Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hsiao HM et al. | Resolvin D1 Reduces Emphysema and Chronic Inflammation. | 2015 | Am. J. Pathol. | pmid:26468975 |
Maekawa T et al. | Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway. | 2015 | Nat Commun | pmid:26374165 |
Herrera BS et al. | LXA4 actions direct fibroblast function and wound closure. | 2015 | Biochem. Biophys. Res. Commun. | pmid:26188508 |
Shevalye H et al. | Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. | 2015 | J. Neurophysiol. | pmid:25925322 |
Fiala M et al. | ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment. | 2015 | FASEB J. | pmid:25805829 |
Guichardant M et al. | Omega-3 polyunsaturated fatty acids and oxygenated metabolism in atherothrombosis. | 2015 | Biochim. Biophys. Acta | pmid:25263947 |
Cox R et al. | Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. | 2015 | Am. J. Respir. Cell Mol. Biol. | pmid:25647402 |
Gavzan H et al. | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. | 2015 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:26018398 |
Chiang N et al. | Identification of resolvin D2 receptor mediating resolution of infections and organ protection. | 2015 | J. Exp. Med. | pmid:26195725 |
Marinho GS et al. | Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. | 2015 | Mar Drugs | pmid:26184241 |
Koh AS et al. | The association between dietary omega-3 fatty acids and cardiovascular death: the Singapore Chinese Health Study. | 2015 | Eur J Prev Cardiol | pmid:24343844 |
Wang X et al. | Resolution of inflammation is altered in Alzheimer's disease. | 2015 | Alzheimers Dement | pmid:24530025 |
Calandria JM et al. | NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival. | 2015 | Cell Death Differ. | pmid:25633199 |
Orban T et al. | Serum levels of lipid metabolites in age-related macular degeneration. | 2015 | FASEB J. | pmid:26187344 |
Serhan CN et al. | Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. | 2015 | Biochim. Biophys. Acta | pmid:25139562 |
Wang CW et al. | Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. | 2015 | Infect. Immun. | pmid:26667839 |
Hashim RB et al. | Fatty acid compositions of silver catfish, Pangasius sp. farmed in several rivers of Pahang, Malaysia. | 2015 | J Oleo Sci | pmid:25748380 |
Tyurina YY et al. | LC/MS analysis of cardiolipins in substantia nigra and plasma of rotenone-treated rats: Implication for mitochondrial dysfunction in Parkinson's disease. | 2015 | Free Radic. Res. | pmid:25740198 |
Clouard C et al. | Dietary linoleic and α-linolenic acids affect anxiety-related responses and exploratory activity in growing pigs. | 2015 | J. Nutr. | pmid:25644359 |
Hsieh JC et al. | High-Oleic Ready-to-Use Therapeutic Food Maintains Docosahexaenoic Acid Status in Severe Malnutrition. | 2015 | J. Pediatr. Gastroenterol. Nutr. | pmid:25633498 |
Wang Y et al. | Mesoscale Simulations and Experimental Studies of pH-Sensitive Micelles for Controlled Drug Delivery. | 2015 | ACS Appl Mater Interfaces | pmid:26539742 |
Ercan S et al. | Induction of omega 6 inflammatory pathway by sodium metabisulfite in rat liver and its attenuation by ghrelin. | 2015 | Lipids Health Dis | pmid:25889219 |
Sekhon-Loodu S et al. | Docosahexaenoic acid ester of phloridzin inhibit lipopolysaccharide-induced inflammation in THP-1 differentiated macrophages. | 2015 | Int. Immunopharmacol. | pmid:25637769 |
Wang Y et al. | Mesoscopic simulation studies on the formation mechanism of drug loaded polymeric micelles. | 2015 | Colloids Surf B Biointerfaces | pmid:26454543 |
Berge RK et al. | Krill oil reduces plasma triacylglycerol level and improves related lipoprotein particle concentration, fatty acid composition and redox status in healthy young adults - a pilot study. | 2015 | Lipids Health Dis | pmid:26666303 |
Morin C et al. | Eicosapentaenoic acid and docosapentaenoic acid monoglycerides are more potent than docosahexaenoic acid monoglyceride to resolve inflammation in a rheumatoid arthritis model. | 2015 | Arthritis Res. Ther. | pmid:26022389 |
