmid:12824268 |
Qian SY et al. | Identification of spin trapped carbon-centered radicals in soybean lipoxygenase-dependent peroxidations of omega-3 polyunsaturated fatty acids by LC/ESR, LC/MS, and tandem MS. | 2003 | Free Radic. Biol. Med. | pmid:12826254 |
Speake BK et al. | Distribution of lipids from the yolk to the tissues during development of the water python (Liasis fuscus). | 2003 | J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol. | pmid:12827419 |
Högyes E et al. | Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. | 2003 | Neuroscience | pmid:12831859 |
Hoffman DR et al. | Visual function in breast-fed term infants weaned to formula with or without long-chain polyunsaturates at 4 to 6 months: a randomized clinical trial. | 2003 | J. Pediatr. | pmid:12838196 |
Strokin M et al. | Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. | 2003 | Br. J. Pharmacol. | pmid:12839876 |
Montgomery C et al. | Maternal docosahexaenoic acid supplementation and fetal accretion. | 2003 | Br. J. Nutr. | pmid:12844385 |