Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hsiao HM et al. | A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. | 2013 | PLoS ONE | pmid:23484005 |
Bazan NG | The docosanoid neuroprotectin D1 induces homeostatic regulation of neuroinflammation and cell survival. | 2013 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:23022417 |
Barros KV et al. | Supplemental intravenous n-3 fatty acids and n-3 fatty acid status and outcome in critically ill elderly patients in the ICU receiving enteral nutrition. | 2013 | Clin Nutr | pmid:23260750 |
Kennedy DO | Reply to MP Pase and C Stough. | 2013 | Am. J. Clin. Nutr. | pmid:24027792 |
Bohr S et al. | Resolvin D2 prevents secondary thrombosis and necrosis in a mouse burn wound model. | 2013 Jan-Feb | Wound Repair Regen | pmid:23110665 |
Piñeiro-Corrales G et al. | [Role of omega-3 fatty acids in cardiovascular disease prevention]. | 2013 Jan-Feb | Nutr Hosp | pmid:23808424 |
Zajdel A et al. | Polyunsaturated fatty acids inhibit melanoma cell growth in vitro. | 2013 Mar-Apr | Acta Pol Pharm | pmid:23614295 |
Docosahexaenoic and arachidonic acid levels in ELBW infants with prolonged exposure to intravenous lipids. | 2013 May-Jun | Neonatal Netw | pmid:23807965 | |
Tatsuno I et al. | Efficacy and safety of TAK-085 compared with eicosapentaenoic acid in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized double-blind (ORD) study. | 2013 May-Jun | J Clin Lipidol | pmid:23725919 |
Nishimura RY et al. | Breast milk fatty acid composition of women living far from the coastal area in Brazil. | 2013 May-Jun | J Pediatr (Rio J) | pmid:23669215 |
Tatsuno I et al. | Long-term safety and efficacy of TAK-085 in Japanese subjects with hypertriglyceridemia undergoing lifestyle modification: the omega-3 fatty acids randomized long-term (ORL) study. | 2013 Nov-Dec | J Clin Lipidol | pmid:24314359 |
Igarashi M et al. | Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24209500 |
Fenton JI et al. | Immunomodulation by dietary long chain omega-3 fatty acids and the potential for adverse health outcomes. | 2013 Nov-Dec | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24183073 |
Hernández E et al. | Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. | 2013 Sep-Oct | Allergy Asthma Proc | pmid:23998234 |
Harris WS et al. | Comparative effects of an acute dose of fish oil on omega-3 fatty acid levels in red blood cells versus plasma: implications for clinical utility. | 2013 Sep-Oct | J Clin Lipidol | pmid:24079284 |
Lagarde M et al. | Structure-function relationships of non-cyclic dioxygenase products from polyunsaturated fatty acids: poxytrins as a class of bioactive derivatives. | 2014 | Biochimie | pmid:25223888 |
Metcalf RG et al. | U-shaped relationship between tissue docosahexaenoic acid and atrial fibrillation following cardiac surgery. | 2014 | Eur J Clin Nutr | pmid:24169465 |
Chatterjee A et al. | The pro-resolving lipid mediator maresin 1 (MaR1) attenuates inflammatory signaling pathways in vascular smooth muscle and endothelial cells. | 2014 | PLoS ONE | pmid:25409514 |
Gong J et al. | Maresin 1 mitigates LPS-induced acute lung injury in mice. | 2014 | Br. J. Pharmacol. | pmid:24697684 |
Abe E et al. | Novel lysophospholipid acyltransferase PLAT1 of Aurantiochytrium limacinum F26-b responsible for generation of palmitate-docosahexaenoate-phosphatidylcholine and phosphatidylethanolamine. | 2014 | PLoS ONE | pmid:25090090 |
Li S et al. | The targeting mechanism of DHA ligand and its conjugate with Gemcitabine for the enhanced tumor therapy. | 2014 | Oncotarget | pmid:25004114 |
Arafiles KH et al. | Value-added lipid production from brown seaweed biomass by two-stage fermentation using acetic acid bacterium and thraustochytrid. | 2014 | Appl. Microbiol. Biotechnol. | pmid:25086614 |
Lane K et al. | Bioavailability and potential uses of vegetarian sources of omega-3 fatty acids: a review of the literature. | 2014 | Crit Rev Food Sci Nutr | pmid:24261532 |
Saito H and Ishikawa S | Lipid classes and fatty acid profile of cultured and wild black rockfish, Sebastes schlegeli. | 2014 | J Oleo Sci | pmid:24829130 |
Koutsos A et al. | Greater impact of dietary fat manipulation than apolipoprotein E genotype on ex vivo cytokine production - insights from the SATgenε study. | 2014 | Cytokine | pmid:24485322 |
