Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hsia JC et al. | alpha-fetoprotein binding specificity for arachidonate, bilirubin, docosahexaenoate, and palmitate. A spin label study. | 1980 | J. Biol. Chem. | pmid:6154708 |
Iritani N et al. | Identification of shellfish fatty acids and their effects on lipogenic enzymes. | 1980 | Biochim. Biophys. Acta | pmid:6104986 |
Castledine AJ and Buckley JT | Distribution and mobility of omega 3 fatty acids in rainbow trout fed varying levels and types of dietary lipid. | 1980 | J. Nutr. | pmid:6445002 |
Giesing M and Zilliken F | Lipid metabolism of developing central nervous tissues in organotypic cultures. III. Ganglionic control of glycerolipids and fatty acids in cortex grey matter. | 1980 | Neurochem. Res. | pmid:6445512 |
Sanders TA and Naismith DJ | The metabolism of alpha-linolenic acid by the foetal rat. | 1980 | Br. J. Nutr. | pmid:6448628 |
Boeynaems JM et al. | Iodination of docosahexaenoic acid by lactoperoxidase and thyroid gland in vitro: formation of an lodolactone. | 1981 | Lipids | pmid:6153054 |
Sanders TA et al. | Effect on blood lipids and haemostasis of a supplement of cod-liver oil, rich in eicosapentaenoic and docosahexaenoic acids, in healthy young men. | 1981 | Clin. Sci. | pmid:6266735 |
Mai J et al. | A new prostaglandin, C22-PGF4 alpha, synthesized from docosahexaenoic acid (C22:6n3) by trout gill. | 1981 | Prostaglandins | pmid:6280241 |
Nissen HP et al. | [Significance of bound fatty acids in human sperm in fertility disorders]. | 1981 Sep-Oct | Andrologia | pmid:6459043 |
De Schrijver R and Privett OS | Effects of dietary long-chain fatty acids on the rat biosynthesis of unsaturated fatty acids in the rat. | 1982 | J. Nutr. | pmid:6279803 |
Nagai M et al. | The fatty acid levels of rat alpha-fetoprotein derived from fetuses, pregnancy and hepatoma sera. | 1982 | Oncodev. Biol. Med. | pmid:6183647 |
Guffy MM et al. | Effect of cellular fatty acid alteration on hyperthermic sensitivity in cultured L1210 murine leukemia cells. | 1982 | Cancer Res. | pmid:6213296 |
Talesnik J and Hsia JC | Coronary flow reactions to arachidonic acid are inhibited by docosahexaenoic acid. | 1982 | Eur. J. Pharmacol. | pmid:6213418 |
Mooibroek J et al. | Comparison of the radiosensitivity of unsaturated fatty acids, structured as micelles or liposomes, under different experimental conditions. | 1982 | Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. | pmid:6219072 |
Bazan NG | Metabolism of phospholipids in the retina. | 1982 | Vision Res. | pmid:6305026 |
Armstrong D et al. | Studies on experimentally induced retinal degeneration. 1. Effect of lipid peroxides on electroretinographic activity in the albino rabbit. | 1982 | Exp. Eye Res. | pmid:7151884 |
Bazan NG et al. | High content of 22:6 (docosahexaenoate) and active [2-3H]glycerol metabolism of phosphatidic acid from photoreceptor membranes. | 1982 | Biochim. Biophys. Acta | pmid:6215065 |
Organisciak DT et al. | Rod outer segment lipid--opsin ratios in the developing normal and retinal dystrophic rat. | 1982 | Exp. Eye Res. | pmid:6461559 |
Studies of docosahexaenoic and eicosapentaenoic acids in trout and frogs. | 1982 | Nutr. Rev. | pmid:6289203 | |
Aveldaño MI and Sprecher H | Synthesis of hydroxy fatty acids from 4, 7, 10, 13, 16, 19-[1-14C] docosahexaenoic acid by human platelets. | 1983 | J. Biol. Chem. | pmid:6223928 |
Rao GH et al. | Effect of docosahexaenoic acid (DHA) on arachidonic acid metabolism and platelet function. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6229254 |
Sanders TA and Roshanai F | The influence of different types of omega 3 polyunsaturated fatty acids on blood lipids and platelet function in healthy volunteers. | 1983 | Clin. Sci. | pmid:6295686 |
Corey EJ et al. | Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. | 1983 | Proc. Natl. Acad. Sci. U.S.A. | pmid:6304720 |
Morisaki N et al. | In vivo effects of cis-5,8,11,14,17-20:5 (n-3) and cis-4,7,10,13,16,19-22:6(n-3) on serum lipoproteins, platelet aggregation, and lipid metabolism in the aorta of rats. | 1983 | Tohoku J. Exp. Med. | pmid:6322383 |
