Dha is a lipid of Fatty Acyls (FA) class. Dha is associated with abnormalities such as Atherosclerosis, Consumption-archaic term for TB, Chronic disease, Cardiovascular Diseases and Diabetes Mellitus, Non-Insulin-Dependent. The involved functions are known as Inflammation, Oxidation, fatty acid oxidation, Fatty Acid Metabolism and Lipid Metabolism. Dha often locates in Hepatic, Protoplasm, Mucous Membrane, Epithelium and outer membrane. The associated genes with DHA are IMPACT gene, FATE1 gene, GAPDH gene, THOC4 gene and SLC33A1 gene. The related lipids are stearidonic acid, Fatty Acids, Total cholesterol, Lipopolysaccharides and Dietary Fatty Acid. The related experimental models are Mouse Model, Transgenic Model, Animal Disease Models and Arthritis, Experimental.
To understand associated biological information of DHA, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
DHA is suspected in Cardiovascular Diseases, Obesity, Ischemia, Hypertensive disease, Coronary Arteriosclerosis, Cerebrovascular accident and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with DHA
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Mouse Model are used in the study 'Homeostatic regulation of photoreceptor cell integrity: significance of the potent mediator neuroprotectin D1 biosynthesized from docosahexaenoic acid: the Proctor Lecture.' (Bazan NG, 2007), Mouse Model are used in the study 'Omega-3 fatty acids EPA and DHA: health benefits throughout life.' (Swanson D et al., 2012), Mouse Model are used in the study 'Docosahexaenoic acid attenuates hepatic inflammation, oxidative stress, and fibrosis without decreasing hepatosteatosis in a Ldlr(-/-) mouse model of western diet-induced nonalcoholic steatohepatitis.' (Depner CM et al., 2013) and Mouse Model are used in the study 'Wax esters from the marine copepod Calanus finmarchicus reduce diet-induced obesity and obesity-related metabolic disorders in mice.' (Höper AC et al., 2014).
Transgenic Model are used in the study 'Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.' (Ma QL et al., 2014).
Animal Disease Models are used in the study 'Fish oil increases muscle protein mass and modulates Akt/FOXO, TLR4, and NOD signaling in weanling piglets after lipopolysaccharide challenge.' (Liu Y et al., 2013).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Reddy TS et al. | Change in content, incorporation and lipoxygenation of docosahexaenoic acid in retina and retinal pigment epithelium in canine ceroid lipofuscinosis. | 1985 | Neurosci. Lett. | pmid:2931631 |
Bourre JM and Dumont O | The administration of pig brain phospholipids versus soybean phospholipids in the diet during the period of brain development in the rat results in greater increments of brain docosahexaenoic acid. | 2002 | Neurosci. Lett. | pmid:12459515 |
Gazzah N et al. | Evidence for brain docosahexaenoate recycling in the free-moving adult rat: implications for measurement of phospholipid synthesis. | 1994 | Neurosci. Lett. | pmid:7824158 |
Sarda N et al. | Docosahexaenoic acid (cervonic acid) incorporation into different brain regions in the awake rat. | 1991 | Neurosci. Lett. | pmid:1829511 |
Young C et al. | Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus. | 1998 | Neurosci. Lett. | pmid:9655627 |
Vaidyanathan VV et al. | Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. | 1994 | Neurosci. Lett. | pmid:7845615 |
Alberghina M et al. | Differential transport of docosahexaenoate and palmitate through the blood-retina and blood-brain barrier of the rat. | 1994 | Neurosci. Lett. | pmid:8084474 |
Fonlupt P et al. | Incorporation of arachidonic and docosahexaenoic acids into phospholipids of rat brain membranes. | 1994 | Neurosci. Lett. | pmid:8084475 |
Kotani S et al. | Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction. | 2006 | Neurosci. Res. | pmid:16905216 |
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Okada M et al. | The chronic administration of docosahexaenoic acid reduces the spatial cognitive deficit following transient forebrain ischemia in rats. | 1996 | Neuroscience | pmid:8834389 |
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Horimoto N et al. | Arachidonic acid activation of potassium channels in rat visual cortex neurons. | 1997 | Neuroscience | pmid:9070743 |
Wu A et al. | Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. | 2008 | Neuroscience | pmid:18620024 |
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