Yoshinaga K et al. | Differential effects of triacylglycerol positional isomers containing n-3 series highly unsaturated fatty acids on lipid metabolism in C57BL/6J mice. | 2015 | J. Nutr. Biochem. | pmid:25448607 |
Hiram R et al. | Resolvin E1 normalizes contractility, Ca2+ sensitivity and smooth muscle cell migration rate in TNF-α- and IL-6-pretreated human pulmonary arteries. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:26320154 |
Cheatham CL and Sheppard KW | Synergistic Effects of Human Milk Nutrients in the Support of Infant Recognition Memory: An Observational Study. | 2015 | Nutrients | pmid:26540073 |
Lucena CF et al. | Omega-3 supplementation improves pancreatic islet redox status: in vivo and in vitro studies. | 2015 | Pancreas | pmid:25426612 |
Samokhvalov V et al. | PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. | 2015 | Toxicol. Lett. | pmid:25300478 |
Wang Y et al. | Maresin 1 Inhibits Epithelial-to-Mesenchymal Transition in Vitro and Attenuates Bleomycin Induced Lung Fibrosis in Vivo. | 2015 | Shock | pmid:26196843 |
Block RC et al. | The effects of aspirin on platelet function and lysophosphatidic acids depend on plasma concentrations of EPA and DHA. | 2015 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:25555354 |
Véricel E et al. | Moderate oral supplementation with docosahexaenoic acid improves platelet function and oxidative stress in type 2 diabetic patients. | 2015 | Thromb. Haemost. | pmid:25832443 |
Wijendran V et al. | Long-chain polyunsaturated fatty acids attenuate the IL-1β-induced proinflammatory response in human fetal intestinal epithelial cells. | 2015 | Pediatr. Res. | pmid:26270575 |
Mansara PP et al. | Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231. | 2015 | PLoS ONE | pmid:26325577 |
Mohajeri S and Newman SA | Review of evidence for dietary influences on atopic dermatitis. | 2014 Jul-Aug | Skin Therapy Lett. | pmid:25188523 |
Akimov MG et al. | [The influence of docosahexaenoic acid moiety on cytotoxic activity of 1,2,4-thiadiazole derivatives]. | 2014 Jul-Aug | Biomed Khim | pmid:25249531 |
Kar S | Omacor and omega-3 fatty acids for treatment of coronary artery disease and the pleiotropic effects. | 2014 Jan-Feb | Am J Ther | pmid:21975796 |
Casanova E et al. | Omega-3 polyunsaturated fatty acids and proanthocyanidins improve postprandial metabolic flexibility in rat. | 2014 Jan-Feb | Biofactors | pmid:23983179 |
Harris WS and Schmitt TL | Unexpected similarity in RBC DHA and AA levels between bottlenose dolphins and humans. | 2014 Feb-Mar | Prostaglandins Leukot. Essent. Fatty Acids | pmid:24393427 |
Ponnampalam EN et al. | Health beneficial long chain omega-3 fatty acid levels in Australian lamb managed under extensive finishing systems. | 2014 | Meat Sci. | pmid:23643471 |
Wang S et al. | Lipid content in hepatic and gonadal adipose tissue parallel aortic cholesterol accumulation in mice fed diets with different omega-6 PUFA to EPA plus DHA ratios. | 2014 | Clin Nutr | pmid:23672804 |
White PJ et al. | Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis. | 2014 | Nat. Med. | pmid:24813250 |
Balas L et al. | Confusion between protectin D1 (PD1) and its isomer protectin DX (PDX). An overview on the dihydroxy-docosatrienes described to date. | 2014 | Biochimie | pmid:24262603 |
Zhao JP et al. | Circulating docosahexaenoic acid levels are associated with fetal insulin sensitivity. | 2014 | PLoS ONE | pmid:24454790 |
Fredman G et al. | Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25246560 |
Hashimoto M et al. | Possibility of polyunsaturated fatty acids for the prevention and treatment of neuropsychiatric illnesses. | 2014 | J. Pharmacol. Sci. | pmid:24561447 |
Höper AC et al. | Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice. | 2014 | J. Nutr. | pmid:24285691 |
Walker CG et al. | Age and sex differences in the incorporation of EPA and DHA into plasma fractions, cells and adipose tissue in humans. | 2014 | Br. J. Nutr. | pmid:24063767 |