Sanders TA et al. | The influence of a maternal diet rich in linoleic acid on brain and retinal docosahexaenoic acid in the rat. | 1984 | Br. J. Nutr. | pmid:6228249 |
Onuma Y et al. | Selective incorporation of docosahexaenoic acid in rat brain. | 1984 | Biochim. Biophys. Acta | pmid:6231055 |
Ishii H et al. | The effect of plasma on platelet function in hypercholesterolemic rabbits and the changes in fatty acid composition of the plasma. | 1984 | Thromb. Res. | pmid:6234679 |
Sanders TA | Dietary polyunsaturated fatty acids and health. | 1984 | Br J Clin Pract Suppl | pmid:6091718 |
Bazan HE et al. | De novo biosynthesis of docosahexaenoyl-phosphatidic acid in bovine retinal microsomes. | 1984 | Biochim. Biophys. Acta | pmid:6091768 |
Kobatake Y et al. | Differential effects of dietary eicosapentaenoic and docosahexaenoic fatty acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. | 1984 | J. Nutr. Sci. Vitaminol. | pmid:6096527 |
Singer P et al. | Clinical studies on lipid and blood pressure lowering effect of eicosa-pentaenoic acid-rich diet. | 1984 | Biomed. Biochim. Acta | pmid:6097237 |
Guffy MM et al. | Effect of cellular fatty acid alteration on adriamycin sensitivity in cultured L1210 murine leukemia cells. | 1984 | Cancer Res. | pmid:6231987 |
Goosey JD et al. | A lipid peroxidative mechanism for posterior subcapsular cataract formation in the rabbit: a possible model for cataract formation in tapetoretinal diseases. | 1984 | Invest. Ophthalmol. Vis. Sci. | pmid:6232239 |
VanRollins M et al. | Oxidation of docosahexaenoic acid by rat liver microsomes. | 1984 | J. Biol. Chem. | pmid:6232277 |
VanRollins M and Murphy RC | Autooxidation of docosahexaenoic acid: analysis of ten isomers of hydroxydocosahexaenoate. | 1984 | J. Lipid Res. | pmid:6234372 |
Harris WS et al. | Will dietary omega-3 fatty acids change the composition of human milk? | 1984 | Am. J. Clin. Nutr. | pmid:6237575 |
Reddy TS et al. | Long-chain acyl-coenzyme A synthetase from rat brain microsomes. Kinetic studies using [1-14C]docosahexaenoic acid substrate. | 1984 | Eur. J. Biochem. | pmid:6237910 |
Bazan NG et al. | Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6240268 |
Karmali RA et al. | Effect of omega-3 fatty acids on growth of a rat mammary tumor. | 1984 | J. Natl. Cancer Inst. | pmid:6087007 |
Neuringer M et al. | Dietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys. | 1984 | J. Clin. Invest. | pmid:6317716 |
Bruckner GG et al. | Biosynthesis of prostanoids, tissue fatty acid composition and thrombotic parameters in rats fed diets enriched with docosahexaenoic (22:6n3) or eicosapentaenoic (20:5n3) acids. | 1984 | Thromb. Res. | pmid:6330927 |
Yorek MA et al. | Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. | 1984 | Biochim. Biophys. Acta | pmid:6089899 |
Bhakoo KK et al. | Regional studies of changes in brain fatty acids following experimental ischaemia and reperfusion in the gerbil. | 1984 | J. Neurochem. | pmid:6236282 |
Fogerty AC et al. | Liver fatty acids and the sudden infant death syndrome. | 1984 | Am. J. Clin. Nutr. | pmid:6230001 |
Fischer S et al. | Uptake, release and metabolism of docosahexaenoic acid (DHA, c22:6 omega 3) in human platelets and neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329189 |
Lee TH et al. | Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. | 1984 | J. Clin. Invest. | pmid:6096400 |
Cendrowski W | [MaxEpa in multiple sclerosis]. | 1985 | Wiad. Lek. | pmid:3913158 |
Simons LA et al. | On the effects of dietary n-3 fatty acids (Maxepa) on plasma lipids and lipoproteins in patients with hyperlipidaemia. | 1985 | Atherosclerosis | pmid:3888229 |
Skorepa J et al. | [The effect of fish oils on plasma lipid levels in hyperlipidemics]. | 1985 | Cas. Lek. Cesk. | pmid:3896497 |
Cartwright IJ et al. | The effects of dietary omega-3 polyunsaturated fatty acids on erythrocyte membrane phospholipids, erythrocyte deformability and blood viscosity in healthy volunteers. | 1985 | Atherosclerosis | pmid:4015748 |