Di Gregorio E et al. | ELOVL5 mutations cause spinocerebellar ataxia 38. | 2014 | Am. J. Hum. Genet. | pmid:25065913 |
Aslan M et al. | A pilot study investigating early postoperative changes of plasma polyunsaturated fatty acids after laparoscopic sleeve gastrectomy. | 2014 | Lipids Health Dis | pmid:24694037 |
Gregory MK and James MJ | Functional characterization of the duck and turkey fatty acyl elongase enzymes ELOVL5 and ELOVL2. | 2014 | J. Nutr. | pmid:24919687 |
Norris JM et al. | Erythrocyte membrane docosapentaenoic acid levels are associated with islet autoimmunity: the Diabetes Autoimmunity Study in the Young. | 2014 | Diabetologia | pmid:24240437 |
Nakagawa F et al. | 4-Hydroxy hexenal derived from dietary n-3 polyunsaturated fatty acids induces anti-oxidative enzyme heme oxygenase-1 in multiple organs. | 2014 | Biochem. Biophys. Res. Commun. | pmid:24361890 |
Yamanushi TT et al. | Oral administration of eicosapentaenoic acid or docosahexaenoic acid modifies cardiac function and ameliorates congestive heart failure in male rats. | 2014 | J. Nutr. | pmid:24523492 |
Meagher KA et al. | Regarding macular xanthophylls and ω-3 long-chain polyunsaturated fatty acids in age-related macular degeneration. | 2014 | JAMA Ophthalmol | pmid:24525935 |
Sánchez-Reyes OB et al. | Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation. | 2014 | Eur. J. Pharmacol. | pmid:24239485 |
Li X et al. | Production of structured phosphatidylcholine with high content of DHA/EPA by immobilized phospholipase Aâ‚-catalyzed transesterification. | 2014 | Int J Mol Sci | pmid:25170810 |
AlSaleh A et al. | Interaction between a CSK gene variant and fish oil intake influences blood pressure in healthy adults. | 2014 | J. Nutr. | pmid:24401815 |
Paterniti I et al. | Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. | 2014 | J Neuroinflammation | pmid:24405628 |
Chen J et al. | Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury. | 2014 | Toxicol. Appl. Pharmacol. | pmid:24709673 |
Recchiuti A et al. | Immunoresolving actions of oral resolvin D1 include selective regulation of the transcription machinery in resolution-phase mouse macrophages. | 2014 | FASEB J. | pmid:24692596 |
Létondor A et al. | Erythrocyte DHA level as a biomarker of DHA status in specific brain regions of n-3 long-chain PUFA-supplemented aged rats. | 2014 | Br. J. Nutr. | pmid:25331622 |
Kermack AJ et al. | A randomised controlled trial of a preconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). | 2014 | BMC Womens Health | pmid:25407227 |
Wang JL et al. | Preparation and characterization of novel lipid carriers containing microalgae oil for food applications. | 2014 | J. Food Sci. | pmid:24446860 |
Giovannelli J et al. | Validation of a short, qualitative food frequency questionnaire in French adults participating in the MONA LISA-NUT study 2005-2007. | 2014 | J Acad Nutr Diet | pmid:24083967 |
Chang G et al. | The relationship of oxygen uptake rate and k(L)a with rheological properties in high cell density cultivation of docosahexaenoic acid by Schizochytrium sp. S31. | 2014 | Bioresour. Technol. | pmid:24292203 |
Zhang B et al. | Polyunsaturated fatty acids for the prevention of atrial fibrillation after cardiac surgery: an updated meta-analysis of randomized controlled trials. | 2014 | J Cardiol | pmid:23911138 |
Rius B et al. | Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis. | 2014 | FASEB J. | pmid:24249635 |
Choi EY et al. | DHA suppresses Prevotella intermedia lipopolysaccharide-induced production of proinflammatory mediators in murine macrophages. | 2014 | Br. J. Nutr. | pmid:24252501 |
Ponnampalam EN et al. | Sources of variation of health claimable long chain omega-3 fatty acids in meat from Australian lamb slaughtered at similar weights. | 2014 | Meat Sci. | pmid:23265412 |
de Waal H et al. | The effect of souvenaid on functional brain network organisation in patients with mild Alzheimer's disease: a randomised controlled study. | 2014 | PLoS ONE | pmid:24475144 |
Desai A et al. | Depletion of brain docosahexaenoic acid impairs recovery from traumatic brain injury. | 2014 | PLoS ONE | pmid:24475126 |
Amiri-Jami M et al. | Engineering of EPA/DHA omega-3 fatty acid production by Lactococcus lactis subsp. cremoris MG1363. | 2014 | Appl. Microbiol. Biotechnol. | pmid:24389665 |