Rebello T and Watts DC | Gastrocnemius muscle lipids in relation to diet in two mouse mutants, 129Re-dy and A2G-adr, with abnormal muscle function. | 1985 | J. Neurochem. | pmid:3158720 |
Lee TH et al. | Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. | 1985 | N. Engl. J. Med. | pmid:2985986 |
Singer P et al. | Influence on serum lipids, lipoproteins and blood pressure of mackerel and herring diet in patients with type IV and V hyperlipoproteinemia. | 1985 | Atherosclerosis | pmid:2992534 |
Barcelli U et al. | Enhancing effect of dietary supplementation with omega-3 fatty acids on plasma fibrinolysis in normal subjects. | 1985 | Thromb. Res. | pmid:2996169 |
von Schacky C et al. | Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. | 1985 | J. Clin. Invest. | pmid:2997286 |
Reddy TS et al. | Change in content, incorporation and lipoxygenation of docosahexaenoic acid in retina and retinal pigment epithelium in canine ceroid lipofuscinosis. | 1985 | Neurosci. Lett. | pmid:2931631 |
Cunnane SC et al. | Magnesium deficiency in the rat increases tissue levels of docosahexaenoic acid. | 1985 | J. Nutr. | pmid:2932544 |
Reynolds JW | Enteral and parenteral nutrition of low birth weight infants. | 1985 | Bol Asoc Med P R | pmid:2933046 |
Mabe H et al. | [Effect of calcium entry blocker, nimodipine, on the cerebral function and metabolic recovery following experimental cerebral ischemia]. | 1985 | No To Shinkei | pmid:2934079 |
Dietary fish oil increases omega-3 long-chain polyunsaturated fatty acids in human milk. | 1985 | Nutr. Rev. | pmid:2934649 | |
Sugiura T et al. | Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2935146 |
Parks JE and Hammerstedt RH | Development changes occurring in the lipids of ram epididymal spermatozoa plasma membrane. | 1985 | Biol. Reprod. | pmid:3158356 |
Singer P et al. | Blood pressure- and lipid-lowering effect of mackerel and herring diet in patients with mild essential hypertension. | 1985 | Atherosclerosis | pmid:3000395 |
von Schacky C and Weber PC | Metabolism and effects on platelet function of the purified eicosapentaenoic and docosahexaenoic acids in humans. | 1985 | J. Clin. Invest. | pmid:3001149 |
Green D et al. | A double-blind, placebo-controlled trial of fish oil concentrate (MaxEpa) in stroke patients. | 1985 Jul-Aug | Stroke | pmid:3895595 |
Cendrowski W | Multiple sclerosis and MaxEPA. | 1986 | Br J Clin Pract | pmid:3542002 |
Applegate KR and Glomset JA | Computer-based modeling of the conformation and packing properties of docosahexaenoic acid. | 1986 | J. Lipid Res. | pmid:2943846 |
Weiner MA | Cholesterol in foods rich in omega-3 fatty acids. | 1986 | N. Engl. J. Med. | pmid:2943996 |
Haines AP et al. | Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. | 1986 | Thromb. Res. | pmid:3020732 |
Croset M and Lagarde M | In vitro incorporation and metabolism of icosapentaenoic and docosahexaenoic acids in human platelets--effect on aggregation. | 1986 | Thromb. Haemost. | pmid:3022414 |
Croft KD et al. | The effect of dietary fish oil on platelet metabolism of 14C arachidonic acid. | 1986 | Thromb. Res. | pmid:3705024 |
Masuzawa Y et al. | Selective acylation of alkyllysophospholipids by docosahexaenoic acid in Ehrlich ascites cells. | 1986 | Biochim. Biophys. Acta | pmid:2936397 |
Hsia JC et al. | Determination of the distribution of fatty acids and diethylstilbestrol between serum albumin and alpha-fetoprotein by concanavalin A affinity chromatography. | 1986 | Biochim. Biophys. Acta | pmid:2417630 |
Huterer S and Wherrett JR | Incorporation of polyunsaturated fatty acids into bis(monoacylglycero)phosphate and other lipids of macrophages and of fibroblasts from control and Niemann-Pick patients. | 1986 | Biochim. Biophys. Acta | pmid:2937457 |
German JB et al. | Lipoxygenase in trout gill tissue acting on arachidonic, eicosapentaenoic and docosahexaenoic acids. | 1986 | Biochim. Biophys. Acta | pmid:3000452 |
Maddaiah VT and Clejan S | Growth hormone and liver mitochondria: time course of effects on respiration and fatty acid composition in hypophysectomized rats. | 1986 | Endocrinology | pmid:2941269 |
Hagve TA and Christophersen BO | Evidence for peroxisomal retroconversion of adrenic acid (22:4(n-6)) and docosahexaenoic acids (22:6(n-3)) in isolated liver cells. | 1986 | Biochim. Biophys. Acta | pmid:2935195 |
German JB and Kinsella JE | Hydroperoxide metabolism in trout gill tissue: effect of glutathione on lipoxygenase products generated from arachidonic acid and docosahexaenoic acid. | 1986 | Biochim. Biophys. Acta | pmid:2946321 |
Bazan NG et al. | Decreased content of docosahexaenoate and arachidonate in plasma phospholipids in Usher's syndrome. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2948509 |
Carlson SE et al. | Docosahexaenoic acid status of preterm infants at birth and following feeding with human milk or formula. | 1986 | Am. J. Clin. Nutr. | pmid:2947455 |
Meduri R et al. | [Effects of zinc and docosahexenoic acid on the corneal and cerebral lesions of rabbits infected with herpesvirus]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947654 |
Scorolli L et al. | [Changes induced by zinc and docosahexenoic acid in acute NaIO3 poisoning]. | 1986 | Bull Mem Soc Fr Ophtalmol | pmid:2947655 |
Hong CY et al. | Effect of phosphatidylcholine, lysophosphatidylcholine, arachidonic acid and docosahexaenoic acid on the motility of human sperm. | 1986 | Int. J. Androl. | pmid:2947864 |
Ziboh VA et al. | Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids. Modulation of clinical course of psoriatic subjects. | 1986 | Arch Dermatol | pmid:3022655 |
Organisciak DT et al. | Rod outer segment lipids in vitamin A-adequate and -deficient rats. | 1986 | Exp. Eye Res. | pmid:2937648 |
Tou JS | Acylation of docosahexaenoic acid into phospholipids by intact human neutrophils. | 1986 | Lipids | pmid:2941637 |
Yergey JA et al. | High-performance liquid chromatography/thermospray mass spectrometry of eicosanoids and novel oxygenated metabolites of docosahexaenoic acid. | 1986 | Anal. Chem. | pmid:2942056 |
Guisto NM et al. | Active labeling of phosphatidylcholines by [1-14C]docosahexaenoate in isolated photoreceptor membranes. | 1986 | Biochim. Biophys. Acta | pmid:2942188 |
Lee TH et al. | Enhancement of plasma levels of biologically active leukotriene B compounds during anaphylaxis in guinea pigs pretreated by indomethacin or by a fish oil-enriched diet. | 1986 | J. Immunol. | pmid:3005414 |
Singer P et al. | Long-term effect of mackerel diet on blood pressure, serum lipids and thromboxane formation in patients with mild essential hypertension. | 1986 | Atherosclerosis | pmid:3026412 |
Norris PG et al. | Effect of dietary supplementation with fish oil on systolic blood pressure in mild essential hypertension. | 1986 | Br Med J (Clin Res Ed) | pmid:3089408 |
Rylance PB et al. | Fish oil modifies lipids and reduces platelet aggregability in haemodialysis patients. | 1986 | Nephron | pmid:3724927 |
Sullivan DR et al. | Paradoxical elevation of LDL apoprotein B levels in hypertriglyceridaemic patients and normal subjects ingesting fish oil. | 1986 | Atherosclerosis | pmid:3753548 |
Claeys M et al. | Diacylglycerols interfere in normal phase HPLC analysis of lipoxygenase products of docosahexaenoic or arachidonic acids. | 1986 | Prostaglandins | pmid:2951768 |
Philbrick DJ et al. | Ingestion of fish oil or a derived n-3 fatty acid concentrate containing eicosapentaenoic acid (EPA) affects fatty acid compositions of individual phospholipids of rat brain, sciatic nerve and retina. | 1987 | J. Nutr. | pmid:2822876 |
Liu YJ | [Biological activity and mechanism of action of eicosapentaenic acid and docosahexaenoic acid from fish oil]. | 1987 | Sheng Li Ke Xue Jin Zhan | pmid:2823380 |
Bjørneboe A et al. | Effect of dietary supplementation with eicosapentaenoic acid in the treatment of atopic dermatitis. | 1987 | Br. J. Dermatol. | pmid:2823859 |
Licensed fish-oil concentrate versus cod-liver oil. | 1987 | Lancet | pmid:2887752 | |
Jones RG and Henderson MJ | Fish oils as medicines. | 1987 | Lancet | pmid:2887931 |
Chamberlain JG and Belton C | Effects of long term consumption of fish oil (Maxepa) on serum lipids and arterial ultrastructure in Japanese quail (Coturnix coturnix japonica). | 1987 | Atherosclerosis | pmid:3689486 |